hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_04871
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2) | UniProt NCBI |
| ARAF | Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks) | UniProt NCBI |
| BRAF | Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1) | UniProt NCBI |
| MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | UniProt NCBI |
| RAF1 | RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Proto-oncogene c-RAF) (cRaf) (Raf-1) | UniProt NCBI |
| CIRBP-AS1 | NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP422 | 1.44017733727e-12 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK Cascade |
| WP:WP2828 | 2.28762317867e-12 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Bladder Cancer |
| REAC:R-HSA-5673000 | 2.91267185745e-12 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | RAF activation |
| KEGG:05219 | 3.40079695758e-12 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Bladder cancer |
| REAC:R-HSA-5674499 | 5.47745657224e-12 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Negative feedback regulation of MAPK pathway |
| REAC:R-HSA-6802948 | 9.24638111139e-12 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5675221 | 1.069112816e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Negative regulation of MAPK pathway |
| REAC:R-HSA-5674135 | 1.6138784755e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAP2K and MAPK activation |
| KEGG:04730 | 2.23888120753e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Long-term depression |
| WP:WP4205 | 2.5407755966e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MET in type 1 papillary renal cell carcinoma |
| REAC:R-HSA-6802946 | 2.66362253258e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-6802955 | 2.66362253258e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| KEGG:05213 | 3.26671148135e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Endometrial cancer |
| WP:WP4155 | 3.92666533094e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Endometrial cancer |
| KEGG:05221 | 4.26098215711e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Acute myeloid leukemia |
| KEGG:04720 | 5.04856971121e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Long-term potentiation |
| KEGG:05218 | 5.04856971121e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Melanoma |
| KEGG:05211 | 5.48379123804e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Renal cell carcinoma |
| KEGG:05223 | 5.94851930906e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Non-small cell lung cancer |
| WP:WP4255 | 7.34422357986e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Non-small cell lung cancer |
| KEGG:05214 | 8.13273383111e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Glioma |
| REAC:R-HSA-6802949 | 9.36875968493e-11 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling by RAS mutants |
| KEGG:01521 | 1.25677936764e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 1.25677936764e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Chronic myeloid leukemia |
| WP:WP2261 | 1.65570004327e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-6802952 | 1.72394634729e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling by BRAF and RAF fusions |
| KEGG:04012 | 1.75833998498e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | ErbB signaling pathway |
| WP:WP4263 | 1.76183466143e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Pancreatic adenocarcinoma pathway |
| WP:WP673 | 1.99042713333e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | ErbB Signaling Pathway |
| KEGG:05210 | 2.1287571985e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Colorectal cancer |
| WP:WP185 | 3.15366669892e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Integrin-mediated Cell Adhesion |
| KEGG:01522 | 3.42884986366e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Endocrine resistance |
| KEGG:05215 | 3.42884986366e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Prostate cancer |
| WP:WP3931 | 4.12089557789e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | ESC Pluripotency Pathways |
| REAC:R-HSA-6802957 | 5.17786010889e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Oncogenic MAPK signaling |
| KEGG:04650 | 5.58011848009e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Natural killer cell mediated cytotoxicity |
| KEGG:04270 | 5.58011848009e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Vascular smooth muscle contraction |
| HP:0001003 | 6.22196518748e-10 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Multiple lentigines |
| WP:WP4549 | 9.31307809019e-10 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Fragile X Syndrome |
| KEGG:04068 | 1.14533506948e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | FoxO signaling pathway |
| KEGG:04910 | 1.82977457169e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Insulin signaling pathway |
| KEGG:05224 | 2.23322702966e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Breast cancer |
| KEGG:05226 | 2.32184714988e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Gastric cancer |
| WP:WP4262 | 2.4398225367e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Breast cancer pathway |
| KEGG:05160 | 2.80813915265e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Hepatitis C |
