hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04709

Confidence: Medium High

Genename	Protein Name	Links
CDK7	Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)	UniProt NCBI
MNAT1	CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)	UniProt NCBI
ERCC5	DNA repair protein complementing XP-G cells (EC 3.1.-.-) (DNA excision repair protein ERCC-5) (Xeroderma pigmentosum group G-complementing protein)	UniProt NCBI
ERCC2	General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD) (EC 3.6.4.12) (Basic transcription factor 2 80 kDa subunit) (BTF2 p80) (CXPD) (DNA excision repair protein ERCC-2) (DNA repair protein complementing XP-D cells) (TFIIH basal transcription factor complex 80 kDa subunit) (TFIIH 80 kDa subunit) (TFIIH p80) (Xeroderma pigmentosum group D-complementing protein)	UniProt NCBI
CCNH	Cyclin-H (MO15-associated protein) (p34) (p37)	UniProt NCBI
TRMT1	tRNA (guanine(26)-N(2))-dimethyltransferase (EC 2.1.1.216) (tRNA 2,2-dimethylguanosine-26 methyltransferase) (tRNA(guanine-26,N(2)-N(2)) methyltransferase) (tRNA(m(2,2)G26)dimethyltransferase)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:2660	4.54011687692e-13	0.666666666667	ERCC2 CDK7 CCNH MNAT1	CAK-ERCC2 complex
CORUM:1030	4.54011687692e-13	0.666666666667	ERCC2 CDK7 CCNH MNAT1	CAK-ERCC2 complex
KEGG:03420	4.9317110036e-11	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Nucleotide excision repair
CORUM:1036	5.71747411144e-11	0.666666666667	ERCC2 CDK7 CCNH MNAT1	TFIIH transcription factor complex
CORUM:107	5.71747411144e-11	0.666666666667	ERCC2 CDK7 CCNH MNAT1	TFIIH transcription factor complex
CORUM:1009	9.5280993066e-11	0.666666666667	ERCC2 CDK7 CCNH MNAT1	TFIIH transcription factor complex
CORUM:1029	9.5280993066e-11	0.666666666667	ERCC2 CDK7 CCNH MNAT1	TFIIH transcription factor complex
REAC:R-HSA-5696395	1.54795319779e-10	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Formation of Incision Complex in GG-NER
REAC:R-HSA-6782135	1.32663300233e-09	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Dual incision in TC-NER
CORUM:1008	2.25356268047e-09	0.5	CDK7 CCNH MNAT1	CAK complex (Cdk-activating kinase complex)
CORUM:1010	2.25356268047e-09	0.5	CDK7 CCNH MNAT1	CAK complex (Cdk-activating kinase complex)
REAC:R-HSA-6781827	3.38820843715e-09	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Transcription-Coupled Nucleotide Excision Repair (TC-NER)
REAC:R-HSA-5696399	4.95311014697e-09	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Global Genome Nucleotide Excision Repair (GG-NER)
GO:0006294	5.82915372209e-09	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	nucleotide-excision repair, preincision complex assembly
REAC:R-HSA-5696398	1.9607809034e-08	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	Nucleotide Excision Repair
REAC:R-HSA-77075	2.10041615528e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Pol II CTD phosphorylation and interaction with CE
REAC:R-HSA-167160	2.10041615528e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
REAC:R-HSA-72086	2.84195159633e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	mRNA Capping
WP:WP405	3.05048674057e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Eukaryotic Transcription Initiation
REAC:R-HSA-73863	3.76416846139e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase I Transcription Termination
KEGG:03022	3.77702354104e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Basal transcription factors
CORUM:2657	4.50508252789e-08	0.5	CDK7 CCNH MNAT1	ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex
REAC:R-HSA-113418	4.89421979513e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of the Early Elongation Complex
REAC:R-HSA-167158	4.89421979513e-08	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of the HIV-1 Early Elongation Complex
REAC:R-HSA-167169	1.62172277992e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	HIV Transcription Elongation
REAC:R-HSA-167200	1.62172277992e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of HIV-1 elongation complex containing HIV-1 Tat
