hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04715
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF19 | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) | UniProt NCBI |
| CDC5L | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | UniProt NCBI |
| CTNNBL1 | Beta-catenin-like protein 1 (Nuclear-associated protein) (NAP) (Testis development protein NYD-SP19) | UniProt NCBI |
| BCAS2 | Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27) | UniProt NCBI |
| TOP2A | DNA topoisomerase 2-alpha (EC 5.6.2.3) (DNA topoisomerase II, alpha isozyme) | UniProt NCBI |
| PLRG1 | Pleiotropic regulator 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1182 | 6.80871178609e-12 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | CDC5L core complex |
| CORUM:1183 | 7.23220064776e-12 | 0.833333333333 | TOP2A CDC5L PRPF19 PLRG1 BCAS2 | CDC5L complex |
| GO:0000974 | 6.3229743118e-11 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | Prp19 complex |
| KEGG:03040 | 1.29360168582e-08 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | Spliceosome |
| CORUM:351 | 2.52353034284e-08 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | Spliceosome |
| REAC:R-HSA-72163 | 2.24555583894e-07 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 2.80323298201e-07 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | mRNA Splicing |
| GO:0005662 | 6.65140313081e-07 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | DNA replication factor A complex |
| REAC:R-HSA-72203 | 9.10267227481e-07 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0043601 | 4.61861792183e-06 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | nuclear replisome |
| GO:0030894 | 6.40626927361e-06 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | replisome |
| GO:0071007 | 1.00004074113e-05 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | U2-type catalytic step 2 spliceosome |
| GO:0043596 | 3.69108895609e-05 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | nuclear replication fork |
| GO:0005681 | 4.12522130453e-05 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | spliceosomal complex |
| REAC:R-HSA-8953854 | 0.000150175559311 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | Metabolism of RNA |
| CORUM:1181 | 0.000169506907486 | 0.5 | CDC5L PLRG1 PRPF19 | C complex spliceosome |
| GO:0005657 | 0.000231008761032 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | replication fork |
| GO:0071013 | 0.000666750687757 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | catalytic step 2 spliceosome |
| GO:1990904 | 0.00081928834971 | 1.0 | PRPF19 BCAS2 CTNNBL1 PLRG1 CDC5L TOP2A | ribonucleoprotein complex |
| GO:0005684 | 0.000968898210955 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | U2-type spliceosomal complex |
| GO:0000398 | 0.00115243061952 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | mRNA splicing, via spliceosome |
| GO:0000377 | 0.00115243061952 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 0.00120907776661 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | RNA splicing, via transesterification reactions |
| GO:0008380 | 0.00270779091032 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | RNA splicing |
| GO:0006397 | 0.00390084589509 | 0.833333333333 | PRPF19 CDC5L CTNNBL1 PLRG1 BCAS2 | mRNA processing |
| GO:0032993 | 0.00506594708818 | 0.666666666667 | PRPF19 CDC5L PLRG1 BCAS2 | protein-DNA complex |
| CORUM:0000000 | 0.0090785708022 | 1.0 | PRPF19 BCAS2 CTNNBL1 PLRG1 CDC5L TOP2A | CORUM root |
| HPA:035010_13 | 0.0300139609548 | 0.5 | CDC5L PLRG1 PRPF19 | placenta; decidual cells[Supported,High] |
| HPA:007030_13 | 0.0361164666626 | 0.5 | CDC5L PLRG1 PRPF19 | cerebellum; cells in molecular layer[Supported,High] |
| HPA:040010_13 | 0.0384299204809 | 0.5 | CDC5L PLRG1 PRPF19 | seminal vesicle; glandular cells[Supported,High] |
| HPA:013020_13 | 0.0419000074614 | 0.5 | CDC5L PLRG1 PRPF19 | endometrium 1; glandular cells[Supported,High] |
| HPA:053010_13 | 0.0467092699772 | 0.5 | CDC5L PLRG1 PRPF19 | testis; Leydig cells[Supported,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PLRG1 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L) bioplex (PLRG1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| BCAS2 | PRPF19 | 1.0 | 0.949 | hein_WMM youn (PRPF19) bioplex (PRPF19) bioplex_WMM youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
| BCAS2 | PLRG1 | 1.0 | 0.949 | hein_WMM bioplex (PLRG1) bioplex_WMM Guru youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
| PRPF19 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L,PRPF19) bioplex (PRPF19) bioplex_WMM youn_WMM Malo gupta_WMM fraction boldt_WMM |
| PLRG1 | PRPF19 | 1.0 | 0.949 | hein_WMM youn (PRPF19) bioplex (PLRG1,PRPF19) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| BCAS2 | CDC5L | 1.0 | 0.949 | hein_WMM youn (CDC5L) bioplex_WMM Guru youn_WMM hein (BCAS2) Malo gupta_WMM fraction |
| CTNNBL1 | BCAS2 | 0.999 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (CTNNBL1) Malo gupta_WMM fraction |
| CTNNBL1 | CDC5L | 0.981 | 0.896 | hein_WMM youn (CDC5L) bioplex_WMM youn_WMM hein (CTNNBL1) gupta_WMM |
| CDC5L | TOP2A | 0.578 | 0.66 | youn (CDC5L) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| PRPF19 | TOP2A | 0.559 | 0.65 | youn (PRPF19) bioplex_WMM youn_WMM gupta_WMM fraction |
| CTNNBL1 | PRPF19 | 0.031 | 0.236 | youn (PRPF19) bioplex (PRPF19) bioplex_WMM youn_WMM gupta_WMM |
| PLRG1 | TOP2A | 0.014 | 0.136 | youn_WMM gupta_WMM fraction |
| BCAS2 | TOP2A | 0.008 | 0.012 | Guru youn_WMM gupta_WMM fraction bioplex_WMM |
| CTNNBL1 | PLRG1 | 0.007 | 0.009 | bioplex_WMM youn_WMM WMM_only |
| CTNNBL1 | TOP2A | 0.007 | 0.005 | youn_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_04715 has an average edge precision of 0.616 which is ranked 1854 out of all 6965 complexes.
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