hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04645
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UFM1 | Ubiquitin-fold modifier 1 | UniProt NCBI |
| PEBP1 | Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)] | UniProt NCBI |
| ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial (EC 1.2.1.3) (Aldehyde dehydrogenase 5) (Aldehyde dehydrogenase family 1 member B1) | UniProt NCBI |
| GPT2 | Alanine aminotransferase 2 (ALT2) (EC 2.6.1.2) (Glutamate pyruvate transaminase 2) (GPT 2) (Glutamic--alanine transaminase 2) (Glutamic--pyruvic transaminase 2) | UniProt NCBI |
| LYPLA1 | Acyl-protein thioesterase 1 (APT-1) (hAPT1) (EC 3.1.2.-) (Lysophospholipase 1) (Lysophospholipase I) (LPL-I) (LysoPLA I) | UniProt NCBI |
| ALDH6A1 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) (EC 1.2.1.18) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) | UniProt NCBI |
| ALDH2 | Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI) | UniProt NCBI |
| ALDH8A1 | 2-aminomuconic semialdehyde dehydrogenase (EC 1.2.1.32) (Aldehyde dehydrogenase 12) (Aldehyde dehydrogenase family 8 member A1) | UniProt NCBI |
| PEPD | Xaa-Pro dipeptidase (X-Pro dipeptidase) (EC 3.4.13.9) (Imidodipeptidase) (Peptidase D) (Proline dipeptidase) (Prolidase) | UniProt NCBI |
| ABAT | 4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT) | UniProt NCBI |
| MDH1 | Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96) | UniProt NCBI |
| GLRX | Glutaredoxin-1 (Thioltransferase-1) (TTase-1) | UniProt NCBI |
| PHGDH | D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37) | UniProt NCBI |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31) | UniProt NCBI |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | UniProt NCBI |
| GOT2 | Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00280 | 5.61230526393e-08 | 0.3125 | HIBADH ALDH6A1 ALDH1B1 ALDH2 ABAT | Valine, leucine and isoleucine degradation |
| KEGG:01200 | 6.95079859603e-08 | 0.375 | SHMT2 PHGDH ALDH6A1 MDH1 GPT2 GOT2 | Carbon metabolism |
| KEGG:01100 | 2.86482522761e-07 | 0.6875 | ALDH6A1 HIBADH ALDH8A1 PHGDH ABAT ALDH1B1 GPT2 SHMT2 MDH1 GOT2 ALDH2 | Metabolic pathways |
| KEGG:00410 | 1.25555016737e-06 | 0.25 | ALDH1B1 ALDH6A1 ALDH2 ABAT | beta-Alanine metabolism |
| GO:0044281 | 1.73564500142e-06 | 0.8125 | GOT2 ALDH6A1 HIBADH ALDH8A1 PHGDH GLRX ABAT ALDH1B1 GPT2 SHMT2 MDH1 PEPD ALDH2 | small molecule metabolic process |
| GO:0006520 | 1.17630904865e-05 | 0.5 | ALDH6A1 HIBADH SHMT2 GOT2 ABAT GPT2 PEPD PHGDH | cellular amino acid metabolic process |
| KEGG:01230 | 4.33519198903e-05 | 0.25 | SHMT2 GOT2 PHGDH GPT2 | Biosynthesis of amino acids |