REAC:R-HSA-167246	1.62172277992e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Tat-mediated elongation of the HIV-1 transcript
GO:0005675	1.80981361376e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription factor TFIIH holo complex
REAC:R-HSA-167152	1.94903788769e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of HIV elongation complex in the absence of HIV Tat
REAC:R-HSA-76042	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-167161	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	HIV Transcription Initiation
REAC:R-HSA-73779	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-73762	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase I Transcription Initiation
REAC:R-HSA-167162	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-73776	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Promoter Escape
REAC:R-HSA-75953	2.13011432628e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Transcription Initiation
REAC:R-HSA-6781823	3.4947873312e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of TC-NER Pre-Incision Complex
REAC:R-HSA-112382	5.42829555401e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Formation of RNA Pol II elongation complex
REAC:R-HSA-75955	5.42829555401e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Transcription Elongation
REAC:R-HSA-6796648	6.65127602182e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	TP53 Regulates Transcription of DNA Repair Genes
GO:0006283	7.3546313708e-07	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	transcription-coupled nucleotide-excision repair
REAC:R-HSA-6782210	7.57405773874e-07	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Gap-filling DNA repair synthesis and ligation in TC-NER
GO:0008353	1.11807235637e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA polymerase II CTD heptapeptide repeat kinase activity
REAC:R-HSA-167172	1.15737262627e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Transcription of the HIV genome
GO:0032806	1.41607269498e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	carboxy-terminal domain protein kinase complex
GO:0019907	1.81637152046e-06	0.5	CDK7 CCNH MNAT1	cyclin-dependent protein kinase activating kinase holoenzyme complex
REAC:R-HSA-674695	2.08093967041e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase II Pre-transcription Events
REAC:R-HSA-73772	3.03740743693e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase I Promoter Escape
REAC:R-HSA-73894	4.35751112638e-06	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	DNA Repair
GO:0006289	4.71954327875e-06	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	nucleotide-excision repair
REAC:R-HSA-427413	5.67316266505e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	NoRC negatively regulates rRNA expression
REAC:R-HSA-5250941	6.35809703042e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Negative epigenetic regulation of rRNA expression
REAC:R-HSA-73854	6.59959719925e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase I Promoter Clearance
REAC:R-HSA-73864	6.84789868567e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA Polymerase I Transcription
GO:0150005	7.26438828159e-06	0.5	CDK7 CCNH MNAT1	enzyme activator complex
CORUM:1007	8.39001385941e-06	0.333333333333	CDK7 CCNH	CAK core complex (Cdk-activating kinase core complex)
GO:0006362	8.66795236882e-06	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription elongation from RNA polymerase I promoter
GO:0006363	1.14807138073e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	termination of RNA polymerase I transcription
GO:0009452	1.31194039242e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	7-methylguanosine RNA capping
GO:0006370	1.31194039242e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	7-methylguanosine mRNA capping
GO:0006361	1.31194039242e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription initiation from RNA polymerase I promoter
REAC:R-HSA-69273	1.36517474966e-05	0.5	CDK7 CCNH MNAT1	Cyclin A/B1/B2 associated events during G2/M transition
