hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04691

Confidence: Medium

Genename	Protein Name	Links
TSHZ3	Teashirt homolog 3 (Zinc finger protein 537)	UniProt NCBI
NBEAL1	Neurobeachin-like protein 1 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 16 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 17 protein)	UniProt NCBI
SMDT1	Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial)	UniProt NCBI
FAM193B	Protein FAM193B	UniProt NCBI
TMED8	Protein TMED8	UniProt NCBI
ORMDL2	ORM1-like protein 2 (Adoplin-2)	UniProt NCBI
GPC4	Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]	UniProt NCBI
DOLPP1	Dolichyldiphosphatase 1 (EC 3.6.1.43) (Dolichyl pyrophosphate phosphatase 1)	UniProt NCBI
GPC3	Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]	UniProt NCBI
SULF1	Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6.-)	UniProt NCBI
P2RX1	P2X purinoceptor 1 (P2X1) (ATP receptor) (Purinergic receptor)	UniProt NCBI
GPC6	Glypican-6 [Cleaved into: Secreted glypican-6]	UniProt NCBI
SDC2	Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)	UniProt NCBI
ITPRIPL1	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	UniProt NCBI
GPR183	G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)	UniProt NCBI
GPC1	Glypican-1 [Cleaved into: Secreted glypican-1]	UniProt NCBI
SDC4	Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein)	UniProt NCBI
TGFBR3	Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-3656237	1.04582530443e-12	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Defective EXT2 causes exostoses 2
REAC:R-HSA-3656253	1.04582530443e-12	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Defective EXT1 causes exostoses 1, TRPS2 and CHDS
REAC:R-HSA-3560783	9.41638541684e-12	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Defective B4GALT7 causes EDS, progeroid type
REAC:R-HSA-3560801	9.41638541684e-12	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Defective B3GAT3 causes JDSSDHD
REAC:R-HSA-4420332	9.41638541684e-12	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Defective B3GALT6 causes EDSP2 and SEMDJL1
REAC:R-HSA-2024096	1.88067421479e-11	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	HS-GAG degradation
REAC:R-HSA-1971475	4.65514102541e-11	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	A tetrasaccharide linker sequence is required for GAG synthesis
REAC:R-HSA-2022928	1.6372331224e-10	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	HS-GAG biosynthesis
REAC:R-HSA-3560782	1.11676140622e-09	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Diseases associated with glycosaminoglycan metabolism
REAC:R-HSA-975634	1.53693711714e-09	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Retinoid metabolism and transport
REAC:R-HSA-6806667	2.40789099818e-09	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Metabolism of fat-soluble vitamins
REAC:R-HSA-1793185	3.65506053948e-09	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Chondroitin sulfate/dermatan sulfate metabolism
REAC:R-HSA-1638091	5.3979562111e-09	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Heparan sulfate/heparin (HS-GAG) metabolism
REAC:R-HSA-2187338	6.72258427434e-08	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Visual phototransduction
REAC:R-HSA-1630316	7.37293367243e-07	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Glycosaminoglycan metabolism
GO:0006027	9.44642336942e-07	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	glycosaminoglycan catabolic process
