hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04643

Confidence: Medium

Genename	Protein Name	Links
AMER1	APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)	UniProt NCBI
CDH1	Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]	UniProt NCBI
CDH2	Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325)	UniProt NCBI
AXIN1	Axin-1 (Axis inhibition protein 1) (hAxin)	UniProt NCBI
APC	Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)	UniProt NCBI
CTNNA3	Catenin alpha-3 (Alpha T-catenin) (Cadherin-associated protein)	UniProt NCBI
CDH12	Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)	UniProt NCBI
CDH4	Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0008013	6.88394579763e-09	0.75	AXIN1 APC CDH2 CTNNA3 CDH1 AMER1	beta-catenin binding
GO:0016342	1.20462168888e-08	0.625	CDH4 CDH12 CDH2 CDH1 APC	catenin complex
GO:0005913	5.32017018997e-08	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	cell-cell adherens junction
REAC:R-HSA-418990	1.05752062485e-07	0.5	CDH12 CDH2 CDH1 CDH4	Adherens junctions interactions
KEGG:05213	6.41254345961e-07	0.5	CTNNA3 AXIN1 APC CDH1	Endometrial cancer
REAC:R-HSA-421270	8.1501499655e-07	0.5	CDH12 CDH2 CDH1 CDH4	Cell-cell junction organization
WP:WP4155	9.52235222351e-07	0.5	CTNNA3 AXIN1 APC CDH1	Endometrial cancer
WP:WP4540	3.7791494928e-06	0.5	CDH12 CDH2 CDH1 CDH4	Pathways Regulating Hippo Signaling
REAC:R-HSA-446728	5.79961458636e-06	0.5	CDH12 CDH2 CDH1 CDH4	Cell junction organization
REAC:R-HSA-4839748	6.54653606528e-06	0.375	AXIN1 APC AMER1	AMER1 mutants destabilize the destruction complex
REAC:R-HSA-5467337	6.54653606528e-06	0.375	AXIN1 APC AMER1	APC truncation mutants have impaired AXIN binding
REAC:R-HSA-5467340	6.54653606528e-06	0.375	AXIN1 APC AMER1	AXIN missense mutants destabilize the destruction complex
REAC:R-HSA-4839735	6.54653606528e-06	0.375	AXIN1 APC AMER1	AXIN mutants destabilize the destruction complex, activating WNT signaling
REAC:R-HSA-4839744	6.54653606528e-06	0.375	AXIN1 APC AMER1	truncated APC mutants destabilize the destruction complex
REAC:R-HSA-5467348	6.54653606528e-06	0.375	AXIN1 APC AMER1	Truncations of AMER1 destabilize the destruction complex
WP:WP4541	7.19165413152e-06	0.5	CDH12 CDH2 CDH1 CDH4	Hippo-Merlin Signaling Dysregulation
REAC:R-HSA-5339716	8.18110847696e-06	0.375	AXIN1 APC AMER1	Misspliced GSK3beta mutants stabilize beta-catenin
REAC:R-HSA-5358747	8.18110847696e-06	0.375	AXIN1 APC AMER1	S33 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358751	8.18110847696e-06	0.375	AXIN1 APC AMER1	S45 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358749	8.18110847696e-06	0.375	AXIN1 APC AMER1	S37 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-5358752	8.18110847696e-06	0.375	AXIN1 APC AMER1	T41 mutants of beta-catenin aren't phosphorylated
REAC:R-HSA-4839743	8.18110847696e-06	0.375	AXIN1 APC AMER1	phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
REAC:R-HSA-196299	1.22205513984e-05	0.375	AXIN1 APC AMER1	Beta-catenin phosphorylation cascade
KEGG:05226	1.87192609274e-05	0.5	CTNNA3 AXIN1 APC CDH1	Gastric cancer
GO:0007043	2.10272659881e-05	0.625	CDH4 CDH12 CDH2 CDH1 APC	cell-cell junction assembly
KEGG:04390	2.58756624072e-05	0.5	CTNNA3 AXIN1 APC CDH1	Hippo signaling pathway
REAC:R-HSA-1500931	2.62086640211e-05	0.5	CDH12 CDH2 CDH1 CDH4	Cell-Cell communication
CORUM:3004	3.50546248845e-05	0.25	AXIN1 APC	APC-AXIN1-CTNNB1 complex
GO:0005911	4.76864162275e-05	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	cell-cell junction
GO:1904885	5.0832789986e-05	0.375	AXIN1 APC AMER1	beta-catenin destruction complex assembly
GO:0045216	5.51628812838e-05	0.625	CDH4 CDH12 CDH2 CDH1 APC	cell-cell junction organization
GO:0016339	6.94441590143e-05	0.5	CDH12 CDH2 CDH1 CDH4	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
CORUM:3166	7.00904180673e-05	0.25	AXIN1 APC	AXIN1-APC-CTNNB1-GSK3B complex
CORUM:6353	7.00904180673e-05	0.25	AXIN1 APC	beta-Catenin destruction complex
REAC:R-HSA-4791275	7.27251966908e-05	0.375	AXIN1 APC AMER1	Signaling by WNT in cancer
REAC:R-HSA-4641262	7.27251966908e-05	0.375	AXIN1 APC AMER1	Disassembly of the destruction complex and recruitment of AXIN to the membrane
GO:0044331	8.88204130675e-05	0.5	CDH12 CDH2 CDH1 CDH4	cell-cell adhesion mediated by cadherin
GO:0019897	0.000101237303578	0.625	CDH4 CDH12 CDH2 CDH1 APC	extrinsic component of plasma membrane
