hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04630
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KPNA1 | Importin subunit alpha-5 (Karyopherin subunit alpha-1) (Nucleoprotein interactor 1) (NPI-1) (RAG cohort protein 2) (SRP1-beta) [Cleaved into: Importin subunit alpha-5, N-terminally processed] | UniProt NCBI |
| KPNA6 | Importin subunit alpha-7 (Karyopherin subunit alpha-6) | UniProt NCBI |
| RNMT | mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | UniProt NCBI |
| KPNA5 | Importin subunit alpha-6 (Karyopherin subunit alpha-5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05164 | 0.000141415901292 | 0.75 | KPNA5 KPNA1 KPNA6 | Influenza A |
| GO:0006607 | 0.000413778117181 | 0.75 | KPNA5 KPNA1 KPNA6 | NLS-bearing protein import into nucleus |
| GO:0008139 | 0.000558907067709 | 0.75 | KPNA5 KPNA1 KPNA6 | nuclear localization sequence binding |
| GO:0005048 | 0.00331394418715 | 0.75 | KPNA5 KPNA1 KPNA6 | signal sequence binding |
| REAC:R-HSA-168276 | 0.00667602194349 | 0.5 | KPNA5 KPNA1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-168253 | 0.0070462802506 | 0.5 | KPNA5 KPNA1 | Host Interactions with Influenza Factors |
| REAC:R-HSA-5663205 | 0.0100576606226 | 0.75 | KPNA5 KPNA1 RNMT | Infectious disease |
| REAC:R-HSA-1169408 | 0.0221036214141 | 0.5 | KPNA5 KPNA1 | ISG15 antiviral mechanism |
| GO:0005643 | 0.0264744736345 | 0.75 | KPNA5 KPNA1 KPNA6 | nuclear pore |
| REAC:R-HSA-1169410 | 0.0269852439715 | 0.5 | KPNA5 KPNA1 | Antiviral mechanism by IFN-stimulated genes |
| MIRNA:hsa-miR-337-3p | 0.0431373399917 | 0.5 | KPNA6 RNMT | hsa-miR-337-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KPNA1 | RNMT | 0.06 | 0.335 | hein_WMM bioplex (RNMT) bioplex_WMM youn_WMM hein (KPNA1) |
| KPNA6 | KPNA1 | 0.05 | 0.296 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| KPNA6 | RNMT | 0.033 | 0.252 | bioplex (RNMT) bioplex_WMM youn_WMM |
| KPNA5 | RNMT | 0.023 | 0.21 | bioplex (RNMT) bioplex_WMM youn_WMM |
| KPNA6 | KPNA5 | 0.012 | 0.146 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KPNA1 | KPNA5 | 0.012 | 0.144 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04630 has an average edge precision of 0.231 which is ranked 5689 out of all 6965 complexes.
Related Complexes