REAC:R-HSA-162599	1.47397775141e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Late Phase of HIV Life Cycle
GO:0036260	1.49273703752e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA capping
REAC:R-HSA-162587	2.14614542567e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	HIV Life Cycle
REAC:R-HSA-212165	2.14614542567e-05	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Epigenetic regulation of gene expression
WP:WP45	5.90727924684e-05	0.5	CDK7 CCNH MNAT1	G1 to S cell cycle control
REAC:R-HSA-69236	6.79649802247e-05	0.5	CDK7 CCNH MNAT1	G1 Phase
REAC:R-HSA-69231	6.79649802247e-05	0.5	CDK7 CCNH MNAT1	Cyclin D associated events in G1
GO:0065004	9.2684330741e-05	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	protein-DNA complex assembly
REAC:R-HSA-162906	0.000117512859518	0.666666666667	ERCC2 CDK7 CCNH MNAT1	HIV Infection
REAC:R-HSA-8953854	0.000150175559311	0.833333333333	MNAT1 CDK7 ERCC2 CCNH TRMT1	Metabolism of RNA
GO:0006360	0.000165563014397	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription by RNA polymerase I
GO:0071824	0.000283624761973	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	protein-DNA complex subunit organization
GO:0016591	0.000373722975929	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA polymerase II, holoenzyme
GO:0006353	0.000395345440439	0.666666666667	ERCC2 CDK7 CCNH MNAT1	DNA-templated transcription, termination
GO:0019908	0.00039905855691	0.5	CDK7 CCNH MNAT1	nuclear cyclin-dependent protein kinase holoenzyme complex
GO:1902554	0.000417891539136	0.666666666667	ERCC2 CDK7 CCNH MNAT1	serine/threonine protein kinase complex
REAC:R-HSA-69202	0.000521133699904	0.5	CDK7 CCNH MNAT1	Cyclin E associated events during G1/S transition
GO:0006368	0.000545393489246	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription elongation from RNA polymerase II promoter
REAC:R-HSA-69656	0.000560531240275	0.5	CDK7 CCNH MNAT1	Cyclin A:Cdk2-associated events at S phase entry
REAC:R-HSA-3700989	0.000694220165361	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Transcriptional Regulation by TP53
REAC:R-HSA-5663205	0.000777047720875	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Infectious disease
GO:1902911	0.00084563217517	0.666666666667	ERCC2 CDK7 CCNH MNAT1	protein kinase complex
GO:0008094	0.00101282970404	0.666666666667	ERCC2 CDK7 CCNH MNAT1	DNA-dependent ATPase activity
HP:0004337	0.00112625143517	0.333333333333	ERCC5 ERCC2	Abnormality of amino acid metabolism
GO:0055029	0.00120362941431	0.666666666667	ERCC2 CDK7 CCNH MNAT1	nuclear DNA-directed RNA polymerase complex
GO:0000428	0.00125526288107	0.666666666667	ERCC2 CDK7 CCNH MNAT1	DNA-directed RNA polymerase complex
GO:0030880	0.00142014462948	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA polymerase complex
GO:0006354	0.00173031461284	0.666666666667	ERCC2 CDK7 CCNH MNAT1	DNA-templated transcription, elongation
REAC:R-HSA-8939236	0.00190266482243	0.5	CDK7 CCNH MNAT1	RUNX1 regulates transcription of genes involved in differentiation of HSCs
REAC:R-HSA-69206	0.00208996561591	0.5	CDK7 CCNH MNAT1	G1/S Transition
HP:0010649	0.00210158306671	0.333333333333	ERCC5 ERCC2	Flat nasal alae
HP:0007587	0.00210158306671	0.333333333333	ERCC5 ERCC2	Numerous pigmented freckles
REAC:R-HSA-453279	0.00302212243809	0.5	CDK7 CCNH MNAT1	Mitotic G1-G1/S phases
REAC:R-HSA-69242	0.00382327070463	0.5	CDK7 CCNH MNAT1	S Phase
HP:0009755	0.00495018352279	0.333333333333	ERCC5 ERCC2	Ankyloblepharon
HP:0003079	0.00495018352279	0.333333333333	ERCC5 ERCC2	Defective DNA repair after ultraviolet radiation damage
REAC:R-HSA-69275	0.00651335516082	0.5	CDK7 CCNH MNAT1	G2/M Transition
GO:0090575	0.0065457435483	0.666666666667	ERCC2 CDK7 CCNH MNAT1	RNA polymerase II transcription factor complex
REAC:R-HSA-453274	0.00672028001895	0.5	CDK7 CCNH MNAT1	Mitotic G2-G2/M phases
GO:0070985	0.00676235117068	0.333333333333	CDK7 CCNH	transcription factor TFIIK complex
HP:0001029	0.00682280818411	0.333333333333	ERCC5 ERCC2	Poikiloderma
