hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04738
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CD3EAP | DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CAST) (CD3E-associated protein) (RNA polymerase I-associated factor PAF49) | UniProt NCBI |
| POLR1E | DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53) | UniProt NCBI |
| POLR3K | DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11) | UniProt NCBI |
| POLR1C | DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40) | UniProt NCBI |
| TWISTNB | DNA-directed RNA polymerase I subunit RPA43 (Twist neighbor protein) | UniProt NCBI |
| POLR1A | DNA-directed RNA polymerase I subunit RPA1 (RNA polymerase I subunit A1) (EC 2.7.7.6) (A190) (DNA-directed RNA polymerase I largest subunit) (DNA-directed RNA polymerase I subunit A) (RNA polymerase I 194 kDa subunit) (RPA194) | UniProt NCBI |
| POLR1D | Protein POLR1D, isoform 2 | UniProt NCBI |
| POLR1B | DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0001054 | 2.13003926586e-17 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA polymerase I activity |
| GO:0005736 | 2.13003926586e-17 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA polymerase I complex |
| KEGG:03020 | 2.42738007125e-17 | 0.875 | POLR1E POLR3K POLR1B POLR1A TWISTNB POLR1C POLR1D | RNA polymerase |
| GO:0003899 | 3.22028160292e-17 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | DNA-directed 5'-3' RNA polymerase activity |
| GO:0034062 | 6.41459319292e-17 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | 5'-3' RNA polymerase activity |
| GO:0097747 | 6.41459319292e-17 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | RNA polymerase activity |
| REAC:R-HSA-73863 | 1.15623710884e-16 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-73762 | 2.76276598137e-15 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA Polymerase I Transcription Initiation |
| GO:0006353 | 1.12120308733e-14 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | DNA-templated transcription, termination |
| GO:0006362 | 1.93554495458e-14 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | transcription elongation from RNA polymerase I promoter |
| GO:0006363 | 3.26058864694e-14 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | termination of RNA polymerase I transcription |
| WP:WP4022 | 3.62773956352e-14 | 0.875 | POLR1E POLR3K POLR1B POLR1A TWISTNB POLR1C POLR1D | Pyrimidine metabolism |
| GO:0006361 | 4.1733078163e-14 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | transcription initiation from RNA polymerase I promoter |
| GO:0055029 | 1.1060204938e-13 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 1.20543806627e-13 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | DNA-directed RNA polymerase complex |
| GO:0030880 | 1.55215269403e-13 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | RNA polymerase complex |
| REAC:R-HSA-5250924 | 3.01934227552e-13 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 3.27379223587e-13 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA Polymerase I Promoter Escape |
| GO:0016779 | 3.68276491178e-13 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | nucleotidyltransferase activity |
| REAC:R-HSA-5250913 | 9.30066761386e-13 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 9.96441195241e-13 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 1.22048227102e-12 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 1.30416374225e-12 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 1.3927138727e-12 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | RNA Polymerase I Transcription |
| GO:0045815 | 4.2231721809e-12 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | positive regulation of gene expression, epigenetic |
| GO:0006360 | 4.2231721809e-12 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | transcription by RNA polymerase I |
| REAC:R-HSA-212165 | 1.05885389445e-11 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | Epigenetic regulation of gene expression |
| GO:0061695 | 1.11425010437e-10 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | transferase complex, transferring phosphorus-containing groups |
