hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04755
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKT1 | RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) | UniProt NCBI |
| AKT2 | RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC-PK-beta) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1559 | 7.82420796608e-06 | 1.0 | AKT2 AKT1 | TFs Regulate miRNAs related to cardiac hypertrophy |
| REAC:R-HSA-211163 | 1.00555407742e-05 | 1.0 | AKT2 AKT1 | AKT-mediated inactivation of FOXO1A |
| REAC:R-HSA-8941332 | 3.51943927099e-05 | 1.0 | AKT2 AKT1 | RUNX2 regulates genes involved in cell migration |
| REAC:R-HSA-198693 | 6.03332446455e-05 | 1.0 | AKT2 AKT1 | AKT phosphorylates targets in the nucleus |
| REAC:R-HSA-9614399 | 9.21757904306e-05 | 1.0 | AKT2 AKT1 | Regulation of localization of FOXO transcription factors |
| REAC:R-HSA-210745 | 9.21757904306e-05 | 1.0 | AKT2 AKT1 | Regulation of gene expression in beta cells |
| HP:0001528 | 9.35041149526e-05 | 1.0 | AKT2 AKT1 | Hemihypertrophy |
| REAC:R-HSA-1358803 | 0.000110610948517 | 1.0 | AKT2 AKT1 | Downregulation of ERBB2:ERBB3 signaling |
| WP:WP4561 | 0.000111774399515 | 1.0 | AKT2 AKT1 | Cell migration and invasion through p75NTR |
| WP:WP26 | 0.000111774399515 | 1.0 | AKT2 AKT1 | Signal Transduction of S1P Receptor |
| KEGG:04973 | 0.000113800084426 | 1.0 | AKT2 AKT1 | Carbohydrate digestion and absorption |
| REAC:R-HSA-6804759 | 0.000130722030065 | 1.0 | AKT2 AKT1 | Regulation of TP53 Activity through Association with Co-factors |
| KEGG:04923 | 0.000138019076752 | 1.0 | AKT2 AKT1 | Regulation of lipolysis in adipocytes |
| WP:WP3965 | 0.000140835743389 | 1.0 | AKT2 AKT1 | Lipid Metabolism Pathway |
| REAC:R-HSA-198323 | 0.000152509035076 | 1.0 | AKT2 AKT1 | AKT phosphorylates targets in the cytosol |
| WP:WP4481 | 0.000162072879297 | 1.0 | AKT2 AKT1 | Resistin as a regulator of inflammation |
| REAC:R-HSA-111447 | 0.000175971963549 | 1.0 | AKT2 AKT1 | Activation of BAD and translocation to mitochondria |
| KEGG:04929 | 0.000208779385658 | 1.0 | AKT2 AKT1 | GnRH secretion |
| WP:WP4564 | 0.000209018127094 | 1.0 | AKT2 AKT1 | Neural Crest Cell Migration during Development |
| KEGG:04370 | 0.000216657853041 | 1.0 | AKT2 AKT1 | VEGF signaling pathway |
| KEGG:04664 | 0.000216657853041 | 1.0 | AKT2 AKT1 | Fc epsilon RI signaling pathway |
| KEGG:04213 | 0.000224682217969 | 1.0 | AKT2 AKT1 | Longevity regulating pathway - multiple species |
| REAC:R-HSA-389513 | 0.000227925590883 | 1.0 | AKT2 AKT1 | CTLA4 inhibitory signaling |
| KEGG:05213 | 0.00023285248044 | 1.0 | AKT2 AKT1 | Endometrial cancer |
| WP:WP4565 | 0.000248139166924 | 1.0 | AKT2 AKT1 | Neural Crest Cell Migration in Cancer |
| KEGG:05221 | 0.00025823865312 | 1.0 | AKT2 AKT1 | Acute myeloid leukemia |
| KEGG:05218 | 0.00027589225596 | 1.0 | AKT2 AKT1 | Melanoma |
| KEGG:04917 | 0.00027589225596 | 1.0 | AKT2 AKT1 | Prolactin signaling pathway |