| WP:WP4666 | 3.02304837427e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Hepatitis B infection |
| CORUM:5872 | 5.40532307664e-09 | 0.6 | BRAF MAP2K1 MAP2K2 | BRAF-MAP2K1-MAP2K2-YWHAE complex |
| KEGG:05161 | 5.44979244342e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Hepatitis B |
| KEGG:05225 | 6.20048608976e-09 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Hepatocellular carcinoma |
| WP:WP2636 | 6.65729208537e-09 | 0.8 | MAP2K2 ARAF MAP2K1 RAF1 | Common Pathways Underlying Drug Addiction |
| CORUM:5877 | 1.35119464053e-08 | 0.6 | BRAF MAP2K1 RAF1 | MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex |
| KEGG:04810 | 1.40867487691e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Regulation of actin cytoskeleton |
| KEGG:05205 | 1.44716326153e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Proteoglycans in cancer |
| HP:0000391 | 1.87774510411e-08 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Thickened helices |
| WP:WP382 | 2.43289665485e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK Signaling Pathway |
| HP:0007392 | 3.44137340076e-08 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Excessive wrinkled skin |
| HP:0002967 | 5.13768545876e-08 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Cubitus valgus |
| REAC:R-HSA-5673001 | 5.33219036036e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 6.06364245636e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK1/MAPK3 signaling |
| KEGG:04010 | 6.87306579932e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK signaling pathway |
| REAC:R-HSA-9607240 | 8.14967192706e-08 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | FLT3 Signaling |
| WP:WP4216 | 8.74750175162e-08 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Chromosomal and microsatellite instability in colorectal cancer |
| KEGG:05212 | 1.12467879664e-07 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Pancreatic cancer |
| REAC:R-HSA-449836 | 1.17849597997e-07 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Other interleukin signaling |
| HP:0100678 | 1.27094190031e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Premature skin wrinkling |
| REAC:R-HSA-5683057 | 1.43383123897e-07 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK family signaling cascades |
| HP:0000974 | 1.7034044586e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hyperextensible skin |
| KEGG:04914 | 1.92475995379e-07 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Progesterone-mediated oocyte maturation |
| WP:WP23 | 2.09744539303e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | B Cell Receptor Signaling Pathway |
| HP:0001004 | 3.6725895107e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Lymphedema |
| KEGG:04726 | 3.68022151048e-07 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Serotonergic synapse |
| WP:WP734 | 3.76235734517e-07 | 0.6 | BRAF MAP2K1 MAP2K2 | Serotonin Receptor 4/6/7 and NR3C Signaling |
| KEGG:04928 | 4.00496985943e-07 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Parathyroid hormone synthesis, secretion and action |
| WP:WP4301 | 5.48118700158e-07 | 0.6 | BRAF ARAF RAF1 | Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells |
| WP:WP3879 | 5.48118700158e-07 | 0.6 | MAP2K2 MAP2K1 RAF1 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| KEGG:04722 | 5.96187048479e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Neurotrophin signaling pathway |
| HP:0001034 | 6.99305873032e-07 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hypermelanotic macule |
| WP:WP732 | 7.65599689843e-07 | 0.6 | MAP2K2 MAP2K1 RAF1 | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling |
| REAC:R-HSA-5663202 | 8.62309350058e-07 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Diseases of signal transduction |
| WP:WP51 | 1.08421920618e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Regulation of Actin Cytoskeleton |
| HP:0002162 | 1.21743581079e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Low posterior hairline |
| HP:0030141 | 1.21743581079e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the posterior hairline |
| KEGG:05200 | 1.3832809713e-06 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Pathways in cancer |
| WP:WP581 | 1.74504852234e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | EPO Receptor Signaling |
| KEGG:04150 | 1.98064768411e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | mTOR signaling pathway |
| HP:0001642 | 1.98072085878e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Pulmonic stenosis |
| HP:0000465 | 1.98072085878e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Webbed neck |
| WP:WP2643 | 2.19831769952e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | Nanoparticle-mediated activation of receptor signaling |
| WP:WP437 | 2.3558861152e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | EGF/EGFR Signaling Pathway |
| HP:0000957 | 3.34518123836e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Cafe-au-lait spot |
| KEGG:05034 | 3.51323493939e-06 | 0.8 | BRAF ARAF MAP2K1 RAF1 | Alcoholism |
| WP:WP3981 | 3.65933272422e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | miRNA regulation of prostate cancer signaling pathways |
| HP:0012733 | 3.8162143365e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Macule |
