hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04646
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SMAD9 | Mothers against decapentaplegic homolog 9 (MAD homolog 9) (Mothers against DPP homolog 9) (Madh6) (SMAD family member 9) (SMAD 9) (Smad9) | UniProt NCBI |
| SMAD2 | Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (JV18-1) (Mad-related protein 2) (hMAD-2) (SMAD family member 2) (SMAD 2) (Smad2) (hSMAD2) | UniProt NCBI |
| SMAD3 | Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3) | UniProt NCBI |
| LEMD3 | Inner nuclear membrane protein Man1 (LEM domain-containing protein 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4331 | 2.57005041727e-07 | 0.75 | SMAD2 SMAD3 SMAD9 | Neovascularisation processes |
| WP:WP4535 | 2.98215510426e-06 | 0.75 | LEMD3 SMAD3 SMAD2 | Envelope proteins and their potential roles in EDMD physiopathology |
| WP:WP560 | 2.98215510426e-06 | 0.75 | SMAD2 SMAD3 SMAD9 | TGF-beta Receptor Signaling |
| GO:0030618 | 3.6323771075e-06 | 0.75 | SMAD2 SMAD3 SMAD9 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity |
| CORUM:6513 | 5.02777038712e-06 | 0.5 | LEMD3 SMAD2 | MAN1-SMAD2 complex |
| GO:0071141 | 1.27120391093e-05 | 0.75 | SMAD2 SMAD3 SMAD9 | SMAD protein complex |
| CORUM:2830 | 1.50819606993e-05 | 0.5 | SMAD2 SMAD3 | TIF1gamma-SMAD2-SMAD3 complex |
| CORUM:2834 | 1.50819606993e-05 | 0.5 | SMAD2 SMAD3 | SMAD4-SMAD2-SMAD3 complex |
| GO:0005072 | 2.03382379613e-05 | 0.75 | SMAD2 SMAD3 SMAD9 | transforming growth factor beta receptor, cytoplasmic mediator activity |
| KEGG:04350 | 2.03941189943e-05 | 0.75 | SMAD2 SMAD3 SMAD9 | TGF-beta signaling pathway |
| CORUM:1827 | 3.01612206104e-05 | 0.5 | SMAD2 SMAD3 | PML-SMAD2/3-SARA complex |
| REAC:R-HSA-3311021 | 3.01639213985e-05 | 0.5 | SMAD2 SMAD3 | SMAD4 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3315487 | 3.01639213985e-05 | 0.5 | SMAD2 SMAD3 | SMAD2/3 MH2 Domain Mutants in Cancer |
| REAC:R-HSA-3304347 | 3.01639213985e-05 | 0.5 | SMAD2 SMAD3 | Loss of Function of SMAD4 in Cancer |
| REAC:R-HSA-3304356 | 6.03224412208e-05 | 0.5 | SMAD2 SMAD3 | SMAD2/3 Phosphorylation Motif Mutants in Cancer |
| REAC:R-HSA-3656532 | 6.03224412208e-05 | 0.5 | SMAD2 SMAD3 | TGFBR1 KD Mutants in Cancer |
| KEGG:04550 | 8.0940739521e-05 | 0.75 | SMAD2 SMAD3 SMAD9 | Signaling pathways regulating pluripotency of stem cells |
| REAC:R-HSA-3656534 | 0.000100528399861 | 0.5 | SMAD2 SMAD3 | Loss of Function of TGFBR1 in Cancer |
| REAC:R-HSA-3304349 | 0.000100528399861 | 0.5 | SMAD2 SMAD3 | Loss of Function of SMAD2/3 in Cancer |
| REAC:R-HSA-3304351 | 0.000150779097211 | 0.5 | SMAD2 SMAD3 | Signaling by TGF-beta Receptor Complex in Cancer |
| REAC:R-HSA-9006936 | 0.000152699585722 | 0.75 | SMAD2 SMAD3 SMAD9 | Signaling by TGF-beta family members |
| WP:WP3859 | 0.000176203894069 | 0.5 | SMAD2 SMAD3 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| WP:WP3874 | 0.000176203894069 | 0.5 | SMAD2 SMAD3 | Canonical and Non-Canonical TGF-B signaling |
| CORUM:2829 | 0.000226087640536 | 0.5 | SMAD2 SMAD3 | RSmad complex |
| REAC:R-HSA-1502540 | 0.000361772624521 | 0.5 | SMAD2 SMAD3 | Signaling by Activin |
