hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04847
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NAA10 | N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (hARD1) (NatA catalytic subunit Naa10) | UniProt NCBI |
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.2) (DNA topoisomerase III alpha) | UniProt NCBI |
| RMI1 | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | UniProt NCBI |
| CCDC69 | Coiled-coil domain-containing protein 69 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5693554 | 7.0533398358e-06 | 0.6 | RMI2 TOP3A RMI1 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5693568 | 1.34474619847e-05 | 0.6 | RMI2 TOP3A RMI1 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 1.47907161009e-05 | 0.6 | RMI2 TOP3A RMI1 | Resolution of D-Loop Structures |
| KEGG:03460 | 1.58618815843e-05 | 0.6 | RMI2 TOP3A RMI1 | Fanconi anemia pathway |
| REAC:R-HSA-5685938 | 1.93500285918e-05 | 0.6 | RMI2 TOP3A RMI1 | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 2.28576897279e-05 | 0.6 | RMI2 TOP3A RMI1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 2.88749669481e-05 | 0.6 | RMI2 TOP3A RMI1 | Homologous DNA Pairing and Strand Exchange |
| CORUM:246 | 4.0241279111e-05 | 0.4 | TOP3A RMI1 | BLM complex III |
| CORUM:2738 | 0.000100576175246 | 0.4 | TOP3A RMI1 | BLM complex II |
| CORUM:2222 | 0.000100576175246 | 0.4 | TOP3A RMI1 | BLM complex II |
| REAC:R-HSA-5685942 | 0.000118030564163 | 0.6 | RMI2 TOP3A RMI1 | HDR through Homologous Recombination (HRR) |
| CORUM:2739 | 0.000241285563976 | 0.4 | TOP3A RMI1 | FA complex (Fanconi anemia complex) |
| REAC:R-HSA-6804756 | 0.000327410819085 | 0.6 | RMI2 TOP3A RMI1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 0.000361148609859 | 0.6 | RMI2 TOP3A RMI1 | G2/M DNA damage checkpoint |
| CORUM:244 | 0.00036853169003 | 0.4 | TOP3A RMI1 | BRAFT complex |
| REAC:R-HSA-5693607 | 0.000397120285508 | 0.6 | RMI2 TOP3A RMI1 | Processing of DNA double-strand break ends |
| REAC:R-HSA-5693567 | 0.000960389260783 | 0.6 | RMI2 TOP3A RMI1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.00110006319269 | 0.6 | RMI2 TOP3A RMI1 | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.00169383519446 | 0.6 | RMI2 TOP3A RMI1 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.00193087050228 | 0.6 | RMI2 TOP3A RMI1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.00203883898451 | 0.6 | RMI2 TOP3A RMI1 | G2/M Checkpoints |
| WP:WP4016 | 0.00992634522128 | 0.4 | TOP3A RMI1 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-69620 | 0.0103005771752 | 0.6 | RMI2 TOP3A RMI1 | Cell Cycle Checkpoints |
| HP:0003758 | 0.0107072942689 | 0.4 | NAA10 TOP3A | Reduced subcutaneous adipose tissue |
| REAC:R-HSA-73894 | 0.0143782387474 | 0.6 | RMI2 TOP3A RMI1 | DNA Repair |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | RMI2 TOP3A RMI1 | Transcriptional Regulation by TP53 |
| GO:0007059 | 0.0197450207423 | 0.8 | RMI2 RMI1 TOP3A NAA10 | chromosome segregation |
| HP:0040063 | 0.0308081945037 | 0.4 | NAA10 TOP3A | Decreased adipose tissue |
| HP:0001001 | 0.0379116132621 | 0.4 | NAA10 TOP3A | Abnormality of subcutaneous fat tissue |
| CORUM:2223 | 0.0499494897235 | 0.2 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RMI2 | RMI1 | 1.0 | 0.949 | bioplex (RMI2) bioplex_WMM |
| RMI2 | TOP3A | 0.952 | 0.858 | bioplex (RMI2) bioplex_WMM |
| RMI1 | CCDC69 | 0.369 | 0.544 | bioplex (CCDC69) bioplex_WMM |
| RMI2 | CCDC69 | 0.192 | 0.446 | bioplex (CCDC69) bioplex_WMM |
| TOP3A | NAA10 | 0.072 | 0.356 | youn_WMM fraction |
| TOP3A | CCDC69 | 0.042 | 0.269 | bioplex (CCDC69) bioplex_WMM |
| TOP3A | RMI1 | 0.032 | 0.244 | hein_WMM bioplex (RMI1) bioplex_WMM |
Images
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Complex HuMAP2_04847 has an average edge precision of 0.524 which is ranked 2376 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NAA10 | HuMAP2_01226 HuMAP2_02064 HuMAP2_04515 HuMAP2_04847 HuMAP2_05134 HuMAP2_05550 |
| RMI2 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |
| TOP3A | HuMAP2_00083 HuMAP2_04847 HuMAP2_06528 |
| RMI1 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |
| CCDC69 | HuMAP2_00083 HuMAP2_04847 |