hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04804
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNAI2 | Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein) | UniProt NCBI |
| GNG5 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 | UniProt NCBI |
| GNG11 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 | UniProt NCBI |
| GNAI3 | Guanine nucleotide-binding protein G(i) subunit alpha (G(i) alpha-3) | UniProt NCBI |
| RIC8A | Synembryn-A (Protein Ric-8A) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-392170 | 1.76788755434e-09 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | ADP signalling through P2Y purinoceptor 12 |
| REAC:R-HSA-202040 | 5.45333158978e-09 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | G-protein activation |
| REAC:R-HSA-392518 | 8.66228610405e-09 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Signal amplification |
| REAC:R-HSA-6814122 | 2.99818273785e-08 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| REAC:R-HSA-418597 | 4.94701294863e-08 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | G alpha (z) signalling events |
| KEGG:04727 | 1.73841213182e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | GABAergic synapse |
| KEGG:05032 | 1.92475995379e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Morphine addiction |
| WP:WP35 | 2.00221502161e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | G Protein Signaling Pathways |
| REAC:R-HSA-9009391 | 2.6233234194e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Extra-nuclear estrogen signaling |
| KEGG:04713 | 2.69671550532e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Circadian entrainment |
| KEGG:04726 | 3.68022151048e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Serotonergic synapse |
| KEGG:04725 | 3.84002380227e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Cholinergic synapse |
| KEGG:04724 | 4.53176595774e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Glutamatergic synapse |
| WP:WP536 | 7.37592908394e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-111885 | 7.72111985662e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Opioid Signalling |
| WP:WP3929 | 8.42167978201e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Chemokine signaling pathway |
| REAC:R-HSA-390466 | 9.28851362611e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Chaperonin-mediated protein folding |
| KEGG:04926 | 9.48333739363e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Relaxin signaling pathway |
| KEGG:04728 | 9.80702381829e-07 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Dopaminergic synapse |
| KEGG:04371 | 1.08278740054e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Apelin signaling pathway |
| REAC:R-HSA-391251 | 1.20719311149e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Protein folding |
| KEGG:04062 | 1.31062068202e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Chemokine signaling pathway |
| KEGG:04723 | 1.39399612223e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Retrograde endocannabinoid signaling |
| GO:0005834 | 1.82141275099e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | heterotrimeric G-protein complex |
| GO:1905360 | 1.82141275099e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | GTPase complex |
| KEGG:05034 | 3.51323493939e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Alcoholism |
| REAC:R-HSA-400042 | 7.0533398358e-06 | 0.6 | GNG11 GNAI2 GNG5 | Adrenaline,noradrenaline inhibits insulin secretion |
| KEGG:05170 | 7.28696714432e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 7.73866414322e-06 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Human cytomegalovirus infection |
| REAC:R-HSA-977444 | 1.34474619847e-05 | 0.6 | GNAI3 GNAI2 GNG5 | GABA B receptor activation |
| REAC:R-HSA-991365 | 1.34474619847e-05 | 0.6 | GNAI3 GNAI2 GNG5 | Activation of GABAB receptors |
| REAC:R-HSA-112314 | 1.3660811252e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-418555 | 1.39777465452e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | G alpha (s) signalling events |