| WP:WP2870 | 0.000502988822667 | 0.5 | SMAD2 SMAD3 | Extracellular vesicle-mediated signaling in recipient cells |
| WP:WP3668 | 0.000502988822667 | 0.5 | SMAD2 SMAD3 | Hypothesized Pathways in Pathogenesis of Cardiovascular Disease |
| WP:WP3850 | 0.000544855726676 | 0.5 | SMAD2 SMAD3 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| GO:0032924 | 0.000734489509778 | 0.75 | LEMD3 SMAD3 SMAD2 | activin receptor signaling pathway |
| REAC:R-HSA-1181150 | 0.00120515287053 | 0.5 | SMAD2 SMAD3 | Signaling by NODAL |
| REAC:R-HSA-9617828 | 0.00136571756437 | 0.5 | SMAD2 SMAD3 | FOXO-mediated transcription of cell cycle genes |
| WP:WP1971 | 0.00151155524127 | 0.5 | SMAD2 SMAD3 | Integrated Cancer Pathway |
| KEGG:05321 | 0.00188834163584 | 0.5 | SMAD2 SMAD3 | Inflammatory bowel disease (IBD) |
| GO:0007178 | 0.00195799214531 | 1.0 | LEMD3 SMAD2 SMAD3 SMAD9 | transmembrane receptor protein serine/threonine kinase signaling pathway |
| REAC:R-HSA-2173788 | 0.00210807296175 | 0.5 | SMAD2 SMAD3 | Downregulation of TGF-beta receptor signaling |
| REAC:R-HSA-9615017 | 0.00253927088831 | 0.5 | SMAD2 SMAD3 | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes |
| REAC:R-HSA-2173795 | 0.00253927088831 | 0.5 | SMAD2 SMAD3 | Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| GO:0071144 | 0.00270494046827 | 0.5 | SMAD2 SMAD3 | heteromeric SMAD protein complex |
| WP:WP2324 | 0.0034749006715 | 0.5 | SMAD2 SMAD3 | AGE/RAGE pathway |
| REAC:R-HSA-2173789 | 0.00352159938331 | 0.5 | SMAD2 SMAD3 | TGF-beta receptor signaling activates SMADs |
| WP:WP4216 | 0.0041492685023 | 0.5 | SMAD2 SMAD3 | Chromosomal and microsatellite instability in colorectal cancer |
| REAC:R-HSA-2173796 | 0.00466369436644 | 0.5 | SMAD2 SMAD3 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| KEGG:05212 | 0.00494838688052 | 0.5 | SMAD2 SMAD3 | Pancreatic cancer |
| WP:WP4263 | 0.00567595707464 | 0.5 | SMAD2 SMAD3 | Pancreatic adenocarcinoma pathway |
| WP:WP4540 | 0.00623747495525 | 0.5 | SMAD2 SMAD3 | Pathways Regulating Hippo Signaling |
| GO:0030512 | 0.0062689516986 | 0.75 | LEMD3 SMAD3 SMAD2 | negative regulation of transforming growth factor beta receptor signaling pathway |
| GO:1903845 | 0.0062689516986 | 0.75 | LEMD3 SMAD3 SMAD2 | negative regulation of cellular response to transforming growth factor beta stimulus |
| KEGG:05210 | 0.00660658678392 | 0.5 | SMAD2 SMAD3 | Colorectal cancer |
| KEGG:04659 | 0.00726841321698 | 0.5 | SMAD2 SMAD3 | Th17 cell differentiation |
| KEGG:04933 | 0.00813974967686 | 0.5 | SMAD2 SMAD3 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-2173793 | 0.00904685478976 | 0.5 | SMAD2 SMAD3 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| WP:WP179 | 0.0110921279178 | 0.5 | SMAD2 SMAD3 | Cell Cycle |
| WP:WP366 | 0.012672821387 | 0.5 | SMAD2 SMAD3 | TGF-beta Signaling Pathway |
| WP:WP2853 | 0.012672821387 | 0.5 | SMAD2 SMAD3 | Endoderm Differentiation |
| WP:WP2857 | 0.0137135792553 | 0.5 | SMAD2 SMAD3 | Mesodermal Commitment Pathway |
| KEGG:04110 | 0.0141554312811 | 0.5 | SMAD2 SMAD3 | Cell cycle |
| WP:WP4239 | 0.015016032698 | 0.5 | SMAD2 SMAD3 | Epithelial to mesenchymal transition in colorectal cancer |
| KEGG:04371 | 0.0151135129134 | 0.5 | SMAD2 SMAD3 | Apelin signaling pathway |
