hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04760
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| PDHX | Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016903 | 2.47053849812e-06 | 1.0 | MRPS36 PDHX DLD OGDHL | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| GO:0045252 | 1.27120391093e-05 | 0.75 | MRPS36 DLD OGDHL | oxoglutarate dehydrogenase complex |
| GO:1990204 | 5.68877655611e-05 | 1.0 | MRPS36 PDHX DLD OGDHL | oxidoreductase complex |
| GO:0045240 | 5.99161085695e-05 | 0.75 | MRPS36 DLD OGDHL | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 0.000103844122491 | 0.75 | MRPS36 DLD OGDHL | tricarboxylic acid cycle enzyme complex |
| KEGG:00020 | 0.000811520562786 | 0.5 | DLD OGDHL | Citrate cycle (TCA cycle) |
| REAC:R-HSA-204174 | 0.00120515287053 | 0.5 | PDHX DLD | Regulation of pyruvate dehydrogenase (PDH) complex |
| REAC:R-HSA-70268 | 0.00407268683926 | 0.5 | PDHX DLD | Pyruvate metabolism |
| REAC:R-HSA-389661 | 0.00436320194063 | 0.5 | PDHX DLD | Glyoxylate metabolism and glycine degradation |
| WP:WP3925 | 0.0063819591539 | 0.5 | PDHX DLD | Amino Acid metabolism |
| REAC:R-HSA-5362517 | 0.0078166615373 | 0.5 | PDHX DLD | Signaling by Retinoic Acid |
| GO:0061732 | 0.00811409485621 | 0.5 | PDHX DLD | mitochondrial acetyl-CoA biosynthetic process from pyruvate |
| KEGG:01200 | 0.012776519361 | 0.5 | DLD OGDHL | Carbon metabolism |
| REAC:R-HSA-71406 | 0.013274030298 | 0.5 | PDHX DLD | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0034604 | 0.0162267366884 | 0.5 | PDHX DLD | pyruvate dehydrogenase (NAD+) activity |
| GO:0034603 | 0.0162267366884 | 0.5 | PDHX DLD | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0004591 | 0.0162267366884 | 0.5 | OGDHL MRPS36 | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| GO:0045254 | 0.0405595771497 | 0.5 | PDHX DLD | pyruvate dehydrogenase complex |
| GO:0004738 | 0.0405595771497 | 0.5 | PDHX DLD | pyruvate dehydrogenase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLD | PDHX | 0.909 | 0.832 | hein_WMM bioplex (DLD,PDHX) bioplex_WMM youn_WMM |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| MRPS36 | PDHX | 0.008 | 0.083 | hein_WMM bioplex_WMM WMM_only |
| OGDHL | PDHX | 0.008 | 0.028 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04760 has an average edge precision of 0.487 which is ranked 2571 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| PDHX | HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06086 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |