hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04797

Confidence: Medium

Genename	Protein Name	Links
TSHZ3	Teashirt homolog 3 (Zinc finger protein 537)	UniProt NCBI
SMDT1	Essential MCU regulator, mitochondrial (Single-pass membrane protein with aspartate-rich tail 1, mitochondrial)	UniProt NCBI
FAM193B	Protein FAM193B	UniProt NCBI
ORMDL2	ORM1-like protein 2 (Adoplin-2)	UniProt NCBI
GPC4	Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4]	UniProt NCBI
GPC3	Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]	UniProt NCBI
GPC6	Glypican-6 [Cleaved into: Secreted glypican-6]	UniProt NCBI
ITPRIPL1	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1	UniProt NCBI
GPR183	G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2) (EBI2) (EBV-induced G-protein coupled receptor 2) (hEBI2)	UniProt NCBI
GPC1	Glypican-1 [Cleaved into: Secreted glypican-1]	UniProt NCBI
SDC4	Syndecan-4 (SYND4) (Amphiglycan) (Ryudocan core protein)	UniProt NCBI
TGFBR3	Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-3656237	6.2527790803e-11	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Defective EXT2 causes exostoses 2
REAC:R-HSA-3656253	6.2527790803e-11	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Defective EXT1 causes exostoses 1, TRPS2 and CHDS
REAC:R-HSA-3560783	3.62462162035e-10	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Defective B4GALT7 causes EDS, progeroid type
REAC:R-HSA-3560801	3.62462162035e-10	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Defective B3GAT3 causes JDSSDHD
REAC:R-HSA-4420332	3.62462162035e-10	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Defective B3GALT6 causes EDSP2 and SEMDJL1
REAC:R-HSA-2024096	6.33811517458e-10	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	HS-GAG degradation
REAC:R-HSA-1971475	1.32231797303e-09	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	A tetrasaccharide linker sequence is required for GAG synthesis
REAC:R-HSA-2022928	3.68728111439e-09	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	HS-GAG biosynthesis
REAC:R-HSA-3560782	1.78069472844e-08	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Diseases associated with glycosaminoglycan metabolism
REAC:R-HSA-975634	2.31591097759e-08	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Retinoid metabolism and transport
REAC:R-HSA-6806667	3.35220774252e-08	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Metabolism of fat-soluble vitamins
REAC:R-HSA-1793185	4.72927411837e-08	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Chondroitin sulfate/dermatan sulfate metabolism
REAC:R-HSA-1638091	6.52464053087e-08	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Heparan sulfate/heparin (HS-GAG) metabolism
REAC:R-HSA-2187338	5.26301227476e-07	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Visual phototransduction
REAC:R-HSA-1630316	3.85323784108e-06	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Glycosaminoglycan metabolism
REAC:R-HSA-418594	5.58769853859e-06	0.5	GPC6 GPC4 GPR183 GPC1 SDC4 GPC3	G alpha (i) signalling events
REAC:R-HSA-3781865	6.46549577386e-06	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Diseases of glycosylation
GO:0006027	1.35060058989e-05	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	glycosaminoglycan catabolic process
GO:0006026	2.0127733255e-05	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	aminoglycan catabolic process
REAC:R-HSA-196854	3.27522839478e-05	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Metabolism of vitamins and cofactors
GO:0001523	9.48856045139e-05	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	retinoid metabolic process
