hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04700
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FBXW11 | F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS) | UniProt NCBI |
| BTRC | F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit) | UniProt NCBI |
| MLPH | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | UniProt NCBI |
| HIVEP1 | Zinc finger protein 40 (Cirhin interaction protein) (CIRIP) (Gate keeper of apoptosis-activating protein) (GAAP) (Human immunodeficiency virus type I enhancer-binding protein 1) (HIV-EP1) (Major histocompatibility complex-binding protein 1) (MBP-1) (Positive regulatory domain II-binding factor 1) (PRDII-BF1) | UniProt NCBI |
| HIVEP2 | Transcription factor HIVEP2 (Human immunodeficiency virus type I enhancer-binding protein 2) (HIV-EP2) (MHC-binding protein 2) (MBP-2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5684264 | 0.00161668141155 | 0.4 | BTRC FBXW11 | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| KEGG:04710 | 0.00173687115815 | 0.4 | BTRC FBXW11 | Circadian rhythm |
| KEGG:04340 | 0.00403884103568 | 0.4 | BTRC FBXW11 | Hedgehog signaling pathway |
| KEGG:05131 | 0.00858395707223 | 0.4 | BTRC FBXW11 | Shigellosis |
| WP:WP231 | 0.0126363339816 | 0.4 | BTRC FBXW11 | TNF alpha Signaling Pathway |
| REAC:R-HSA-5676590 | 0.0229182830201 | 0.4 | BTRC FBXW11 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0237053784759 | 0.4 | BTRC FBXW11 | Dectin-1 mediated noncanonical NF-kB signaling |
| KEGG:04114 | 0.024007198204 | 0.4 | BTRC FBXW11 | Oocyte meiosis |
| REAC:R-HSA-450294 | 0.0261457156832 | 0.4 | BTRC FBXW11 | MAP kinase activation |
| REAC:R-HSA-1169091 | 0.0287045163353 | 0.4 | BTRC FBXW11 | Activation of NF-kappaB in B cells |
| REAC:R-HSA-448424 | 0.0313816354582 | 0.4 | BTRC FBXW11 | Interleukin-17 signaling |
| KEGG:04120 | 0.0353865382697 | 0.4 | BTRC FBXW11 | Ubiquitin mediated proteolysis |
| REAC:R-HSA-2871837 | 0.0380875604325 | 0.4 | BTRC FBXW11 | FCERI mediated NF-kB activation |
| REAC:R-HSA-1168372 | 0.0390979640759 | 0.4 | BTRC FBXW11 | Downstream signaling events of B Cell Receptor (BCR) |
| KEGG:04390 | 0.0421802717446 | 0.4 | BTRC FBXW11 | Hippo signaling pathway |
| WP:WP3594 | 0.0426212197502 | 0.4 | BTRC FBXW11 | Circadian rhythm related genes |
| KEGG:04218 | 0.0439700127241 | 0.4 | BTRC FBXW11 | Cellular senescence |
| REAC:R-HSA-975871 | 0.0443461879505 | 0.4 | BTRC FBXW11 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 0.0443461879505 | 0.4 | BTRC FBXW11 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 0.0443461879505 | 0.4 | BTRC FBXW11 | Toll Like Receptor 5 (TLR5) Cascade |
| KEGG:04310 | 0.0451834163131 | 0.4 | BTRC FBXW11 | Wnt signaling pathway |
| REAC:R-HSA-2565942 | 0.0465369402216 | 0.4 | BTRC FBXW11 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-975138 | 0.0465369402216 | 0.4 | BTRC FBXW11 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-5668541 | 0.0476518941102 | 0.4 | BTRC FBXW11 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-168181 | 0.0476518941102 | 0.4 | BTRC FBXW11 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0476518941102 | 0.4 | BTRC FBXW11 | MyD88 dependent cascade initiated on endosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FBXW11 | BTRC | 0.987 | 0.902 | hein_WMM bioplex (BTRC,FBXW11) bioplex_WMM youn_WMM gupta_WMM |
| HIVEP1 | BTRC | 0.966 | 0.876 | bioplex (BTRC) bioplex_WMM |
| HIVEP2 | BTRC | 0.873 | 0.805 | bioplex (BTRC) bioplex_WMM |
| BTRC | MLPH | 0.744 | 0.74 | bioplex (BTRC) bioplex_WMM |
| FBXW11 | HIVEP2 | 0.03 | 0.239 | bioplex (FBXW11) bioplex_WMM |
| FBXW11 | HIVEP1 | 0.026 | 0.22 | bioplex (FBXW11) bioplex_WMM youn_WMM |
| HIVEP1 | HIVEP2 | 0.011 | 0.141 | bioplex_WMM WMM_only |
| HIVEP2 | MLPH | 0.008 | 0.091 | bioplex_WMM WMM_only |
| HIVEP1 | MLPH | 0.008 | 0.091 | bioplex_WMM WMM_only |
| FBXW11 | MLPH | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04700 has an average edge precision of 0.411 which is ranked 3193 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FBXW11 | HuMAP2_01350 HuMAP2_03573 HuMAP2_04700 HuMAP2_05993 |
| BTRC | HuMAP2_04363 HuMAP2_04700 HuMAP2_05993 |
| MLPH | HuMAP2_04363 HuMAP2_04700 HuMAP2_05993 |
| HIVEP1 | HuMAP2_03573 HuMAP2_04363 HuMAP2_04700 HuMAP2_05993 |
| HIVEP2 | HuMAP2_03573 HuMAP2_04363 HuMAP2_04700 HuMAP2_05993 |