hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04805
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | UniProt NCBI |
| MPP5 | MAGUK p55 subfamily member 5 | UniProt NCBI |
| YAP1 | Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog) | UniProt NCBI |
| CRB3 | Protein crumbs homolog 3 | UniProt NCBI |
| AMOTL2 | Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP) | UniProt NCBI |
| AMOTL1 | Angiomotin-like protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:848 | 7.88270302729e-08 | 0.5 | MPP5 AMOTL1 AMOTL2 | RICH1/AMOT polarity complex, Flag-Amot precipitated |
| REAC:R-HSA-2028269 | 5.75676182894e-06 | 0.5 | YAP1 AMOTL1 AMOTL2 | Signaling by Hippo |
| KEGG:04530 | 5.8954604486e-06 | 0.666666666667 | AMOTL1 MPP5 AMOTL2 CRB3 | Tight junction |
| GO:0035329 | 2.40824494048e-05 | 0.666666666667 | YAP1 TEAD3 AMOTL1 AMOTL2 | hippo signaling |
| REAC:R-HSA-8951671 | 0.000465187760645 | 0.333333333333 | YAP1 TEAD3 | RUNX3 regulates YAP1-mediated transcription |
| WP:WP3967 | 0.000668966778113 | 0.333333333333 | YAP1 TEAD3 | miR-509-3p alteration of YAP1/ECM axis |
| KEGG:04390 | 0.00076933519084 | 0.5 | MPP5 TEAD3 YAP1 | Hippo signaling pathway |
| REAC:R-HSA-2032785 | 0.00201328766088 | 0.333333333333 | YAP1 TEAD3 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| KEGG:04392 | 0.0020262364794 | 0.333333333333 | YAP1 TEAD3 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-420029 | 0.00232260810736 | 0.333333333333 | MPP5 CRB3 | Tight junction interactions |
| WP:WP4542 | 0.00241892882621 | 0.333333333333 | YAP1 TEAD3 | Overview of leukocyte-intrinsic Hippo pathway functions |
| MIRNA:hsa-miR-6859-5p | 0.00707938846677 | 0.5 | YAP1 AMOTL1 AMOTL2 | hsa-miR-6859-5p |
| MIRNA:hsa-miR-3125 | 0.00721186441345 | 0.5 | YAP1 AMOTL1 AMOTL2 | hsa-miR-3125 |
| MIRNA:hsa-miR-3916 | 0.00775815062419 | 0.5 | YAP1 AMOTL1 AMOTL2 | hsa-miR-3916 |
| GO:0003365 | 0.020283420769 | 0.333333333333 | AMOTL2 AMOTL1 | establishment of cell polarity involved in ameboidal cell migration |
| REAC:R-HSA-421270 | 0.0208171179433 | 0.333333333333 | MPP5 CRB3 | Cell-cell junction organization |
| MIRNA:hsa-miR-4639-5p | 0.0461159505368 | 0.333333333333 | MPP5 YAP1 | hsa-miR-4639-5p |
| WP:WP4239 | 0.049358027697 | 0.333333333333 | MPP5 CRB3 | Epithelial to mesenchymal transition in colorectal cancer |
| CORUM:461 | 0.0499726005494 | 0.166666666667 | MPP5 | MPP4-MPP5-CRB1 complex |
| CORUM:6651 | 0.0499726005494 | 0.166666666667 | YAP1 | WWTR1-YAP1 complex |
| CORUM:460 | 0.0499726005494 | 0.166666666667 | MPP5 | CRB1-MPP5-INADL complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRB3 | MPP5 | 0.782 | 0.756 | bioplex (MPP5) bioplex_WMM |
| AMOTL2 | MPP5 | 0.587 | 0.662 | hein_WMM bioplex (MPP5) bioplex_WMM |
| MPP5 | AMOTL1 | 0.082 | 0.351 | hein_WMM bioplex (MPP5) bioplex_WMM gupta_WMM |
| AMOTL1 | YAP1 | 0.081 | 0.351 | hein_WMM bioplex_WMM hein (YAP1) |
| TEAD3 | YAP1 | 0.062 | 0.344 | hein_WMM hein (YAP1) |
| AMOTL2 | YAP1 | 0.055 | 0.304 | hein_WMM bioplex_WMM hein (YAP1) |
| MPP5 | YAP1 | 0.015 | 0.143 | hein_WMM bioplex (MPP5) bioplex_WMM hein (YAP1) |
| AMOTL2 | AMOTL1 | 0.009 | 0.097 | hein_WMM bioplex_WMM WMM_only |
| CRB3 | AMOTL2 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| MPP5 | TEAD3 | 0.008 | 0.062 | hein_WMM WMM_only |
| CRB3 | AMOTL1 | 0.008 | 0.061 | bioplex_WMM WMM_only |
| AMOTL2 | TEAD3 | 0.008 | 0.034 | hein_WMM WMM_only |
| TEAD3 | AMOTL1 | 0.008 | 0.032 | hein_WMM bioplex_WMM WMM_only |
| CRB3 | YAP1 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04805 has an average edge precision of 0.235 which is ranked 5618 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TEAD3 | HuMAP2_02068 HuMAP2_02569 HuMAP2_04011 HuMAP2_04016 HuMAP2_04805 |
| MPP5 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| YAP1 | HuMAP2_03679 HuMAP2_04011 HuMAP2_04020 HuMAP2_04805 |
| CRB3 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04805 |
| AMOTL2 | HuMAP2_01171 HuMAP2_02238 HuMAP2_03001 HuMAP2_04011 HuMAP2_04805 |
| AMOTL1 | HuMAP2_02204 HuMAP2_04805 |