| GO:0006354 | 2.80996417058e-10 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | DNA-templated transcription, elongation |
| WP:WP405 | 3.45861239295e-10 | 0.625 | POLR1D POLR1E POLR1B POLR3K POLR1A | Eukaryotic Transcription Initiation |
| GO:0140098 | 1.52860686774e-09 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | catalytic activity, acting on RNA |
| GO:0044452 | 7.45760867662e-09 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | nucleolar part |
| CORUM:5233 | 1.67296632195e-08 | 0.5 | POLR1E POLR1A POLR1B CD3EAP | TNF-alpha/NF-kappa B signaling complex 5 |
| GO:0006352 | 3.83118471953e-08 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | DNA-templated transcription, initiation |
| GO:0040029 | 4.17776614225e-07 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | regulation of gene expression, epigenetic |
| REAC:R-HSA-74160 | 5.36908321467e-07 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | Gene expression (Transcription) |
| GO:1990234 | 1.1325412216e-06 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | transferase complex |
| GO:0016772 | 2.59637798767e-06 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | transferase activity, transferring phosphorus-containing groups |
| REAC:R-HSA-73780 | 1.46609667673e-05 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Chain Elongation |
| REAC:R-HSA-73980 | 3.17792583502e-05 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription Termination |
| REAC:R-HSA-76066 | 5.2434024277e-05 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-76071 | 5.87113050867e-05 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| REAC:R-HSA-76061 | 5.87113050867e-05 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| GO:1902494 | 8.40314286631e-05 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | catalytic complex |
| REAC:R-HSA-76046 | 0.000127702698548 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription Initiation |
| KEGG:04623 | 0.000148815094067 | 0.375 | POLR1C POLR3K POLR1D | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-74158 | 0.000190419512819 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Transcription |
| REAC:R-HSA-749476 | 0.000190419512819 | 0.375 | POLR1C POLR3K POLR1D | RNA Polymerase III Abortive And Retractive Initiation |
| WP:WP4655 | 0.000253783817803 | 0.375 | POLR1C POLR3K POLR1D | Cytosolic DNA-sensing pathway |
| GO:0005730 | 0.000302961899326 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | nucleolus |
| REAC:R-HSA-1834949 | 0.00070543068915 | 0.375 | POLR1C POLR3K POLR1D | Cytosolic sensors of pathogen-associated DNA |
| GO:0016740 | 0.0024739987919 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | transferase activity |
| HP:0011219 | 0.00248871678952 | 0.25 | POLR1C POLR1D | Short face |
| GO:0001056 | 0.002838758576 | 0.375 | POLR1C POLR3K POLR1D | RNA polymerase III activity |
| GO:0005666 | 0.00413439262839 | 0.375 | POLR1C POLR3K POLR1D | RNA polymerase III complex |
| HP:0009795 | 0.00464310919637 | 0.25 | POLR1C POLR1D | Branchial fistula |
| HP:0005701 | 0.00464310919637 | 0.25 | POLR1C POLR1D | Multiple enchondromatosis |
| HP:0000453 | 0.00848886175965 | 0.375 | POLR1C POLR1D POLR1A | Choanal atresia |
| HP:0008551 | 0.00905007554403 | 0.375 | POLR1C POLR1D POLR1A | Microtia |
| HP:0009794 | 0.00911304494741 | 0.25 | POLR1C POLR1D | Branchial anomaly |
| HP:0005990 | 0.00911304494741 | 0.25 | POLR1C POLR1D | Thyroid hypoplasia |
| HP:0000415 | 0.00993705207292 | 0.375 | POLR1C POLR1D POLR1A | Abnormality of the choanae |
| HP:0000327 | 0.0102449952412 | 0.375 | POLR1C POLR1D POLR1A | Hypoplasia of the maxilla |
| HP:0008772 | 0.0102449952412 | 0.375 | POLR1C POLR1D POLR1A | Aplasia/Hypoplasia of the external ear |
| HP:0011386 | 0.0109327161708 | 0.25 | POLR1C POLR1D | Narrow internal auditory canal |
| HP:0008771 | 0.0115398037056 | 0.375 | POLR1C POLR1D POLR1A | Aplasia/Hypoplasia of the ear |
| HP:0002006 | 0.0129170117165 | 0.25 | POLR1C POLR1D | Facial cleft |
| HP:0000326 | 0.0144445297722 | 0.375 | POLR1C POLR1D POLR1A | Abnormality of the maxilla |
| GO:0006351 | 0.0145078913523 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | transcription, DNA-templated |