| GO:0019752 | 7.00630078813e-05 | 0.625 | ALDH6A1 HIBADH ALDH8A1 GOT2 ABAT GPT2 SHMT2 MDH1 PEPD PHGDH | carboxylic acid metabolic process |
| WP:WP3925 | 0.000153714055319 | 0.25 | GOT2 MDH1 HIBADH GPT2 | Amino Acid metabolism |
| GO:0043436 | 0.000157401478284 | 0.625 | ALDH6A1 HIBADH ALDH8A1 GOT2 ABAT GPT2 SHMT2 MDH1 PEPD PHGDH | oxoacid metabolic process |
| GO:0005759 | 0.000160329906211 | 0.5 | ALDH6A1 HIBADH SHMT2 ABAT ALDH1B1 GPT2 GOT2 ALDH2 | mitochondrial matrix |
| GO:0006082 | 0.000181214765439 | 0.625 | ALDH6A1 HIBADH ALDH8A1 GOT2 ABAT GPT2 SHMT2 MDH1 PEPD PHGDH | organic acid metabolic process |
| KEGG:00250 | 0.000285502175256 | 0.1875 | ABAT GOT2 GPT2 | Alanine, aspartate and glutamate metabolism |
| KEGG:00380 | 0.00040552526984 | 0.1875 | ALDH8A1 ALDH2 ALDH1B1 | Tryptophan metabolism |
| KEGG:00620 | 0.000476350346716 | 0.1875 | MDH1 ALDH2 ALDH1B1 | Pyruvate metabolism |
| GO:1901605 | 0.000711687675298 | 0.375 | ALDH6A1 HIBADH SHMT2 GPT2 GOT2 PHGDH | alpha-amino acid metabolic process |
| KEGG:00270 | 0.000787603544719 | 0.1875 | MDH1 GOT2 PHGDH | Cysteine and methionine metabolism |
| KEGG:00330 | 0.000896215443374 | 0.1875 | GOT2 ALDH2 ALDH1B1 | Arginine and proline metabolism |
| REAC:R-HSA-1430728 | 0.00104342796208 | 0.625 | ALDH6A1 ALDH2 SHMT2 PHGDH GOT2 ALDH1B1 LYPLA1 MDH1 GLRX HIBADH | Metabolism |
| GO:0016620 | 0.001372917994 | 0.25 | ALDH1B1 ALDH6A1 ALDH2 ALDH8A1 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| GO:0016491 | 0.0019801490201 | 0.5 | ALDH6A1 HIBADH PHGDH ALDH8A1 ALDH1B1 MDH1 GLRX ALDH2 | oxidoreductase activity |
| GO:0009063 | 0.0037429903632 | 0.3125 | SHMT2 ALDH6A1 GOT2 HIBADH ABAT | cellular amino acid catabolic process |
| GO:0016903 | 0.00439029992427 | 0.25 | ALDH1B1 ALDH6A1 ALDH2 ALDH8A1 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| WP:WP106 | 0.00556145696181 | 0.125 | ABAT GOT2 | Alanine and aspartate metabolism |
| WP:WP4018 | 0.00622718325826 | 0.1875 | MDH1 PHGDH SHMT2 | Pathways in clear cell renal cell carcinoma |
| KEGG:01210 | 0.0076480448873 | 0.125 | GPT2 GOT2 | 2-Oxocarboxylic acid metabolism |
| KEGG:00340 | 0.00960424705023 | 0.125 | ALDH2 ALDH1B1 | Histidine metabolism |
| KEGG:00220 | 0.010664700693 | 0.125 | GPT2 GOT2 | Arginine biosynthesis |
| REAC:R-HSA-71384 | 0.0131645018518 | 0.125 | ALDH2 ALDH1B1 | Ethanol oxidation |
| KEGG:00053 | 0.0141742213941 | 0.125 | ALDH2 ALDH1B1 | Ascorbate and aldarate metabolism |
| WP:WP4595 | 0.0175960202369 | 0.125 | MDH1 GOT2 | Urea cycle and associated pathways |
| GO:0050662 | 0.0187218605075 | 0.3125 | ALDH1B1 ALDH6A1 SHMT2 ALDH2 ABAT | coenzyme binding |
| KEGG:00630 | 0.0242640523254 | 0.125 | MDH1 SHMT2 | Glyoxylate and dicarboxylate metabolism |
