hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04717
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EEF1A1 | Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7) | UniProt NCBI |
| EEF1A2 | Elongation factor 1-alpha 2 (EF-1-alpha-2) (Eukaryotic elongation factor 1 A-2) (eEF1A-2) (Statin-S1) | UniProt NCBI |
| EEF1B2 | Elongation factor 1-beta (EF-1-beta) | UniProt NCBI |
| EEF1G | Elongation factor 1-gamma (EF-1-gamma) (eEF-1B gamma) | UniProt NCBI |
| VARS | Valine--tRNA ligase (EC 6.1.1.9) (Protein G7a) (Valyl-tRNA synthetase) (ValRS) | UniProt NCBI |
| EIF5B | Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2) | UniProt NCBI |
| MATR3 | Matrin-3 | UniProt NCBI |
| EEF1D | Elongation factor 1-delta (EF-1-delta) (Antigen NY-CO-4) | UniProt NCBI |
| CARS | Cysteine--tRNA ligase, cytoplasmic (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 5.23724644636e-12 | 0.666666666667 | EIF5B EEF1B2 EEF1D EEF1A1 EEF1G EEF1A2 | Translation Factors |
| REAC:R-HSA-72766 | 3.30959676583e-11 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | Translation |
| REAC:R-HSA-156842 | 1.98320468808e-07 | 0.555555555556 | EEF1A1 EEF1D EEF1A2 EEF1G EEF1B2 | Eukaryotic Translation Elongation |
| GO:0006412 | 8.07160157434e-07 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | translation |
| GO:0043043 | 1.14827468906e-06 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | peptide biosynthetic process |
| CORUM:1335 | 4.26913068447e-06 | 0.333333333333 | MATR3 EEF1G EEF1A1 | SNW1 complex |
| GO:0043604 | 4.88678760079e-06 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | amide biosynthetic process |
| GO:0006518 | 5.07287743933e-06 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | peptide metabolic process |
| GO:0005853 | 7.62876038594e-06 | 0.333333333333 | EEF1A1 EEF1B2 EEF1D | eukaryotic translation elongation factor 1 complex |
| GO:0008135 | 1.32414658176e-05 | 0.555555555556 | EEF1A1 EEF1D EIF5B EEF1A2 EEF1B2 | translation factor activity, RNA binding |
| GO:0090079 | 3.74437348488e-05 | 0.555555555556 | EEF1A1 EEF1D EIF5B EEF1A2 EEF1B2 | translation regulator activity, nucleic acid binding |
| GO:0043603 | 4.04416485796e-05 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | cellular amide metabolic process |
| REAC:R-HSA-392499 | 7.4753048218e-05 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | Metabolism of proteins |
| KEGG:05134 | 0.00011699921376 | 0.333333333333 | EEF1A1 EEF1A2 EEF1G | Legionellosis |
| GO:0045182 | 0.000123387316731 | 0.555555555556 | EEF1A1 EEF1D EIF5B EEF1A2 EEF1B2 | translation regulator activity |
| GO:0006414 | 0.000191696474427 | 0.555555555556 | EEF1A1 EEF1D EEF1A2 EEF1G EEF1B2 | translational elongation |
| GO:1901566 | 0.00210375565508 | 0.888888888889 | EIF5B EEF1B2 EEF1D EEF1A2 EEF1A1 EEF1G CARS VARS | organonitrogen compound biosynthetic process |
| GO:0003746 | 0.00276765042703 | 0.333333333333 | EEF1A1 EEF1A2 EEF1B2 | translation elongation factor activity |
| KEGG:03013 | 0.0043669845381 | 0.333333333333 | EEF1A1 EEF1A2 EIF5B | RNA transport |
| KEGG:00970 | 0.0155091288123 | 0.222222222222 | CARS VARS | Aminoacyl-tRNA biosynthesis |
| REAC:R-HSA-379716 | 0.0177234980319 | 0.222222222222 | CARS VARS | Cytosolic tRNA aminoacylation |
