hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04653

Confidence: Medium

Genename	Protein Name	Links
MGME1	Mitochondrial genome maintenance exonuclease 1 (EC 3.1.-.-)	UniProt NCBI
MAP3K7	Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)	UniProt NCBI
TAB1	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1)	UniProt NCBI
ALMS1	Alstrom syndrome protein 1	UniProt NCBI
TRIM45	Tripartite motif-containing protein 45 (RING finger protein 99)	UniProt NCBI
AARSD1	Alanyl-tRNA editing protein Aarsd1 (Alanyl-tRNA synthetase domain-containing protein 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2758	2.0123342217e-05	0.4	TAB1 MAP3K7	TAK1 complex
CORUM:5268	0.000187691761896	0.4	TAB1 MAP3K7	TNF-alpha/NF-kappa B signaling complex 7
REAC:R-HSA-937042	0.000606744453221	0.4	TAB1 MAP3K7	IRAK2 mediated activation of TAK1 complex
CORUM:6344	0.000703182488552	0.4	TAB1 MAP3K7	TNF-R1-associated signaling complex
REAC:R-HSA-9014325	0.000741476933235	0.4	TAB1 MAP3K7	TICAM1,TRAF6-dependent induction of TAK1 complex
WP:WP3851	0.00108182147376	0.4	TAB1 MAP3K7	TLR4 Signaling and Tolerance
REAC:R-HSA-937072	0.00122631290825	0.4	TAB1 MAP3K7	TRAF6-mediated induction of TAK1 complex within TLR4 complex
REAC:R-HSA-975163	0.00122631290825	0.4	TAB1 MAP3K7	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
WP:WP4496	0.00135089978967	0.4	TAB1 MAP3K7	Signal transduction through IL1R
WP:WP4329	0.00144719807027	0.4	TAB1 MAP3K7	miRNAs involvement in the immune response in sepsis
REAC:R-HSA-450321	0.0031096034254	0.4	TAB1 MAP3K7	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
REAC:R-HSA-450302	0.00340529843133	0.4	TAB1 MAP3K7	activated TAK1 mediates p38 MAPK activation
WP:WP2637	0.00390244145107	0.4	TAB1 MAP3K7	Structural Pathway of Interleukin 1 (IL-1)
WP:WP195	0.00422982513182	0.4	TAB1 MAP3K7	IL-1 signaling pathway
WP:WP2018	0.00439842637514	0.4	TAB1 MAP3K7	RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
REAC:R-HSA-5357956	0.00546022370076	0.4	TAB1 MAP3K7	TNFR1-induced NFkappaB signaling pathway
REAC:R-HSA-445989	0.00584945327803	0.4	TAB1 MAP3K7	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
KEGG:05140	0.00680203716674	0.4	TAB1 MAP3K7	Leishmaniasis
REAC:R-HSA-168638	0.00799559968784	0.4	TAB1 MAP3K7	NOD1/2 Signaling Pathway
REAC:R-HSA-75893	0.0104745816743	0.4	TAB1 MAP3K7	TNF signaling
WP:WP231	0.0126363339816	0.4	TAB1 MAP3K7	TNF alpha Signaling Pathway
WP:WP75	0.0126363339816	0.4	TAB1 MAP3K7	Toll-like Receptor Signaling Pathway
KEGG:04064	0.0130921728933	0.4	TAB1 MAP3K7	NF-kappa B signaling pathway
KEGG:04620	0.0155166515839	0.4	TAB1 MAP3K7	Toll-like receptor signaling pathway
KEGG:04668	0.018144370474	0.4	TAB1 MAP3K7	TNF signaling pathway
REAC:R-HSA-168643	0.0184727645209	0.4	TAB1 MAP3K7	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
