hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04711
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| COP1 | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | UniProt NCBI |
| ATF2 | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1) | UniProt NCBI |
| ATF7 | Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A) | UniProt NCBI |
| CREB5 | Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa) | UniProt NCBI |
| FOSL2 | Fos-related antigen 2 (FRA-2) | UniProt NCBI |
| JUN | Transcription factor AP-1 (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05030 | 2.5364610263e-05 | 0.5 | JUN CREB5 ATF2 | Cocaine addiction |
| KEGG:05031 | 6.30413655994e-05 | 0.5 | JUN CREB5 ATF2 | Amphetamine addiction |
| KEGG:04668 | 0.000215290076423 | 0.5 | JUN CREB5 ATF2 | TNF signaling pathway |
| KEGG:04926 | 0.000464025836468 | 0.5 | JUN CREB5 ATF2 | Relaxin signaling pathway |
| KEGG:04915 | 0.00048767047927 | 0.5 | JUN CREB5 ATF2 | Estrogen signaling pathway |
| WP:WP4666 | 0.000731117090022 | 0.5 | JUN CREB5 ATF2 | Hepatitis B infection |
| REAC:R-HSA-450341 | 0.000996295422965 | 0.333333333333 | JUN ATF2 | Activation of the AP-1 family of transcription factors |
| KEGG:05161 | 0.00100038089965 | 0.5 | JUN CREB5 ATF2 | Hepatitis B |
| KEGG:05203 | 0.0017821830589 | 0.5 | JUN CREB5 ATF2 | Viral carcinogenesis |
| KEGG:05166 | 0.00204927990704 | 0.5 | JUN CREB5 ATF2 | Human T-cell leukemia virus 1 infection |
| WP:WP2516 | 0.00411387831475 | 0.333333333333 | JUN ATF2 | ATM Signaling Pathway |
| WP:WP3611 | 0.00599288611144 | 0.333333333333 | JUN ATF2 | Photodynamic therapy-induced AP-1 survival signaling. |
| WP:WP195 | 0.0070633221054 | 0.333333333333 | JUN ATF2 | IL-1 signaling pathway |
| KEGG:04927 | 0.00989523261713 | 0.333333333333 | CREB5 ATF2 | Cortisol synthesis and secretion |
| REAC:R-HSA-450282 | 0.0102563889288 | 0.333333333333 | JUN ATF2 | MAPK targets/ Nuclear events mediated by MAP kinases |
| WP:WP2324 | 0.0114940114472 | 0.333333333333 | JUN ATF2 | AGE/RAGE pathway |
| KEGG:04918 | 0.0140958050009 | 0.333333333333 | CREB5 ATF2 | Thyroid hormone synthesis |
| KEGG:04911 | 0.015804666162 | 0.333333333333 | CREB5 ATF2 | Insulin secretion |
| WP:WP69 | 0.0161342034025 | 0.333333333333 | JUN ATF2 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| KEGG:04211 | 0.0204981178463 | 0.333333333333 | CREB5 ATF2 | Longevity regulating pathway |
| WP:WP23 | 0.021066272601 | 0.333333333333 | JUN ATF2 | B Cell Receptor Signaling Pathway |
| KEGG:04925 | 0.0236020276363 | 0.333333333333 | CREB5 ATF2 | Aldosterone synthesis and secretion |
| WP:WP4321 | 0.0271822427146 | 0.333333333333 | CREB5 ATF2 | Thermogenesis |
| KEGG:04922 | 0.0280749165362 | 0.333333333333 | CREB5 ATF2 | Glucagon signaling pathway |
