hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04817
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | UniProt NCBI |
| USP13 | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | UniProt NCBI |
| AGL | Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)] | UniProt NCBI |
| EIF5A | Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D) | UniProt NCBI |
| EIF5A2 | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 1.08753805614e-08 | 0.6 | EIF5A2 DOHH EIF5A | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 1.77393158174e-05 | 0.6 | EIF5A2 DOHH EIF5A | Gamma carboxylation, hypusine formation and arylsulfatase activation |
| GO:0045901 | 0.0270421395626 | 0.4 | EIF5A2 EIF5A | positive regulation of translational elongation |
| REAC:R-HSA-597592 | 0.035484350726 | 0.8 | EIF5A2 USP13 DOHH EIF5A | Post-translational protein modification |
| WP:WP3302 | 0.0497141369515 | 0.2 | EIF5A | eIF5A regulation in response to inhibition of the nuclear export system |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF5A2 | DOHH | 1.0 | 0.949 | bioplex (DOHH) bioplex_WMM fraction |
| DOHH | EIF5A | 0.385 | 0.551 | bioplex (DOHH) bioplex_WMM |
| USP13 | EIF5A2 | 0.088 | 0.353 | fraction |
| AGL | DOHH | 0.05 | 0.297 | bioplex (DOHH) fraction |
| EIF5A2 | EIF5A | 0.008 | 0.082 | bioplex_WMM gupta_WMM WMM_only |
| USP13 | EIF5A | 0.007 | 0.004 | hein_WMM gupta_WMM WMM_only |
| AGL | EIF5A | 0.007 | 0.002 | bioplex_WMM WMM_only |
| USP13 | DOHH | 0.0 | 0.002 | fraction |
| AGL | EIF5A2 | 0.0 | 0.0 | fraction |
Images
Click to enlarge
Complex HuMAP2_04817 has an average edge precision of 0.249 which is ranked 5395 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DOHH | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 HuMAP2_05181 |
| USP13 | HuMAP2_00125 HuMAP2_00526 HuMAP2_04392 HuMAP2_04817 |
| AGL | HuMAP2_00261 HuMAP2_01589 HuMAP2_04817 HuMAP2_05275 |
| EIF5A | HuMAP2_01097 HuMAP2_02542 HuMAP2_04788 HuMAP2_04817 |
| EIF5A2 | HuMAP2_00526 HuMAP2_02855 HuMAP2_04817 HuMAP2_05181 |