hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04642

Confidence: Very High

Genename	Protein Name	Links
SDHAF2	Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)	UniProt NCBI
SDHB	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC 1.3.5.1) (Iron-sulfur subunit of complex II) (Ip)	UniProt NCBI
SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)	UniProt NCBI
SDHAF4	Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0003639	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Elevated urinary epinephrine
HP:0000740	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Episodic paroxysmal anxiety
HP:0010532	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Paroxysmal vertigo
HP:0008629	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Pulsatile tinnitus
HP:0002864	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Paraganglioma of head and neck
HP:0006737	5.03496710668e-07	0.75	SDHB SDHAF2 SDHA	Extraadrenal pheochromocytoma
HP:0012222	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Arachnoid hemangiomatosis
HP:0006748	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Adrenal pheochromocytoma
HP:0001095	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Hypertensive retinopathy
HP:0003574	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Positive regitine blocking test
HP:0100642	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Neoplasm of the adrenal medulla
HP:0003345	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Elevated urinary norepinephrine
HP:0009711	6.71295121779e-07	0.75	SDHB SDHAF2 SDHA	Retinal capillary hemangioma
HP:0002331	8.72639684801e-07	0.75	SDHB SDHAF2 SDHA	Recurrent paroxysmal headache
HP:0011979	8.72639684801e-07	0.75	SDHB SDHAF2 SDHA	Elevated urinary dopamine
HP:0002640	8.72639684801e-07	0.75	SDHB SDHAF2 SDHA	Hypertension associated with pheochromocytoma
HP:0003528	1.11057635982e-06	0.75	SDHB SDHAF2 SDHA	Elevated calcitonin
HP:0010797	1.11057635982e-06	0.75	SDHB SDHAF2 SDHA	Hemangioblastoma
HP:0002668	1.38815049192e-06	0.75	SDHB SDHAF2 SDHA	Paraganglioma
HP:0002666	1.38815049192e-06	0.75	SDHB SDHAF2 SDHA	Pheochromocytoma
GO:0005749	1.45302402969e-06	0.75	SDHB SDHAF4 SDHA	mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
GO:0045283	1.45302402969e-06	0.75	SDHB SDHAF4 SDHA	fumarate reductase complex
GO:0045281	1.45302402969e-06	0.75	SDHB SDHAF4 SDHA	succinate dehydrogenase complex
GO:0045273	1.45302402969e-06	0.75	SDHB SDHAF4 SDHA	respiratory chain complex II
GO:0045257	1.45302402969e-06	0.75	SDHB SDHAF4 SDHA	succinate dehydrogenase complex (ubiquinone)
HP:0031284	2.07438943256e-06	0.75	SDHB SDHAF2 SDHA	Flushing
HP:0001069	2.07438943256e-06	0.75	SDHB SDHAF2 SDHA	Episodic hyperhidrosis
HP:0009594	2.07438943256e-06	0.75	SDHB SDHAF2 SDHA	Retinal hamartoma
HP:0011703	2.48914185619e-06	0.75	SDHB SDHAF2 SDHA	Sinus tachycardia
HP:0011281	3.47712703514e-06	0.75	SDHB SDHAF2 SDHA	Abnormality of urine catecholamine concentration
HP:0011976	3.47712703514e-06	0.75	SDHB SDHAF2 SDHA	Elevated urinary catecholamines
HP:0010568	4.69669804797e-06	0.75	SDHB SDHAF2 SDHA	Hamartoma of the eye
HP:0001293	4.69669804797e-06	0.75	SDHB SDHAF2 SDHA	Cranial nerve compression
