hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04754

Confidence: Medium High

Genename	Protein Name	Links
EIF4E	Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)	UniProt NCBI
EIF4E2	Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)	UniProt NCBI
ANGEL1	Protein angel homolog 1	UniProt NCBI
EIF4EBP2	Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2)	UniProt NCBI
EIF4EBP1	Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)	UniProt NCBI
EIF4ENIF1	Eukaryotic translation initiation factor 4E transporter (4E-T) (eIF4E transporter) (Eukaryotic translation initiation factor 4E nuclear import factor 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0031369	3.88005641427e-06	0.666666666667	EIF4EBP2 ANGEL1 EIF4EBP1 EIF4E	translation initiation factor binding
KEGG:03013	7.31795821712e-06	0.666666666667	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4E	RNA transport
WP:WP107	2.92137873708e-05	0.5	EIF4EBP2 EIF4EBP1 EIF4E	Translation Factors
GO:0008190	3.63109651748e-05	0.5	EIF4EBP2 EIF4EBP1 ANGEL1	eukaryotic initiation factor 4E binding
KEGG:01521	0.000107857457806	0.5	EIF4E EIF4EBP1 EIF4E2	EGFR tyrosine kinase inhibitor resistance
KEGG:04211	0.000147172017102	0.5	EIF4E EIF4EBP1 EIF4E2	Longevity regulating pathway
KEGG:04066	0.000267985848775	0.5	EIF4E EIF4EBP1 EIF4E2	HIF-1 signaling pathway
GO:0006417	0.000386631010052	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	regulation of translation
KEGG:04910	0.000524612840052	0.5	EIF4E EIF4EBP1 EIF4E2	Insulin signaling pathway
KEGG:04150	0.000802296549804	0.5	EIF4E EIF4EBP1 EIF4E2	mTOR signaling pathway
WP:WP3879	0.000852627081304	0.333333333333	EIF4E EIF4EBP1	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
WP:WP516	0.000852627081304	0.333333333333	EIF4E EIF4EBP1	Hypertrophy Model
GO:0034248	0.000870085575899	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	regulation of cellular amide metabolic process
GO:0017148	0.00160072832698	0.666666666667	EIF4EBP2 EIF4ENIF1 EIF4EBP1 EIF4E2	negative regulation of translation
GO:0045182	0.00208860909913	0.666666666667	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4E	translation regulator activity
GO:0034249	0.00249974066558	0.666666666667	EIF4EBP2 EIF4ENIF1 EIF4EBP1 EIF4E2	negative regulation of cellular amide metabolic process
WP:WP3932	0.00399196485232	0.5	EIF4E EIF4EBP1 EIF4E2	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
REAC:R-HSA-166208	0.00510333351271	0.333333333333	EIF4E EIF4EBP1	mTORC1-mediated signalling
WP:WP4172	0.00560540779735	0.5	EIF4E EIF4EBP1 EIF4E2	PI3K-Akt Signaling Pathway
WP:WP4566	0.00573889859296	0.333333333333	EIF4E EIF4EBP1	Translation inhibitors in chronically activated PDGFRA cells
KEGG:04151	0.00716177546378	0.5	EIF4E EIF4EBP1 EIF4E2	PI3K-Akt signaling pathway
WP:WP585	0.00792327646772	0.333333333333	EIF4E EIF4EBP1	Interferon type I signaling pathways
GO:0010608	0.0111407474037	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	posttranscriptional regulation of gene expression
GO:0006412	0.0137308239878	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	translation
WP:WP2034	0.014901555017	0.333333333333	EIF4E EIF4EBP1	Leptin signaling pathway
REAC:R-HSA-165159	0.0163206320028	0.333333333333	EIF4E EIF4EBP1	mTOR signalling
GO:0043043	0.0170964795605	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	peptide biosynthetic process
WP:WP4549	0.0358990321007	0.333333333333	EIF4EBP2 EIF4E	Fragile X Syndrome
REAC:R-HSA-72662	0.0388379782234	0.333333333333	EIF4E EIF4EBP1	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
WP:WP3915	0.0416969783243	0.333333333333	EIF4E EIF4EBP1	Angiopoietin Like Protein 8 Regulatory Pathway
GO:0043604	0.0420836853755	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	amide biosynthetic process
GO:0006518	0.0430733890744	0.833333333333	EIF4EBP2 EIF4E2 EIF4EBP1 EIF4ENIF1 EIF4E	peptide metabolic process
REAC:R-HSA-1169408	0.0484536768126	0.333333333333	EIF4E EIF4E2	ISG15 antiviral mechanism

Edges

Protein 1	Protein 2	Score	Precision	Evidence
EIF4ENIF1	EIF4E	1.0	0.949	youn (EIF4ENIF1) bioplex (EIF4E) bioplex_WMM youn_WMM
EIF4E	EIF4EBP1	0.978	0.893	bioplex (EIF4E) bioplex_WMM fraction
EIF4E2	EIF4ENIF1	0.862	0.799	youn (EIF4ENIF1) bioplex (EIF4E2) bioplex_WMM youn_WMM
EIF4E	EIF4EBP2	0.716	0.729	bioplex (EIF4E) bioplex_WMM fraction
ANGEL1	EIF4E	0.595	0.665	bioplex (EIF4E) bioplex_WMM
EIF4EBP2	EIF4EBP1	0.103	0.366	bioplex_WMM fraction
EIF4E2	EIF4EBP2	0.044	0.278	bioplex (EIF4E2) bioplex_WMM
EIF4ENIF1	EIF4EBP1	0.009	0.097	bioplex_WMM gupta_WMM WMM_only
ANGEL1	EIF4EBP2	0.008	0.024	bioplex_WMM WMM_only
EIF4ENIF1	ANGEL1	0.008	0.025	bioplex_WMM WMM_only
ANGEL1	EIF4EBP1	0.007	0.004	bioplex_WMM WMM_only
EIF4E2	EIF4E	0.006	0.004	bioplex_WMM youn_WMM WMM_only
EIF4E2	EIF4EBP1	0.003	0.02	bioplex (EIF4E2) bioplex_WMM
EIF4ENIF1	EIF4EBP2	0.0	0.008	bioplex_WMM fraction

Images

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Complex HuMAP2_04754 has an average edge precision of 0.347 which is ranked 4015 out of all 6965 complexes.

Related Complexes

Genename	Complexes
EIF4E	HuMAP2_00638 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719
EIF4E2	HuMAP2_00038 HuMAP2_02468 HuMAP2_02713 HuMAP2_02934 HuMAP2_04239 HuMAP2_04647 HuMAP2_04754 HuMAP2_05137
ANGEL1	HuMAP2_00135 HuMAP2_01287 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719 HuMAP2_06115
EIF4EBP2	HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05137 HuMAP2_05719
EIF4EBP1	HuMAP2_00638 HuMAP2_02769 HuMAP2_03226 HuMAP2_04754 HuMAP2_05719
EIF4ENIF1	HuMAP2_00038 HuMAP2_00638 HuMAP2_04239 HuMAP2_04647 HuMAP2_04754 HuMAP2_05137

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04754