hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04707
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPTBN4 | Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3) | UniProt NCBI |
| HOMER1 | Homer protein homolog 1 (Homer-1) | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0035256 | 3.6323771075e-06 | 0.75 | HOMER3 HOMER1 HOMER2 | G protein-coupled glutamate receptor binding |
| GO:2001256 | 2.03382379613e-05 | 0.75 | HOMER3 HOMER1 HOMER2 | regulation of store-operated calcium entry |
| REAC:R-HSA-6794361 | 3.15562563454e-05 | 0.75 | HOMER3 HOMER1 HOMER2 | Neurexins and neuroligins |
| KEGG:04724 | 4.32996100123e-05 | 0.75 | HOMER3 HOMER1 HOMER2 | Glutamatergic synapse |
| KEGG:04068 | 6.43452048828e-05 | 0.75 | HOMER3 HOMER1 HOMER2 | FoxO signaling pathway |
| GO:0007216 | 0.000103844122491 | 0.75 | HOMER3 HOMER1 HOMER2 | G protein-coupled glutamate receptor signaling pathway |
| REAC:R-HSA-6794362 | 0.000114768773277 | 0.75 | HOMER3 HOMER1 HOMER2 | Protein-protein interactions at synapses |
| GO:0002115 | 0.000132158586819 | 0.75 | HOMER3 HOMER1 HOMER2 | store-operated calcium entry |
| GO:0035254 | 0.000165189908538 | 0.75 | HOMER3 HOMER1 HOMER2 | glutamate receptor binding |
| GO:0010959 | 0.00211187044194 | 1.0 | HOMER3 HOMER1 SPTBN4 HOMER2 | regulation of metal ion transport |
| REAC:R-HSA-112316 | 0.00869575285043 | 0.75 | HOMER3 HOMER1 HOMER2 | Neuronal System |
| GO:0036477 | 0.010329129492 | 1.0 | HOMER3 HOMER1 SPTBN4 HOMER2 | somatodendritic compartment |
| GO:0043269 | 0.011836710023 | 1.0 | HOMER3 HOMER1 SPTBN4 HOMER2 | regulation of ion transport |
| GO:0007215 | 0.0165706850483 | 0.75 | HOMER3 HOMER1 HOMER2 | glutamate receptor signaling pathway |
| CORUM:74 | 0.0499140284799 | 0.25 | HOMER3 | HOMER3-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HOMER2 | HOMER1 | 1.0 | 0.949 | bioplex (HOMER1) bioplex_WMM |
| HOMER3 | HOMER1 | 1.0 | 0.949 | hein_WMM bioplex (HOMER1,HOMER3) bioplex_WMM hein (HOMER1) |
| HOMER3 | HOMER2 | 0.929 | 0.845 | bioplex (HOMER3) bioplex_WMM |
| HOMER1 | SPTBN4 | 0.867 | 0.801 | bioplex (HOMER1) bioplex_WMM |
| HOMER2 | SPTBN4 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| HOMER3 | SPTBN4 | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04707 has an average edge precision of 0.618 which is ranked 1845 out of all 6965 complexes.
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