HP:0030670	4.69669804797e-06	0.75	SDHB SDHAF2 SDHA	Hamartoma of the orbital region
HP:0025269	8.91842784173e-06	0.75	SDHB SDHAF2 SDHA	Panic attack
HP:0100634	8.91842784173e-06	0.75	SDHB SDHAF2 SDHA	Neuroendocrine neoplasm
HP:0031801	9.98813548614e-06	0.75	SDHB SDHAF2 SDHA	Vocal cord dysfunction
HP:0002574	9.98813548614e-06	0.75	SDHB SDHAF2 SDHA	Episodic abdominal pain
HP:0001605	9.98813548614e-06	0.75	SDHB SDHAF2 SDHA	Vocal cord paralysis
HP:0032148	9.98813548614e-06	0.75	SDHB SDHAF2 SDHA	Episodic pain
HP:0100631	1.11400508422e-05	0.75	SDHB SDHAF2 SDHA	Neoplasm of the adrenal gland
HP:0100530	1.23772100297e-05	0.75	SDHB SDHAF2 SDHA	Abnormal calcium-phosphate regulating hormone level
HP:0000360	1.82389859666e-05	0.75	SDHB SDHAF2 SDHA	Tinnitus
HP:0000526	1.82389859666e-05	0.75	SDHB SDHAF2 SDHA	Aniridia
HP:0100012	2.17602308369e-05	0.75	SDHB SDHAF2 SDHA	Neoplasm of the eye
HP:0003072	3.2479768623e-05	0.75	SDHB SDHAF2 SDHA	Hypercalcemia
HP:0100007	3.2479768623e-05	0.75	SDHB SDHAF2 SDHA	Neoplasm of the peripheral nervous system
HP:0001342	3.49764472726e-05	0.75	SDHB SDHAF2 SDHA	Cerebral hemorrhage
HP:0011702	4.62400081268e-05	0.75	SDHB SDHAF2 SDHA	Abnormal electrophysiology of sinoatrial node origin
HP:0002018	4.939024284e-05	0.75	SDHB SDHAF2 SDHA	Nausea
HP:0000096	6.34193111797e-05	0.75	SDHB SDHAF2 SDHA	Glomerulosclerosis
HP:0005584	6.34193111797e-05	0.75	SDHB SDHAF2 SDHA	Renal cell carcinoma
HP:0030074	6.81856710606e-05	0.5	SDHB SDHAF2	Chemodectoma
HP:0003001	6.81856710606e-05	0.5	SDHB SDHAF2	Glomus jugular tumor
HP:0001962	8.4395655229e-05	0.75	SDHB SDHAF2 SDHA	Palpitations
HP:0010566	0.000120860429779	0.75	SDHB SDHAF2 SDHA	Hamartoma
HP:0100749	0.000126797979354	0.75	SDHB SDHAF2 SDHA	Chest pain
HP:0025191	0.000136359131835	0.5	SDHB SDHA	Segmental myoclonic seizures
HP:0011732	0.00015941280611	0.75	SDHB SDHAF2 SDHA	Abnormality of adrenal morphology
HP:0100835	0.000173880942073	0.75	SDHB SDHAF2 SDHA	Benign neoplasm of the central nervous system
HP:0001618	0.000181431813171	0.75	SDHB SDHAF2 SDHA	Dysphonia
HP:0040196	0.000227244870274	0.5	SDHB SDHA	Mild microcephaly
WP:WP78	0.000228185108581	0.5	SDHB SDHA	TCA Cycle (aka Krebs or citric acid cycle)
HP:0002321	0.000279357285882	0.75	SDHB SDHAF2 SDHA	Vertigo
HP:0002170	0.000333559712077	0.75	SDHB SDHAF2 SDHA	Intracranial hemorrhage
HP:0009726	0.000333559712077	0.75	SDHB SDHAF2 SDHA	Renal neoplasm
HP:0003756	0.000340836782771	0.5	SDHB SDHA	Skeletal myopathy
HP:0012817	0.000340836782771	0.5	SDHB SDHA	Noncompaction cardiomyopathy
HP:0004363	0.000369216596452	0.75	SDHB SDHAF2 SDHA	Abnormal circulating calcium concentration
HP:0100568	0.0004073240164	0.75	SDHB SDHAF2 SDHA	Neoplasm of the endocrine system
GO:0045333	0.000419088323416	1.0	SDHB SDHAF4 SDHAF2 SDHA	cellular respiration
HP:0008053	0.000434130330519	0.75	SDHB SDHAF2 SDHA	Aplasia/Hypoplasia of the iris
HP:0008055	0.000434130330519	0.75	SDHB SDHAF2 SDHA	Aplasia/Hypoplasia affecting the uvea
HP:0008062	0.000491214063164	0.75	SDHB SDHAF2 SDHA	Aplasia/Hypoplasia affecting the anterior segment of the eye
HP:0010927	0.000491214063164	0.75	SDHB SDHAF2 SDHA	Abnormal blood inorganic cation concentration
HP:0010786	0.000553085565358	0.75	SDHB SDHAF2 SDHA	Urinary tract neoplasm
