hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04705
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERCC4 | DNA repair endonuclease XPF (EC 3.1.-.-) (DNA excision repair protein ERCC-4) (DNA repair protein complementing XP-F cells) (Xeroderma pigmentosum group F-complementing protein) | UniProt NCBI |
| XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | UniProt NCBI |
| DDX4 | Probable ATP-dependent RNA helicase DDX4 (EC 3.6.4.13) (DEAD box protein 4) (Vasa homolog) | UniProt NCBI |
| DDX28 | Probable ATP-dependent RNA helicase DDX28 (EC 3.6.4.13) (Mitochondrial DEAD box protein 28) | UniProt NCBI |
| RPUSD4 | Mitochondrial RNA pseudouridine synthase RPUSD4 (EC 5.4.99.-) (RNA pseudouridylate synthase domain-containing protein 4) | UniProt NCBI |
| NUP43 | Nucleoporin Nup43 (Nup107-160 subcomplex subunit Nup43) (p42) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:531 | 2.51655344529e-05 | 0.333333333333 | XPA ERCC4 | XPA-ERCC1-ERCC4 complex |
| HP:0010649 | 0.00210158306671 | 0.333333333333 | XPA ERCC4 | Flat nasal alae |
| HP:0009755 | 0.00495018352279 | 0.333333333333 | XPA ERCC4 | Ankyloblepharon |
| HP:0003079 | 0.00495018352279 | 0.333333333333 | XPA ERCC4 | Defective DNA repair after ultraviolet radiation damage |
| KEGG:03420 | 0.00587890830807 | 0.333333333333 | XPA ERCC4 | Nucleotide excision repair |
| GO:1901255 | 0.00676235117068 | 0.333333333333 | XPA ERCC4 | nucleotide-excision repair involved in interstrand cross-link repair |
| HP:0001029 | 0.00682280818411 | 0.333333333333 | XPA ERCC4 | Poikiloderma |
| HP:0003254 | 0.00787106080828 | 0.333333333333 | XPA ERCC4 | Abnormality of DNA repair |
| HP:0000524 | 0.0128094019441 | 0.333333333333 | XPA ERCC4 | Conjunctival telangiectasia |
| HP:0000621 | 0.0128094019441 | 0.333333333333 | XPA ERCC4 | Entropion |
| HP:0008054 | 0.0172946302375 | 0.333333333333 | XPA ERCC4 | Abnormal morphology of the conjunctival vasculature |
| REAC:R-HSA-5696400 | 0.0180541440856 | 0.333333333333 | XPA ERCC4 | Dual Incision in GG-NER |
| REAC:R-HSA-5696395 | 0.019874448248 | 0.333333333333 | XPA ERCC4 | Formation of Incision Complex in GG-NER |
| GO:0000110 | 0.020283420769 | 0.333333333333 | XPA ERCC4 | nucleotide-excision repair factor 1 complex |
| HP:0004493 | 0.0243148377528 | 0.333333333333 | XPA ERCC4 | Craniofacial hyperostosis |
| HP:0001059 | 0.0262553193116 | 0.333333333333 | XPA ERCC4 | Pterygium |
| HP:0100579 | 0.0370683023611 | 0.333333333333 | XPA ERCC4 | Mucosal telangiectasiae |
| REAC:R-HSA-6782135 | 0.0455991929544 | 0.333333333333 | XPA ERCC4 | Dual incision in TC-NER |
| HP:0100012 | 0.0470489782673 | 0.333333333333 | XPA ERCC4 | Neoplasm of the eye |
| HP:0012740 | 0.0497285764978 | 0.333333333333 | XPA ERCC4 | Papilloma |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUP43 | XPA | 0.408 | 0.567 | bioplex (XPA) bioplex_WMM |
| NUP43 | DDX4 | 0.135 | 0.406 | bioplex (NUP43) bioplex_WMM |
| DDX4 | DDX28 | 0.129 | 0.399 | bioplex (DDX28) bioplex_WMM |
| ERCC4 | XPA | 0.028 | 0.229 | bioplex (XPA) bioplex_WMM |
| DDX28 | RPUSD4 | 0.02 | 0.188 | hein_WMM bioplex (DDX28) bioplex_WMM youn_WMM |
| DDX4 | RPUSD4 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| NUP43 | ERCC4 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| NUP43 | DDX28 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04705 has an average edge precision of 0.228 which is ranked 5728 out of all 6965 complexes.
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