hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04638
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110) | UniProt NCBI |
| STAM | Signal transducing adapter molecule 1 (STAM-1) | UniProt NCBI |
| STAM2 | Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0033565 | 9.08185760231e-08 | 1.0 | HGS STAM2 STAM | ESCRT-0 complex |
| REAC:R-HSA-8875360 | 1.63653275606e-07 | 1.0 | HGS STAM2 STAM | InlB-mediated entry of Listeria monocytogenes into host cell |
| REAC:R-HSA-8876384 | 4.35659406764e-07 | 1.0 | HGS STAM2 STAM | Listeria monocytogenes entry into host cells |
| REAC:R-HSA-6807004 | 5.12540478546e-07 | 1.0 | HGS STAM2 STAM | Negative regulation of MET activity |
| REAC:R-HSA-182971 | 1.03407289531e-06 | 1.0 | HGS STAM2 STAM | EGFR downregulation |
| REAC:R-HSA-917729 | 2.02093811497e-06 | 1.0 | HGS STAM2 STAM | Endosomal Sorting Complex Required For Transport (ESCRT) |
| REAC:R-HSA-177929 | 5.54847547872e-06 | 1.0 | HGS STAM2 STAM | Signaling by EGFR |
| CORUM:7287 | 1.00675659188e-05 | 0.666666666667 | HGS STAM | SIMPLE-HRS-STAM1 complex |
| CORUM:3677 | 1.00675659188e-05 | 0.666666666667 | HGS STAM2 | RIN1-STAM2-HRS complex |
| REAC:R-HSA-6806834 | 2.79631294769e-05 | 1.0 | HGS STAM2 STAM | Signaling by MET |
| WP:WP437 | 4.31497733684e-05 | 1.0 | HGS STAM2 STAM | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-8856825 | 5.10580236014e-05 | 1.0 | HGS STAM2 STAM | Cargo recognition for clathrin-mediated endocytosis |
| KEGG:04144 | 6.09806140287e-05 | 1.0 | HGS STAM2 STAM | Endocytosis |
| REAC:R-HSA-8856828 | 0.000157135918784 | 1.0 | HGS STAM2 STAM | Clathrin-mediated endocytosis |
| GO:0036452 | 0.000208882724853 | 1.0 | HGS STAM2 STAM | ESCRT complex |
| GO:0036258 | 0.000368723418654 | 1.0 | HGS STAM2 STAM | multivesicular body assembly |
| GO:0036257 | 0.000408229499224 | 1.0 | HGS STAM2 STAM | multivesicular body organization |
| GO:0042059 | 0.000766145507331 | 1.0 | HGS STAM2 STAM | negative regulation of epidermal growth factor receptor signaling pathway |
| GO:1901185 | 0.00104259725275 | 1.0 | HGS STAM2 STAM | negative regulation of ERBB signaling pathway |
| REAC:R-HSA-5688426 | 0.0013944517953 | 1.0 | HGS STAM2 STAM | Deubiquitination |
| KEGG:04630 | 0.00323398213006 | 0.666666666667 | STAM STAM2 | JAK-STAT signaling pathway |
| REAC:R-HSA-5663205 | 0.00340936351327 | 1.0 | HGS STAM2 STAM | Infectious disease |
| GO:0042058 | 0.00435066388439 | 1.0 | HGS STAM2 STAM | regulation of epidermal growth factor receptor signaling pathway |
| GO:0007032 | 0.00497140885151 | 1.0 | HGS STAM2 STAM | endosome organization |
| REAC:R-HSA-9006934 | 0.00501472976187 | 1.0 | HGS STAM2 STAM | Signaling by Receptor Tyrosine Kinases |
| GO:1901184 | 0.00541641987402 | 1.0 | HGS STAM2 STAM | regulation of ERBB signaling pathway |
| GO:0007173 | 0.0121736852044 | 1.0 | HGS STAM2 STAM | epidermal growth factor receptor signaling pathway |
| REAC:R-HSA-199991 | 0.0146202486223 | 1.0 | HGS STAM2 STAM | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0171761243356 | 1.0 | HGS STAM2 STAM | Vesicle-mediated transport |
| GO:0038127 | 0.0218385980648 | 1.0 | HGS STAM2 STAM | ERBB signaling pathway |
| WP:WP3888 | 0.0226746026379 | 0.666666666667 | HGS STAM | VEGFA-VEGFR2 Signaling Pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STAM | HGS | 1.0 | 0.949 | bioplex (STAM) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| HGS | STAM2 | 0.988 | 0.901 | Guru youn_WMM Malo gupta_WMM fraction |
| STAM | STAM2 | 0.008 | 0.07 | youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04638 has an average edge precision of 0.64 which is ranked 1716 out of all 6965 complexes.
Related Complexes