| KEGG:05211 | 0.000284937903697 | 1.0 | AKT2 AKT1 | Renal cell carcinoma |
| REAC:R-HSA-9634638 | 0.000286582912066 | 1.0 | AKT2 AKT1 | Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
| REAC:R-HSA-389357 | 0.000286582912066 | 1.0 | AKT2 AKT1 | CD28 dependent PI3K/Akt signaling |
| WP:WP2036 | 0.00029061343874 | 1.0 | AKT2 AKT1 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| KEGG:05223 | 0.000294129448977 | 1.0 | AKT2 AKT1 | Non-small cell lung cancer |
| KEGG:04920 | 0.000294129448977 | 1.0 | AKT2 AKT1 | Adipocytokine signaling pathway |
| KEGG:05230 | 0.000322579470084 | 1.0 | AKT2 AKT1 | Central carbon metabolism in cancer |
| KEGG:04662 | 0.000322579470084 | 1.0 | AKT2 AKT1 | B cell receptor signaling pathway |
| KEGG:05214 | 0.000332354605541 | 1.0 | AKT2 AKT1 | Glioma |
| REAC:R-HSA-392451 | 0.000351943927099 | 1.0 | AKT2 AKT1 | G beta:gamma signalling through PI3Kgamma |
| KEGG:05212 | 0.000362555397177 | 1.0 | AKT2 AKT1 | Pancreatic cancer |
| KEGG:01524 | 0.00037291412281 | 1.0 | AKT2 AKT1 | Platinum drug resistance |
| WP:WP4566 | 0.000385621678328 | 1.0 | AKT2 AKT1 | Translation inhibitors in chronically activated PDGFRA cells |
| KEGG:01521 | 0.00039406926671 | 1.0 | AKT2 AKT1 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.00039406926671 | 1.0 | AKT2 AKT1 | Chronic myeloid leukemia |
| WP:WP4539 | 0.000402760419587 | 1.0 | AKT2 AKT1 | Synaptic signaling pathways associated with autism spectrum disorder |
| WP:WP2795 | 0.000420271742178 | 1.0 | AKT2 AKT1 | Cardiac Hypertrophic Response |
| REAC:R-HSA-8863795 | 0.000424008635981 | 1.0 | AKT2 AKT1 | Downregulation of ERBB2 signaling |
| KEGG:04012 | 0.000449510333482 | 1.0 | AKT2 AKT1 | ErbB signaling pathway |
| KEGG:05235 | 0.000461036239468 | 1.0 | AKT2 AKT1 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04914 | 0.000472708042999 | 1.0 | AKT2 AKT1 | Progesterone-mediated oocyte maturation |
| KEGG:05210 | 0.000484525744074 | 1.0 | AKT2 AKT1 | Colorectal cancer |
| KEGG:04211 | 0.000484525744074 | 1.0 | AKT2 AKT1 | Longevity regulating pathway |
| WP:WP2018 | 0.000494042845858 | 1.0 | AKT2 AKT1 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| REAC:R-HSA-5674400 | 0.000502777038712 | 1.0 | AKT2 AKT1 | Constitutive Signaling by AKT1 E17K in Cancer |
| KEGG:04620 | 0.000533255523815 | 1.0 | AKT2 AKT1 | Toll-like receptor signaling pathway |
| REAC:R-HSA-5218920 | 0.000544675125272 | 1.0 | AKT2 AKT1 | VEGFR2 mediated vascular permeability |
| KEGG:04666 | 0.000558495798951 | 1.0 | AKT2 AKT1 | Fc gamma R-mediated phagocytosis |
| KEGG:05142 | 0.000558495798951 | 1.0 | AKT2 AKT1 | Chagas disease (American trypanosomiasis) |
| KEGG:04625 | 0.000558495798951 | 1.0 | AKT2 AKT1 | C-type lectin receptor signaling pathway |
| KEGG:05231 | 0.000571334782835 | 1.0 | AKT2 AKT1 | Choline metabolism in cancer |