REAC:R-HSA-3781865	1.37222670144e-06	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Diseases of glycosylation
GO:0006026	1.53108078206e-06	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	aminoglycan catabolic process
REAC:R-HSA-418594	3.61139339141e-06	0.388888888889	GPR183 GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	G alpha (i) signalling events
REAC:R-HSA-196854	9.58350021846e-06	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Metabolism of vitamins and cofactors
GO:0001523	9.95958896415e-06	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	retinoid metabolic process
GO:0016101	1.17645224801e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	diterpenoid metabolic process
GO:0005796	1.4975492099e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Golgi lumen
GO:0006721	2.03593127689e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	terpenoid metabolic process
GO:0043202	2.19305398517e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	lysosomal lumen
GO:0006024	4.11730755001e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	glycosaminoglycan biosynthetic process
GO:0006023	4.69482694285e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	aminoglycan biosynthetic process
GO:0006720	5.33800848018e-05	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	isoprenoid metabolic process
REAC:R-HSA-71387	0.000124299096817	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Metabolism of carbohydrates
GO:0030203	0.000186861017441	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	glycosaminoglycan metabolic process
GO:0006022	0.000252174917028	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	aminoglycan metabolic process
REAC:R-HSA-388396	0.000496083925149	0.388888888889	GPR183 GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	GPCR downstream signalling
GO:1901136	0.00052394746322	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	carbohydrate derivative catabolic process
REAC:R-HSA-372790	0.000857107937238	0.388888888889	GPR183 GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	Signaling by GPCR
GO:0005775	0.00100306490853	0.333333333333	GPC6 SDC2 GPC4 GPC3 SDC4 GPC1	vacuolar lumen
HP:0009101	0.00116908443968	0.111111111111	GPC3 GPC4	Submucous cleft lip
HP:0008416	0.00116908443968	0.111111111111	GPC3 GPC4	Six lumbar vertebrae
HP:0006176	0.00116908443968	0.111111111111	GPC3 GPC4	Two carpal ossification centers present at birth
GO:0009986	0.00132099772475	0.444444444444	TGFBR3 SULF1 GPC6 SDC2 GPC4 SDC4 GPC3 GPC1	cell surface
HP:0005580	0.00350474118486	0.111111111111	GPC3 GPC4	Duplication of renal pelvis
KEGG:05205	0.00365132312496	0.222222222222	GPC3 SDC2 GPC1 SDC4	Proteoglycans in cancer
HP:0002946	0.00700446189716	0.111111111111	GPC3 GPC4	Supernumerary vertebrae
HP:0003517	0.00700446189716	0.111111111111	GPC3 GPC4	Birth length greater than 97th percentile
HP:0003185	0.00700446189716	0.111111111111	GPC3 GPC4	Short sacroiliac notch
HP:0030304	0.00700446189716	0.111111111111	GPC3 GPC4	Abnormal number of vertebrae
HP:0000216	0.00700446189716	0.111111111111	GPC3 GPC4	Broad secondary alveolar ridge
HP:0008523	0.0116657420292	0.111111111111	GPC3 GPC4	Posterior helix pit
GO:0016477	0.017442995657	0.5	GPR183 TGFBR3 SULF1 GPC6 SDC2 GPC4 SDC4 GPC3 GPC1	cell migration
KEGG:05418	0.0239390858481	0.166666666667	SDC4 GPC1 SDC2	Fluid shear stress and atherosclerosis
HP:0008803	0.0244629812898	0.111111111111	GPC3 GPC4	Narrow sacroiliac notch
HP:0002884	0.0244629812898	0.111111111111	GPC3 GPC4	Hepatoblastoma
