hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04714
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FZR1 | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) | UniProt NCBI |
| RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2) | UniProt NCBI |
| RRM2 | Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4584 | 0.000100657255092 | 0.666666666667 | RRM2B RRM2 | Biomarkers for pyrimidine metabolism disorders |
| WP:WP4225 | 0.000130363431616 | 0.666666666667 | RRM2B RRM2 | Pyrimidine metabolism and related diseases |
| WP:WP404 | 0.000163898158608 | 0.666666666667 | RRM2B RRM2 | Nucleotide Metabolism |
| KEGG:00480 | 0.00052554917631 | 0.666666666667 | RRM2B RRM2 | Glutathione metabolism |
| KEGG:00240 | 0.000547422499549 | 0.666666666667 | RRM2B RRM2 | Pyrimidine metabolism |
| KEGG:04115 | 0.000900335185999 | 0.666666666667 | RRM2B RRM2 | p53 signaling pathway |
| KEGG:00983 | 0.0011410864499 | 0.666666666667 | RRM2B RRM2 | Drug metabolism - other enzymes |
| REAC:R-HSA-499943 | 0.00234745427481 | 0.666666666667 | RRM2B RRM2 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00230 | 0.00272070891872 | 0.666666666667 | RRM2B RRM2 | Purine metabolism |
| WP:WP4022 | 0.00294510433123 | 0.666666666667 | RRM2B RRM2 | Pyrimidine metabolism |
| GO:0004748 | 0.00405722906526 | 0.666666666667 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| GO:0016728 | 0.00405722906526 | 0.666666666667 | RRM2B RRM2 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| GO:0061731 | 0.00405722906526 | 0.666666666667 | RRM2B RRM2 | ribonucleoside-diphosphate reductase activity |
| REAC:R-HSA-15869 | 0.0243796532655 | 0.666666666667 | RRM2B RRM2 | Metabolism of nucleotides |
| GO:0016725 | 0.0486736709081 | 0.666666666667 | RRM2B RRM2 | oxidoreductase activity, acting on CH or CH2 groups |
| GO:0009263 | 0.0486736709081 | 0.666666666667 | RRM2B RRM2 | deoxyribonucleotide biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RRM2B | RRM2 | 0.99 | 0.909 | bioplex (RRM2,RRM2B) bioplex_WMM |
| FZR1 | RRM2 | 0.508 | 0.628 | hein_WMM bioplex (FZR1,RRM2) bioplex_WMM |
| FZR1 | RRM2B | 0.007 | 0.005 | bioplex (FZR1) bioplex_WMM |
Images
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Complex HuMAP2_04714 has an average edge precision of 0.514 which is ranked 2420 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FZR1 | HuMAP2_00729 HuMAP2_01190 HuMAP2_02668 HuMAP2_03601 HuMAP2_04374 HuMAP2_04714 |
| RRM2B | HuMAP2_01536 HuMAP2_02802 HuMAP2_03254 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |
| RRM2 | HuMAP2_01536 HuMAP2_04276 HuMAP2_04714 HuMAP2_05291 |