| KEGG:05215 | 0.000584319664263 | 1.0 | AKT2 AKT1 | Prostate cancer |
| KEGG:01522 | 0.000584319664263 | 1.0 | AKT2 AKT1 | Endocrine resistance |
| KEGG:04660 | 0.000584319664263 | 1.0 | AKT2 AKT1 | T cell receptor signaling pathway |
| WP:WP4205 | 0.000594639805422 | 1.0 | AKT2 AKT1 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04933 | 0.000597450443235 | 1.0 | AKT2 AKT1 | AGE-RAGE signaling pathway in diabetic complications |
| KEGG:05222 | 0.000610727119751 | 1.0 | AKT2 AKT1 | Small cell lung cancer |
| KEGG:04668 | 0.000624149693812 | 1.0 | AKT2 AKT1 | TNF signaling pathway |
| REAC:R-HSA-389356 | 0.000633499068778 | 1.0 | AKT2 AKT1 | CD28 co-stimulation |
| REAC:R-HSA-397795 | 0.000633499068778 | 1.0 | AKT2 AKT1 | G-protein beta:gamma signalling |
| KEGG:05145 | 0.000637718165416 | 1.0 | AKT2 AKT1 | Toxoplasmosis |
| KEGG:04922 | 0.000665292801258 | 1.0 | AKT2 AKT1 | Glucagon signaling pathway |
| KEGG:04725 | 0.000665292801258 | 1.0 | AKT2 AKT1 | Cholinergic synapse |
| REAC:R-HSA-186712 | 0.000680424925724 | 1.0 | AKT2 AKT1 | Regulation of beta-cell development |
| WP:WP4155 | 0.000704551298279 | 1.0 | AKT2 AKT1 | Endometrial cancer |
| KEGG:04066 | 0.000722192843471 | 1.0 | AKT2 AKT1 | HIF-1 signaling pathway |
| REAC:R-HSA-6804758 | 0.000729026706133 | 1.0 | AKT2 AKT1 | Regulation of TP53 Activity through Acetylation |
| REAC:R-HSA-114452 | 0.000729026706133 | 1.0 | AKT2 AKT1 | Activation of BH3-only proteins |
| WP:WP1403 | 0.000751123964743 | 1.0 | AKT2 AKT1 | AMP-activated Protein Kinase (AMPK) Signaling |
| KEGG:04931 | 0.000751518249842 | 1.0 | AKT2 AKT1 | Insulin resistance |
| KEGG:04380 | 0.000766399799344 | 1.0 | AKT2 AKT1 | Osteoclast differentiation |
| KEGG:04722 | 0.000827384972793 | 1.0 | AKT2 AKT1 | Neurotrophin signaling pathway |
| KEGG:04071 | 0.000858752944782 | 1.0 | AKT2 AKT1 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.000890704506947 | 1.0 | AKT2 AKT1 | Platelet activation |
| WP:WP4255 | 0.000899783916099 | 1.0 | AKT2 AKT1 | Non-small cell lung cancer |
| KEGG:04152 | 0.000906899134346 | 1.0 | AKT2 AKT1 | AMPK signaling pathway |
| KEGG:05135 | 0.000906899134346 | 1.0 | AKT2 AKT1 | Yersinia infection |
| KEGG:04919 | 0.00092323965929 | 1.0 | AKT2 AKT1 | Thyroid hormone signaling pathway |
| WP:WP4216 | 0.000925864609319 | 1.0 | AKT2 AKT1 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:04068 | 0.000939726081777 | 1.0 | AKT2 AKT1 | FoxO signaling pathway |
| REAC:R-HSA-6804757 | 0.000997174460113 | 1.0 | AKT2 AKT1 | Regulation of TP53 Degradation |
| KEGG:04926 | 0.00104170846513 | 1.0 | AKT2 AKT1 | Relaxin signaling pathway |
| REAC:R-HSA-6806003 | 0.0010558317813 | 1.0 | AKT2 AKT1 | Regulation of TP53 Expression and Degradation |
| KEGG:04630 | 0.00105921617042 | 1.0 | AKT2 AKT1 | JAK-STAT signaling pathway |
| KEGG:04728 | 0.00105921617042 | 1.0 | AKT2 AKT1 | Dopaminergic synapse |