| GO:0044429 | 0.0271286011077 | 0.5 | ALDH6A1 HIBADH SHMT2 ABAT ALDH1B1 GPT2 GOT2 ALDH2 | mitochondrial part |
| KEGG:00640 | 0.0312139520618 | 0.125 | ALDH6A1 ABAT | Propanoate metabolism |
| WP:WP241 | 0.031534230305 | 0.125 | SHMT2 GLRX | One Carbon Metabolism |
| WP:WP2525 | 0.0362439527682 | 0.125 | SHMT2 PHGDH | Trans-sulfuration and one carbon metabolism |
| GO:0008652 | 0.0390120091047 | 0.25 | SHMT2 GOT2 PHGDH GPT2 | cellular amino acid biosynthetic process |
| GO:0008483 | 0.0410946998182 | 0.1875 | ABAT GOT2 GPT2 | transaminase activity |
| KEGG:00260 | 0.0411002116404 | 0.125 | SHMT2 PHGDH | Glycine, serine and threonine metabolism |
| KEGG:00071 | 0.0476664784105 | 0.125 | ALDH2 ALDH1B1 | Fatty acid degradation |
| GO:0043648 | 0.0488304065597 | 0.25 | MDH1 GPT2 GOT2 SHMT2 | dicarboxylic acid metabolic process |
| REAC:R-HSA-70895 | 0.0497437360808 | 0.125 | ALDH6A1 HIBADH | Branched-chain amino acid catabolism |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH2 | ALDH6A1 | 1.0 | 0.949 | bioplex (ALDH2) bioplex_WMM fraction |
| ALDH6A1 | ABAT | 0.982 | 0.898 | fraction |
| ALDH6A1 | PEPD | 0.877 | 0.811 | fraction |
| MDH1 | GLRX | 0.795 | 0.761 | fraction |
| PEBP1 | GLRX | 0.777 | 0.752 | fraction |
| ALDH2 | PEPD | 0.709 | 0.728 | bioplex_WMM fraction treiber_WMM |
| ALDH2 | UFM1 | 0.624 | 0.678 | bioplex (UFM1) bioplex_WMM fraction |
| ALDH6A1 | ALDH1B1 | 0.572 | 0.655 | bioplex_WMM fraction |
| ALDH2 | PHGDH | 0.473 | 0.608 | bioplex (ALDH2) bioplex_WMM gupta_WMM fraction treiber_WMM |
| ALDH6A1 | MDH1 | 0.472 | 0.608 | fraction |
| ALDH1B1 | UFM1 | 0.47 | 0.605 | bioplex (UFM1) bioplex_WMM fraction |
| ALDH6A1 | ALDH8A1 | 0.392 | 0.554 | bioplex (ALDH8A1) bioplex_WMM |
| PHGDH | HIBADH | 0.384 | 0.55 | bioplex_WMM fraction |
| GOT2 | SHMT2 | 0.364 | 0.544 | bioplex (GOT2) bioplex_WMM Guru fraction boldt_WMM treiber_WMM |
| ALDH2 | HIBADH | 0.357 | 0.539 | bioplex_WMM fraction |
| ALDH2 | SHMT2 | 0.351 | 0.538 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| PEPD | ALDH1B1 | 0.331 | 0.521 | bioplex_WMM fraction treiber_WMM |
| ABAT | MDH1 | 0.319 | 0.51 | bioplex (ABAT) fraction treiber_WMM |
| ALDH6A1 | GLRX | 0.311 | 0.504 | fraction |
| GOT2 | UFM1 | 0.256 | 0.478 | bioplex (UFM1) bioplex_WMM fraction |
| GOT2 | GLRX | 0.25 | 0.473 | fraction |
| PEPD | SHMT2 | 0.249 | 0.472 | bioplex_WMM fraction treiber_WMM |
| ALDH6A1 | LYPLA1 | 0.206 | 0.454 | fraction |
| MDH1 | UFM1 | 0.204 | 0.454 | bioplex (UFM1) bioplex_WMM fraction |
| SHMT2 | HIBADH | 0.203 | 0.454 | bioplex_WMM fraction |
| MDH1 | HIBADH | 0.203 | 0.454 | bioplex_WMM fraction treiber_WMM |
| PHGDH | GPT2 | 0.187 | 0.439 | fraction treiber_WMM |
