hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04721
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC25A4 | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | UniProt NCBI |
| SLC25A5 | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | UniProt NCBI |
| RIC3 | Protein RIC-3 (Resistant to inhibitor of cholinesterase 3) | UniProt NCBI |
| PHB | Prohibitin | UniProt NCBI |
| VDAC2 | Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | UniProt NCBI |
| VDAC3 | Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6289 | 2.25288169953e-08 | 0.5 | SLC25A5 PHB VDAC2 | prohibitin 2 complex, mitochondrial |
| KEGG:05012 | 3.34705576874e-06 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Parkinson disease |
| KEGG:04022 | 5.26734672914e-06 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | cGMP-PKG signaling pathway |
| KEGG:04218 | 5.8954604486e-06 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Cellular senescence |
| KEGG:04217 | 7.12741080039e-06 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Necroptosis |
| KEGG:04020 | 8.54245982196e-06 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Calcium signaling pathway |
| REAC:R-HSA-8949215 | 1.05150257754e-05 | 0.5 | VDAC3 PHB VDAC2 | Mitochondrial calcium ion transport |
| KEGG:05016 | 1.28484416656e-05 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Huntington disease |
| KEGG:05166 | 2.01963878258e-05 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-180897 | 6.65030189148e-05 | 0.333333333333 | SLC25A4 SLC25A5 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization |
| REAC:R-HSA-382551 | 0.000100936220679 | 0.833333333333 | VDAC3 SLC25A5 VDAC2 PHB SLC25A4 | Transport of small molecules |
| REAC:R-HSA-83936 | 0.0012174763081 | 0.333333333333 | SLC25A4 SLC25A5 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
| WP:WP4313 | 0.00390360990759 | 0.333333333333 | VDAC3 VDAC2 | Ferroptosis |
| KEGG:04216 | 0.00437348887795 | 0.333333333333 | VDAC3 VDAC2 | Ferroptosis |
| KEGG:04979 | 0.00561269140337 | 0.333333333333 | VDAC3 VDAC2 | Cholesterol metabolism |
| GO:0015207 | 0.00676235117068 | 0.333333333333 | SLC25A4 SLC25A5 | adenine transmembrane transporter activity |
| GO:0031966 | 0.0109160303478 | 0.833333333333 | VDAC3 SLC25A5 VDAC2 PHB SLC25A4 | mitochondrial membrane |
| REAC:R-HSA-176033 | 0.0116417903194 | 0.333333333333 | SLC25A4 SLC25A5 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-425397 | 0.0138833050625 | 0.333333333333 | SLC25A4 SLC25A5 | Transport of vitamins, nucleosides, and related molecules |
| GO:0005740 | 0.0151221141199 | 0.833333333333 | VDAC3 SLC25A5 VDAC2 PHB SLC25A4 | mitochondrial envelope |
| WP:WP111 | 0.0235215924424 | 0.333333333333 | SLC25A4 SLC25A5 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0005471 | 0.0405595771497 | 0.333333333333 | SLC25A4 SLC25A5 | ATP:ADP antiporter activity |
| GO:0008509 | 0.0480888208923 | 0.666666666667 | VDAC3 SLC25A5 SLC25A4 VDAC2 | anion transmembrane transporter activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SLC25A5 | VDAC2 | 0.988 | 0.901 | bioplex (SLC25A5,VDAC2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PHB | VDAC2 | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| SLC25A5 | PHB | 0.988 | 0.902 | hein_WMM bioplex (PHB,SLC25A5) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| VDAC3 | PHB | 0.733 | 0.738 | hein_WMM bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| VDAC2 | SLC25A4 | 0.71 | 0.729 | bioplex (SLC25A4) bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| RIC3 | PHB | 0.693 | 0.717 | bioplex (RIC3) bioplex_WMM |
| VDAC3 | SLC25A4 | 0.616 | 0.675 | bioplex (VDAC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| SLC25A5 | VDAC3 | 0.549 | 0.643 | bioplex (VDAC3) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PHB | SLC25A4 | 0.43 | 0.578 | bioplex (PHB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SLC25A5 | SLC25A4 | 0.157 | 0.416 | bioplex_WMM boldt fraction boldt_WMM |
| VDAC3 | VDAC2 | 0.022 | 0.209 | hein_WMM bioplex (VDAC3) bioplex_WMM boldt boldt_WMM treiber_WMM |
| SLC25A5 | RIC3 | 0.006 | 0.009 | bioplex (RIC3) |
| RIC3 | VDAC3 | 0.0 | 0.009 | bioplex (RIC3) bioplex_WMM |
Images
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Complex HuMAP2_04721 has an average edge precision of 0.571 which is ranked 2074 out of all 6965 complexes.
Related Complexes