| WP:WP1544 | 0.0010618567954 | 1.0 | AKT2 AKT1 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04915 | 0.00107686977326 | 1.0 | AKT2 AKT1 | Estrogen signaling pathway |
| KEGG:04550 | 0.00109466927365 | 1.0 | AKT2 AKT1 | Signaling pathways regulating pluripotency of stem cells |
| KEGG:04371 | 0.00111261467158 | 1.0 | AKT2 AKT1 | Apelin signaling pathway |
| KEGG:04910 | 0.00113070596705 | 1.0 | AKT2 AKT1 | Insulin signaling pathway |
| KEGG:04210 | 0.00113070596705 | 1.0 | AKT2 AKT1 | Apoptosis |
| KEGG:05418 | 0.00113070596705 | 1.0 | AKT2 AKT1 | Fluid shear stress and atherosclerosis |
| KEGG:04072 | 0.00114894316007 | 1.0 | AKT2 AKT1 | Phospholipase D signaling pathway |
| KEGG:05162 | 0.00118585523873 | 1.0 | AKT2 AKT1 | Measles |
| KEGG:04261 | 0.00120453012438 | 1.0 | AKT2 AKT1 | Adrenergic signaling in cardiomyocytes |
| KEGG:04062 | 0.00122335090758 | 1.0 | AKT2 AKT1 | Chemokine signaling pathway |
| KEGG:05224 | 0.00122335090758 | 1.0 | AKT2 AKT1 | Breast cancer |
| WP:WP2261 | 0.00123734260264 | 1.0 | AKT2 AKT1 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-3769402 | 0.00124185928562 | 1.0 | AKT2 AKT1 | Deactivation of the beta-catenin transactivating complex |
| REAC:R-HSA-165159 | 0.00124185928562 | 1.0 | AKT2 AKT1 | mTOR signalling |
| KEGG:05226 | 0.00124231758831 | 1.0 | AKT2 AKT1 | Gastric cancer |
| WP:WP4263 | 0.00126789427184 | 1.0 | AKT2 AKT1 | Pancreatic adenocarcinoma pathway |
| KEGG:04932 | 0.00128068864242 | 1.0 | AKT2 AKT1 | Non-alcoholic fatty liver disease (NAFLD) |
| KEGG:04140 | 0.00128068864242 | 1.0 | AKT2 AKT1 | Autophagy - animal |
| WP:WP673 | 0.00133011535423 | 1.0 | AKT2 AKT1 | ErbB Signaling Pathway |
| KEGG:05160 | 0.00133933945516 | 1.0 | AKT2 AKT1 | Hepatitis C |
| WP:WP75 | 0.00142624133782 | 1.0 | AKT2 AKT1 | Toll-like Receptor Signaling Pathway |
| KEGG:04022 | 0.00144000876062 | 1.0 | AKT2 AKT1 | cGMP-PKG signaling pathway |
| REAC:R-HSA-1227986 | 0.0014429701011 | 1.0 | AKT2 AKT1 | Signaling by ERBB2 |
| KEGG:04150 | 0.00150216111442 | 1.0 | AKT2 AKT1 | mTOR signaling pathway |
| KEGG:04218 | 0.00152317036077 | 1.0 | AKT2 AKT1 | Cellular senescence |
| KEGG:05164 | 0.00158707348511 | 1.0 | AKT2 AKT1 | Influenza A |
| WP:WP185 | 0.00159390293709 | 1.0 | AKT2 AKT1 | Integrin-mediated Cell Adhesion |
| KEGG:05152 | 0.00163040505571 | 1.0 | AKT2 AKT1 | Tuberculosis |
| WP:WP4658 | 0.00166357564612 | 1.0 | AKT2 AKT1 | Small cell lung cancer |
| KEGG:05161 | 0.00174128718926 | 1.0 | AKT2 AKT1 | Hepatitis B |
| WP:WP3931 | 0.00177087906966 | 1.0 | AKT2 AKT1 | ESC Pluripotency Pathways |
| KEGG:05225 | 0.00183261905189 | 1.0 | AKT2 AKT1 | Hepatocellular carcinoma |
| KEGG:05167 | 0.00197399377215 | 1.0 | AKT2 AKT1 | Kaposi sarcoma-associated herpesvirus infection |
| HP:0100555 | 0.00198696244274 | 1.0 | AKT2 AKT1 | Asymmetric growth |
| WP:WP710 | 0.00199554561268 | 1.0 | AKT2 AKT1 | DNA Damage Response (only ATM dependent) |