| ALDH6A1 | PHGDH | 0.185 | 0.44 | bioplex_WMM gupta_WMM fraction |
| ABAT | PEBP1 | 0.176 | 0.435 | bioplex (ABAT) bioplex_WMM fraction |
| ALDH2 | GPT2 | 0.163 | 0.42 | bioplex_WMM fraction treiber_WMM |
| PEPD | ABAT | 0.148 | 0.41 | fraction treiber_WMM |
| GOT2 | HIBADH | 0.146 | 0.409 | bioplex_WMM fraction |
| ALDH2 | MDH1 | 0.135 | 0.406 | bioplex_WMM fraction treiber_WMM |
| ALDH2 | GOT2 | 0.128 | 0.399 | bioplex (GOT2) bioplex_WMM fraction treiber_WMM |
| ABAT | PHGDH | 0.113 | 0.382 | bioplex (ABAT) fraction treiber_WMM |
| SHMT2 | PEBP1 | 0.108 | 0.373 | bioplex_WMM gupta_WMM fraction boldt_WMM |
| ALDH2 | PEBP1 | 0.105 | 0.37 | bioplex_WMM fraction |
| ALDH6A1 | UFM1 | 0.101 | 0.363 | fraction |
| PEPD | MDH1 | 0.101 | 0.362 | bioplex_WMM fraction treiber_WMM |
| SHMT2 | LYPLA1 | 0.098 | 0.357 | bioplex_WMM fraction |
| ALDH1B1 | GPT2 | 0.09 | 0.355 | bioplex_WMM fraction treiber_WMM |
| ABAT | UFM1 | 0.082 | 0.35 | fraction |
| SHMT2 | UFM1 | 0.079 | 0.352 | bioplex (UFM1) bioplex_WMM gupta_WMM fraction |
| ALDH8A1 | PHGDH | 0.076 | 0.356 | bioplex (ALDH8A1) fraction |
| ALDH8A1 | GLRX | 0.073 | 0.357 | fraction |
| GOT2 | GPT2 | 0.072 | 0.356 | fraction treiber_WMM |
| ALDH6A1 | PEBP1 | 0.063 | 0.347 | bioplex_WMM fraction |
| GPT2 | PEBP1 | 0.063 | 0.346 | fraction |
| ALDH1B1 | PHGDH | 0.061 | 0.336 | bioplex (ALDH1B1) bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| SHMT2 | GLRX | 0.061 | 0.334 | fraction |
| MDH1 | ALDH1B1 | 0.059 | 0.328 | bioplex (ALDH1B1) bioplex_WMM fraction treiber_WMM |
| MDH1 | PHGDH | 0.056 | 0.316 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| GPT2 | LYPLA1 | 0.054 | 0.302 | fraction |
| ALDH8A1 | MDH1 | 0.053 | 0.301 | bioplex_WMM fraction |
| UFM1 | GPT2 | 0.052 | 0.301 | fraction |
| HIBADH | PEBP1 | 0.048 | 0.293 | bioplex_WMM fraction |
| PEPD | UFM1 | 0.046 | 0.292 | bioplex_WMM fraction |
| PEPD | ALDH8A1 | 0.046 | 0.292 | fraction |
| ABAT | LYPLA1 | 0.04 | 0.267 | fraction |
| ALDH1B1 | HIBADH | 0.039 | 0.264 | bioplex_WMM fraction |
| ALDH6A1 | HIBADH | 0.035 | 0.263 | bioplex_WMM fraction |
| GOT2 | ABAT | 0.035 | 0.265 | bioplex (ABAT) fraction treiber_WMM |
| MDH1 | PEBP1 | 0.028 | 0.231 | bioplex (MDH1) bioplex_WMM fraction boldt_WMM treiber_WMM |
| ALDH2 | ALDH1B1 | 0.026 | 0.219 | bioplex (ALDH1B1,ALDH2) bioplex_WMM treiber_WMM |
| PEPD | HIBADH | 0.014 | 0.143 | bioplex_WMM fraction |
| ALDH1B1 | PEBP1 | 0.013 | 0.151 | bioplex (ALDH1B1) bioplex_WMM gupta_WMM fraction |
| PHGDH | GLRX | 0.011 | 0.144 | gupta_WMM fraction |
| ALDH6A1 | GOT2 | 0.01 | 0.13 | fraction |
| ALDH1B1 | LYPLA1 | 0.009 | 0.09 | fraction |
