hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04786
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAS | Neuroendocrine secretory protein 55 (NESP55) [Cleaved into: LHAL tetrapeptide; GPIPIRRH peptide] | UniProt NCBI |
| GNAL | Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012049 | 0.00015027447046 | 1.0 | GNAL GNAS | Laryngeal dystonia |
| KEGG:05146 | 0.000520854232564 | 1.0 | GNAL GNAS | Amoebiasis |
| KEGG:05142 | 0.000558495798951 | 1.0 | GNAL GNAS | Chagas disease (American trypanosomiasis) |
| KEGG:04728 | 0.00105921617042 | 1.0 | GNAL GNAS | Dopaminergic synapse |
| WP:WP4540 | 0.00139382676196 | 1.0 | GNAL GNAS | Pathways Regulating Hippo Signaling |
| WP:WP35 | 0.00139382676196 | 1.0 | GNAL GNAS | G Protein Signaling Pathways |
| KEGG:04020 | 0.00183261905189 | 1.0 | GNAL GNAS | Calcium signaling pathway |
| HP:0004373 | 0.0085355899221 | 1.0 | GNAL GNAS | Focal dystonia |
| HP:0001618 | 0.0085355899221 | 1.0 | GNAL GNAS | Dysphonia |
| GO:0007191 | 0.00946729163895 | 1.0 | GNAL GNAS | adenylate cyclase-activating dopamine receptor signaling pathway |
| REAC:R-HSA-418555 | 0.0258092213206 | 1.0 | GNAL GNAS | G alpha (s) signalling events |
| HP:0005605 | 0.0497341708567 | 0.5 | GNAS | Large cafe-au-lait macules with irregular margins |
| HP:0009852 | 0.0497341708567 | 0.5 | GNAS | Broad proximal phalanges of the hand |
| HP:0010027 | 0.0497341708567 | 0.5 | GNAS | Broad 1st metacarpal |
| HP:0010734 | 0.0497341708567 | 0.5 | GNAS | Fibrous dysplasia of the bones |
| HP:0010735 | 0.0497341708567 | 0.5 | GNAS | Polyostotic fibrous dysplasia |
| HP:0025027 | 0.0497341708567 | 0.5 | GNAS | Osteoma cutis |
| CORUM:7144 | 0.0499173803268 | 0.5 | GNAS | GNAS-L-GNB3-GNG1 complex |
| CORUM:7143 | 0.0499173803268 | 0.5 | GNAS | GNAS-L-GNB2-GNG1 complex |
| CORUM:7097 | 0.0499173803268 | 0.5 | GNAS | GNAS-L-GNB1-GNG1 complex |
| CORUM:7145 | 0.0499173803268 | 0.5 | GNAS | GNAS-L-GNB4-GNG1 complex |
| CORUM:7146 | 0.0499173803268 | 0.5 | GNAS | GNAS-L-GNB1-GNG1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAS | GNAL | 1.0 | 0.949 | bioplex (GNAS) bioplex_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_04786 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAS | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |
| GNAL | HuMAP2_00029 HuMAP2_00231 HuMAP2_03216 HuMAP2_04786 HuMAP2_06032 |