WP:WP2064	0.000355275761306	0.375	CDH2 AXIN1 CDH1	Neural Crest Differentiation
GO:0007156	0.000666904519799	0.5	CDH12 CDH2 CDH1 CDH4	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0034329	0.000781906481464	0.625	CDH4 CDH12 CDH2 CDH1 APC	cell junction assembly
KEGG:04514	0.000795052913263	0.375	CDH4 CDH1 CDH2	Cell adhesion molecules (CAMs)
GO:0045295	0.000837474301274	0.375	CDH2 CDH1 APC	gamma-catenin binding
GO:0005912	0.00105961614518	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	adherens junction
GO:0070161	0.00122189928453	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	anchoring junction
WP:WP3859	0.00133684180395	0.25	CDH2 CDH1	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
REAC:R-HSA-195253	0.00156566042435	0.375	AXIN1 APC AMER1	Degradation of beta-catenin by the destruction complex
WP:WP3664	0.00173059816734	0.25	AXIN1 APC	Regulation of Wnt/B-catenin Signaling by Small Molecule Compounds
GO:0034330	0.00177398727307	0.625	CDH4 CDH12 CDH2 CDH1 APC	cell junction organization
GO:0019898	0.00185663151637	0.625	CDH4 CDH12 CDH2 CDH1 APC	extrinsic component of membrane
KEGG:05200	0.00285664338154	0.5	CTNNA3 AXIN1 APC CDH1	Pathways in cancer
WP:WP2870	0.00380929807672	0.25	AXIN1 APC	Extracellular vesicle-mediated signaling in recipient cells
HP:0006572	0.00464310919637	0.25	AXIN1 APC	Subacute progressive viral hepatitis
GO:1904886	0.00577307926818	0.375	AXIN1 APC AMER1	beta-catenin destruction complex disassembly
HP:0200040	0.0059681081945	0.25	CDH1 APC	Epidermoid cyst
GO:0034332	0.00894888598316	0.5	CDH12 CDH2 CDH1 CDH4	adherens junction organization
HP:0031105	0.00963529148538	0.375	AXIN1 APC CDH1	Abnormal uterus morphology
GO:0045296	0.0114232635758	0.625	CDH4 CDH12 CDH2 CDH1 CTNNA3	cadherin binding
GO:0030054	0.012189998323	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	cell junction
HP:0006562	0.0129170117165	0.25	AXIN1 APC	Viral hepatitis
GO:0016328	0.0131467756501	0.375	AXIN1 APC CDH1	lateral plasma membrane
REAC:R-HSA-525793	0.0133460514177	0.25	CDH4 CDH2	Myogenesis
WP:000000	0.0134045376724	1.0	CDH12 AXIN1 APC CDH2 CTNNA3 CDH4 CDH1 AMER1	WIKIPATHWAYS
WP:WP363	0.0148364293629	0.25	AXIN1 APC	Wnt Signaling Pathway
HP:0025245	0.0150657984869	0.25	CDH1 APC	Cutaneous cyst
KEGG:05217	0.0184225203577	0.25	AXIN1 APC	Basal cell carcinoma
GO:0098742	0.0194680313645	0.5	CDH12 CDH2 CDH1 CDH4	cell-cell adhesion via plasma-membrane adhesion molecules
HP:0001413	0.0224977761754	0.25	AXIN1 APC	Micronodular cirrhosis
WP:WP3680	0.0245464965472	0.25	AXIN1 APC	Association Between Physico-Chemical Features and Toxicity Associated Pathways
KEGG:04520	0.0279665014883	0.25	CDH1 CTNNA3	Adherens junction
WP:WP2118	0.0294384226193	0.25	CDH2 CTNNA3	Arrhythmogenic Right Ventricular Cardiomyopathy
REAC:R-HSA-111465	0.0295328318157	0.25	CDH1 APC	Apoptotic cleavage of cellular proteins
HP:0001428	0.0301849509731	0.375	AXIN1 APC CDH1	Somatic mutation
KEGG:05412	0.0304453229215	0.25	CDH2 CTNNA3	Arrhythmogenic right ventricular cardiomyopathy (ARVC)
REAC:R-HSA-201681	0.0306958072782	0.375	AXIN1 APC AMER1	TCF dependent signaling in response to WNT
WP:WP4216	0.0311658749905	0.25	AXIN1 APC	Chromosomal and microsatellite instability in colorectal cancer
KEGG:05100	0.0312945198834	0.25	CDH1 CTNNA3	Bacterial invasion of epithelial cells
GO:0098797	0.0348252240904	0.625	CDH4 CDH12 CDH2 CDH1 APC	plasma membrane protein complex
WP:WP4336	0.0375915830035	0.25	AXIN1 APC	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
HP:0012126	0.0381618271547	0.25	CDH1 APC	Stomach cancer
KEGG:05210	0.0394512249973	0.25	AXIN1 APC	Colorectal cancer
HP:0000130	0.0463747669761	0.375	AXIN1 APC CDH1	Abnormality of the uterus
WP:WP4258	0.0467166389275	0.25	AXIN1 APC	LncRNA involvement in canonical Wnt signaling and colorectal cancer
CORUM:5319	0.0497224828424	0.125	CDH1	CDH1-CKS1B complex
CORUM:3168	0.0497224828424	0.125	AXIN1	DAXX-AXIN complex
CORUM:933	0.0497224828424	0.125	APC	SCRIB-APC complex
CORUM:1844	0.0497224828424	0.125	APC	APC-IQGAP1 complex
CORUM:1909	0.0497224828424	0.125	APC	APC-DLG4 complex
CORUM:2968	0.0497224828424	0.125	AXIN1	Axin-SMAD3 complex
CORUM:6269	0.0497224828424	0.125	CDH2	DLL1-CTNNB1-CDH2 complex
CORUM:5320	0.0497224828424	0.125	CDH1	CDH1-SKP2 complex
CORUM:5281	0.0497224828424	0.125	CDH1	Cell-cell junction complex (CDH1-CTNNB1)
GO:0007155	0.0497467228403	0.75	CDH12 APC CDH2 CTNNA3 CDH4 CDH1	cell adhesion

