hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04784
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK7 | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit) | UniProt NCBI |
| MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | UniProt NCBI |
| CDK11A | Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2) | UniProt NCBI |
| HSP90AB1 | Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) | UniProt NCBI |
| CAPN3 | Calpain-3 (EC 3.4.22.54) (Calcium-activated neutral proteinase 3) (CANP 3) (Calpain L3) (Calpain p94) (Muscle-specific calcium-activated neutral protease 3) (New calpain 1) (nCL-1) | UniProt NCBI |
| BTK | Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase) | UniProt NCBI |
| CDK9 | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) | UniProt NCBI |
| SMYD3 | Histone-lysine N-methyltransferase SMYD3 (EC 2.1.1.43) (SET and MYND domain-containing protein 3) (Zinc finger MYND domain-containing protein 1) | UniProt NCBI |
| ITK | Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (Interleukin-2-inducible T-cell kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) | UniProt NCBI |
| FKBP5 | Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase) | UniProt NCBI |
| AKT3 | RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2) | UniProt NCBI |
| MYLK4 | Myosin light chain kinase family member 4 (EC 2.7.11.1) (Sugen kinase 85) (SgK085) | UniProt NCBI |
| AFF3 | AF4/FMR2 family member 3 (Lymphoid nuclear protein related to AF4) (Protein LAF-4) | UniProt NCBI |
| STK32C | Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3) | UniProt NCBI |
| AGO3 | Protein argonaute-3 (Argonaute3) (hAgo3) (EC 3.1.26.n2) (Argonaute RISC catalytic component 3) (Eukaryotic translation initiation factor 2C 3) (eIF-2C 3) (eIF2C 3) | UniProt NCBI |
| HSP90AA5P | NCBI | |
| HSP90AB4P | NCBI | |
| HSP90AB2P | NCBI | |
| HSP90AB3P | NCBI | |
| HSP90AA4P | NCBI | |
| PSKH2 | Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004672 | 2.25767878265e-05 | 0.5625 | AKT3 MYLK4 CDK7 CDK11A MAP2K2 STK32C BTK CDK9 ITK | protein kinase activity |
| GO:0016773 | 0.000100872141423 | 0.5625 | AKT3 MYLK4 CDK7 CDK11A MAP2K2 STK32C BTK CDK9 ITK | phosphotransferase activity, alcohol group as acceptor |
| GO:0016301 | 0.000211926152719 | 0.5625 | AKT3 MYLK4 CDK7 CDK11A MAP2K2 STK32C BTK CDK9 ITK | kinase activity |
| GO:0140096 | 0.000258071704349 | 0.75 | AKT3 MYLK4 MAP2K2 CDK7 CAPN3 CDK11A FKBP5 SMYD3 STK32C BTK CDK9 ITK | catalytic activity, acting on a protein |
| KEGG:04915 | 0.00037917940363 | 0.25 | HSP90AB1 AKT3 FKBP5 MAP2K2 | Estrogen signaling pathway |
