hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04677

Confidence: Medium High

Genename	Protein Name	Links
ATP6V0A1	V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)	UniProt NCBI
LEPR	Leptin receptor (LEP-R) (HuB219) (OB receptor) (OB-R) (CD antigen CD295)	UniProt NCBI
ATP6V0D1	V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)	UniProt NCBI
MVD	Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)	UniProt NCBI
SNX19	Sorting nexin-19	UniProt NCBI
ATP6V0A2	V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2) (Lysosomal H(+)-transporting ATPase V0 subunit a2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:04966	3.85535461709e-06	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Collecting duct acid secretion
REAC:R-HSA-77387	1.20153549581e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Insulin receptor recycling
REAC:R-HSA-917977	2.16753530756e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Transferrin endocytosis and recycling
KEGG:05110	2.88915337154e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Vibrio cholerae infection
REAC:R-HSA-1222556	2.94091318094e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	ROS and RNS production in phagocytes
KEGG:05323	4.62479008493e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Rheumatoid arthritis
KEGG:05120	6.00000658266e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Epithelial cell signaling in Helicobacter pylori infection
KEGG:04721	7.9791370908e-05	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Synaptic vesicle cycle
REAC:R-HSA-917937	0.000146580428081	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Iron uptake and transport
REAC:R-HSA-74752	0.000191968063148	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Signaling by Insulin receptor
KEGG:00190	0.000441153492847	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Oxidative phosphorylation
KEGG:04142	0.000441153492847	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Lysosome
KEGG:04145	0.000661047116041	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Phagosome
GO:0046961	0.000824951429902	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	proton-transporting ATPase activity, rotational mechanism
KEGG:05152	0.000906757296751	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Tuberculosis
GO:0016471	0.00123252169378	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	vacuolar proton-transporting V-type ATPase complex
GO:0033176	0.00175581235783	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	proton-transporting V-type ATPase complex
GO:0007035	0.00175581235783	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	vacuolar acidification
REAC:R-HSA-983712	0.0038957340756	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Ion channel transport
GO:0044769	0.00416378298645	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
GO:0090383	0.00529364410104	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	phagosome acidification
KEGG:05165	0.0080443443451	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	Human papillomavirus infection
GO:0033572	0.00986527098502	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	transferrin transport
GO:0009678	0.0118307664632	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	pyrophosphate hydrolysis-driven proton transmembrane transporter activity
GO:0090382	0.0129043378459	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	phagosome maturation
GO:0030670	0.0165096938447	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	phagocytic vesicle membrane
GO:0051452	0.0192515670318	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	intracellular pH reduction
GO:0016469	0.0192515670318	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	proton-transporting two-sector ATPase complex
GO:0045851	0.0207293189685	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	pH reduction
CORUM:1992	0.0249904952816	0.166666666667	LEPR	LEPR homodimer complex
KEGG:01100	0.0331288091988	0.666666666667	ATP6V0D1 ATP6V0A2 MVD ATP6V0A1	Metabolic pathways
WP:WP4189	0.0332875339197	0.166666666667	MVD	Mevalonate arm of cholesterol biosynthesis pathway with inhibitors
GO:0019829	0.0447070305646	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	ATPase-coupled cation transmembrane transporter activity
GO:0006826	0.0472791215337	0.5	ATP6V0D1 ATP6V0A2 ATP6V0A1	iron ion transport

Edges

Protein 1	Protein 2	Score	Precision	Evidence
ATP6V0D1	ATP6V0A1	1.0	0.949	hein_WMM bioplex (ATP6V0D1) bioplex_WMM Guru fraction
ATP6V0D1	ATP6V0A2	0.533	0.637	bioplex (ATP6V0A2,ATP6V0D1) bioplex_WMM
MVD	ATP6V0D1	0.45	0.594	hein_WMM bioplex (ATP6V0D1) bioplex_WMM
ATP6V0A1	ATP6V0A2	0.324	0.512	bioplex (ATP6V0A2) bioplex_WMM gupta_WMM
ATP6V0D1	LEPR	0.265	0.482	bioplex (ATP6V0D1) bioplex_WMM
ATP6V0D1	SNX19	0.042	0.269	bioplex (ATP6V0D1) bioplex_WMM
MVD	SNX19	0.009	0.095	bioplex_WMM WMM_only
LEPR	SNX19	0.008	0.082	bioplex_WMM WMM_only
MVD	LEPR	0.008	0.082	bioplex_WMM WMM_only
ATP6V0A2	SNX19	0.008	0.026	bioplex_WMM gupta_WMM WMM_only
MVD	ATP6V0A2	0.008	0.012	bioplex_WMM WMM_only
ATP6V0A1	SNX19	0.007	0.012	bioplex_WMM gupta_WMM WMM_only
MVD	ATP6V0A1	0.007	0.006	bioplex_WMM WMM_only
ATP6V0A2	LEPR	0.007	0.001	bioplex_WMM WMM_only
ATP6V0A1	LEPR	0.007	0.009	bioplex_WMM WMM_only

Images

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Complex HuMAP2_04677 has an average edge precision of 0.251 which is ranked 5360 out of all 6965 complexes.

Related Complexes

Genename	Complexes
ATP6V0A1	HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_02034 HuMAP2_02651 HuMAP2_04677
LEPR	HuMAP2_01018 HuMAP2_04677 HuMAP2_06925
ATP6V0D1	HuMAP2_00515 HuMAP2_00772 HuMAP2_01018 HuMAP2_01065 HuMAP2_01270 HuMAP2_02034 HuMAP2_02651 HuMAP2_04677 HuMAP2_06925
MVD	HuMAP2_00480 HuMAP2_03289 HuMAP2_04677 HuMAP2_05112 HuMAP2_06034
SNX19	HuMAP2_01018 HuMAP2_04677 HuMAP2_06925
ATP6V0A2	HuMAP2_00515 HuMAP2_01018 HuMAP2_01270 HuMAP2_02034 HuMAP2_04677

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04677