hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04616
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ICE2 | Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2) | UniProt NCBI |
| APCDD1 | Protein APCDD1 (Adenomatosis polyposis coli down-regulated 1 protein) | UniProt NCBI |
| ELANE | Neutrophil elastase (EC 3.4.21.37) (Bone marrow serine protease) (Elastase-2) (Human leukocyte elastase) (HLE) (Medullasin) (PMN elastase) | UniProt NCBI |
| MUC5AC | Mucin-5AC (MUC-5AC) (Gastric mucin) (Lewis B blood group antigen) (LeB) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) | UniProt NCBI |
| CTSG | Cathepsin G (CG) (EC 3.4.21.20) | UniProt NCBI |
| MPO | Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1592389 | 0.0102563889288 | 0.333333333333 | ELANE CTSG | Activation of Matrix Metalloproteinases |
| REAC:R-HSA-6803157 | 0.029137346631 | 0.333333333333 | ELANE CTSG | Antimicrobial peptides |
| REAC:R-HSA-168249 | 0.0291400473135 | 0.666666666667 | ELANE MPO CTSG MUC5AC | Innate Immune System |
| KEGG:05322 | 0.0388413362769 | 0.333333333333 | ELANE CTSG | Systemic lupus erythematosus |
| CORUM:5388 | 0.0499726005494 | 0.166666666667 | ELANE | SERPINA1-ELA2 complex |
| CORUM:5389 | 0.0499726005494 | 0.166666666667 | CTSG | SERPINA3-CTSG complex |
| CORUM:5391 | 0.0499726005494 | 0.166666666667 | CTSG | SERPINA1-CTSG complex |
| CORUM:6825 | 0.0499726005494 | 0.166666666667 | MPO | CP-MPO complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ICE2 | MPO | 0.844 | 0.788 | bioplex (ICE2) bioplex_WMM |
| ICE2 | CTSG | 0.466 | 0.604 | bioplex (ICE2) bioplex_WMM |
| ICE2 | ELANE | 0.291 | 0.492 | bioplex (ICE2) bioplex_WMM |
| ICE2 | MUC5AC | 0.097 | 0.358 | bioplex (ICE2) bioplex_WMM |
| CTSG | APCDD1 | 0.033 | 0.253 | bioplex (APCDD1) bioplex_WMM |
| MPO | APCDD1 | 0.028 | 0.23 | bioplex (APCDD1) bioplex_WMM |
| MPO | CTSG | 0.01 | 0.12 | bioplex_WMM WMM_only treiber_WMM |
| MPO | MUC5AC | 0.009 | 0.098 | bioplex_WMM WMM_only |
| MUC5AC | CTSG | 0.009 | 0.095 | bioplex_WMM WMM_only |
| ELANE | MUC5AC | 0.008 | 0.091 | bioplex_WMM WMM_only |
| ELANE | CTSG | 0.008 | 0.092 | bioplex_WMM WMM_only treiber_WMM |
| MPO | ELANE | 0.008 | 0.082 | bioplex_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_04616 has an average edge precision of 0.275 which is ranked 4951 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ICE2 | HuMAP2_03305 HuMAP2_04616 HuMAP2_05455 HuMAP2_06200 |
| APCDD1 | HuMAP2_04616 HuMAP2_05455 HuMAP2_06200 |
| ELANE | HuMAP2_04616 HuMAP2_05455 HuMAP2_06200 |
| MUC5AC | HuMAP2_04616 HuMAP2_04838 |
| CTSG | HuMAP2_04616 HuMAP2_05455 HuMAP2_06200 |
| MPO | HuMAP2_03305 HuMAP2_04616 HuMAP2_05455 HuMAP2_06200 |