| REAC:R-HSA-8939211 | 0.000481878753826 | 0.3125 | AKT3 FKBP5 AGO3 CDK9 HSP90AB1 | ESR-mediated signaling |
| CORUM:5285 | 0.000499973695795 | 0.125 | HSP90AB1 FKBP5 | TNF-alpha/NF-kappa B signaling complex 9 |
| CORUM:5269 | 0.00074949055696 | 0.125 | HSP90AB1 FKBP5 | TNF-alpha/NF-kappa B signaling complex 8 |
| GO:0016772 | 0.00109859794067 | 0.5625 | AKT3 MYLK4 CDK7 CDK11A MAP2K2 STK32C BTK CDK9 ITK | transferase activity, transferring phosphorus-containing groups |
| REAC:R-HSA-9006931 | 0.00116006451787 | 0.3125 | AKT3 FKBP5 AGO3 CDK9 HSP90AB1 | Signaling by Nuclear Receptors |
| WP:WP2795 | 0.00133870425946 | 0.1875 | CDK7 CDK9 MAP2K2 | Cardiac Hypertrophic Response |
| KEGG:04664 | 0.00135318048793 | 0.1875 | AKT3 BTK MAP2K2 | Fc epsilon RI signaling pathway |
| CORUM:5268 | 0.00139729614548 | 0.125 | HSP90AB1 FKBP5 | TNF-alpha/NF-kappa B signaling complex 7 |
| KEGG:04662 | 0.00245154680702 | 0.1875 | AKT3 BTK MAP2K2 | B cell receptor signaling pathway |
| GO:0004674 | 0.00246092006349 | 0.4375 | AKT3 MYLK4 CDK7 CDK11A MAP2K2 STK32C CDK9 | protein serine/threonine kinase activity |
| CORUM:2639 | 0.00388028812786 | 0.125 | CDK7 CDK9 | HES1 promoter-Notch enhancer complex |
| WP:WP1544 | 0.00534226168418 | 0.1875 | CDK7 CDK9 MAP2K2 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04660 | 0.00592210645452 | 0.1875 | AKT3 ITK MAP2K2 | T cell receptor signaling pathway |
| KEGG:05215 | 0.00592210645452 | 0.1875 | HSP90AB1 AKT3 MAP2K2 | Prostate cancer |
| WP:WP185 | 0.00975194728956 | 0.1875 | AKT3 CAPN3 MAP2K2 | Integrin-mediated Cell Adhesion |
| WP:WP22 | 0.0100864224332 | 0.125 | MAP2K2 CDK9 | IL-9 Signaling Pathway |
| KEGG:04611 | 0.0110286978801 | 0.1875 | AKT3 MYLK4 BTK | Platelet activation |
| KEGG:04371 | 0.0152885713441 | 0.1875 | AKT3 MYLK4 MAP2K2 | Apelin signaling pathway |
| WP:WP1449 | 0.0197327190368 | 0.1875 | AKT3 BTK MAP2K2 | Regulation of toll-like receptor signaling pathway |
| KEGG:04022 | 0.0222946567186 | 0.1875 | AKT3 MYLK4 MAP2K2 | cGMP-PKG signaling pathway |
| WP:WP2643 | 0.031534230305 | 0.125 | AKT3 MAP2K2 | Nanoparticle-mediated activation of receptor signaling |
| HP:0009023 | 0.0403711390123 | 0.125 | MAP2K2 CAPN3 | Abdominal wall muscle weakness |
| WP:WP3981 | 0.0439100645245 | 0.125 | AKT3 MAP2K2 | miRNA regulation of prostate cancer signaling pathways |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SMYD3 | HSP90AB3P | 0.998 | 0.939 | bioplex (SMYD3) bioplex_WMM |
| MYLK4 | HSP90AB3P | 0.959 | 0.863 | bioplex (MYLK4) bioplex_WMM |