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CTNNA3	CDH4	0.998	0.939	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH12	0.722	0.732	bioplex (CTNNA3) bioplex_WMM
CTNNA3	CDH1	0.435	0.579	bioplex (CTNNA3) bioplex_WMM
CTNNA3	APC	0.145	0.408	bioplex (CTNNA3) bioplex_WMM
AMER1	APC	0.144	0.406	hein_WMM bioplex_WMM youn_WMM hein (APC)
CTNNA3	CDH2	0.083	0.349	bioplex (CTNNA3) bioplex_WMM
AXIN1	AMER1	0.031	0.24	hein_WMM hein (AXIN1)
AXIN1	APC	0.029	0.233	hein_WMM hein (APC,AXIN1) gupta_WMM
CDH12	CDH4	0.009	0.095	bioplex_WMM WMM_only
CDH2	CDH1	0.008	0.094	bioplex_WMM WMM_only
CDH4	CDH1	0.008	0.085	bioplex_WMM WMM_only
CDH12	CDH1	0.008	0.085	bioplex_WMM WMM_only
CDH12	APC	0.008	0.042	bioplex_WMM WMM_only
CDH4	APC	0.008	0.042	bioplex_WMM WMM_only
CDH12	AMER1	0.008	0.033	bioplex_WMM WMM_only
CDH4	AMER1	0.008	0.033	bioplex_WMM WMM_only
CDH1	APC	0.007	0.006	bioplex_WMM WMM_only
CDH1	AMER1	0.007	0.016	bioplex_WMM WMM_only
CDH12	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH4	CDH2	0.007	0.016	bioplex_WMM WMM_only
CDH2	APC	0.007	0.006	bioplex_WMM WMM_only
CDH2	AMER1	0.006	0.006	bioplex_WMM WMM_only
CTNNA3	AMER1	0.004	0.011	bioplex (CTNNA3) bioplex_WMM

Images

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Complex HuMAP2_04643 has an average edge precision of 0.194 which is ranked 6250 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AMER1	HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022
CDH1	HuMAP2_01324 HuMAP2_01868 HuMAP2_02274 HuMAP2_02710 HuMAP2_04643 HuMAP2_04810 HuMAP2_05168 HuMAP2_06022
CDH2	HuMAP2_00477 HuMAP2_00625 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
AXIN1	HuMAP2_00965 HuMAP2_02771 HuMAP2_04332 HuMAP2_04384 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022 HuMAP2_06340
APC	HuMAP2_02274 HuMAP2_04643 HuMAP2_05355 HuMAP2_06022
CTNNA3	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_02274 HuMAP2_04278 HuMAP2_04643 HuMAP2_05168 HuMAP2_06022
CDH12	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022
CDH4	HuMAP2_00477 HuMAP2_00625 HuMAP2_02259 HuMAP2_04278 HuMAP2_04643 HuMAP2_06022

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04643