| KEGG:04928 | 0.0286608208008 | 0.333333333333 | CREB5 ATF2 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04380 | 0.0323009379161 | 0.333333333333 | JUN FOSL2 | Osteoclast differentiation |
| REAC:R-HSA-8943724 | 0.0350388564803 | 0.333333333333 | JUN ATF2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-6796648 | 0.0414781208299 | 0.333333333333 | JUN ATF2 | TP53 Regulates Transcription of DNA Repair Genes |
| WP:WP366 | 0.0416969783243 | 0.333333333333 | JUN ATF2 | TGF-beta Signaling Pathway |
| REAC:R-HSA-450294 | 0.0428303754683 | 0.333333333333 | JUN ATF2 | MAP kinase activation |
| KEGG:04728 | 0.0444979624084 | 0.333333333333 | CREB5 ATF2 | Dopaminergic synapse |
| WP:WP289 | 0.0464992674716 | 0.333333333333 | JUN ATF2 | Myometrial Relaxation and Contraction Pathways |
| CORUM:6092 | 0.0499726005494 | 0.166666666667 | JUN | c-Jun-ATF3 complex |
| CORUM:2700 | 0.0499726005494 | 0.166666666667 | JUN | ESR1-JUN complex |
| CORUM:2693 | 0.0499726005494 | 0.166666666667 | JUN | NFAT-JUN-FOS DNA-protein complex |
| CORUM:1317 | 0.0499726005494 | 0.166666666667 | ATF7 | ATF7-TAF12 complex |
| CORUM:6975 | 0.0499726005494 | 0.166666666667 | JUN | JUN-FBW7-PRR7 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATF7 | FOSL2 | 1.0 | 0.949 | hein_WMM bioplex (FOSL2) bioplex_WMM hein (FOSL2) |
| JUN | CREB5 | 0.995 | 0.924 | hein_WMM bioplex (CREB5) bioplex_WMM hein (JUN) |
| JUN | FOSL2 | 0.99 | 0.906 | hein_WMM bioplex (FOSL2) bioplex_WMM hein (FOSL2,JUN) |
| ATF2 | FOSL2 | 0.959 | 0.864 | hein_WMM bioplex (FOSL2) bioplex_WMM |
| CREB5 | FOSL2 | 0.941 | 0.854 | hein_WMM bioplex (FOSL2) bioplex_WMM |
| JUN | ATF2 | 0.78 | 0.754 | hein_WMM bioplex (ATF2) bioplex_WMM hein (JUN) |
| FOSL2 | COP1 | 0.667 | 0.701 | hein_WMM bioplex (FOSL2) bioplex_WMM hein (FOSL2) |
| CREB5 | ATF7 | 0.5 | 0.621 | hein_WMM bioplex (CREB5) bioplex_WMM |
| ATF7 | ATF2 | 0.453 | 0.594 | hein_WMM bioplex (ATF2) bioplex_WMM |
| JUN | ATF7 | 0.435 | 0.579 | hein_WMM bioplex_WMM hein (JUN) |
| CREB5 | ATF2 | 0.212 | 0.461 | hein_WMM bioplex (ATF2,CREB5) bioplex_WMM |
| JUN | COP1 | 0.009 | 0.09 | hein_WMM bioplex (COP1) bioplex_WMM |
| ATF7 | COP1 | 0.009 | 0.091 | hein_WMM bioplex_WMM WMM_only |
| CREB5 | COP1 | 0.009 | 0.098 | bioplex_WMM WMM_only |
| ATF2 | COP1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04711 has an average edge precision of 0.571 which is ranked 2075 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| COP1 | HuMAP2_04711 HuMAP2_05311 HuMAP2_05946 HuMAP2_06278 |
| ATF2 | HuMAP2_04193 HuMAP2_04711 HuMAP2_05234 |
| ATF7 | HuMAP2_04193 HuMAP2_04711 HuMAP2_05234 |
| CREB5 | HuMAP2_02962 HuMAP2_04193 HuMAP2_04711 |
| FOSL2 | HuMAP2_04193 HuMAP2_04711 HuMAP2_05234 HuMAP2_05753 |
| JUN | HuMAP2_02962 HuMAP2_04193 HuMAP2_04711 |