| SMYD3 | HSP90AB4P | 0.938 | 0.85 | bioplex (SMYD3) bioplex_WMM |
| HSP90AB3P | CDK9 | 0.738 | 0.738 | bioplex (CDK9) bioplex_WMM boldt_WMM |
| AGO3 | HSP90AB3P | 0.68 | 0.709 | bioplex (AGO3) bioplex_WMM |
| HSP90AB4P | MYLK4 | 0.629 | 0.681 | bioplex (MYLK4) bioplex_WMM |
| HSP90AB4P | CDK9 | 0.256 | 0.478 | bioplex (CDK9) bioplex_WMM |
| CDK9 | HSP90AA4P | 0.243 | 0.468 | bioplex (CDK9) bioplex_WMM |
| CDK9 | AFF3 | 0.203 | 0.455 | bioplex (CDK9) bioplex_WMM |
| CDK7 | HSP90AA4P | 0.196 | 0.449 | bioplex (CDK7) bioplex_WMM |
| PSKH2 | HSP90AA4P | 0.186 | 0.44 | bioplex (PSKH2) bioplex_WMM |
| HSP90AB3P | AKT3 | 0.18 | 0.437 | bioplex (AKT3) bioplex_WMM |
| MYLK4 | HSP90AA5P | 0.167 | 0.425 | bioplex (MYLK4) bioplex_WMM |
| SMYD3 | HSP90AA5P | 0.15 | 0.41 | bioplex (SMYD3) bioplex_WMM |
| CDK7 | HSP90AB3P | 0.146 | 0.409 | bioplex (CDK7) bioplex_WMM |
| SMYD3 | HSP90AB1 | 0.133 | 0.406 | bioplex (SMYD3) bioplex_WMM fraction boldt_WMM |
| HSP90AA4P | STK32C | 0.132 | 0.404 | bioplex (STK32C) bioplex_WMM |
| AGO3 | HSP90AB4P | 0.124 | 0.394 | bioplex (AGO3) bioplex_WMM |
| MYLK4 | HSP90AB1 | 0.118 | 0.392 | bioplex (MYLK4) bioplex_WMM |
| CDK11A | HSP90AB3P | 0.118 | 0.391 | bioplex (CDK11A) bioplex_WMM |
| HSP90AB4P | AKT3 | 0.088 | 0.353 | bioplex (AKT3) bioplex_WMM |
| HSP90AB3P | HSP90AB2P | 0.074 | 0.356 | bioplex_WMM boldt boldt_WMM |
| AGO3 | HSP90AA5P | 0.066 | 0.349 | bioplex (AGO3) bioplex_WMM |
| AKT3 | HSP90AA4P | 0.062 | 0.345 | bioplex (AKT3) bioplex_WMM |
| HSP90AA5P | STK32C | 0.06 | 0.336 | bioplex (STK32C) bioplex_WMM |
| HSP90AB4P | CDK7 | 0.051 | 0.299 | bioplex (CDK7) bioplex_WMM |
| PSKH2 | HSP90AA5P | 0.05 | 0.297 | bioplex (PSKH2) bioplex_WMM |
| HSP90AB2P | HSP90AB1 | 0.044 | 0.279 | bioplex_WMM boldt boldt_WMM |
| MAP2K2 | HSP90AA4P | 0.043 | 0.269 | bioplex (MAP2K2) bioplex_WMM boldt boldt_WMM |
| HSP90AB3P | HSP90AB1 | 0.037 | 0.266 | bioplex_WMM boldt boldt_WMM |
| CDK9 | FKBP5 | 0.037 | 0.266 | hein_WMM bioplex (CDK9) bioplex_WMM youn_WMM fraction |
| CDK11A | FKBP5 | 0.036 | 0.264 | bioplex (CDK11A) bioplex_WMM boldt youn_WMM |
| HSP90AB3P | ITK | 0.034 | 0.261 | bioplex (ITK) bioplex_WMM |
| MAP2K2 | HSP90AB3P | 0.031 | 0.242 | bioplex (MAP2K2) bioplex_WMM |
| HSP90AB2P | HSP90AA4P | 0.03 | 0.231 | bioplex_WMM boldt boldt_WMM |
| CDK11A | HSP90AA5P | 0.028 | 0.23 | bioplex (CDK11A) bioplex_WMM |
| HSP90AB1 | HSP90AA5P | 0.028 | 0.229 | bioplex_WMM WMM_only boldt_WMM |
| AKT3 | HSP90AA5P | 0.028 | 0.231 | bioplex (AKT3) bioplex_WMM |
| CAPN3 | HSP90AB1 | 0.026 | 0.22 | bioplex (CAPN3) fraction |
| HSP90AB4P | HSP90AB3P | 0.026 | 0.216 | bioplex_WMM WMM_only |