| REAC:R-HSA-9614085 | 0.0165385846138 | 0.5 | SMAD2 SMAD3 | FOXO-mediated transcription |
| KEGG:05226 | 0.0168647432957 | 0.5 | SMAD2 SMAD3 | Gastric cancer |
| WP:WP4666 | 0.0173163427152 | 0.5 | SMAD2 SMAD3 | Hepatitis B infection |
| KEGG:04390 | 0.0198080875546 | 0.5 | SMAD2 SMAD3 | Hippo signaling pathway |
| GO:0090101 | 0.0198185309013 | 0.75 | LEMD3 SMAD3 SMAD2 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| KEGG:04218 | 0.0206513420529 | 0.5 | SMAD2 SMAD3 | Cellular senescence |
| GO:0017015 | 0.0225145500348 | 0.75 | LEMD3 SMAD3 SMAD2 | regulation of transforming growth factor beta receptor signaling pathway |
| GO:1903844 | 0.0225145500348 | 0.75 | LEMD3 SMAD3 SMAD2 | regulation of cellular response to transforming growth factor beta stimulus |
| REAC:R-HSA-170834 | 0.0227713839361 | 0.5 | SMAD2 SMAD3 | Signaling by TGF-beta Receptor Complex |
| KEGG:05225 | 0.0248155779574 | 0.5 | SMAD2 SMAD3 | Hepatocellular carcinoma |
| CORUM:3039 | 0.0249595281251 | 0.25 | SMAD2 | SMAD2-FAST1 complex |
| GO:0071363 | 0.0288632862702 | 1.0 | LEMD3 SMAD2 SMAD3 SMAD9 | cellular response to growth factor stimulus |
| GO:0070848 | 0.0333189905195 | 1.0 | LEMD3 SMAD2 SMAD3 SMAD9 | response to growth factor |
| KEGG:05166 | 0.0380105899241 | 0.5 | SMAD2 SMAD3 | Human T-cell leukemia virus 1 infection |
| GO:0090288 | 0.0410761885593 | 0.75 | LEMD3 SMAD3 SMAD2 | negative regulation of cellular response to growth factor stimulus |
| MIRNA:hsa-miR-323a-3p | 0.0418723532423 | 0.5 | SMAD2 SMAD3 | hsa-miR-323a-3p |
| GO:0030509 | 0.0454154921687 | 0.75 | LEMD3 SMAD9 SMAD2 | BMP signaling pathway |
| CORUM:3199 | 0.0499140284799 | 0.25 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3198 | 0.0499140284799 | 0.25 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3038 | 0.0499140284799 | 0.25 | SMAD2 | SMAD2-SMAD4-FAST1 complex |
| CORUM:3749 | 0.0499140284799 | 0.25 | SMAD2 | CREBBP-SMAD2 hexameric complex |
| CORUM:2968 | 0.0499140284799 | 0.25 | SMAD3 | Axin-SMAD3 complex |
| CORUM:2813 | 0.0499140284799 | 0.25 | SMAD3 | BRCA1-SMAD3 complex |
| CORUM:3733 | 0.0499140284799 | 0.25 | SMAD3 | SKI-SMAD3 complex |
| CORUM:3729 | 0.0499140284799 | 0.25 | SMAD2 | SKI-SMAD2 complex |
| CORUM:3750 | 0.0499140284799 | 0.25 | SMAD3 | CREBBP-SMAD3 hexameric complex |
| HP:0004334 | 0.049965329079 | 0.5 | LEMD3 SMAD3 | Dermal atrophy |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMAD3 | SMAD2 | 1.0 | 0.949 | bioplex (SMAD3) bioplex_WMM |
| SMAD3 | SMAD9 | 0.998 | 0.945 | bioplex (SMAD3) bioplex_WMM |
| SMAD3 | LEMD3 | 0.953 | 0.858 | hein_WMM bioplex (SMAD3) bioplex_WMM hein (SMAD3) |
| SMAD9 | LEMD3 | 0.027 | 0.228 | bioplex (SMAD9) bioplex_WMM |
| SMAD2 | SMAD9 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| SMAD2 | LEMD3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04646 has an average edge precision of 0.514 which is ranked 2422 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SMAD9 | HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| SMAD2 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| SMAD3 | HuMAP2_04331 HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |
| LEMD3 | HuMAP2_04646 HuMAP2_05074 HuMAP2_05149 HuMAP2_06844 |