HP:0030266	0.0418764982277	0.111111111111	GPC3 GPC4	Abnormality of the sacroiliac notch
HP:0001233	0.0418764982277	0.111111111111	GPC3 GPC4	2-3 finger syndactyly
HP:0000891	0.0418764982277	0.111111111111	GPC3 GPC4	Cervical ribs
GO:0048870	0.0449808497697	0.5	GPR183 TGFBR3 SULF1 GPC6 SDC2 GPC4 SDC4 GPC3 GPC1	cell motility
GO:0051674	0.0449808497697	0.5	GPR183 TGFBR3 SULF1 GPC6 SDC2 GPC4 SDC4 GPC3 GPC1	localization of cell

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SDC2	GPR183	0.844	0.788	bioplex (GPR183) bioplex_WMM
DOLPP1	GPR183	0.798	0.764	bioplex (GPR183) bioplex_WMM
GPR183	TMED8	0.279	0.485	bioplex (GPR183) bioplex_WMM
GPR183	SDC4	0.275	0.487	bioplex (GPR183) bioplex_WMM
GPR183	GPC1	0.165	0.42	bioplex (GPR183) bioplex_WMM
GPR183	ITPRIPL1	0.125	0.398	bioplex (GPR183) bioplex_WMM
P2RX1	TMED8	0.121	0.393	bioplex (P2RX1) bioplex_WMM
GPR183	GPC3	0.108	0.373	bioplex (GPR183) bioplex_WMM
GPR183	ORMDL2	0.06	0.333	bioplex (GPR183) bioplex_WMM
SDC2	NBEAL1	0.053	0.301	bioplex (SDC2) bioplex_WMM
GPR183	SMDT1	0.043	0.27	bioplex (GPR183) bioplex_WMM
GPR183	TGFBR3	0.04	0.266	bioplex (GPR183) bioplex_WMM
GPC4	GPC6	0.038	0.265	bioplex (GPC4,GPC6) bioplex_WMM
GPR183	GPC4	0.036	0.265	bioplex (GPR183) bioplex_WMM
FAM193B	GPR183	0.034	0.264	bioplex (GPR183) bioplex_WMM
SDC2	SDC4	0.029	0.232	bioplex (SDC2) bioplex_WMM
GPR183	TSHZ3	0.022	0.198	bioplex (GPR183) bioplex_WMM
SDC2	SULF1	0.021	0.194	bioplex (SDC2) bioplex_WMM
SDC2	GPC1	0.011	0.143	hein_WMM bioplex_WMM WMM_only
SDC4	GPC1	0.011	0.143	bioplex_WMM WMM_only
GPC1	GPC3	0.011	0.141	bioplex_WMM WMM_only
SDC2	GPC3	0.01	0.129	bioplex_WMM WMM_only
SDC4	GPC3	0.009	0.105	bioplex_WMM WMM_only
GPC3	GPC4	0.009	0.105	bioplex_WMM WMM_only
GPC1	TGFBR3	0.009	0.109	bioplex_WMM WMM_only
SDC4	TGFBR3	0.009	0.09	bioplex_WMM WMM_only
SDC2	TGFBR3	0.009	0.099	bioplex_WMM WMM_only
FAM193B	SDC4	0.009	0.098	bioplex_WMM WMM_only
GPC1	GPC6	0.008	0.094	bioplex_WMM WMM_only
SDC2	GPC4	0.008	0.095	bioplex_WMM WMM_only
NBEAL1	SDC4	0.008	0.087	bioplex_WMM WMM_only
FAM193B	GPC1	0.008	0.085	bioplex_WMM WMM_only
FAM193B	SMDT1	0.008	0.084	bioplex_WMM WMM_only
FAM193B	TSHZ3	0.008	0.081	bioplex_WMM youn_WMM WMM_only
FAM193B	TMED8	0.008	0.084	bioplex_WMM WMM_only
FAM193B	DOLPP1	0.008	0.084	bioplex_WMM youn_WMM WMM_only
FAM193B	SDC2	0.008	0.08	bioplex_WMM WMM_only
FAM193B	ORMDL2	0.008	0.082	bioplex_WMM WMM_only
SDC4	SMDT1	0.008	0.079	bioplex_WMM WMM_only
SDC2	GPC6	0.008	0.079	bioplex_WMM WMM_only
SDC4	GPC4	0.008	0.082	bioplex_WMM WMM_only
SDC4	TSHZ3	0.008	0.072	bioplex_WMM WMM_only
SDC4	TMED8	0.008	0.068	bioplex_WMM WMM_only
DOLPP1	SDC4	0.008	0.067	bioplex_WMM WMM_only
NBEAL1	SULF1	0.008	0.067	bioplex_WMM WMM_only
GPC3	TGFBR3	0.008	0.07	bioplex_WMM WMM_only
SDC4	ORMDL2	0.008	0.066	bioplex_WMM WMM_only
SDC4	GPC6	0.008	0.06	bioplex_WMM WMM_only
DOLPP1	TSHZ3	0.008	0.052	bioplex_WMM youn_WMM WMM_only
GPC1	SMDT1	0.008	0.052	bioplex_WMM WMM_only
DOLPP1	SMDT1	0.008	0.046	bioplex_WMM WMM_only
GPC1	TSHZ3	0.008	0.042	bioplex_WMM WMM_only
SMDT1	TSHZ3	0.008	0.045	bioplex_WMM WMM_only
GPC1	TMED8	0.008	0.044	bioplex_WMM WMM_only
DOLPP1	TMED8	0.008	0.046	bioplex_WMM youn_WMM WMM_only
SMDT1	TMED8	0.008	0.043	bioplex_WMM WMM_only
DOLPP1	GPC1	0.008	0.04	bioplex_WMM WMM_only
DOLPP1	SDC2	0.008	0.04	bioplex_WMM WMM_only
DOLPP1	ORMDL2	0.008	0.032	bioplex_WMM gupta_WMM WMM_only
FAM193B	GPC6	0.008	0.035	bioplex_WMM WMM_only
SDC2	SMDT1	0.008	0.037	bioplex_WMM WMM_only
TSHZ3	TMED8	0.008	0.037	bioplex_WMM WMM_only
GPC1	ORMDL2	0.008	0.037	bioplex_WMM WMM_only
ORMDL2	SMDT1	0.008	0.033	bioplex_WMM WMM_only
