hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04771
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PDHA1 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I) | UniProt NCBI |
| PDHB | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00020 | 5.9234402919e-05 | 1.0 | PDHA1 PDHB | Citrate cycle (TCA cycle) |
| WP:WP4206 | 7.07904530264e-05 | 1.0 | PDHA1 PDHB | Hereditary leiomyomatosis and renal cell carcinoma pathway |
| KEGG:00620 | 0.000108110080204 | 1.0 | PDHA1 PDHB | Pyruvate metabolism |
| REAC:R-HSA-204174 | 0.000201110815485 | 1.0 | PDHA1 PDHB | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00010 | 0.000284937903697 | 1.0 | PDHA1 PDHB | Glycolysis / Gluconeogenesis |
| WP:WP4290 | 0.000320792526609 | 1.0 | PDHA1 PDHB | Metabolic reprogramming in colon cancer |
| KEGG:05230 | 0.000322579470084 | 1.0 | PDHA1 PDHB | Central carbon metabolism in cancer |
| KEGG:04922 | 0.000665292801258 | 1.0 | PDHA1 PDHB | Glucagon signaling pathway |
| REAC:R-HSA-70268 | 0.000680424925724 | 1.0 | PDHA1 PDHB | Pyruvate metabolism |
| KEGG:04066 | 0.000722192843471 | 1.0 | PDHA1 PDHB | HIF-1 signaling pathway |
| REAC:R-HSA-389661 | 0.000729026706133 | 1.0 | PDHA1 PDHB | Glyoxylate metabolism and glycine degradation |
| KEGG:01200 | 0.000939726081777 | 1.0 | PDHA1 PDHB | Carbon metabolism |
| REAC:R-HSA-5362517 | 0.00130722030065 | 1.0 | PDHA1 PDHB | Signaling by Retinoic Acid |
| REAC:R-HSA-71406 | 0.00222227451111 | 1.0 | PDHA1 PDHB | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004738 | 0.00676235117068 | 1.0 | PDHA1 PDHB | pyruvate dehydrogenase activity |
| GO:0045254 | 0.00676235117068 | 1.0 | PDHA1 PDHB | pyruvate dehydrogenase complex |
| REAC:R-HSA-1428517 | 0.0226752444459 | 1.0 | PDHA1 PDHB | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0006086 | 0.029754345151 | 1.0 | PDHA1 PDHB | acetyl-CoA biosynthetic process from pyruvate |
| HP:0003128 | 0.0373181601641 | 1.0 | PDHA1 PDHB | Lactic acidosis |
| WP:WP528 | 0.038834152205 | 0.5 | PDHA1 | Acetylcholine Synthesis |
| REAC:R-HSA-9006931 | 0.0496844269656 | 1.0 | PDHA1 PDHB | Signaling by Nuclear Receptors |
| WP:WP4297 | 0.0499262710315 | 0.5 | PDHA1 | Thiamine metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PDHA1 | PDHB | 1.0 | 0.949 | hein_WMM bioplex (PDHB) bioplex_WMM Guru Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04771 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PDHA1 | HuMAP2_03652 HuMAP2_04771 HuMAP2_06086 |
| PDHB | HuMAP2_04771 HuMAP2_06086 |