hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04827
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APLF | Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | UniProt NCBI |
| PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03410 | 0.000221829243661 | 0.666666666667 | PARP2 LIG3 | Base excision repair |
| REAC:R-HSA-5685939 | 0.000301184970683 | 0.666666666667 | PARP2 LIG3 | HDR through MMEJ (alt-NHEJ) |
| REAC:R-HSA-73933 | 0.00397787610966 | 0.666666666667 | PARP2 LIG3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5696399 | 0.0232544758505 | 0.666666666667 | PARP2 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-73884 | 0.0249521708712 | 0.666666666667 | PARP2 LIG3 | Base Excision Repair |
| REAC:R-HSA-5696398 | 0.0399448421955 | 0.666666666667 | PARP2 LIG3 | Nucleotide Excision Repair |
| CORUM:212 | 0.0499776345577 | 0.333333333333 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 0.0499776345577 | 0.333333333333 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 0.0499776345577 | 0.333333333333 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:7352 | 0.0499776345577 | 0.333333333333 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| APLF | LIG3 | 0.938 | 0.85 | bioplex (APLF) bioplex_WMM |
| PARP2 | APLF | 0.543 | 0.644 | bioplex (APLF) bioplex_WMM |
| PARP2 | LIG3 | 0.012 | 0.147 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04827 has an average edge precision of 0.547 which is ranked 2212 out of all 6965 complexes.
Related Complexes