| REAC:R-HSA-8939211 | 2.53107371053e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | ESR-mediated signaling |
| REAC:R-HSA-76002 | 3.61955824501e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Platelet activation, signaling and aggregation |
| REAC:R-HSA-112315 | 3.8873456186e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Transmission across Chemical Synapses |
| REAC:R-HSA-977443 | 4.10976418258e-05 | 0.6 | GNAI3 GNAI2 GNG5 | GABA receptor activation |
| REAC:R-HSA-9006931 | 5.19415811062e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Signaling by Nuclear Receptors |
| REAC:R-HSA-418594 | 6.804840425e-05 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | G alpha (i) signalling events |
| REAC:R-HSA-422356 | 0.000141520021869 | 0.6 | GNG11 GNAI2 GNG5 | Regulation of insulin secretion |
| GO:0031234 | 0.000164422098058 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | extrinsic component of cytoplasmic side of plasma membrane |
| REAC:R-HSA-112316 | 0.000198489420183 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Neuronal System |
| KEGG:05200 | 0.000217862252065 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Pathways in cancer |
| REAC:R-HSA-163685 | 0.000397120285508 | 0.6 | GNG11 GNAI2 GNG5 | Integration of energy metabolism |
| WP:WP26 | 0.000998738671819 | 0.4 | GNAI3 GNAI2 | Signal Transduction of S1P Receptor |
| GO:0019897 | 0.00113692677057 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | extrinsic component of plasma membrane |
| REAC:R-HSA-109582 | 0.0012064681881 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Hemostasis |
| REAC:R-HSA-388396 | 0.00122449193088 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | GPCR downstream signalling |
| REAC:R-HSA-170670 | 0.00122631290825 | 0.4 | GNAI3 GNAI2 | Adenylate cyclase inhibitory pathway |
| GO:0009898 | 0.001292590007 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | cytoplasmic side of plasma membrane |
| REAC:R-HSA-8964315 | 0.00161668141155 | 0.4 | GNG5 GNG11 | G beta:gamma signalling through BTK |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | Signaling by GPCR |
| REAC:R-HSA-392851 | 0.00183199274719 | 0.4 | GNG5 GNG11 | Prostacyclin signalling through prostacyclin receptor |
| REAC:R-HSA-418217 | 0.00206071490935 | 0.4 | GNG5 GNG11 | G beta:gamma signalling through PLC beta |
| REAC:R-HSA-8964616 | 0.00206071490935 | 0.4 | GNG5 GNG11 | G beta:gamma signalling through CDC42 |
| REAC:R-HSA-500657 | 0.00230284247734 | 0.4 | GNG5 GNG11 | Presynaptic function of Kainate receptors |
| GO:0098562 | 0.0023227175406 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | cytoplasmic side of membrane |
| REAC:R-HSA-392451 | 0.00282729215335 | 0.4 | GNG5 GNG11 | G beta:gamma signalling through PI3Kgamma |
| REAC:R-HSA-420092 | 0.00282729215335 | 0.4 | GNG5 GNG11 | Glucagon-type ligand receptors |
| REAC:R-HSA-428930 | 0.00282729215335 | 0.4 | GNG5 GNG11 | Thromboxane signalling through TP receptor |
| GO:0007186 | 0.00290907799633 | 1.0 | RIC8A GNAI3 GNG11 GNAI2 GNG5 | G protein-coupled receptor signaling pathway |
| REAC:R-HSA-418592 | 0.0031096034254 | 0.4 | GNG5 GNG11 | ADP signalling through P2Y purinoceptor 1 |
| KEGG:04923 | 0.00403884103568 | 0.4 | GNAI3 GNAI2 | Regulation of lipolysis in adipocytes |
| KEGG:05030 | 0.00441762805526 | 0.4 | GNAI3 GNAI2 | Cocaine addiction |
| REAC:R-HSA-451326 | 0.00472180750517 | 0.4 | GNG5 GNG11 | Activation of kainate receptors upon glutamate binding |
| REAC:R-HSA-397795 | 0.00508433997358 | 0.4 | GNG5 GNG11 | G-protein beta:gamma signalling |
| REAC:R-HSA-456926 | 0.00508433997358 | 0.4 | GNG5 GNG11 | Thrombin signalling through proteinase activated receptors (PARs) |
| KEGG:04924 | 0.00587609842855 | 0.4 | GNAI3 GNAI2 | Renin secretion |
| KEGG:04730 | 0.00587609842855 | 0.4 | GNAI3 GNAI2 | Long-term depression |
| REAC:R-HSA-163359 | 0.00625202329777 | 0.4 | GNG5 GNG11 | Glucagon signaling in metabolic regulation |
| WP:WP2032 | 0.00688743357746 | 0.4 | GNAI3 GNAI2 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| KEGG:05133 | 0.00754056801043 | 0.4 | GNAI3 GNAI2 | Pertussis |