| REAC:R-HSA-109606 | 0.00205300624141 | 1.0 | AKT2 AKT1 | Intrinsic Pathway for Apoptosis |
| KEGG:04024 | 0.00209581822151 | 1.0 | AKT2 AKT1 | cAMP signaling pathway |
| KEGG:04015 | 0.00217066366165 | 1.0 | AKT2 AKT1 | Rap1 signaling pathway |
| REAC:R-HSA-388841 | 0.00239824647466 | 1.0 | AKT2 AKT1 | Costimulation by the CD28 family |
| KEGG:05169 | 0.00242963180249 | 1.0 | AKT2 AKT1 | Epstein-Barr virus infection |
| KEGG:04014 | 0.00245633105307 | 1.0 | AKT2 AKT1 | Ras signaling pathway |
| KEGG:05205 | 0.00256458703081 | 1.0 | AKT2 AKT1 | Proteoglycans in cancer |
| WP:WP1449 | 0.00257192893285 | 1.0 | AKT2 AKT1 | Regulation of toll-like receptor signaling pathway |
| KEGG:04510 | 0.00259201576911 | 1.0 | AKT2 AKT1 | Focal adhesion |
| MIRNA:hsa-miR-184 | 0.00268864564617 | 1.0 | AKT2 AKT1 | hsa-miR-184 |
| GO:0010746 | 0.00270494046827 | 1.0 | AKT2 AKT1 | regulation of long-chain fatty acid import across plasma membrane |
| GO:0140213 | 0.00270494046827 | 1.0 | AKT2 AKT1 | negative regulation of long-chain fatty acid import into cell |
| GO:0010748 | 0.00270494046827 | 1.0 | AKT2 AKT1 | negative regulation of long-chain fatty acid import across plasma membrane |
| REAC:R-HSA-9614085 | 0.00277030148331 | 1.0 | AKT2 AKT1 | FOXO-mediated transcription |
| KEGG:05166 | 0.00281669798708 | 1.0 | AKT2 AKT1 | Human T-cell leukemia virus 1 infection |
| WP:WP3915 | 0.00284130523568 | 1.0 | AKT2 AKT1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP3929 | 0.00284130523568 | 1.0 | AKT2 AKT1 | Chemokine signaling pathway |
| KEGG:05170 | 0.00287432751701 | 1.0 | AKT2 AKT1 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.0029618660435 | 1.0 | AKT2 AKT1 | Human cytomegalovirus infection |
| HP:0000147 | 0.00330603835011 | 1.0 | AKT2 AKT1 | Polycystic ovaries |
| WP:WP4239 | 0.00336999814539 | 1.0 | AKT2 AKT1 | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4396 | 0.00347096768628 | 1.0 | AKT2 AKT1 | Nonalcoholic fatty liver disease |
| WP:WP4262 | 0.00357342755251 | 1.0 | AKT2 AKT1 | Breast cancer pathway |
| REAC:R-HSA-9009391 | 0.00359485582679 | 1.0 | AKT2 AKT1 | Extra-nuclear estrogen signaling |
| MIRNA:hsa-miR-126-3p | 0.00374237747518 | 1.0 | AKT2 AKT1 | hsa-miR-126-3p |
| REAC:R-HSA-1445148 | 0.00381775364729 | 1.0 | AKT2 AKT1 | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| REAC:R-HSA-8948751 | 0.00381775364729 | 1.0 | AKT2 AKT1 | Regulation of PTEN stability and activity |
| WP:WP4666 | 0.00388974910314 | 1.0 | AKT2 AKT1 | Hepatitis B infection |
| HP:0000138 | 0.00392717282801 | 1.0 | AKT2 AKT1 | Ovarian cyst |
| REAC:R-HSA-2219528 | 0.004164669804 | 1.0 | AKT2 AKT1 | PI3K/AKT Signaling in Cancer |
| WP:WP481 | 0.00438938066897 | 1.0 | AKT2 AKT1 | Insulin Signaling |
| WP:WP4223 | 0.00444675819405 | 1.0 | AKT2 AKT1 | Ras Signaling |
| GO:2000192 | 0.00450823411379 | 1.0 | AKT2 AKT1 | negative regulation of fatty acid transport |
