hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04753
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | UniProt NCBI |
| AKAP2 | A-kinase anchor protein 2 (AKAP-2) (AKAP-KL) (Protein kinase A-anchoring protein 2) (PRKA2) | UniProt NCBI |
| AKAP3 | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | UniProt NCBI |
| PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | UniProt NCBI |
| GPR161 | G-protein coupled receptor 161 (G-protein coupled receptor RE2) | UniProt NCBI |
| C2orf88 | Small membrane A-kinase anchor protein (Small membrane AKAP) (smAKAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 0.000157102141644 | 0.5 | PRKAR1B AKAP3 PRKAR1A | G Protein Signaling Pathways |
| REAC:R-HSA-442720 | 0.0012174763081 | 0.333333333333 | PRKAR1B PRKAR1A | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| REAC:R-HSA-5610787 | 0.00129954570423 | 0.5 | PRKAR1B GPR161 PRKAR1A | Hedgehog 'off' state |
| WP:WP3869 | 0.00140863716749 | 0.333333333333 | PRKAR1B PRKAR1A | Cannabinoid receptor signaling |
| WP:WP2012 | 0.00180854165103 | 0.333333333333 | PRKAR1B PRKAR1A | miRs in Muscle Cell Differentiation |
| WP:WP3965 | 0.00210271928468 | 0.333333333333 | PRKAR1B PRKAR1A | Lipid Metabolism Pathway |
| REAC:R-HSA-163615 | 0.00265393377546 | 0.333333333333 | PRKAR1B PRKAR1A | PKA activation |
| REAC:R-HSA-5358351 | 0.00272420329871 | 0.5 | PRKAR1B GPR161 PRKAR1A | Signaling by Hedgehog |
| REAC:R-HSA-164378 | 0.0030072528049 | 0.333333333333 | PRKAR1B PRKAR1A | PKA activation in glucagon signalling |
| REAC:R-HSA-111931 | 0.00338255333894 | 0.333333333333 | PRKAR1B PRKAR1A | PKA-mediated phosphorylation of CREB |
| REAC:R-HSA-180024 | 0.0055883638448 | 0.333333333333 | PRKAR1B PRKAR1A | DARPP-32 events |
| REAC:R-HSA-163359 | 0.0102563889288 | 0.333333333333 | PRKAR1B PRKAR1A | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111997 | 0.0116417903194 | 0.333333333333 | PRKAR1B PRKAR1A | CaM pathway |
| REAC:R-HSA-111933 | 0.0116417903194 | 0.333333333333 | PRKAR1B PRKAR1A | Calmodulin induced events |
| REAC:R-HSA-381676 | 0.0131143608537 | 0.333333333333 | PRKAR1B PRKAR1A | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-111996 | 0.0131143608537 | 0.333333333333 | PRKAR1B PRKAR1A | Ca-dependent events |
| REAC:R-HSA-432040 | 0.0146740061797 | 0.333333333333 | PRKAR1B PRKAR1A | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-1489509 | 0.0163206320028 | 0.333333333333 | PRKAR1B PRKAR1A | DAG and IP3 signaling |
| REAC:R-HSA-445717 | 0.0163206320028 | 0.333333333333 | PRKAR1B PRKAR1A | Aquaporin-mediated transport |
| WP:WP4540 | 0.0205911896387 | 0.333333333333 | PRKAR1B PRKAR1A | Pathways Regulating Hippo Signaling |
| GO:0051018 | 0.0207293189685 | 0.5 | PRKAR1B AKAP3 PRKAR1A | protein kinase A binding |
| REAC:R-HSA-112043 | 0.0280217040903 | 0.333333333333 | PRKAR1B PRKAR1A | PLC beta mediated events |
| WP:WP4541 | 0.0282758493646 | 0.333333333333 | PRKAR1B PRKAR1A | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-112040 | 0.029137346631 | 0.333333333333 | PRKAR1B PRKAR1A | G-protein mediated events |
| WP:WP536 | 0.0390677259104 | 0.333333333333 | PRKAR1B PRKAR1A | Calcium Regulation in the Cardiac Cell |
| WP:WP706 | 0.0444098499457 | 0.333333333333 | PRKAR1B PRKAR1A | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 0.0464992674716 | 0.333333333333 | PRKAR1B PRKAR1A | Myometrial Relaxation and Contraction Pathways |
| KEGG:04910 | 0.0474671394747 | 0.333333333333 | PRKAR1B PRKAR1A | Insulin signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAR1A | PRKAR1B | 1.0 | 0.949 | hein_WMM bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1A | AKAP3 | 0.969 | 0.881 | bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1A | GPR161 | 0.74 | 0.739 | bioplex (GPR161,PRKAR1A) bioplex_WMM |
| PRKAR1A | AKAP2 | 0.377 | 0.548 | bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1A | C2orf88 | 0.37 | 0.545 | bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1B | GPR161 | 0.076 | 0.355 | bioplex (GPR161) bioplex_WMM |
| AKAP2 | PRKAR1B | 0.009 | 0.107 | bioplex_WMM WMM_only |
| AKAP2 | AKAP3 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| GPR161 | AKAP3 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| AKAP3 | C2orf88 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| AKAP2 | GPR161 | 0.009 | 0.094 | bioplex_WMM WMM_only |
| AKAP2 | C2orf88 | 0.008 | 0.093 | bioplex_WMM WMM_only |
| GPR161 | C2orf88 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKAR1B | AKAP3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PRKAR1B | C2orf88 | 0.008 | 0.039 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04753 has an average edge precision of 0.32 which is ranked 4342 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAR1A | HuMAP2_00037 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706 |
| AKAP2 | HuMAP2_01832 HuMAP2_04753 HuMAP2_06335 |
| AKAP3 | HuMAP2_02640 HuMAP2_04753 HuMAP2_05706 |
| PRKAR1B | HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706 |
| GPR161 | HuMAP2_02640 HuMAP2_04753 HuMAP2_05706 |
| C2orf88 | HuMAP2_04753 HuMAP2_05706 |