| KEGG:05140 | 0.0260590585698 | 0.222222222222 | EEF1A1 EEF1A2 | Leishmaniasis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VARS | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1G) bioplex_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A1 | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1,EEF1G) bioplex_WMM Guru boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| VARS | EEF1A1 | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1) bioplex_WMM hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| EEF1A1 | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1,EEF1D) bioplex_WMM boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| EEF1D | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1D,EEF1G) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1B2 | EEF1A1 | 1.0 | 0.949 | hein_WMM bioplex (EEF1A1) bioplex_WMM Guru boldt hein (EEF1A1) Malo fraction boldt_WMM treiber_WMM |
| VARS | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1D) bioplex_WMM Malo gupta_WMM fraction boldt_WMM |
| EEF1B2 | VARS | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo gupta_WMM fraction boldt_WMM |
| EEF1B2 | EEF1D | 1.0 | 0.949 | hein_WMM bioplex (EEF1D) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1B2 | EEF1G | 1.0 | 0.949 | hein_WMM bioplex (EEF1G) bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A2 | EEF1G | 0.982 | 0.898 | bioplex (EEF1A2,EEF1G) bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| MATR3 | EEF1G | 0.971 | 0.882 | gupta_WMM fraction treiber_WMM |
| EEF1A1 | MATR3 | 0.802 | 0.766 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| CARS | EEF1A1 | 0.741 | 0.74 | hein_WMM bioplex (EEF1A1) bioplex_WMM hein (EEF1A1) fraction boldt_WMM treiber_WMM |
| EEF1B2 | EIF5B | 0.628 | 0.68 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1A2 | EEF1A1 | 0.397 | 0.557 | bioplex (EEF1A1,EEF1A2) bioplex_WMM treiber_WMM |
| CARS | EEF1D | 0.32 | 0.512 | hein_WMM bioplex (EEF1D) bioplex_WMM boldt_WMM |
| CARS | EEF1G | 0.21 | 0.457 | hein_WMM bioplex (EEF1G) bioplex_WMM fraction boldt_WMM treiber_WMM |
| EEF1D | EIF5B | 0.145 | 0.408 | boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EEF1G | EIF5B | 0.107 | 0.372 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| EEF1A2 | CARS | 0.103 | 0.366 | bioplex (EEF1A2) bioplex_WMM fraction |
| EEF1A2 | VARS | 0.074 | 0.357 | bioplex (EEF1A2) bioplex_WMM fraction |
| EEF1A2 | EEF1D | 0.044 | 0.275 | bioplex (EEF1A2,EEF1D) bioplex_WMM youn_WMM treiber_WMM |
| EEF1B2 | MATR3 | 0.029 | 0.23 | gupta_WMM fraction treiber_WMM |
| EEF1A1 | EIF5B | 0.007 | 0.004 | boldt boldt_WMM treiber_WMM |
| EEF1A2 | MATR3 | 0.007 | 0.004 | gupta_WMM WMM_only treiber_WMM |
| VARS | EIF5B | 0.007 | 0.007 | gupta_WMM WMM_only boldt_WMM treiber_WMM |
| CARS | MATR3 | 0.007 | 0.001 | WMM_only treiber_WMM |
| MATR3 | EIF5B | 0.007 | 0.002 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EEF1A2 | EIF5B | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| EEF1D | MATR3 | 0.006 | 0.001 | hein_WMM bioplex (EEF1D) gupta_WMM fraction treiber_WMM |
| EEF1A2 | EEF1B2 | 0.004 | 0.012 | bioplex (EEF1A2) bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| CARS | EEF1B2 | 0.0 | 0.01 | hein_WMM bioplex_WMM fraction boldt_WMM |
| CARS | EIF5B | 0.0 | 0.009 | bioplex_WMM fraction boldt_WMM treiber_WMM |
| VARS | MATR3 | 0.0 | 0.002 | gupta_WMM fraction treiber_WMM |
| CARS | VARS | 0.0 | 0.001 | hein_WMM bioplex_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04717 has an average edge precision of 0.473 which is ranked 2670 out of all 6965 complexes.
Related Complexes