hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04655
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYO18A | Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210) | UniProt NCBI |
| MYL12B | Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1) | UniProt NCBI |
| MYL6 | Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5627117 | 0.00114404160216 | 0.666666666667 | MYL12B MYL6 | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00114404160216 | 0.666666666667 | MYL12B MYL6 | RHO GTPases activate CIT |
| REAC:R-HSA-416572 | 0.00114404160216 | 0.666666666667 | MYL12B MYL6 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627123 | 0.00127110038679 | 0.666666666667 | MYL12B MYL6 | RHO GTPases activate PAKs |
| REAC:R-HSA-400685 | 0.00169234301901 | 0.666666666667 | MYL12B MYL6 | Sema4D in semaphorin signaling |
| REAC:R-HSA-3928663 | 0.00217366618564 | 0.666666666667 | MYL12B MYL6 | EPHA-mediated growth cone collapse |
| REAC:R-HSA-445355 | 0.00353026371942 | 0.666666666667 | MYL12B MYL6 | Smooth Muscle Contraction |
| KEGG:04530 | 0.00464549646756 | 0.666666666667 | MYL12B MYL6 | Tight junction |
| REAC:R-HSA-373755 | 0.011426592715 | 0.666666666667 | MYL12B MYL6 | Semaphorin interactions |
| REAC:R-HSA-2682334 | 0.0243796532655 | 0.666666666667 | MYL12B MYL6 | EPH-Ephrin signaling |
| REAC:R-HSA-5625740 | 0.0285262244305 | 0.666666666667 | MYL12B MYL6 | RHO GTPases activate PKNs |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MYL6 | MYO18A | 0.98 | 0.896 | hein_WMM bioplex (MYL6) bioplex_WMM hein (MYO18A) |
| MYL12B | MYL6 | 0.875 | 0.809 | hein_WMM bioplex (MYL6) bioplex_WMM boldt youn_WMM hein (MYL12B) gupta_WMM boldt_WMM treiber_WMM |
| MYL12B | MYO18A | 0.102 | 0.364 | hein_WMM bioplex_WMM hein (MYL12B,MYO18A) |
Images
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Complex HuMAP2_04655 has an average edge precision of 0.69 which is ranked 1417 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYO18A | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| MYL12B | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04655 |
| MYL6 | HuMAP2_01307 HuMAP2_02178 HuMAP2_03956 HuMAP2_04152 HuMAP2_04655 |