hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04788
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | UniProt NCBI |
| EIF5A | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | UniProt NCBI |
| PAH | Phenylalanine-4-hydroxylase (PAH) (EC 1.14.16.1) (Phe-4-monooxygenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 4.01687864169e-05 | 0.666666666667 | EIF5A DOHH | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 0.00397787610966 | 0.666666666667 | EIF5A DOHH | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| KEGG:00400 | 0.0133366105748 | 0.333333333333 | PAH | Phenylalanine, tyrosine and tryptophan biosynthesis |
| WP:WP3302 | 0.0285649389616 | 0.333333333333 | EIF5A | eIF5A regulation in response to inhibition of the nuclear export system |
| KEGG:00360 | 0.0466467988893 | 0.333333333333 | PAH | Phenylalanine metabolism |
| REAC:R-HSA-2160456 | 0.0498572752401 | 0.333333333333 | PAH | Phenylketonuria |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DOHH | EIF5A | 0.385 | 0.551 | bioplex (DOHH) bioplex_WMM |
| DOHH | PAH | 0.028 | 0.231 | fraction |
Images
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Complex HuMAP2_04788 has an average edge precision of 0.391 which is ranked 3412 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DOHH | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 HuMAP2_05181 |
| EIF5A | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 |
| PAH | HuMAP2_04788 |