hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04830
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KMT2A | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | UniProt NCBI |
| POGZ | Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635) | UniProt NCBI |
| CHAMP1 | Chromosome alignment-maintaining phosphoprotein 1 (Zinc finger protein 828) | UniProt NCBI |
| BAZ1B | Tyrosine-protein kinase BAZ1B (EC 2.7.10.2) (Bromodomain adjacent to zinc finger domain protein 1B) (Williams syndrome transcription factor) (Williams-Beuren syndrome chromosomal region 10 protein) (Williams-Beuren syndrome chromosomal region 9 protein) (hWALp2) | UniProt NCBI |
| ZNF428 | Zinc finger protein 428 (Enzyme-like protein PIT13) | UniProt NCBI |
| CBX1 | Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta) | UniProt NCBI |
| ZNF576 | Zinc finger protein 576 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002020 | 0.00128496882655 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Gastroesophageal reflux |
| HP:0000307 | 0.00131134073925 | 0.428571428571 | BAZ1B POGZ CHAMP1 | Pointed chin |
| HP:0000722 | 0.0020041380536 | 0.428571428571 | BAZ1B KMT2A POGZ | Obsessive-compulsive behavior |
| HP:0000539 | 0.00864057114734 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormality of refraction |
| HP:0002577 | 0.0127908609105 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormality of the stomach |
| HP:0000288 | 0.0130310742177 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormality of the philtrum |
| HP:0000540 | 0.0132077175076 | 0.428571428571 | BAZ1B POGZ CHAMP1 | Hypermetropia |
| HP:0000733 | 0.0154734133885 | 0.428571428571 | CHAMP1 KMT2A POGZ | Stereotypy |
| HP:0025270 | 0.0185739527091 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormality of esophagus physiology |
| HP:0000297 | 0.0265508883611 | 0.285714285714 | POGZ CHAMP1 | Facial hypotonia |
| HP:0011338 | 0.029102183295 | 0.428571428571 | CHAMP1 KMT2A POGZ | Abnormality of mouth shape |
| HP:0000369 | 0.0306041581548 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Low-set ears |
| HP:0010880 | 0.0373216957502 | 0.285714285714 | BAZ1B KMT2A | Increased nuchal translucency |
| HP:0000357 | 0.0385459664679 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormal location of ears |
| HP:0000177 | 0.044224183566 | 0.571428571429 | CHAMP1 BAZ1B KMT2A POGZ | Abnormality of upper lip |
| CORUM:236 | 0.0499886427319 | 0.142857142857 | BAZ1B | WICH complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHAMP1 | POGZ | 0.722 | 0.732 | hein_WMM bioplex_WMM youn_WMM hein (CHAMP1) gupta_WMM |
| POGZ | ZNF428 | 0.61 | 0.674 | bioplex (ZNF428) bioplex_WMM |
| CHAMP1 | ZNF428 | 0.526 | 0.634 | bioplex (ZNF428) bioplex_WMM |
| POGZ | CBX1 | 0.268 | 0.483 | hein_WMM bioplex_WMM youn_WMM hein (CBX1) gupta_WMM |
| CHAMP1 | CBX1 | 0.181 | 0.436 | hein_WMM bioplex_WMM youn_WMM hein (CBX1,CHAMP1) gupta_WMM |
| POGZ | ZNF576 | 0.062 | 0.34 | bioplex (ZNF576) bioplex_WMM youn_WMM |
| CBX1 | BAZ1B | 0.031 | 0.241 | hein_WMM youn_WMM hein (CBX1) gupta_WMM |
| CBX1 | KMT2A | 0.023 | 0.208 | hein_WMM youn_WMM hein (CBX1) gupta_WMM |
| POGZ | KMT2A | 0.009 | 0.097 | hein_WMM youn_WMM gupta_WMM WMM_only |
| KMT2A | BAZ1B | 0.008 | 0.051 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CHAMP1 | KMT2A | 0.007 | 0.01 | hein_WMM youn_WMM gupta_WMM WMM_only |
| POGZ | BAZ1B | 0.007 | 0.005 | hein_WMM youn_WMM gupta_WMM WMM_only |
| CHAMP1 | BAZ1B | 0.007 | 0.008 | hein_WMM youn_WMM gupta_WMM WMM_only |
| BAZ1B | ZNF576 | 0.007 | 0.002 | youn_WMM WMM_only |
| ZNF428 | CBX1 | 0.006 | 0.004 | bioplex (ZNF428) bioplex_WMM |
| CBX1 | ZNF576 | 0.005 | 0.009 | bioplex (ZNF576) |
Images
Click to enlarge
Complex HuMAP2_04830 has an average edge precision of 0.246 which is ranked 5442 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| KMT2A | HuMAP2_02172 HuMAP2_03873 HuMAP2_04830 |
| POGZ | HuMAP2_01343 HuMAP2_04830 HuMAP2_05129 HuMAP2_05573 |
| CHAMP1 | HuMAP2_01343 HuMAP2_04830 HuMAP2_05129 HuMAP2_05573 |
| BAZ1B | HuMAP2_04830 |
| ZNF428 | HuMAP2_01343 HuMAP2_04830 HuMAP2_05573 |
| CBX1 | HuMAP2_02094 HuMAP2_04830 |
| ZNF576 | HuMAP2_04830 HuMAP2_05573 |