| GO:0015911 | 0.00450823411379 | 1.0 | AKT2 AKT1 | long-chain fatty acid import across plasma membrane |
| GO:0010918 | 0.00450823411379 | 1.0 | AKT2 AKT1 | positive regulation of mitochondrial membrane potential |
| KEGG:04010 | 0.00476209584058 | 1.0 | AKT2 AKT1 | MAPK signaling pathway |
| REAC:R-HSA-199418 | 0.00477638186777 | 1.0 | AKT2 AKT1 | Negative regulation of the PI3K/AKT network |
| REAC:R-HSA-5628897 | 0.0052959181411 | 1.0 | AKT2 AKT1 | TP53 Regulates Metabolic Genes |
| REAC:R-HSA-69202 | 0.00556574181855 | 1.0 | AKT2 AKT1 | Cyclin E associated events during G1/S transition |
| REAC:R-HSA-69656 | 0.00584226918984 | 1.0 | AKT2 AKT1 | Cyclin A:Cdk2-associated events at S phase entry |
| REAC:R-HSA-8876198 | 0.00598304676068 | 1.0 | AKT2 AKT1 | RAB GEFs exchange GTP for GDP on RABs |
| KEGG:04151 | 0.00654350485448 | 1.0 | AKT2 AKT1 | PI3K-Akt signaling pathway |
| WP:WP306 | 0.00654923464894 | 1.0 | AKT2 AKT1 | Focal Adhesion |
| GO:0060644 | 0.00676235117068 | 1.0 | AKT2 AKT1 | mammary gland epithelial cell differentiation |
| GO:0140212 | 0.00676235117068 | 1.0 | AKT2 AKT1 | regulation of long-chain fatty acid import into cell |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | AKT2 AKT1 | VEGFA-VEGFR2 Pathway |
| HP:0000771 | 0.00694601996791 | 1.0 | AKT2 AKT1 | Gynecomastia |
| KEGG:05165 | 0.00707836525128 | 1.0 | AKT2 AKT1 | Human papillomavirus infection |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | AKT2 AKT1 | Signaling by VEGF |
| WP:WP382 | 0.00889388896944 | 1.0 | AKT2 AKT1 | MAPK Signaling Pathway |
| REAC:R-HSA-8878166 | 0.00897624606448 | 1.0 | AKT2 AKT1 | Transcriptional regulation by RUNX2 |
| GO:0045838 | 0.00946729163895 | 1.0 | AKT2 AKT1 | positive regulation of membrane potential |
| KEGG:05168 | 0.010450786984 | 1.0 | AKT2 AKT1 | Herpes simplex virus 1 infection |
| WP:WP2366 | 0.0110973349652 | 0.5 | AKT1 | Butyrate-induced histone acetylation |
| REAC:R-HSA-9007101 | 0.011178409494 | 1.0 | AKT2 AKT1 | Rab regulation of trafficking |
| MIRNA:hsa-miR-708-5p | 0.0113683542171 | 1.0 | AKT2 AKT1 | hsa-miR-708-5p |
| WP:WP3932 | 0.0121610546673 | 1.0 | AKT2 AKT1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0032891 | 0.0126230555186 | 1.0 | AKT2 AKT1 | negative regulation of organic acid transport |
| REAC:R-HSA-69206 | 0.014052618232 | 1.0 | AKT2 AKT1 | G1/S Transition |
| REAC:R-HSA-6807070 | 0.0151587277172 | 1.0 | AKT2 AKT1 | PTEN Regulation |
| WP:WP4172 | 0.015291110435 | 1.0 | AKT2 AKT1 | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0157394270613 | 1.0 | AKT2 AKT1 | Pathways in cancer |
| HP:0031065 | 0.0161995879155 | 1.0 | AKT2 AKT1 | Abnormal ovarian morphology |
| GO:1903960 | 0.0162296428096 | 1.0 | AKT2 AKT1 | negative regulation of anion transmembrane transport |
| REAC:R-HSA-453279 | 0.0179843346747 | 1.0 | AKT2 AKT1 | Mitotic G1-G1/S phases |