FAM193B	GPC3	0.008	0.033	bioplex_WMM WMM_only
SDC2	TSHZ3	0.008	0.033	bioplex_WMM WMM_only
DOLPP1	GPC6	0.008	0.032	bioplex_WMM WMM_only
SDC2	TMED8	0.008	0.024	bioplex_WMM WMM_only
ORMDL2	TSHZ3	0.008	0.022	bioplex_WMM WMM_only
GPR183	GPC6	0.008	0.021	bioplex (GPR183) bioplex_WMM
ORMDL2	TMED8	0.008	0.021	bioplex_WMM WMM_only
SULF1	SDC4	0.008	0.025	bioplex_WMM WMM_only
SDC2	ORMDL2	0.008	0.027	bioplex_WMM WMM_only
FAM193B	TGFBR3	0.008	0.027	bioplex_WMM WMM_only
GPC3	GPC6	0.008	0.016	bioplex_WMM WMM_only
GPC6	TMED8	0.007	0.008	bioplex_WMM WMM_only
DOLPP1	GPC3	0.007	0.01	bioplex_WMM WMM_only
DOLPP1	TGFBR3	0.007	0.009	bioplex_WMM WMM_only
GPC6	SMDT1	0.007	0.012	bioplex_WMM WMM_only
GPC6	TGFBR3	0.007	0.01	bioplex_WMM WMM_only
GPC3	SMDT1	0.007	0.007	bioplex_WMM WMM_only
GPC6	TSHZ3	0.007	0.011	bioplex_WMM WMM_only
FAM193B	GPC4	0.007	0.003	bioplex_WMM WMM_only
GPC3	TSHZ3	0.007	0.01	bioplex_WMM WMM_only
GPC3	TMED8	0.007	0.009	bioplex_WMM WMM_only
GPC6	ORMDL2	0.007	0.007	bioplex_WMM WMM_only
DOLPP1	GPC4	0.007	0.007	bioplex_WMM WMM_only
SMDT1	TGFBR3	0.007	0.005	bioplex_WMM WMM_only
GPC3	ORMDL2	0.007	0.008	bioplex_WMM WMM_only
TSHZ3	TGFBR3	0.007	0.006	bioplex_WMM WMM_only
ITPRIPL1	TMED8	0.007	0.006	bioplex_WMM WMM_only
TMED8	TGFBR3	0.007	0.006	bioplex_WMM WMM_only
SULF1	GPC4	0.007	0.0	bioplex_WMM WMM_only
FAM193B	ITPRIPL1	0.007	0.005	bioplex_WMM WMM_only
ORMDL2	TGFBR3	0.007	0.003	bioplex_WMM WMM_only
DOLPP1	ITPRIPL1	0.007	0.0	bioplex_WMM WMM_only
SDC4	ITPRIPL1	0.007	0.006	bioplex_WMM WMM_only
GPC4	SMDT1	0.007	0.0	bioplex_WMM WMM_only
GPC4	TSHZ3	0.007	0.004	bioplex_WMM WMM_only
GPC4	TMED8	0.007	0.005	bioplex_WMM WMM_only
SDC2	ITPRIPL1	0.007	0.004	bioplex_WMM WMM_only
GPC4	ORMDL2	0.007	0.004	bioplex_WMM WMM_only
GPC1	ITPRIPL1	0.007	0.004	bioplex_WMM WMM_only
ITPRIPL1	SMDT1	0.007	0.003	bioplex_WMM WMM_only
ITPRIPL1	TSHZ3	0.007	0.006	bioplex_WMM WMM_only
GPC4	TGFBR3	0.007	0.005	bioplex_WMM WMM_only
ORMDL2	ITPRIPL1	0.007	0.005	bioplex_WMM WMM_only
ITPRIPL1	TGFBR3	0.006	0.005	bioplex_WMM WMM_only
GPC6	ITPRIPL1	0.006	0.007	bioplex_WMM WMM_only
GPC3	ITPRIPL1	0.006	0.008	bioplex_WMM WMM_only
ITPRIPL1	P2RX1	0.005	0.007	bioplex (P2RX1) bioplex_WMM
GPC4	ITPRIPL1	0.005	0.008	bioplex_WMM WMM_only
GPC1	GPC4	0.005	0.014	bioplex (GPC1) bioplex_WMM

Images

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Complex HuMAP2_04691 has an average edge precision of 0.094 which is ranked 6947 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TSHZ3	HuMAP2_04691 HuMAP2_04797 HuMAP2_05207 HuMAP2_05499
NBEAL1	HuMAP2_01740 HuMAP2_02199 HuMAP2_04691
SMDT1	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
FAM193B	HuMAP2_00258 HuMAP2_02019 HuMAP2_04691 HuMAP2_04797 HuMAP2_06457
TMED8	HuMAP2_04691 HuMAP2_05131
ORMDL2	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
GPC4	HuMAP2_03070 HuMAP2_04691 HuMAP2_04797
DOLPP1	HuMAP2_00669 HuMAP2_00939 HuMAP2_02772 HuMAP2_04691
GPC3	HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352
SULF1	HuMAP2_02199 HuMAP2_04691
P2RX1	HuMAP2_04691 HuMAP2_05131 HuMAP2_06678
GPC6	HuMAP2_03070 HuMAP2_04691 HuMAP2_04797
SDC2	HuMAP2_00939 HuMAP2_01740 HuMAP2_02199 HuMAP2_04691
ITPRIPL1	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797 HuMAP2_05920
GPR183	HuMAP2_00939 HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
GPC1	HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352
SDC4	HuMAP2_02199 HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
TGFBR3	HuMAP2_04691 HuMAP2_04797

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04691