GO:0006281	0.00761654730624	0.833333333333	ERCC2 CDK7 CCNH ERCC5 MNAT1	DNA repair
HP:0003254	0.00787106080828	0.333333333333	ERCC5 ERCC2	Abnormality of DNA repair
REAC:R-HSA-8878171	0.00995111812887	0.5	CDK7 CCNH MNAT1	Transcriptional regulation by RUNX1
HP:0006970	0.0114630974264	0.333333333333	TRMT1 ERCC2	Periventricular leukomalacia
GO:0000307	0.0118307664632	0.5	CDK7 CCNH MNAT1	cyclin-dependent protein kinase holoenzyme complex
GO:0006367	0.0120717988454	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transcription initiation from RNA polymerase II promoter
HP:0000621	0.0128094019441	0.333333333333	ERCC5 ERCC2	Entropion
HP:0000524	0.0128094019441	0.333333333333	ERCC5 ERCC2	Conjunctival telangiectasia
GO:0044798	0.0135624164426	0.666666666667	ERCC2 CDK7 CCNH MNAT1	nuclear transcription factor complex
HP:0006739	0.0157252084881	0.333333333333	ERCC5 ERCC2	Squamous cell carcinoma of the skin
HP:0008054	0.0172946302375	0.333333333333	ERCC5 ERCC2	Abnormal morphology of the conjunctival vasculature
REAC:R-HSA-5696400	0.0180541440856	0.333333333333	ERCC5 ERCC2	Dual Incision in GG-NER
HP:0004493	0.0243148377528	0.333333333333	ERCC5 ERCC2	Craniofacial hyperostosis
HP:0001059	0.0262553193116	0.333333333333	ERCC5 ERCC2	Pterygium
GO:0006352	0.027645228968	0.666666666667	ERCC2 CDK7 CCNH MNAT1	DNA-templated transcription, initiation
GO:0042623	0.0287203705471	0.666666666667	ERCC2 CDK7 CCNH MNAT1	ATPase activity, coupled
HP:0005487	0.030358517586	0.333333333333	ERCC5 ERCC2	Prominent metopic ridge
GO:0061695	0.0358414221529	0.666666666667	ERCC2 CDK7 CCNH MNAT1	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-1643685	0.0363076318173	0.666666666667	ERCC2 CDK7 CCNH MNAT1	Disease
WP:WP179	0.0365222779269	0.333333333333	CDK7 CCNH	Cell Cycle
HP:0100579	0.0370683023611	0.333333333333	ERCC5 ERCC2	Mucosal telangiectasiae
HP:0007108	0.0394527338604	0.333333333333	ERCC5 ERCC2	Demyelinating peripheral neuropathy
HP:0001838	0.0419110169922	0.333333333333	ERCC5 ERCC2	Rocker bottom foot
KEGG:04110	0.0437703225478	0.333333333333	CDK7 CCNH	Cell cycle
HP:0008365	0.044443111782	0.333333333333	ERCC5 ERCC2	Abnormality of the talus
HP:0100012	0.0470489782673	0.333333333333	ERCC5 ERCC2	Neoplasm of the eye
HP:0005556	0.0497285764978	0.333333333333	ERCC5 ERCC2	Abnormality of the metopic suture
HP:0012740	0.0497285764978	0.333333333333	ERCC5 ERCC2	Papilloma
CORUM:7222	0.0499726005494	0.166666666667	ERCC2	MMS19-XPD complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CCNH	MNAT1	1.0	0.949	hein_WMM bioplex (CCNH,MNAT1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction
CCNH	CDK7	0.948	0.857	hein_WMM bioplex (CCNH,CDK7) bioplex_WMM youn_WMM Malo fraction
CCNH	ERCC5	0.82	0.773	hein_WMM bioplex (CCNH) bioplex_WMM
MNAT1	CDK7	0.779	0.753	hein_WMM bioplex (CDK7,MNAT1) bioplex_WMM youn_WMM Malo fraction
CCNH	ERCC2	0.219	0.466	hein_WMM bioplex (CCNH) bioplex_WMM
CDK7	ERCC2	0.07	0.348	hein_WMM bioplex (CDK7) bioplex_WMM
ERCC2	TRMT1	0.066	0.347	bioplex (TRMT1) bioplex_WMM youn_WMM fraction
MNAT1	ERCC2	0.027	0.23	hein_WMM bioplex (MNAT1) bioplex_WMM
ERCC5	CDK7	0.012	0.148	hein_WMM bioplex_WMM youn_WMM WMM_only
ERCC5	MNAT1	0.011	0.145	hein_WMM bioplex_WMM youn_WMM WMM_only
ERCC5	ERCC2	0.009	0.11	hein_WMM bioplex_WMM WMM_only
MNAT1	TRMT1	0.007	0.005	bioplex_WMM youn_WMM WMM_only
CDK7	TRMT1	0.007	0.004	bioplex_WMM youn_WMM WMM_only
ERCC5	TRMT1	0.007	0.003	youn_WMM WMM_only
CCNH	TRMT1	0.007	0.003	youn_WMM WMM_only

Images

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Complex HuMAP2_04709 has an average edge precision of 0.343 which is ranked 4090 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CDK7	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_04784
MNAT1	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709
ERCC5	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709 HuMAP2_06407
ERCC2	HuMAP2_01967 HuMAP2_04709
CCNH	HuMAP2_01125 HuMAP2_01967 HuMAP2_04709
TRMT1	HuMAP2_04709 HuMAP2_05448

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04709