| REAC:R-HSA-5633007 | 0.0205233587202 | 1.0 | AKT2 AKT1 | Regulation of TP53 Activity |
| REAC:R-HSA-69242 | 0.0210512746109 | 1.0 | AKT2 AKT1 | S Phase |
| REAC:R-HSA-109581 | 0.0237914094719 | 1.0 | AKT2 AKT1 | Apoptosis |
| REAC:R-HSA-5357801 | 0.0246461304377 | 1.0 | AKT2 AKT1 | Programmed Cell Death |
| GO:0045725 | 0.0247952876258 | 1.0 | AKT2 AKT1 | positive regulation of glycogen biosynthetic process |
| CORUM:3847 | 0.0249595281251 | 0.5 | AKT1 | TCL1(trimer)-AKT1 complex |
| CORUM:3848 | 0.0249595281251 | 0.5 | AKT2 | TCL1(trimer)-AKT2 complex |
| GO:0031998 | 0.029754345151 | 1.0 | AKT2 AKT1 | regulation of fatty acid beta-oxidation |
| GO:0070875 | 0.029754345151 | 1.0 | AKT2 AKT1 | positive regulation of glycogen metabolic process |
| WP:WP4186 | 0.0332875339197 | 0.5 | AKT1 | Somatroph axis (GH) and its relationship to dietary restriction and aging |
| WP:WP4191 | 0.0332875339197 | 0.5 | AKT1 | Caloric restriction and aging |
| REAC:R-HSA-8939211 | 0.0347016712119 | 1.0 | AKT2 AKT1 | ESR-mediated signaling |
| GO:1903792 | 0.0351642260875 | 1.0 | AKT2 AKT1 | negative regulation of anion transport |
| GO:2000191 | 0.0351642260875 | 1.0 | AKT2 AKT1 | regulation of fatty acid transport |
| HP:0003581 | 0.0393418563663 | 1.0 | AKT2 AKT1 | Adult onset |
| GO:0140354 | 0.0410249304355 | 1.0 | AKT2 AKT1 | lipid import into cell |
| GO:0044539 | 0.0410249304355 | 1.0 | AKT2 AKT1 | long-chain fatty acid import into cell |
| REAC:R-HSA-201681 | 0.0411120784555 | 1.0 | AKT2 AKT1 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.0422332712518 | 1.0 | AKT2 AKT1 | PIP3 activates AKT signaling |
| WP:WP3634 | 0.0443803979089 | 0.5 | AKT2 | Insulin signalling in human adipocytes (normal condition) |
| WP:WP3635 | 0.0443803979089 | 0.5 | AKT2 | Insulin signalling in human adipocytes (diabetic condition) |
| HP:0009124 | 0.0496840793666 | 1.0 | AKT2 AKT1 | Abnormal adipose tissue morphology |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | AKT2 AKT1 | Signaling by Nuclear Receptors |
| HP:0007403 | 0.0497341708567 | 0.5 | AKT1 | Hypertrophy of skin of soles |
| HP:0004472 | 0.0497341708567 | 0.5 | AKT1 | Mandibular hyperostosis |
| HP:0007483 | 0.0497341708567 | 0.5 | AKT1 | Depigmentation/hyperpigmentation of skin |
| REAC:R-HSA-165160 | 0.0499173803268 | 0.5 | AKT2 | PDE3B signalling |
| CORUM:7266 | 0.0499173803268 | 0.5 | AKT1 | AKT1-NQO2 complex |
| REAC:R-HSA-109703 | 0.0499173803268 | 0.5 | AKT2 | PKB-mediated events |
| CORUM:2156 | 0.0499173803268 | 0.5 | AKT1 | YBX1-AKT1 complex |
| CORUM:3138 | 0.0499173803268 | 0.5 | AKT2 | POSH-AKT2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKT2 | AKT1 | 0.999 | 0.949 | bioplex (AKT1) bioplex_WMM youn_WMM |
Images
Click to enlarge
Complex HuMAP2_04755 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| AKT1 | HuMAP2_01854 HuMAP2_04755 |
| AKT2 | HuMAP2_01854 HuMAP2_04755 |