HP:0001751	0.000569323965231	0.75	SDHB SDHAF2 SDHA	Vestibular dysfunction
HP:0012614	0.000585876554513	0.75	SDHB SDHAF2 SDHA	Abnormal urine cytology
HP:0000790	0.000585876554513	0.75	SDHB SDHAF2 SDHA	Hematuria
HP:0003470	0.000585876554513	0.75	SDHB SDHAF2 SDHA	Paralysis
HP:0001028	0.000585876554513	0.75	SDHB SDHAF2 SDHA	Hemangioma
HP:0000975	0.000619936255745	0.75	SDHB SDHAF2 SDHA	Hyperhidrosis
HP:0100742	0.000619936255745	0.75	SDHB SDHAF2 SDHA	Vascular neoplasm
HP:0007083	0.000636114718594	0.5	SDHB SDHA	Hyperactive patellar reflex
HP:0100006	0.000710792961621	0.75	SDHB SDHAF2 SDHA	Neoplasm of the central nervous system
HP:0000980	0.000810101694231	0.75	SDHB SDHAF2 SDHA	Pallor
KEGG:00020	0.000811520562786	0.5	SDHB SDHA	Citrate cycle (TCA cycle)
HP:0007272	0.000817788537784	0.5	SDHB SDHA	Progressive psychomotor deterioration
HP:0000095	0.000964043113657	0.75	SDHB SDHAF2 SDHA	Abnormality of renal glomerulus morphology
HP:0031263	0.000964043113657	0.75	SDHB SDHAF2 SDHA	Abnormal renal corpuscle morphology
HP:0011166	0.00102214412276	0.5	SDHB SDHA	Focal myoclonic seizures
HP:0000093	0.00124335446085	0.75	SDHB SDHAF2 SDHA	Proteinuria
HP:0011343	0.00124917537299	0.5	SDHB SDHA	Moderate global developmental delay
HP:0004375	0.00138633858335	0.75	SDHB SDHAF2 SDHA	Neoplasm of the nervous system
GO:0006099	0.00147288799354	0.75	SDHB SDHAF2 SDHA	tricarboxylic acid cycle
HP:0020129	0.00147716207969	0.75	SDHB SDHAF2 SDHA	Abnormal urine protein level
HP:0007350	0.00149887618857	0.5	SDHB SDHA	Hyperreflexia in upper limbs
HP:0011035	0.00157185823159	0.75	SDHB SDHAF2 SDHA	Abnormal renal cortex morphology
GO:0015980	0.00157802566628	1.0	SDHB SDHAF4 SDHAF2 SDHA	energy derivation by oxidation of organic compounds
HP:0000834	0.00163717999905	0.75	SDHB SDHAF2 SDHA	Abnormality of the adrenal glands
HP:0007379	0.00170428221874	0.75	SDHB SDHAF2 SDHA	Neoplasm of the genitourinary tract
HP:0007550	0.00170428221874	0.75	SDHB SDHAF2 SDHA	Hypohidrosis or hyperhidrosis
HP:0100833	0.00177124047018	0.5	SDHB SDHA	Neoplasm of the small intestine
HP:0002333	0.00177124047018	0.5	SDHB SDHA	Motor deterioration
HP:0100723	0.00177124047018	0.5	SDHB SDHA	Gastrointestinal stroma tumor
HP:0025276	0.00191650845368	0.75	SDHB SDHAF2 SDHA	Abnormality of skin adnexa physiology
REAC:R-HSA-71403	0.00210807296175	0.5	SDHB SDHA	Citric acid cycle (TCA cycle)
HP:0008046	0.00214561105026	0.75	SDHB SDHAF2 SDHA	Abnormal retinal vascular morphology
HP:0001635	0.00226669049436	0.75	SDHB SDHAF2 SDHA	Congestive heart failure
HP:0002474	0.00238393503741	0.5	SDHB SDHA	Expressive language delay
HP:0006895	0.00238393503741	0.5	SDHB SDHA	Lower limb hypertonia
HP:0012575	0.0023922283415	0.75	SDHB SDHAF2 SDHA	Abnormal nephron morphology
HP:0010929	0.00270293563817	0.75	SDHB SDHAF2 SDHA	Abnormal blood cation concentration
GO:0000104	0.00270494046827	0.5	SDHA SDHAF4	succinate dehydrogenase activity
GO:0008177	0.00270494046827	0.5	SDHA SDHAF4	succinate dehydrogenase (ubiquinone) activity
HP:0100751	0.00272425312749	0.5	SDHB SDHA	Esophageal neoplasm
HP:0012288	0.00347280043641	0.5	SDHB SDHA	Neoplasm of head and neck
HP:0003111	0.00385156742772	0.75	SDHB SDHAF2 SDHA	Abnormal blood ion concentration
HP:0002027	0.00433834919234	0.75	SDHB SDHAF2 SDHA	Abdominal pain