| HSP90AB2P | HSP90AA5P | 0.025 | 0.218 | bioplex_WMM WMM_only boldt_WMM |
| BTK | HSP90AB3P | 0.023 | 0.206 | bioplex (BTK) bioplex_WMM |
| HSP90AA5P | FKBP5 | 0.022 | 0.208 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AB2P | FKBP5 | 0.022 | 0.204 | bioplex_WMM boldt boldt_WMM |
| HSP90AB3P | HSP90AA5P | 0.021 | 0.194 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AB4P | HSP90AA5P | 0.021 | 0.194 | bioplex_WMM WMM_only |
| HSP90AB4P | HSP90AB1 | 0.021 | 0.191 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AB4P | HSP90AB2P | 0.02 | 0.187 | bioplex_WMM WMM_only |
| HSP90AA4P | HSP90AB1 | 0.019 | 0.182 | bioplex_WMM boldt boldt_WMM |
| HSP90AB1 | FKBP5 | 0.019 | 0.186 | hein_WMM bioplex_WMM boldt boldt_WMM |
| HSP90AA4P | HSP90AA5P | 0.018 | 0.183 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AB3P | HSP90AA4P | 0.016 | 0.155 | bioplex_WMM boldt boldt_WMM |
| MAP2K2 | HSP90AA5P | 0.015 | 0.14 | bioplex (MAP2K2) bioplex_WMM |
| HSP90AB3P | FKBP5 | 0.014 | 0.14 | bioplex_WMM boldt boldt_WMM |
| HSP90AB4P | FKBP5 | 0.014 | 0.137 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AA4P | FKBP5 | 0.012 | 0.15 | bioplex_WMM boldt boldt_WMM |
| HSP90AB4P | HSP90AA4P | 0.012 | 0.146 | bioplex_WMM WMM_only boldt_WMM |
| HSP90AA5P | ITK | 0.01 | 0.105 | bioplex (ITK) bioplex_WMM |
| CDK11A | HSP90AB2P | 0.009 | 0.11 | bioplex (CDK11A) bioplex_WMM |
| HSP90AB4P | MAP2K2 | 0.009 | 0.09 | bioplex (MAP2K2) bioplex_WMM boldt_WMM |
| AKT3 | HSP90AB2P | 0.008 | 0.034 | bioplex (AKT3) bioplex_WMM |
| AKT3 | HSP90AB1 | 0.008 | 0.033 | bioplex (AKT3) bioplex_WMM |
| AFF3 | HSP90AA4P | 0.008 | 0.026 | bioplex_WMM WMM_only |
| AFF3 | HSP90AB2P | 0.008 | 0.025 | bioplex_WMM WMM_only |
| HSP90AB4P | AFF3 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| HSP90AB3P | AFF3 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| CDK11A | CDK9 | 0.008 | 0.011 | youn_WMM gupta_WMM WMM_only |
| AFF3 | FKBP5 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| MAP2K2 | CDK9 | 0.007 | 0.007 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| CDK7 | HSP90AB2P | 0.007 | 0.005 | bioplex (CDK7) bioplex_WMM |
| AFF3 | HSP90AA5P | 0.007 | 0.009 | bioplex_WMM WMM_only |
| CDK11A | CDK7 | 0.007 | 0.008 | youn_WMM WMM_only |
| AGO3 | MAP2K2 | 0.007 | 0.011 | bioplex_WMM youn_WMM WMM_only |
| AFF3 | HSP90AB1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| MAP2K2 | CDK7 | 0.007 | 0.008 | youn_WMM WMM_only |
| CDK7 | CDK9 | 0.007 | 0.007 | bioplex (CDK7) youn_WMM |
| MAP2K2 | HSP90AB2P | 0.007 | 0.001 | bioplex (MAP2K2) bioplex_WMM |