| GO:0097659 | 0.0148177261561 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | nucleic acid-templated transcription |
| HP:0008188 | 0.0150657984869 | 0.25 | POLR1C POLR1D | Thyroid dysgenesis |
| GO:0032774 | 0.0151333353827 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | RNA biosynthetic process |
| MIRNA:hsa-miR-6884-5p | 0.016060133538 | 0.5 | POLR1E POLR1A POLR3K CD3EAP | hsa-miR-6884-5p |
| HP:0011384 | 0.0173789434513 | 0.25 | POLR1C POLR1D | Abnormality of the internal auditory canal |
| HP:0030038 | 0.0173789434513 | 0.25 | POLR1C POLR1D | Enchondroma |
| MIRNA:hsa-miR-485-5p | 0.0209725564287 | 0.5 | POLR1E POLR1A POLR3K CD3EAP | hsa-miR-485-5p |
| GO:0010628 | 0.021583283936 | 0.875 | POLR1E CD3EAP POLR1A TWISTNB POLR1C POLR1D POLR1B | positive regulation of gene expression |
| HP:0002763 | 0.0224977761754 | 0.25 | POLR1C POLR1D | Abnormal cartilage morphology |
| HP:0000143 | 0.0224977761754 | 0.25 | POLR1C POLR1D | Rectovaginal fistula |
| HP:0100590 | 0.0253031982095 | 0.25 | POLR1C POLR1D | Rectal fistula |
| HP:0000561 | 0.0282724469862 | 0.25 | POLR1C POLR1D | Absent eyelashes |
| HP:0100819 | 0.0347018940535 | 0.25 | POLR1C POLR1D | Intestinal fistula |
| HP:0000162 | 0.0347018940535 | 0.25 | POLR1C POLR1D | Glossoptosis |
| HP:0002550 | 0.0381618271547 | 0.25 | POLR1C POLR1D | Absent facial hair |
| MIRNA:hsa-miR-4768-3p | 0.0385435443003 | 0.5 | POLR1E POLR1A POLR3K CD3EAP | hsa-miR-4768-3p |
| HP:0004320 | 0.0417850566195 | 0.25 | POLR1C POLR1D | Vaginal fistula |
| GO:0034654 | 0.0465658023825 | 1.0 | POLR1E POLR3K CD3EAP POLR1A TWISTNB POLR1D POLR1C POLR1B | nucleobase-containing compound biosynthetic process |
| CORUM:1558 | 0.0497224828424 | 0.125 | POLR1B | POLR1B-RRN3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR1A | POLR1B | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (POLR1A) Malo fraction treiber_WMM |
| POLR1C | POLR1A | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM hein (POLR1A) Malo fraction |
| POLR1A | POLR1D | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (POLR1A) Malo fraction |
| POLR1C | POLR1B | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM boldt Malo fraction boldt_WMM |
| POLR1D | POLR1B | 1.0 | 0.949 | hein_WMM bioplex_WMM Malo fraction |
| POLR1C | POLR1D | 1.0 | 0.949 | hein_WMM bioplex (POLR1C) bioplex_WMM Malo fraction |
| TWISTNB | POLR1A | 0.999 | 0.949 | hein_WMM bioplex (TWISTNB) bioplex_WMM hein (POLR1A) Malo fraction |
| TWISTNB | POLR1B | 0.937 | 0.85 | hein_WMM bioplex (TWISTNB) bioplex_WMM Malo fraction |
| TWISTNB | POLR1D | 0.935 | 0.85 | hein_WMM bioplex (TWISTNB) bioplex_WMM Malo fraction |
| TWISTNB | POLR1C | 0.903 | 0.827 | hein_WMM bioplex (POLR1C,TWISTNB) bioplex_WMM Malo fraction |
| POLR1A | CD3EAP | 0.743 | 0.739 | hein_WMM bioplex_WMM hein (POLR1A) |
| POLR1E | POLR1A | 0.721 | 0.732 | hein_WMM bioplex_WMM hein (POLR1A) |
| POLR1C | CD3EAP | 0.672 | 0.705 | hein_WMM bioplex (POLR1C) bioplex_WMM |
| POLR1C | POLR3K | 0.638 | 0.685 | hein_WMM bioplex (POLR1C) bioplex_WMM fraction |
| POLR1E | POLR1C | 0.487 | 0.615 | hein_WMM bioplex (POLR1C) bioplex_WMM |
| POLR1E | CD3EAP | 0.352 | 0.538 | hein_WMM bioplex_WMM Malo fraction |
| POLR3K | POLR1D | 0.036 | 0.266 | hein_WMM bioplex_WMM fraction |
| POLR1D | CD3EAP | 0.014 | 0.138 | hein_WMM bioplex_WMM WMM_only |
| CD3EAP | POLR1B | 0.012 | 0.144 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | POLR1D | 0.011 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| POLR3K | CD3EAP | 0.01 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | POLR1B | 0.01 | 0.119 | hein_WMM bioplex_WMM WMM_only |
| POLR1A | POLR3K | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | POLR3K | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| TWISTNB | CD3EAP | 0.008 | 0.034 | hein_WMM bioplex_WMM WMM_only |
| POLR3K | POLR1B | 0.007 | 0.008 | hein_WMM bioplex_WMM WMM_only |
| POLR1E | TWISTNB | 0.007 | 0.004 | hein_WMM bioplex_WMM WMM_only |
| TWISTNB | POLR3K | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04738 has an average edge precision of 0.514 which is ranked 2419 out of all 6965 complexes.
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