hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04864
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WIPF2 | WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein) | UniProt NCBI |
| NCK1 | Cytoplasmic protein NCK1 (NCK adaptor protein 1) (Nck-1) (SH2/SH3 adaptor protein NCK-alpha) | UniProt NCBI |
| WIPF3 | WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog) | UniProt NCBI |
| MEA1 | Male-enhanced antigen 1 (MEA-1) | UniProt NCBI |
| WASL | Neural Wiskott-Aldrich syndrome protein (N-WASP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5663213 | 1.90901811802e-08 | 0.8 | WIPF2 WIPF3 NCK1 WASL | RHO GTPases Activate WASPs and WAVEs |
| REAC:R-HSA-2029482 | 1.65722225947e-07 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Regulation of actin dynamics for phagocytic cup formation |
| REAC:R-HSA-2029480 | 5.75239291324e-07 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:05130 | 4.54881150182e-06 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Pathogenic Escherichia coli infection |
| GO:0000147 | 1.81582264982e-05 | 0.6 | WIPF3 WIPF2 WASL | actin cortical patch assembly |
| GO:0044396 | 1.81582264982e-05 | 0.6 | WIPF3 WIPF2 WASL | actin cortical patch organization |
| GO:0051666 | 3.17736949706e-05 | 0.6 | WIPF3 WIPF2 WASL | actin cortical patch localization |
| REAC:R-HSA-195258 | 0.00013381858755 | 0.8 | WIPF2 WIPF3 NCK1 WASL | RHO GTPase Effectors |
| GO:0002433 | 0.000147692374511 | 0.8 | WIPF2 WIPF3 NCK1 WASL | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| GO:0038094 | 0.000147692374511 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Fc-gamma receptor signaling pathway |
| GO:0038096 | 0.000147692374511 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Fc-gamma receptor signaling pathway involved in phagocytosis |
| GO:0002431 | 0.000164422098058 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Fc receptor mediated stimulatory signaling pathway |
| KEGG:05135 | 0.000194978614983 | 0.6 | WIPF3 WIPF2 WASL | Yersinia infection |
| REAC:R-HSA-194315 | 0.000501262158212 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Signaling by Rho GTPases |
| GO:0030479 | 0.000507918241599 | 0.6 | WIPF3 WIPF2 WASL | actin cortical patch |
| GO:0061645 | 0.000507918241599 | 0.6 | WIPF3 WIPF2 WASL | endocytic patch |
| REAC:R-HSA-418885 | 0.00105126658749 | 0.4 | WASL NCK1 | DCC mediated attractive signaling |
| KEGG:04144 | 0.00171388219445 | 0.6 | WIPF3 WIPF2 WASL | Endocytosis |
| REAC:R-HSA-373753 | 0.0031096034254 | 0.4 | WASL NCK1 | Nephrin family interactions |
| GO:0030866 | 0.00330982532021 | 0.6 | WIPF3 WIPF2 WASL | cortical actin cytoskeleton organization |
| GO:0038093 | 0.00334368339407 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Fc receptor signaling pathway |
| WP:WP2272 | 0.00439842637514 | 0.4 | WASL NCK1 | Pathogenic Escherichia coli infection |
| GO:0030865 | 0.0049400991777 | 0.6 | WIPF3 WIPF2 WASL | cortical cytoskeleton organization |
| GO:0006909 | 0.0064877001777 | 0.8 | WIPF2 WIPF3 NCK1 WASL | phagocytosis |
| REAC:R-HSA-168249 | 0.0093160298358 | 0.8 | WIPF2 WIPF3 NCK1 WASL | Innate Immune System |
| REAC:R-HSA-373752 | 0.0132857243802 | 0.4 | WASL NCK1 | Netrin-1 signaling |
| CORUM:2513 | 0.0249780992026 | 0.2 | WASL | N-WASp homomer complex |
| GO:0002429 | 0.0309921425814 | 0.8 | WIPF2 WIPF3 NCK1 WASL | immune response-activating cell surface receptor signaling pathway |
| GO:0002768 | 0.0413212587053 | 0.8 | WIPF2 WIPF3 NCK1 WASL | immune response-regulating cell surface receptor signaling pathway |
| GO:0030864 | 0.0472676873043 | 0.6 | WIPF3 WIPF2 WASL | cortical actin cytoskeleton |
| CORUM:2297 | 0.0499494897235 | 0.2 | WASL | ABI1-WASL complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WIPF3 | WASL | 0.968 | 0.88 | bioplex (WASL) bioplex_WMM |
| WIPF2 | WASL | 0.833 | 0.78 | hein_WMM bioplex (WASL) bioplex_WMM |
| NCK1 | WIPF2 | 0.116 | 0.389 | hein_WMM bioplex_WMM youn_WMM hein (NCK1) |
| MEA1 | WASL | 0.085 | 0.348 | fraction |
| NCK1 | WASL | 0.02 | 0.189 | hein_WMM bioplex_WMM youn_WMM hein (NCK1) gupta_WMM |
| WIPF2 | WIPF3 | 0.014 | 0.141 | bioplex_WMM WMM_only |
| NCK1 | WIPF3 | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04864 has an average edge precision of 0.402 which is ranked 3298 out of all 6965 complexes.
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