hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04651
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NELFCD | Negative elongation factor C/D (NELF-C/D) (TH1-like protein) | UniProt NCBI |
| IGHMBP2 | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | UniProt NCBI |
| NELFE | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | UniProt NCBI |
| BAD | Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death) | UniProt NCBI |
| NELFA | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | UniProt NCBI |
| NELFB | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | UniProt NCBI |
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| CHL1 | Neural cell adhesion molecule L1-like protein (Close homolog of L1) [Cleaved into: Processed neural cell adhesion molecule L1-like protein] | UniProt NCBI |
| ANK1 | Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2598 | 2.54036423996e-12 | 0.444444444444 | NELFCD NELFB NELFE NELFA | NELF complex (Negative elongation factor complex) |
| CORUM:281 | 2.54036423996e-12 | 0.444444444444 | NELFCD NELFB NELFE NELFA | NELF complex (Negative elongation factor complex) |
| GO:0032021 | 3.07384073035e-09 | 0.444444444444 | NELFCD NELFB NELFE NELFA | NELF complex |
| WP:WP3414 | 1.00181892753e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Initiation of transcription and translation elongation at the HIV-1 LTR |
| REAC:R-HSA-167242 | 1.07889289355e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Abortive elongation of HIV-1 transcript in the absence of Tat |
| GO:0034244 | 3.86783944726e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | negative regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-167243 | 4.37077268179e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 4.37077268179e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-113418 | 4.9723001016e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 4.9723001016e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-167287 | 5.63375764035e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | HIV elongation arrest and recovery |
| REAC:R-HSA-167290 | 5.63375764035e-07 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Pausing and recovery of HIV elongation |
| GO:0032785 | 1.01246124774e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | negative regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167246 | 1.64467190992e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 1.64467190992e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | HIV Transcription Elongation |
| REAC:R-HSA-167200 | 1.64467190992e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167152 | 1.97598063205e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-112382 | 5.4917903421e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 5.4917903421e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 6.7258150276e-06 | 0.444444444444 | NELFCD NELFB NELFE NELFA | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-167172 | 1.16864190892e-05 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Transcription of the HIV genome |
| REAC:R-HSA-674695 | 2.09746804746e-05 | 0.444444444444 | NELFCD NELFB NELFE NELFA | RNA Polymerase II Pre-transcription Events |
| GO:0034243 | 5.3613412156e-05 | 0.444444444444 | NELFCD NELFB NELFE NELFA | regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-162599 | 0.000147346986949 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.000214088994436 | 0.444444444444 | NELFCD NELFB NELFE NELFA | HIV Life Cycle |
| GO:0050434 | 0.00027821218892 | 0.444444444444 | NELFCD NELFB NELFE NELFA | positive regulation of viral transcription |
| GO:0032784 | 0.000495971138644 | 0.444444444444 | NELFCD NELFB NELFE NELFA | regulation of DNA-templated transcription, elongation |
| GO:0008023 | 0.000699201682235 | 0.444444444444 | NELFCD NELFB NELFE NELFA | transcription elongation factor complex |
| REAC:R-HSA-162906 | 0.00115768487299 | 0.444444444444 | NELFCD NELFB NELFE NELFA | HIV Infection |
| GO:0046782 | 0.00137843937587 | 0.444444444444 | NELFCD NELFB NELFE NELFA | regulation of viral transcription |
| REAC:R-HSA-447041 | 0.00180707658479 | 0.222222222222 | CHL1 ANK1 | CHL1 interactions |
| GO:0006368 | 0.0045261649793 | 0.444444444444 | NELFCD NELFB NELFE NELFA | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-3700989 | 0.00670117694776 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 0.00748844333445 | 0.444444444444 | NELFCD NELFB NELFE NELFA | Infectious disease |
| GO:0048524 | 0.00996136852053 | 0.444444444444 | NELFCD NELFB NELFE NELFA | positive regulation of viral process |
| GO:0006354 | 0.0142994300381 | 0.444444444444 | NELFCD NELFB NELFE NELFA | DNA-templated transcription, elongation |
| REAC:R-HSA-1643685 | 0.0210172589272 | 0.555555555556 | NELFA NELFCD NELFB NELFE BAD | Disease |
| HP:0040078 | 0.0235719846951 | 0.222222222222 | APTX IGHMBP2 | Axonal degeneration |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NELFB | NELFE | 1.0 | 0.949 | hein_WMM bioplex (NELFE) bioplex_WMM youn_WMM hein (NELFE) gupta_WMM fraction |
| NELFE | NELFA | 1.0 | 0.949 | hein_WMM bioplex (NELFA,NELFE) bioplex_WMM youn_WMM hein (NELFA,NELFE) gupta_WMM |
| NELFE | NELFCD | 0.999 | 0.949 | hein_WMM bioplex (NELFE) bioplex_WMM youn_WMM hein (NELFE) gupta_WMM fraction |
| NELFB | NELFA | 0.994 | 0.923 | hein_WMM bioplex (NELFA) bioplex_WMM youn_WMM hein (NELFA) |
| NELFA | NELFCD | 0.972 | 0.886 | hein_WMM bioplex (NELFA) bioplex_WMM youn_WMM hein (NELFA) |
| NELFE | IGHMBP2 | 0.713 | 0.727 | bioplex (NELFE) bioplex_WMM |
| NELFB | ANK1 | 0.127 | 0.398 | bioplex (ANK1) fraction |
| IGHMBP2 | NELFA | 0.043 | 0.269 | bioplex (NELFA) bioplex_WMM |
| BAD | NELFE | 0.031 | 0.236 | fraction |
| ANK1 | CHL1 | 0.027 | 0.225 | bioplex (CHL1) bioplex_WMM |
| APTX | BAD | 0.024 | 0.213 | hein_WMM bioplex (APTX) bioplex_WMM |
| NELFB | NELFCD | 0.016 | 0.16 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| IGHMBP2 | NELFCD | 0.011 | 0.144 | bioplex_WMM WMM_only |
| NELFB | IGHMBP2 | 0.011 | 0.144 | bioplex_WMM WMM_only |
| BAD | NELFB | 0.007 | 0.0 | WMM_only boldt_WMM |
| ANK1 | NELFE | 0.004 | 0.008 | bioplex (ANK1) bioplex_WMM |
Images
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Complex HuMAP2_04651 has an average edge precision of 0.449 which is ranked 2885 out of all 6965 complexes.
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