HP:0007700	0.00446611555555	0.75	SDHB SDHAF2 SDHA	Ocular anterior segment dysgenesis
HP:0001291	0.00466241342294	0.75	SDHB SDHAF2 SDHA	Abnormal cranial nerve morphology
HP:0011029	0.00486435946898	0.75	SDHB SDHAF2 SDHA	Internal hemorrhage
HP:0100659	0.00528551172659	0.75	SDHB SDHAF2 SDHA	Abnormality of the cerebral vasculature
HP:0001824	0.00543109559899	0.75	SDHB SDHAF2 SDHA	Weight loss
HP:0011028	0.00557931827591	0.75	SDHB SDHAF2 SDHA	Abnormality of blood circulation
HP:0000739	0.00604005240459	0.75	SDHB SDHAF2 SDHA	Anxiety
HP:0006801	0.00626129254237	0.5	SDHB SDHA	Hyperactive deep tendon reflexes
HP:0100852	0.00627960088635	0.75	SDHB SDHAF2 SDHA	Abnormal fear/anxiety-related behavior
HP:0002315	0.00652537513546	0.75	SDHB SDHAF2 SDHA	Headache
HP:0011792	0.00652537513546	0.75	SDHB SDHAF2 SDHA	Neoplasm by histology
HP:0011153	0.00680514289491	0.5	SDHB SDHA	Focal motor seizure
WP:WP111	0.0071289861505	0.5	SDHB SDHA	Electron Transport Chain (OXPHOS system in mitochondria)
HP:0000822	0.00803948285574	0.75	SDHB SDHAF2 SDHA	Hypertension
GO:0006121	0.00811409485621	0.5	SDHA SDHAF2	mitochondrial electron transport, succinate to ubiquinone
GO:0016635	0.00811409485621	0.5	SDHA SDHAF4	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
HP:0008047	0.00813515731085	0.75	SDHB SDHAF2 SDHA	Abnormality of the vasculature of the eye
HP:0000405	0.00862487853069	0.75	SDHB SDHAF2 SDHA	Conductive hearing impairment
HP:0011452	0.00892789465924	0.75	SDHB SDHAF2 SDHA	Functional abnormality of the middle ear
HP:0006957	0.00920632571228	0.5	SDHB SDHA	Loss of ability to walk
HP:0032263	0.0112489013074	0.75	SDHB SDHAF2 SDHA	Increased blood pressure
HP:0012378	0.0116099650177	0.75	SDHB SDHAF2 SDHA	Fatigue
HP:0100743	0.0119684664945	0.5	SDHB SDHA	Neoplasm of the rectum
KEGG:01200	0.012776519361	0.5	SDHB SDHA	Carbon metabolism
REAC:R-HSA-71406	0.013274030298	0.5	SDHB SDHA	Pyruvate metabolism and Citric Acid (TCA) cycle
HP:0003117	0.0135309297604	0.75	SDHB SDHAF2 SDHA	Abnormal circulating hormone level
KEGG:00190	0.0136880283161	0.5	SDHB SDHA	Oxidative phosphorylation
HP:0002395	0.0150911756538	0.5	SDHB SDHA	Lower limb hyperreflexia
HP:0001285	0.0150911756538	0.5	SDHB SDHA	Spastic tetraparesis
WP:WP4396	0.0154631487697	0.5	SDHB SDHA	Nonalcoholic fatty liver disease
KEGG:05012	0.0156041830743	0.5	SDHB SDHA	Parkinson disease
HP:0002313	0.0159281461127	0.5	SDHB SDHA	Spastic paraparesis
GO:0034552	0.0162267366884	0.5	SDHAF2 SDHAF4	respiratory chain complex II assembly
GO:0034553	0.0162267366884	0.5	SDHAF2 SDHAF4	mitochondrial respiratory chain complex II assembly
HP:0011675	0.0164047655465	0.75	SDHB SDHAF2 SDHA	Arrhythmia
HP:0008056	0.0167125722923	0.75	SDHB SDHAF2 SDHA	Aplasia/Hypoplasia affecting the eye
HP:0000525	0.0170241838094	0.75	SDHB SDHAF2 SDHA	Abnormality iris morphology
HP:0001608	0.0173396229329	0.75	SDHB SDHAF2 SDHA	Abnormality of the voice
KEGG:04932	0.0173825101547	0.5	SDHB SDHA	Non-alcoholic fatty liver disease (NAFLD)
HP:0002344	0.0176695962482	0.5	SDHB SDHA	Progressive neurologic deterioration
HP:0000544	0.0176695962482	0.5	SDHB SDHA	External ophthalmoplegia
HP:0002017	0.0181451162859	0.75	SDHB SDHAF2 SDHA	Nausea and vomiting