KEGG:05145	0.0185363159266	0.4	TAB1 MAP3K7	Toxoplasmosis
KEGG:04380	0.0222496587654	0.4	TAB1 MAP3K7	Osteoclast differentiation
WP:WP1449	0.0226950547009	0.4	TAB1 MAP3K7	Regulation of toll-like receptor signaling pathway
WP:WP366	0.0250517914711	0.4	TAB1 MAP3K7	TGF-beta Signaling Pathway
REAC:R-HSA-450294	0.0261457156832	0.4	TAB1 MAP3K7	MAP kinase activation
KEGG:05135	0.0262966325762	0.4	TAB1 MAP3K7	Yersinia infection
REAC:R-HSA-448424	0.0313816354582	0.4	TAB1 MAP3K7	Interleukin-17 signaling
WP:WP4666	0.0341988987854	0.4	TAB1 MAP3K7	Hepatitis B infection
HP:0004437	0.0360671162807	0.4	ALMS1 MAP3K7	Cranial hyperostosis
REAC:R-HSA-2871837	0.0380875604325	0.4	TAB1 MAP3K7	FCERI mediated NF-kB activation
HP:0000815	0.0398018408038	0.4	ALMS1 MGME1	Hypergonadotropic hypogonadism
REAC:R-HSA-975871	0.0443461879505	0.4	TAB1 MAP3K7	MyD88 cascade initiated on plasma membrane
REAC:R-HSA-168142	0.0443461879505	0.4	TAB1 MAP3K7	Toll Like Receptor 10 (TLR10) Cascade
REAC:R-HSA-168176	0.0443461879505	0.4	TAB1 MAP3K7	Toll Like Receptor 5 (TLR5) Cascade
REAC:R-HSA-975138	0.0465369402216	0.4	TAB1 MAP3K7	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REAC:R-HSA-168181	0.0476518941102	0.4	TAB1 MAP3K7	Toll Like Receptor 7/8 (TLR7/8) Cascade
REAC:R-HSA-975155	0.0476518941102	0.4	TAB1 MAP3K7	MyD88 dependent cascade initiated on endosome
HP:0100774	0.0478196851342	0.4	ALMS1 MAP3K7	Hyperostosis
CORUM:748	0.0499494897235	0.2	MAP3K7	TRAF6-TAK1 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TRIM45	AARSD1	0.931	0.846	bioplex (AARSD1) bioplex_WMM
MGME1	TRIM45	0.629	0.681	bioplex (MGME1) bioplex_WMM
TAB1	MAP3K7	0.021	0.188	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
ALMS1	AARSD1	0.021	0.186	bioplex (AARSD1) bioplex_WMM
TAB1	AARSD1	0.02	0.185	bioplex (AARSD1) bioplex_WMM
MAP3K7	AARSD1	0.018	0.18	bioplex (AARSD1) bioplex_WMM
TRIM45	MAP3K7	0.007	0.01	bioplex_WMM WMM_only
MAP3K7	ALMS1	0.007	0.006	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM
TAB1	TRIM45	0.007	0.004	bioplex_WMM WMM_only
TRIM45	ALMS1	0.007	0.003	bioplex_WMM WMM_only
TAB1	ALMS1	0.006	0.009	bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM

Images

Click to enlarge

Complex HuMAP2_04653 has an average edge precision of 0.209 which is ranked 6042 out of all 6965 complexes.

Related Complexes

Genename	Complexes
MGME1	HuMAP2_00307 HuMAP2_02275 HuMAP2_03324 HuMAP2_04653 HuMAP2_06336
MAP3K7	HuMAP2_00347 HuMAP2_04653
TAB1	HuMAP2_00142 HuMAP2_00347 HuMAP2_01481 HuMAP2_04653
ALMS1	HuMAP2_00618 HuMAP2_01481 HuMAP2_03324 HuMAP2_03772 HuMAP2_04653
TRIM45	HuMAP2_00307 HuMAP2_01481 HuMAP2_02275 HuMAP2_03032 HuMAP2_03324 HuMAP2_04653 HuMAP2_06336
AARSD1	HuMAP2_01481 HuMAP2_03032 HuMAP2_03324 HuMAP2_04653 HuMAP2_06336

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_04653