| AGO3 | CDK9 | 0.007 | 0.003 | bioplex_WMM youn_WMM WMM_only |
| CDK11A | AGO3 | 0.007 | 0.004 | youn_WMM WMM_only |
| CDK11A | MAP2K2 | 0.007 | 0.003 | boldt youn_WMM boldt_WMM |
| SMYD3 | HSP90AB2P | 0.007 | 0.002 | bioplex (SMYD3) bioplex_WMM |
| AGO3 | PSKH2 | 0.007 | 0.008 | bioplex (PSKH2) bioplex_WMM |
| PSKH2 | HSP90AB2P | 0.007 | 0.005 | bioplex (PSKH2) bioplex_WMM |
| HSP90AB2P | ITK | 0.007 | 0.006 | bioplex (ITK) bioplex_WMM |
| MAP2K2 | FKBP5 | 0.007 | 0.005 | boldt youn_WMM boldt_WMM |
| BTK | HSP90AB2P | 0.007 | 0.006 | bioplex (BTK) bioplex_WMM |
| CDK9 | ITK | 0.007 | 0.003 | bioplex (ITK) bioplex_WMM |
| CDK9 | PSKH2 | 0.007 | 0.001 | bioplex (PSKH2) bioplex_WMM |
| PSKH2 | FKBP5 | 0.007 | 0.003 | bioplex (PSKH2) bioplex_WMM |
| CAPN3 | HSP90AB2P | 0.007 | 0.005 | bioplex (CAPN3) |
| AGO3 | HSP90AA4P | 0.007 | 0.005 | bioplex_WMM WMM_only |
| AGO3 | CDK7 | 0.007 | 0.005 | bioplex (CDK7) bioplex_WMM youn_WMM |
| CDK9 | STK32C | 0.006 | 0.002 | bioplex (STK32C) |
| HSP90AB2P | STK32C | 0.006 | 0.007 | bioplex (STK32C) bioplex_WMM |
| MYLK4 | HSP90AB2P | 0.006 | 0.011 | bioplex (MYLK4) bioplex_WMM |
| MAP2K2 | HSP90AB1 | 0.006 | 0.006 | bioplex (MAP2K2) bioplex_WMM boldt boldt_WMM treiber_WMM |
| BTK | HSP90AB1 | 0.006 | 0.002 | bioplex (BTK) bioplex_WMM |
| CDK7 | HSP90AB1 | 0.006 | 0.009 | bioplex (CDK7) bioplex_WMM |
| AGO3 | HSP90AB2P | 0.006 | 0.003 | bioplex (AGO3) bioplex_WMM |
| HSP90AB1 | ITK | 0.006 | 0.01 | bioplex (ITK) bioplex_WMM |
| AGO3 | ITK | 0.005 | 0.007 | bioplex (ITK) |
| AGO3 | AKT3 | 0.005 | 0.011 | bioplex (AKT3) |
| CDK11A | HSP90AB1 | 0.005 | 0.01 | bioplex (CDK11A) bioplex_WMM boldt boldt_WMM |
| AGO3 | HSP90AB1 | 0.005 | 0.005 | bioplex (AGO3) bioplex_WMM treiber_WMM |
| PSKH2 | HSP90AB1 | 0.004 | 0.012 | bioplex (PSKH2) bioplex_WMM |
| CDK7 | FKBP5 | 0.003 | 0.007 | bioplex (CDK7) bioplex_WMM |
| AKT3 | FKBP5 | 0.0 | 0.01 | bioplex (AKT3) bioplex_WMM fraction |
| CDK9 | HSP90AA5P | 0.0 | 0.009 | bioplex (CDK9) bioplex_WMM |
| CDK9 | HSP90AB2P | 0.0 | 0.012 | bioplex (CDK9) bioplex_WMM |
| AGO3 | FKBP5 | 0.0 | 0.008 | bioplex (AGO3) bioplex_WMM youn_WMM |
| CDK9 | AKT3 | 0.0 | 0.007 | bioplex (AKT3) fraction |
| HSP90AB1 | STK32C | 0.0 | 0.007 | bioplex (STK32C) bioplex_WMM |
| CDK7 | HSP90AA5P | 0.0 | 0.003 | bioplex (CDK7) bioplex_WMM |
| CDK9 | HSP90AB1 | 0.0 | 0.003 | hein_WMM bioplex (CDK9) bioplex_WMM boldt boldt_WMM treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_04784 has an average edge precision of 0.176 which is ranked 6466 out of all 6965 complexes.
Related Complexes