hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_04808

Confidence: Medium

Genename	Protein Name	Links
CDH24	Cadherin-24	UniProt NCBI
CTNND1	Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas))	UniProt NCBI
TMTC3	Protein O-mannosyl-transferase TMTC3 (EC 2.4.1.109) (Protein SMILE) (Transmembrane and TPR repeat-containing protein 3)	UniProt NCBI
PKP4	Plakophilin-4 (p0071)	UniProt NCBI
CDH11	Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)	UniProt NCBI
ARVCF	Armadillo repeat protein deleted in velo-cardio-facial syndrome	UniProt NCBI
CDH8	Cadherin-8	UniProt NCBI
CDH5	Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005913	8.51454521698e-11	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell-cell adherens junction
GO:0007043	1.00008445533e-10	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell-cell junction assembly
REAC:R-HSA-418990	1.30844262732e-10	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	Adherens junctions interactions
GO:0045216	3.927453121e-10	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell-cell junction organization
REAC:R-HSA-421270	1.75513696041e-09	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	Cell-cell junction organization
GO:0016342	1.20462168888e-08	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	catenin complex
GO:0034329	1.67484893479e-08	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell junction assembly
REAC:R-HSA-446728	2.09464996215e-08	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	Cell junction organization
GO:0034330	5.33572408057e-08	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell junction organization
REAC:R-HSA-1500931	1.40078811705e-07	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	Cell-Cell communication
GO:0044331	1.48175348117e-07	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	cell-cell adhesion mediated by cadherin
GO:0005911	2.47148081259e-07	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell-cell junction
GO:0045296	7.4420655065e-07	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cadherin binding
WP:WP4540	3.7791494928e-06	0.5	CDH5 CDH24 CDH11 CDH8	Pathways Regulating Hippo Signaling
WP:WP4541	7.19165413152e-06	0.5	CDH5 CDH24 CDH11 CDH8	Hippo-Merlin Signaling Dysregulation
GO:0050839	7.54335900711e-06	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell adhesion molecule binding
GO:0005912	9.38935094752e-06	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	adherens junction
GO:0070161	1.1099078314e-05	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	anchoring junction
GO:0098609	1.81709340655e-05	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell-cell adhesion
GO:0034332	5.02570571668e-05	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	adherens junction organization
GO:0016339	6.94441590143e-05	0.5	CDH5 CDH24 CDH11 CDH8	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
CORUM:6337	7.00904180673e-05	0.25	CTNND1 CDH11	Amot-cadherin-11-beta-catenin-p120 complex
GO:0019897	0.000101237303578	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	extrinsic component of plasma membrane
GO:0030054	0.000165675583467	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell junction
GO:0007156	0.000666904519799	0.5	CDH5 CDH24 CDH11 CDH8	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0007155	0.000868137842232	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	cell adhesion
GO:0022610	0.000910687487507	0.875	ARVCF CDH5 CDH8 CDH24 CDH11 CTNND1 PKP4	biological adhesion
GO:0019898	0.00185663151637	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	extrinsic component of membrane
MIRNA:hsa-miR-27b-3p	0.00865957504794	0.5	CDH5 TMTC3 CDH11 CTNND1	hsa-miR-27b-3p
REAC:R-HSA-5218920	0.0144543373882	0.25	CTNND1 CDH5	VEGFR2 mediated vascular permeability
HP:0100338	0.0150657984869	0.25	CTNND1 CDH11	Non-midline cleft palate
GO:0098742	0.0194680313645	0.5	CDH5 CDH24 CDH11 CDH8	cell-cell adhesion via plasma-membrane adhesion molecules
CORUM:6599	0.0248670854284	0.125	CTNND1	CTNND1-GLIS2 complex
HP:0000670	0.02771617409	0.375	CTNND1 CDH11 ARVCF	Carious teeth
HP:0004378	0.0334690521408	0.375	CTNND1 CDH11 ARVCF	Abnormality of the anus
GO:0098797	0.0348252240904	0.625	CDH5 CDH24 CDH11 CDH8 CTNND1	plasma membrane protein complex
KEGG:04670	0.0454007036402	0.25	CTNND1 CDH5	Leukocyte transendothelial migration
CORUM:829	0.0497224828424	0.125	CDH5	PAR-6-VE-cadherin complex, endothelial

Edges

Protein 1	Protein 2	Score	Precision	Evidence
CDH8	CDH11	0.962	0.87	bioplex (CDH8) bioplex_WMM
ARVCF	CDH8	0.518	0.632	bioplex (CDH8) bioplex_WMM
CDH8	PKP4	0.447	0.591	bioplex (CDH8) bioplex_WMM
CDH24	CDH8	0.359	0.541	bioplex (CDH8) bioplex_WMM
PKP4	CDH5	0.194	0.447	bioplex (CDH5) bioplex_WMM
CDH8	CTNND1	0.092	0.356	bioplex (CDH8) bioplex_WMM
ARVCF	CDH5	0.062	0.34	bioplex (CDH5) bioplex_WMM
TMTC3	CDH5	0.027	0.225	bioplex (CDH5) bioplex_WMM
CTNND1	CDH5	0.013	0.151	bioplex (CDH5) bioplex_WMM
ARVCF	CTNND1	0.012	0.147	hein_WMM bioplex_WMM gupta_WMM WMM_only
ARVCF	PKP4	0.01	0.131	hein_WMM bioplex_WMM gupta_WMM WMM_only
CDH24	ARVCF	0.009	0.112	bioplex_WMM WMM_only
CDH24	PKP4	0.009	0.112	bioplex_WMM WMM_only
CDH24	CDH11	0.008	0.091	bioplex_WMM WMM_only
CDH11	PKP4	0.008	0.066	bioplex_WMM WMM_only
ARVCF	CDH11	0.008	0.066	bioplex_WMM WMM_only
CDH24	CTNND1	0.008	0.058	bioplex_WMM WMM_only
CTNND1	PKP4	0.008	0.023	hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only
CDH11	CTNND1	0.007	0.005	bioplex_WMM WMM_only
TMTC3	PKP4	0.007	0.003	bioplex_WMM youn_WMM gupta_WMM WMM_only
ARVCF	TMTC3	0.007	0.003	bioplex_WMM gupta_WMM WMM_only
CDH24	TMTC3	0.007	0.006	bioplex_WMM WMM_only
CDH11	TMTC3	0.007	0.004	bioplex_WMM WMM_only
CTNND1	TMTC3	0.006	0.002	bioplex_WMM youn_WMM gupta_WMM WMM_only
CDH8	TMTC3	0.004	0.011	bioplex (CDH8) bioplex_WMM

Images

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Complex HuMAP2_04808 has an average edge precision of 0.2 which is ranked 6176 out of all 6965 complexes.

Related Complexes

Genename	Complexes
CDH24	HuMAP2_00625 HuMAP2_04278 HuMAP2_04808 HuMAP2_05814
CTNND1	HuMAP2_01324 HuMAP2_01826 HuMAP2_02710 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814
TMTC3	HuMAP2_02507 HuMAP2_04808 HuMAP2_05415 HuMAP2_06746
PKP4	HuMAP2_04808 HuMAP2_05814
CDH11	HuMAP2_00784 HuMAP2_01438 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814
ARVCF	HuMAP2_00784 HuMAP2_04808 HuMAP2_05814
CDH8	HuMAP2_00784 HuMAP2_01438 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814
CDH5	HuMAP2_04808 HuMAP2_05814

hu.MAP 2.0: Complex View

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Complex: HuMAP2_04808