| KEGG:04971 | 0.00779513141567 | 0.4 | GNAI3 GNAI2 | Gastric acid secretion |
| REAC:R-HSA-381676 | 0.00799559968784 | 0.4 | GNG5 GNG11 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-432040 | 0.00894729002053 | 0.4 | GNG5 GNG11 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.00995219083388 | 0.4 | GNG5 GNG11 | Aquaporin-mediated transport |
| WP:WP2806 | 0.0104424923561 | 0.4 | GNAI3 GNAI2 | Human Complement System |
| GO:0019898 | 0.0116598248695 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | extrinsic component of membrane |
| WP:WP4540 | 0.0123508080289 | 0.4 | GNAI3 GNAI2 | Pathways Regulating Hippo Signaling |
| KEGG:04914 | 0.0137641082753 | 0.4 | GNAI3 GNAI2 | Progesterone-mediated oocyte maturation |
| KEGG:04540 | 0.01480317908 | 0.4 | GNAI3 GNAI2 | Gap junction |
| KEGG:04670 | 0.0162467151192 | 0.4 | GNAI3 GNAI2 | Leukocyte transendothelial migration |
| KEGG:05142 | 0.0162467151192 | 0.4 | GNAI3 GNAI2 | Chagas disease (American trypanosomiasis) |
| KEGG:04916 | 0.016617964273 | 0.4 | GNAI3 GNAI2 | Melanogenesis |
| REAC:R-HSA-112043 | 0.0170965985867 | 0.4 | GNAI3 GNAI2 | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.017778070678 | 0.4 | GNAI3 GNAI2 | G-protein mediated events |
| GO:0003924 | 0.0179259894308 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | GTPase activity |
| REAC:R-HSA-4086398 | 0.0184727645209 | 0.4 | GNG5 GNG11 | Ca2+ pathway |
| KEGG:05145 | 0.0185363159266 | 0.4 | GNAI3 GNAI2 | Toxoplasmosis |
| KEGG:04928 | 0.0197369504817 | 0.4 | GNAI3 GNAI2 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04071 | 0.0249106474345 | 0.4 | GNAI3 GNAI2 | Sphingolipid signaling pathway |
| REAC:R-HSA-373080 | 0.0253191001807 | 0.4 | GNG5 GNG11 | Class B/2 (Secretin family receptors) |
| KEGG:04611 | 0.0258305316126 | 0.4 | GNAI3 GNAI2 | Platelet activation |
| WP:WP289 | 0.0279458043607 | 0.4 | GNG5 GNG11 | Myometrial Relaxation and Contraction Pathways |
| KEGG:04915 | 0.0311830645807 | 0.4 | GNAI3 GNAI2 | Estrogen signaling pathway |
| KEGG:05012 | 0.0332521613209 | 0.4 | GNAI3 GNAI2 | Parkinson disease |
| KEGG:04261 | 0.0348468299156 | 0.4 | GNAI3 GNAI2 | Adrenergic signaling in cardiomyocytes |
| REAC:R-HSA-416482 | 0.0351349281697 | 0.4 | GNG5 GNG11 | G alpha (12/13) signalling events |
| KEGG:04921 | 0.0381461453689 | 0.4 | GNAI3 GNAI2 | Oxytocin signaling pathway |
| WP:WP4223 | 0.0390434201563 | 0.4 | GNG5 GNG11 | Ras Signaling |
| REAC:R-HSA-418346 | 0.0390979640759 | 0.4 | GNG5 GNG11 | Platelet homeostasis |
| KEGG:04934 | 0.0415917953149 | 0.4 | GNAI3 GNAI2 | Cushing syndrome |
| KEGG:04022 | 0.0415917953149 | 0.4 | GNAI3 GNAI2 | cGMP-PKG signaling pathway |
| GO:0098552 | 0.0464577202339 | 0.8 | GNAI3 GNG11 GNAI2 GNG5 | side of membrane |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNAI2 | GNAI3 | 1.0 | 0.949 | hein_WMM bioplex (GNAI3) bioplex_WMM youn_WMM |
| GNG11 | GNAI3 | 0.83 | 0.778 | bioplex (GNAI3) bioplex_WMM |
| GNAI3 | GNG5 | 0.746 | 0.741 | bioplex (GNAI3) bioplex_WMM |
| RIC8A | GNAI3 | 0.745 | 0.74 | bioplex (GNAI3,RIC8A) bioplex_WMM youn_WMM |
| RIC8A | GNAI2 | 0.5 | 0.621 | bioplex (GNAI2,RIC8A) bioplex_WMM treiber_WMM |
| GNG11 | RIC8A | 0.011 | 0.141 | bioplex_WMM WMM_only |
| RIC8A | GNG5 | 0.01 | 0.104 | bioplex_WMM WMM_only |
| GNG11 | GNG5 | 0.009 | 0.096 | bioplex_WMM WMM_only |
| GNG11 | GNAI2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| GNAI2 | GNG5 | 0.0 | 0.004 | bioplex (GNAI2) bioplex_WMM |
Images
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Complex HuMAP2_04804 has an average edge precision of 0.418 which is ranked 3124 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNAI2 | HuMAP2_01804 HuMAP2_03884 HuMAP2_04804 HuMAP2_05902 |
| GNG5 | HuMAP2_02804 HuMAP2_04026 HuMAP2_04804 HuMAP2_05902 |
| GNG11 | HuMAP2_00508 HuMAP2_01804 HuMAP2_02804 HuMAP2_04804 HuMAP2_05902 |
| GNAI3 | HuMAP2_01804 HuMAP2_02804 HuMAP2_03884 HuMAP2_04026 HuMAP2_04804 HuMAP2_05902 |
| RIC8A | HuMAP2_01804 HuMAP2_04804 HuMAP2_05902 |