hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04608
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | UniProt NCBI |
| ZNF589 | Zinc finger protein 589 (Stem cell zinc finger protein 1) | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | UniProt NCBI |
| ZNF268 | Zinc finger protein 268 (Zinc finger protein HZF3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3113 | 1.35146690511e-09 | 0.6 | RBPJ MAML1 NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2897 | 1.35146690511e-09 | 0.6 | RBPJ MAML1 NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 1.35146690511e-09 | 0.6 | RBPJ MAML1 NOTCH1 | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2639 | 3.86130280192e-07 | 0.6 | RBPJ MAML1 NOTCH1 | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-8941856 | 7.76884875116e-07 | 0.6 | RBPJ MAML1 NOTCH1 | RUNX3 regulates NOTCH signaling |
| GO:0002193 | 9.08185760231e-07 | 0.6 | RBPJ MAML1 NOTCH1 | MAML1-RBP-Jkappa- ICN1 complex |
| REAC:R-HSA-210744 | 9.88662921473e-07 | 0.6 | RBPJ MAML1 NOTCH1 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| WP:WP3845 | 1.35872715505e-06 | 0.6 | RBPJ MAML1 NOTCH1 | Canonical and Non-canonical Notch signaling |
| REAC:R-HSA-9013695 | 2.63058148282e-06 | 0.6 | RBPJ MAML1 NOTCH1 | NOTCH4 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9013508 | 4.80586315819e-06 | 0.6 | RBPJ MAML1 NOTCH1 | NOTCH3 Intracellular Domain Regulates Transcription |
| WP:WP268 | 6.12580709064e-06 | 0.6 | RBPJ MAML1 NOTCH1 | Notch Signaling |
| CORUM:2907 | 6.70868171695e-06 | 0.4 | RBPJ NOTCH1 | RBP-Jkappa-Notch1 complex |
| REAC:R-HSA-350054 | 7.93420714119e-06 | 0.6 | RBPJ MAML1 NOTCH1 | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 9.90965664735e-06 | 0.6 | RBPJ MAML1 NOTCH1 | Regulation of beta-cell development |
| KEGG:04330 | 1.39628931268e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Notch signaling pathway |
| WP:WP61 | 1.85486617316e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Notch Signaling Pathway |
| CORUM:2946 | 2.0123342217e-05 | 0.4 | RBPJ NOTCH1 | YY1-Notch1-RBP-Jkappa complex |
| REAC:R-HSA-2122947 | 3.34215806492e-05 | 0.6 | RBPJ MAML1 NOTCH1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9012852 | 3.58634423945e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH3 |
| KEGG:04658 | 4.90975651011e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-2644603 | 6.33776832781e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644606 | 6.33776832781e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 6.33776832781e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2644602 | 6.33776832781e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894858 | 6.33776832781e-05 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-1980143 | 0.000112594374126 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH1 |
| WP:WP4147 | 0.000120106591846 | 0.4 | RBPJ NOTCH1 | PTF1A related regulatory pathway |
| REAC:R-HSA-9013694 | 0.000213382377717 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH4 |
| REAC:R-HSA-212436 | 0.000239251603487 | 1.0 | ZNF589 NOTCH1 ZNF268 MAML1 RBPJ | Generic Transcription Pathway |
| REAC:R-HSA-1912408 | 0.000327410819085 | 0.6 | RBPJ MAML1 NOTCH1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-8878159 | 0.000338412904811 | 0.6 | RBPJ MAML1 NOTCH1 | Transcriptional regulation by RUNX3 |
| REAC:R-HSA-73857 | 0.000412889072144 | 1.0 | ZNF589 NOTCH1 ZNF268 MAML1 RBPJ | RNA Polymerase II Transcription |
| REAC:R-HSA-2197563 | 0.000485460775426 | 0.4 | RBPJ MAML1 | NOTCH2 intracellular domain regulates transcription |
| REAC:R-HSA-1912422 | 0.000534065976599 | 0.6 | RBPJ MAML1 NOTCH1 | Pre-NOTCH Expression and Processing |
| GO:0007221 | 0.000616695699567 | 0.6 | RBPJ MAML1 NOTCH1 | positive regulation of transcription of Notch receptor target |
| REAC:R-HSA-74160 | 0.000713316403356 | 1.0 | ZNF589 NOTCH1 ZNF268 MAML1 RBPJ | Gene expression (Transcription) |
