hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04674
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AGO1 | Protein argonaute-1 (Argonaute1) (hAgo1) (Argonaute RISC catalytic component 1) (Eukaryotic translation initiation factor 2C 1) (eIF-2C 1) (eIF2C 1) (Putative RNA-binding protein Q99) | UniProt NCBI |
| AGO2 | Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-426496 | 3.51943927099e-05 | 1.0 | AGO2 AGO1 | Post-transcriptional silencing by small RNAs |
| REAC:R-HSA-8948700 | 4.69258569465e-05 | 1.0 | AGO2 AGO1 | Competing endogenous RNAs (ceRNAs) regulate PTEN translation |
| REAC:R-HSA-426486 | 6.03332446455e-05 | 1.0 | AGO2 AGO1 | Small interfering RNA (siRNA) biogenesis |
| REAC:R-HSA-8943723 | 6.03332446455e-05 | 1.0 | AGO2 AGO1 | Regulation of PTEN mRNA translation |
| REAC:R-HSA-8934593 | 0.000227925590883 | 1.0 | AGO2 AGO1 | Regulation of RUNX1 Expression and Activity |
| REAC:R-HSA-203927 | 0.000462554875615 | 1.0 | AGO2 AGO1 | MicroRNA (miRNA) biogenesis |
| REAC:R-HSA-9022692 | 0.000680424925724 | 1.0 | AGO2 AGO1 | Regulation of MECP2 expression and activity |
| REAC:R-HSA-4086398 | 0.00230942253115 | 1.0 | AGO2 AGO1 | Ca2+ pathway |
| REAC:R-HSA-8986944 | 0.00230942253115 | 1.0 | AGO2 AGO1 | Transcriptional Regulation by MECP2 |
| REAC:R-HSA-5628897 | 0.0052959181411 | 1.0 | AGO2 AGO1 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-5687128 | 0.00626962967274 | 1.0 | AGO2 AGO1 | MAPK6/MAPK4 signaling |
| REAC:R-HSA-1912408 | 0.00686290657842 | 1.0 | AGO2 AGO1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5578749 | 0.00863268175469 | 1.0 | AGO2 AGO1 | Transcriptional regulation by small RNAs |
| GO:0035280 | 0.00946729163895 | 1.0 | AGO2 AGO1 | miRNA loading onto RISC involved in gene silencing by miRNA |
| REAC:R-HSA-1912422 | 0.00950416195513 | 1.0 | AGO2 AGO1 | Pre-NOTCH Expression and Processing |
| MIRNA:hsa-miR-3616-3p | 0.0116182081559 | 1.0 | AGO2 AGO1 | hsa-miR-3616-3p |
| GO:0010501 | 0.0126230555186 | 1.0 | AGO2 AGO1 | RNA secondary structure unwinding |
| REAC:R-HSA-211000 | 0.0144900342557 | 1.0 | AGO2 AGO1 | Gene Silencing by RNA |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | AGO2 AGO1 | PTEN Regulation |
| REAC:R-HSA-3858494 | 0.0156129029755 | 1.0 | AGO2 AGO1 | Beta-catenin independent WNT signaling |
| GO:0070922 | 0.0162296428096 | 1.0 | AGO2 AGO1 | small RNA loading onto RISC |
| GO:0070578 | 0.0162296428096 | 1.0 | AGO2 AGO1 | RISC-loading complex |
| REAC:R-HSA-9018519 | 0.0165413645736 | 1.0 | AGO2 AGO1 | Estrogen-dependent gene expression |
| MIRNA:hsa-miR-6165 | 0.0184294437929 | 1.0 | AGO2 AGO1 | hsa-miR-6165 |
| MIRNA:hsa-miR-99a-5p | 0.0217291452677 | 1.0 | AGO2 AGO1 | hsa-miR-99a-5p |
| MIRNA:hsa-miR-652-3p | 0.0311665630662 | 1.0 | AGO2 AGO1 | hsa-miR-652-3p |
| WP:WP2805 | 0.0332875339197 | 0.5 | AGO2 | exRNA mechanism of action and biogenesis |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | AGO2 AGO1 | ESR-mediated signaling |
| GO:0045974 | 0.0351642260875 | 1.0 | AGO2 AGO1 | regulation of translation, ncRNA-mediated |
| GO:0040033 | 0.0351642260875 | 1.0 | AGO2 AGO1 | negative regulation of translation, ncRNA-mediated |
| GO:0035278 | 0.0351642260875 | 1.0 | AGO2 AGO1 | miRNA mediated inhibition of translation |
| GO:0031332 | 0.0351642260875 | 1.0 | AGO2 AGO1 | RNAi effector complex |
| GO:0016442 | 0.0351642260875 | 1.0 | AGO2 AGO1 | RISC complex |
| REAC:R-HSA-8878171 | 0.0400059689703 | 1.0 | AGO2 AGO1 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-157118 | 0.0403729962086 | 1.0 | AGO2 AGO1 | Signaling by NOTCH |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | AGO2 AGO1 | PIP3 activates AKT signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | AGO2 AGO1 | MAPK family signaling cascades |
| GO:0031054 | 0.0473364581948 | 1.0 | AGO2 AGO1 | pre-miRNA processing |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | AGO2 AGO1 | Signaling by Nuclear Receptors |
| CORUM:1387 | 0.0499173803268 | 0.5 | AGO2 | TTP-AGO2 complex |
| CORUM:5360 | 0.0499173803268 | 0.5 | AGO2 | AGO2-FXR1-TNF(alpha)ARE-RNP complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AGO1 | AGO2 | 0.822 | 0.774 | youn (AGO2) bioplex_WMM youn_WMM treiber_WMM |
Images
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Complex HuMAP2_04674 has an average edge precision of 0.774 which is ranked 1020 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AGO1 | HuMAP2_00153 HuMAP2_00288 HuMAP2_00478 HuMAP2_00976 HuMAP2_04674 |
| AGO2 | HuMAP2_00288 HuMAP2_00976 HuMAP2_03926 HuMAP2_04674 HuMAP2_06846 |