GO:0016101	0.000108944354088	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	diterpenoid metabolic process
GO:0005796	0.000133099892462	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Golgi lumen
GO:0006721	0.000171756530117	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	terpenoid metabolic process
GO:0043202	0.000182694702141	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	lysosomal lumen
REAC:R-HSA-71387	0.000280411627255	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	Metabolism of carbohydrates
GO:0006024	0.000308346355104	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	glycosaminoglycan biosynthetic process
GO:0006023	0.000343902385581	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	aminoglycan biosynthetic process
GO:0006720	0.000382652309876	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	isoprenoid metabolic process
REAC:R-HSA-388396	0.000400543874478	0.5	GPC6 GPC4 GPR183 GPC1 SDC4 GPC3	GPCR downstream signalling
HP:0008416	0.000472291192873	0.166666666667	GPC4 GPC3	Six lumbar vertebrae
HP:0006176	0.000472291192873	0.166666666667	GPC4 GPC3	Two carpal ossification centers present at birth
HP:0009101	0.000472291192873	0.166666666667	GPC4 GPC3	Submucous cleft lip
REAC:R-HSA-372790	0.000646084585696	0.5	GPC6 GPC4 GPR183 GPC1 SDC4 GPC3	Signaling by GPCR
GO:0030203	0.00108586962274	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	glycosaminoglycan metabolic process
GO:0006022	0.0013940417556	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	aminoglycan metabolic process
HP:0005580	0.00141623929015	0.166666666667	GPC4 GPC3	Duplication of renal pelvis
GO:1901136	0.00256545824841	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	carbohydrate derivative catabolic process
HP:0030304	0.00283121057841	0.166666666667	GPC4 GPC3	Abnormal number of vertebrae
HP:0000216	0.00283121057841	0.166666666667	GPC4 GPC3	Broad secondary alveolar ridge
HP:0003517	0.00283121057841	0.166666666667	GPC4 GPC3	Birth length greater than 97th percentile
HP:0003185	0.00283121057841	0.166666666667	GPC4 GPC3	Short sacroiliac notch
HP:0002946	0.00283121057841	0.166666666667	GPC4 GPC3	Supernumerary vertebrae
GO:0005775	0.00441219368658	0.416666666667	SDC4 GPC1 GPC6 GPC4 GPC3	vacuolar lumen
HP:0008523	0.00471657191883	0.166666666667	GPC4 GPC3	Posterior helix pit
HP:0008803	0.00989593507166	0.166666666667	GPC4 GPC3	Narrow sacroiliac notch
HP:0002884	0.00989593507166	0.166666666667	GPC4 GPC3	Hepatoblastoma
HP:0001233	0.0169492751151	0.166666666667	GPC4 GPC3	2-3 finger syndactyly
HP:0000891	0.0169492751151	0.166666666667	GPC4 GPC3	Cervical ribs
HP:0030266	0.0169492751151	0.166666666667	GPC4 GPC3	Abnormality of the sacroiliac notch
KEGG:05205	0.0181995337666	0.25	GPC1 GPC3 SDC4	Proteoglycans in cancer
HP:0006264	0.0211771097175	0.166666666667	GPC4 GPC3	Aplasia/Hypoplasia of the 2nd finger
HP:0009536	0.0211771097175	0.166666666667	GPC4 GPC3	Short 2nd finger
HP:0004510	0.0258715475833	0.166666666667	GPC4 GPC3	Pancreatic islet-cell hyperplasia
HP:0001748	0.0310319595847	0.166666666667	GPC4 GPC3	Polysplenia
GO:0009986	0.0335697677028	0.5	GPC6 GPC4 GPC3 GPC1 SDC4 TGFBR3	cell surface
GO:0015026	0.0350652467019	0.25	TGFBR3 GPC4 GPC6	coreceptor activity
HP:0001540	0.0427481923386	0.166666666667	GPC4 GPC3	Diastasis recti
HP:0100781	0.0427481923386	0.166666666667	GPC4 GPC3	Abnormality of the sacroiliac joint
HP:0005622	0.0490733163669	0.25	GPC6 GPC4 GPC3	Broad long bones
HP:0000187	0.0493027576903	0.166666666667	GPC4 GPC3	Broad alveolar ridges