| KEGG:05165 | 0.00420236199627 | 0.6 | RBPJ MAML1 NOTCH1 | Human papillomavirus infection |
| MIRNA:hsa-miR-30a-3p | 0.0043801570081 | 0.6 | NOTCH1 MAML1 ZNF268 | hsa-miR-30a-3p |
| GO:0045747 | 0.0044914523029 | 0.6 | RBPJ MAML1 NOTCH1 | positive regulation of Notch signaling pathway |
| REAC:R-HSA-157118 | 0.0046564839046 | 0.6 | RBPJ MAML1 NOTCH1 | Signaling by NOTCH |
| HP:0004050 | 0.00487153229182 | 0.4 | RBPJ NOTCH1 | Absent hand |
| HP:0004935 | 0.00487153229182 | 0.4 | RBPJ NOTCH1 | Pulmonary artery atresia |
| REAC:R-HSA-1980145 | 0.00508433997358 | 0.4 | RBPJ MAML1 | Signaling by NOTCH2 |
| WP:WP2840 | 0.00606287998997 | 0.4 | RBPJ NOTCH1 | Hair Follicle Development: Cytodifferentiation (Part 3 of 3) |
| HP:0002040 | 0.00630809873773 | 0.4 | RBPJ NOTCH1 | Esophageal varix |
| HP:0006970 | 0.00709565752293 | 0.4 | RBPJ NOTCH1 | Periventricular leukomalacia |
| HP:0001362 | 0.00709565752293 | 0.4 | RBPJ NOTCH1 | Calvarial skull defect |
| WP:WP2064 | 0.00942314458108 | 0.4 | RBPJ NOTCH1 | Neural Crest Differentiation |
| HP:0002132 | 0.0138999712057 | 0.4 | RBPJ NOTCH1 | Porencephalic cyst |
| REAC:R-HSA-5663202 | 0.016617401989 | 0.6 | RBPJ MAML1 NOTCH1 | Diseases of signal transduction |
| HP:0001817 | 0.0215275853758 | 0.4 | RBPJ NOTCH1 | Absent fingernail |
| HP:0001804 | 0.0215275853758 | 0.4 | RBPJ NOTCH1 | Hypoplastic fingernail |
| HP:0001057 | 0.0229596708254 | 0.4 | RBPJ NOTCH1 | Aplasia cutis congenita |
| WP:WP4239 | 0.0296692241758 | 0.4 | RBPJ NOTCH1 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0001409 | 0.0360671162807 | 0.4 | RBPJ NOTCH1 | Portal hypertension |
| GO:0008593 | 0.0394222084305 | 0.6 | RBPJ MAML1 NOTCH1 | regulation of Notch signaling pathway |
| HP:0002612 | 0.0398018408038 | 0.4 | RBPJ NOTCH1 | Congenital hepatic fibrosis |
| HP:0006707 | 0.0398018408038 | 0.4 | RBPJ NOTCH1 | Abnormality of the hepatic vasculature |
| GO:0003256 | 0.0450641792523 | 0.4 | RBPJ NOTCH1 | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| GO:0003160 | 0.0450641792523 | 0.4 | RBPJ NOTCH1 | endocardium morphogenesis |
| GO:0061419 | 0.0450641792523 | 0.4 | RBPJ NOTCH1 | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia |
| HP:0100026 | 0.0457467210618 | 0.4 | RBPJ NOTCH1 | Arteriovenous malformation |
| HP:0001171 | 0.0478196851342 | 0.4 | RBPJ NOTCH1 | Split hand |
| GO:0035051 | 0.0493791608738 | 0.6 | RBPJ MAML1 NOTCH1 | cardiocyte differentiation |
| HP:0001641 | 0.0499382869304 | 0.4 | RBPJ NOTCH1 | Abnormal pulmonary valve morphology |
| CORUM:2947 | 0.0499494897235 | 0.2 | NOTCH1 | YY1-Notch1 complex |
| CORUM:2908 | 0.0499494897235 | 0.2 | RBPJ | RBP-Jkappa-SHARP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 1.0 | 0.949 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | NOTCH1 | 0.863 | 0.799 | hein_WMM bioplex (RBPJ) bioplex_WMM hein (RBPJ) |
| RBPJ | ZNF589 | 0.329 | 0.518 | bioplex (RBPJ) bioplex_WMM |
| ZNF268 | RBPJ | 0.095 | 0.359 | bioplex (RBPJ) bioplex_WMM |
| MAML1 | NOTCH1 | 0.01 | 0.136 | hein_WMM bioplex_WMM WMM_only |
| ZNF268 | MAML1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| MAML1 | ZNF589 | 0.009 | 0.101 | bioplex_WMM WMM_only |
| ZNF268 | NOTCH1 | 0.008 | 0.086 | bioplex_WMM WMM_only |
| ZNF589 | NOTCH1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| ZNF268 | ZNF589 | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04608 has an average edge precision of 0.323 which is ranked 4310 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RBPJ | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| ZNF589 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |
| MAML1 | HuMAP2_01320 HuMAP2_01458 HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| NOTCH1 | HuMAP2_04096 HuMAP2_04608 HuMAP2_05094 HuMAP2_06455 |
| ZNF268 | HuMAP2_01320 HuMAP2_04096 HuMAP2_04608 HuMAP2_06455 |