GO:0098803	0.0181462528862	0.75	SDHB SDHAF4 SDHA	respiratory chain complex
HP:0030972	0.0184741317158	0.75	SDHB SDHAF2 SDHA	Abnormal systemic blood pressure
HP:0002505	0.01857406376	0.5	SDHB SDHA	Progressive inability to walk
GO:0005746	0.0189701239271	0.75	SDHB SDHAF4 SDHA	mitochondrial respirasome
GO:0006091	0.0197812720484	1.0	SDHB SDHAF4 SDHAF2 SDHA	generation of precursor metabolites and energy
HP:0030956	0.0210685962912	0.75	SDHB SDHAF2 SDHA	Abnormality of cardiovascular system electrophysiology
GO:0009060	0.0215903857674	0.75	SDHB SDHAF2 SDHA	aerobic respiration
HP:0001892	0.0223577043802	0.75	SDHB SDHAF2 SDHA	Abnormal bleeding
GO:0070469	0.0225145500348	0.75	SDHB SDHAF4 SDHA	respirasome
KEGG:05010	0.0232850911193	0.5	SDHB SDHA	Alzheimer disease
HP:0005162	0.025534627766	0.5	SDHB SDHA	Left ventricular dysfunction
HP:0005214	0.0277254502169	0.5	SDHB SDHA	Intestinal obstruction
HP:0005150	0.0277254502169	0.5	SDHB SDHA	Abnormal atrioventricular conduction
HP:0000370	0.0278183273244	0.75	SDHB SDHAF2 SDHA	Abnormality of the middle ear
HP:0100273	0.0288545127028	0.5	SDHB SDHA	Neoplasm of the colon
KEGG:05016	0.03037774612	0.5	SDHB SDHA	Huntington disease
HP:0002385	0.0311799098191	0.5	SDHB SDHA	Paraparesis
HP:0000553	0.0331125866707	0.75	SDHB SDHAF2 SDHA	Abnormal uvea morphology
HP:0006380	0.0335949626331	0.5	SDHB SDHA	Knee flexion contracture
HP:0001337	0.0338486678119	0.75	SDHB SDHAF2 SDHA	Tremor
HP:0006753	0.0360996225593	0.5	SDHB SDHA	Neoplasm of the stomach
HP:0004796	0.0386938410225	0.5	SDHB SDHA	Gastrointestinal obstruction
GO:1990204	0.0396936057372	0.75	SDHB SDHAF4 SDHA	oxidoreductase complex
HP:0030872	0.0400245195282	0.5	SDHB SDHA	Abnormal cardiac ventricular function
HP:0003388	0.0400245195282	0.5	SDHB SDHA	Easy fatigability
GO:0055114	0.0422401319933	1.0	SDHB SDHAF4 SDHAF2 SDHA	oxidation-reduction process
KEGG:04714	0.0427485725169	0.5	SDHB SDHA	Thermogenesis
HP:0031466	0.0435417391965	0.75	SDHB SDHAF2 SDHA	Impairment in personality functioning
REAC:R-HSA-611105	0.0435915557177	0.5	SDHB SDHA	Respiratory electron transport
GO:0022904	0.0439367749778	0.75	SDHB SDHAF2 SDHA	respiratory electron transport chain
GO:0022900	0.0454154921687	0.75	SDHB SDHAF2 SDHA	electron transport chain
HP:0001712	0.0455708870915	0.5	SDHB SDHA	Left ventricular hypertrophy
HP:0100834	0.0470133620262	0.5	SDHB SDHA	Neoplasm of the large intestine

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SDHA	SDHB	0.999	0.949	bioplex (SDHA,SDHB) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM
SDHAF2	SDHA	0.983	0.899	hein_WMM bioplex (SDHA) bioplex_WMM hein (SDHAF2)
SDHA	SDHAF4	0.939	0.85	bioplex (SDHA) bioplex_WMM fraction
SDHB	SDHAF4	0.009	0.091	bioplex_WMM WMM_only
SDHAF2	SDHAF4	0.008	0.091	bioplex_WMM WMM_only
SDHAF2	SDHB	0.008	0.024	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04642 has an average edge precision of 0.484 which is ranked 2599 out of all 6965 complexes.

Related Complexes

Genename	Complexes
SDHAF2	HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446
SDHB	HuMAP2_03232 HuMAP2_04642
SDHA	HuMAP2_03232 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446
SDHAF4	HuMAP2_04609 HuMAP2_04642 HuMAP2_04832 HuMAP2_05446

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04642