Edges

Protein 1	Protein 2	Score	Precision	Evidence
GPR183	SDC4	0.275	0.487	bioplex (GPR183) bioplex_WMM
GPR183	GPC1	0.165	0.42	bioplex (GPR183) bioplex_WMM
GPR183	ITPRIPL1	0.125	0.398	bioplex (GPR183) bioplex_WMM
GPR183	GPC3	0.108	0.373	bioplex (GPR183) bioplex_WMM
GPR183	ORMDL2	0.06	0.333	bioplex (GPR183) bioplex_WMM
GPR183	SMDT1	0.043	0.27	bioplex (GPR183) bioplex_WMM
GPR183	TGFBR3	0.04	0.266	bioplex (GPR183) bioplex_WMM
GPC4	GPC6	0.038	0.265	bioplex (GPC4,GPC6) bioplex_WMM
GPR183	GPC4	0.036	0.265	bioplex (GPR183) bioplex_WMM
FAM193B	GPR183	0.034	0.264	bioplex (GPR183) bioplex_WMM
GPR183	TSHZ3	0.022	0.198	bioplex (GPR183) bioplex_WMM
SDC4	GPC1	0.011	0.143	bioplex_WMM WMM_only
GPC1	GPC3	0.011	0.141	bioplex_WMM WMM_only
SDC4	GPC3	0.009	0.105	bioplex_WMM WMM_only
GPC3	GPC4	0.009	0.105	bioplex_WMM WMM_only
GPC1	TGFBR3	0.009	0.109	bioplex_WMM WMM_only
SDC4	TGFBR3	0.009	0.09	bioplex_WMM WMM_only
FAM193B	SDC4	0.009	0.098	bioplex_WMM WMM_only
GPC1	GPC6	0.008	0.094	bioplex_WMM WMM_only
FAM193B	GPC1	0.008	0.085	bioplex_WMM WMM_only
FAM193B	SMDT1	0.008	0.084	bioplex_WMM WMM_only
FAM193B	TSHZ3	0.008	0.081	bioplex_WMM youn_WMM WMM_only
FAM193B	ORMDL2	0.008	0.082	bioplex_WMM WMM_only
SDC4	SMDT1	0.008	0.079	bioplex_WMM WMM_only
SDC4	GPC4	0.008	0.082	bioplex_WMM WMM_only
SDC4	TSHZ3	0.008	0.072	bioplex_WMM WMM_only
GPC3	TGFBR3	0.008	0.07	bioplex_WMM WMM_only
SDC4	ORMDL2	0.008	0.066	bioplex_WMM WMM_only
SDC4	GPC6	0.008	0.06	bioplex_WMM WMM_only
GPC1	SMDT1	0.008	0.052	bioplex_WMM WMM_only
GPC1	TSHZ3	0.008	0.042	bioplex_WMM WMM_only
SMDT1	TSHZ3	0.008	0.045	bioplex_WMM WMM_only
FAM193B	GPC6	0.008	0.035	bioplex_WMM WMM_only
GPC1	ORMDL2	0.008	0.037	bioplex_WMM WMM_only
ORMDL2	SMDT1	0.008	0.033	bioplex_WMM WMM_only
FAM193B	GPC3	0.008	0.033	bioplex_WMM WMM_only
ORMDL2	TSHZ3	0.008	0.022	bioplex_WMM WMM_only
GPR183	GPC6	0.008	0.021	bioplex (GPR183) bioplex_WMM
FAM193B	TGFBR3	0.008	0.027	bioplex_WMM WMM_only
GPC3	GPC6	0.008	0.016	bioplex_WMM WMM_only
GPC6	SMDT1	0.007	0.012	bioplex_WMM WMM_only
GPC6	TGFBR3	0.007	0.01	bioplex_WMM WMM_only
GPC3	SMDT1	0.007	0.007	bioplex_WMM WMM_only
GPC6	TSHZ3	0.007	0.011	bioplex_WMM WMM_only
FAM193B	GPC4	0.007	0.003	bioplex_WMM WMM_only
GPC3	TSHZ3	0.007	0.01	bioplex_WMM WMM_only
GPC6	ORMDL2	0.007	0.007	bioplex_WMM WMM_only
SMDT1	TGFBR3	0.007	0.005	bioplex_WMM WMM_only
GPC3	ORMDL2	0.007	0.008	bioplex_WMM WMM_only
TSHZ3	TGFBR3	0.007	0.006	bioplex_WMM WMM_only
FAM193B	ITPRIPL1	0.007	0.005	bioplex_WMM WMM_only
ORMDL2	TGFBR3	0.007	0.003	bioplex_WMM WMM_only
SDC4	ITPRIPL1	0.007	0.006	bioplex_WMM WMM_only
GPC4	SMDT1	0.007	0.0	bioplex_WMM WMM_only
GPC4	TSHZ3	0.007	0.004	bioplex_WMM WMM_only
GPC4	ORMDL2	0.007	0.004	bioplex_WMM WMM_only
GPC1	ITPRIPL1	0.007	0.004	bioplex_WMM WMM_only
ITPRIPL1	SMDT1	0.007	0.003	bioplex_WMM WMM_only
ITPRIPL1	TSHZ3	0.007	0.006	bioplex_WMM WMM_only
GPC4	TGFBR3	0.007	0.005	bioplex_WMM WMM_only
ORMDL2	ITPRIPL1	0.007	0.005	bioplex_WMM WMM_only
ITPRIPL1	TGFBR3	0.006	0.005	bioplex_WMM WMM_only
GPC6	ITPRIPL1	0.006	0.007	bioplex_WMM WMM_only
GPC3	ITPRIPL1	0.006	0.008	bioplex_WMM WMM_only
GPC4	ITPRIPL1	0.005	0.008	bioplex_WMM WMM_only
GPC1	GPC4	0.005	0.014	bioplex (GPC1) bioplex_WMM

Images

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Complex HuMAP2_04797 has an average edge precision of 0.087 which is ranked 6958 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TSHZ3	HuMAP2_04691 HuMAP2_04797 HuMAP2_05207 HuMAP2_05499
SMDT1	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
FAM193B	HuMAP2_00258 HuMAP2_02019 HuMAP2_04691 HuMAP2_04797 HuMAP2_06457
ORMDL2	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
GPC4	HuMAP2_03070 HuMAP2_04691 HuMAP2_04797
GPC3	HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352
GPC6	HuMAP2_03070 HuMAP2_04691 HuMAP2_04797
ITPRIPL1	HuMAP2_03731 HuMAP2_04691 HuMAP2_04797 HuMAP2_05920
GPR183	HuMAP2_00939 HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
GPC1	HuMAP2_02605 HuMAP2_04691 HuMAP2_04797 HuMAP2_06352
SDC4	HuMAP2_02199 HuMAP2_03731 HuMAP2_04691 HuMAP2_04797
TGFBR3	HuMAP2_04691 HuMAP2_04797

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04797