hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04867
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCGF2 | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | UniProt NCBI |
| CBX8 | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | UniProt NCBI |
| CBX2 | Chromobox protein homolog 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:115 | 2.81642660396e-14 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 4.82788957091e-14 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| REAC:R-HSA-4655427 | 4.83670638587e-13 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation of DNA methylation proteins |
| REAC:R-HSA-3899300 | 1.0583202737e-10 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 1.36803536737e-10 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation of RNA binding proteins |
| GO:0035102 | 1.47519544769e-10 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | PRC1 complex |
| REAC:R-HSA-4551638 | 1.32663300233e-09 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 2.09044250377e-09 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation of DNA damage response and repair proteins |
| GO:0000152 | 4.17250787048e-08 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | nuclear ubiquitin ligase complex |
| GO:0031519 | 6.72200990848e-08 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | PcG protein complex |
| REAC:R-HSA-8939243 | 7.04303391184e-08 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3108232 | 1.57856898216e-07 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 1.88863196375e-07 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | SUMOylation |
| REAC:R-HSA-8943724 | 4.71230645899e-07 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Regulation of PTEN gene transcription |
| REAC:R-HSA-2559580 | 1.04049680701e-05 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 1.56538396855e-05 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | PTEN Regulation |
| REAC:R-HSA-8953750 | 3.54699593753e-05 | 0.5 | PCGF2 PHC1 PHC3 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-2559583 | 5.92853293102e-05 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Cellular Senescence |
| REAC:R-HSA-8878171 | 0.000109298820952 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 0.000121788581155 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.000227296904657 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Intracellular signaling by second messengers |
| GO:0000151 | 0.000435366064664 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | ubiquitin ligase complex |
| REAC:R-HSA-2262752 | 0.00129372739211 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Cellular responses to stress |
| REAC:R-HSA-212436 | 0.00148146469319 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.00253857262834 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | RNA Polymerase II Transcription |
| REAC:R-HSA-8953897 | 0.00265671127538 | 0.666666666667 | CBX8 PHC1 PHC3 CBX2 | Cellular responses to external stimuli |
| REAC:R-HSA-597592 | 0.00391856777133 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.00435080618405 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | Gene expression (Transcription) |
| GO:0070317 | 0.0140408309691 | 0.5 | PCGF2 PHC1 PHC3 | negative regulation of G0 to G1 transition |
| GO:0070316 | 0.0152420239566 | 0.5 | PCGF2 PHC1 PHC3 | regulation of G0 to G1 transition |
| GO:0045023 | 0.0178456165824 | 0.5 | PCGF2 PHC1 PHC3 | G0 to G1 transition |
| REAC:R-HSA-392499 | 0.0232605972232 | 0.833333333333 | PHC3 CBX8 PHC1 CBX2 PCGF2 | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CBX8 | PHC1 | 0.986 | 0.901 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM hein (CBX8) |
| SCMH1 | PHC1 | 0.965 | 0.874 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PCGF2 | 0.955 | 0.862 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | SCMH1 | 0.926 | 0.844 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC3 | 0.871 | 0.804 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | CBX2 | 0.765 | 0.749 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC1 | 0.706 | 0.727 | bioplex (PCGF2,PHC1) bioplex_WMM |
| PHC1 | CBX2 | 0.6 | 0.67 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| PHC1 | PHC3 | 0.364 | 0.543 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| CBX8 | PHC3 | 0.123 | 0.395 | hein_WMM bioplex_WMM youn_WMM hein (CBX8) |
| CBX8 | CBX2 | 0.01 | 0.126 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX8 | SCMH1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CBX2 | PHC3 | 0.01 | 0.1 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SCMH1 | CBX2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| SCMH1 | PHC3 | 0.009 | 0.107 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_04867 has an average edge precision of 0.527 which is ranked 2351 out of all 6965 complexes.
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