| PEPD | PEBP1 | 0.008 | 0.082 | bioplex_WMM fraction |
| PEPD | GLRX | 0.008 | 0.077 | fraction |
| GOT2 | ALDH8A1 | 0.007 | 0.002 | bioplex (ALDH8A1) |
| ALDH8A1 | PEBP1 | 0.007 | 0.003 | bioplex (ALDH8A1) |
| ABAT | GPT2 | 0.007 | 0.001 | WMM_only treiber_WMM |
| PEPD | GPT2 | 0.007 | 0.001 | WMM_only treiber_WMM |
| MDH1 | GPT2 | 0.007 | 0.003 | WMM_only treiber_WMM |
| ALDH2 | ALDH8A1 | 0.007 | 0.005 | bioplex (ALDH8A1) |
| ABAT | SHMT2 | 0.006 | 0.004 | bioplex (ABAT) treiber_WMM |
| SHMT2 | GPT2 | 0.006 | 0.003 | WMM_only treiber_WMM |
| ALDH2 | ABAT | 0.006 | 0.003 | bioplex (ABAT) bioplex_WMM treiber_WMM |
| ABAT | ALDH1B1 | 0.006 | 0.004 | bioplex (ABAT) treiber_WMM |
| GOT2 | LYPLA1 | 0.006 | 0.0 | bioplex_WMM fraction |
| ALDH8A1 | ALDH1B1 | 0.006 | 0.004 | bioplex (ALDH8A1) |
| GLRX | LYPLA1 | 0.005 | 0.008 | fraction |
| MDH1 | SHMT2 | 0.005 | 0.01 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| PHGDH | UFM1 | 0.004 | 0.011 | bioplex (UFM1) youn_WMM gupta_WMM fraction |
| UFM1 | HIBADH | 0.004 | 0.011 | bioplex (UFM1) bioplex_WMM fraction |
| UFM1 | PEBP1 | 0.004 | 0.01 | bioplex (UFM1) bioplex_WMM fraction |
| GOT2 | PHGDH | 0.004 | 0.015 | bioplex (GOT2) bioplex_WMM fraction boldt_WMM treiber_WMM |
| UFM1 | LYPLA1 | 0.003 | 0.011 | fraction |
| GOT2 | ALDH1B1 | 0.0 | 0.013 | bioplex (ALDH1B1,GOT2) bioplex_WMM fraction treiber_WMM |
| ALDH8A1 | LYPLA1 | 0.0 | 0.017 | fraction |
| ALDH8A1 | ABAT | 0.0 | 0.016 | fraction |
| ALDH6A1 | SHMT2 | 0.0 | 0.006 | bioplex_WMM gupta_WMM fraction |
| ALDH2 | LYPLA1 | 0.0 | 0.013 | bioplex_WMM fraction |
| HIBADH | LYPLA1 | 0.0 | 0.013 | bioplex_WMM fraction |
| PEPD | LYPLA1 | 0.0 | 0.011 | fraction |
| PEPD | PHGDH | 0.0 | 0.009 | fraction treiber_WMM |
| PHGDH | LYPLA1 | 0.0 | 0.0 | fraction |
| ALDH1B1 | SHMT2 | 0.0 | 0.003 | bioplex (ALDH1B1) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| PEPD | GOT2 | 0.0 | 0.002 | bioplex_WMM fraction treiber_WMM |
| PHGDH | PEBP1 | 0.0 | 0.002 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM |
| PHGDH | SHMT2 | 0.0 | 0.001 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| UFM1 | GLRX | 0.0 | 0.001 | fraction |
| PEBP1 | LYPLA1 | 0.0 | 0.001 | bioplex_WMM fraction treiber_WMM |
| GOT2 | PEBP1 | 0.0 | 0.001 | bioplex (GOT2) bioplex_WMM fraction boldt_WMM treiber_WMM |
| GOT2 | MDH1 | 0.0 | 0.001 | bioplex (GOT2) bioplex_WMM fraction boldt_WMM treiber_WMM |
| MDH1 | LYPLA1 | 0.0 | 0.001 | bioplex_WMM fraction |
Images
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Complex HuMAP2_04645 has an average edge precision of 0.274 which is ranked 4968 out of all 6965 complexes.
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