| KEGG:04024 | 3.86679299989e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | cAMP signaling pathway |
| HP:0011039 | 3.98374493402e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the helix |
| WP:WP313 | 4.0130568427e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | Signaling of Hepatocyte Growth Factor Receptor |
| KEGG:04015 | 4.14895276519e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Rap1 signaling pathway |
| HP:0031654 | 4.51951245557e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal pulmonary valve physiology |
| HP:0007495 | 4.90551985117e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Prematurely aged appearance |
| WP:WP127 | 5.65516175491e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | IL-5 Signaling Pathway |
| WP:WP2332 | 6.12580709064e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | Interleukin-11 Signaling Pathway |
| WP:WP49 | 6.62182592439e-06 | 0.6 | MAP2K2 MAP2K1 RAF1 | IL-2 Signaling Pathway |
| KEGG:05216 | 6.69757781836e-06 | 0.6 | BRAF MAP2K1 MAP2K2 | Thyroid cancer |
| CORUM:5923 | 6.70868171695e-06 | 0.4 | BRAF RAF1 | RAF1-BRAF complex, RAS stimulated |
| REAC:R-HSA-449147 | 6.91462379682e-06 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signaling by Interleukins |
| HP:0008067 | 6.95633979726e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormally lax or hyperextensible skin |
| HP:0007400 | 8.94984932436e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Irregular hyperpigmentation |
| HP:0006191 | 9.05787850785e-06 | 0.6 | BRAF MAP2K1 MAP2K2 | Deep palmar crease |
| HP:0000958 | 9.92382253095e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Dry skin |
| HP:0002997 | 9.92382253095e-06 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the ulna |
| WP:WP2795 | 1.15828605529e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Cardiac Hypertrophic Response |
| HP:0002212 | 1.24298757708e-05 | 0.6 | BRAF MAP2K1 RAF1 | Curly hair |
| WP:WP3863 | 1.31231633883e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| HP:0000982 | 1.50896487458e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Palmoplantar keratoderma |
| WP:WP304 | 1.85486617316e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Kit receptor signaling pathway |
| HP:0010719 | 1.85904416172e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of hair texture |
| HP:0001048 | 1.89101201992e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Cavernous hemangioma |
| HP:0009553 | 1.96938383538e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the hairline |
| CORUM:5873 | 2.0123342217e-05 | 0.4 | RAF1 MAP2K1 | RAF1-MAP2K1-YWHAE complex |
| CORUM:5920 | 2.0123342217e-05 | 0.4 | RAF1 MAP2K1 | KSR1-RAF1-MEK complex |
| CORUM:5919 | 2.0123342217e-05 | 0.4 | BRAF RAF1 | BRAF-RAF1-14-3-3 complex |
| CORUM:5921 | 2.0123342217e-05 | 0.4 | BRAF MAP2K1 | KSR1-BRAF-MEK complex |
| KEGG:04929 | 2.13438745038e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | GnRH secretion |
| HP:0008391 | 2.14866062081e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Dystrophic fingernails |
| KEGG:04664 | 2.25729723653e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Fc epsilon RI signaling pathway |
| KEGG:04370 | 2.25729723653e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | VEGF signaling pathway |
| HP:0010647 | 2.46047759935e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal elasticity of skin |
| HP:0011361 | 2.73785465735e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Congenital abnormal hair pattern |
| WP:WP2374 | 2.78566821912e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Oncostatin M Signaling Pathway |
| WP:WP2032 | 2.92016358744e-05 | 0.6 | BRAF MAP2K1 RAF1 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| HP:0010669 | 3.05951432408e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Hypoplasia of the zygomatic bone |
| REAC:R-HSA-1280215 | 3.15061991054e-05 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Cytokine Signaling in Immune system |
| KEGG:04917 | 3.25178756029e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Prolactin signaling pathway |
| HP:0011363 | 3.41219105177e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of hair growth rate |
| HP:0002217 | 3.41219105177e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Slow-growing hair |
| HP:0040170 | 3.79094101603e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of hair growth |
| HP:0010720 | 4.08743818679e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal hair pattern |
| KEGG:05230 | 4.11682217947e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Central carbon metabolism in cancer |
| KEGG:04662 | 4.11682217947e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | B cell receptor signaling pathway |
| HP:0040072 | 4.28572779488e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of forearm bone |
| WP:WP2037 | 4.32977577664e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Prolactin Signaling Pathway |
| WP:WP2034 | 4.32977577664e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Leptin signaling pathway |
| HP:0002973 | 4.49113443655e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the forearm |
| WP:WP1544 | 4.69458396902e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP69 | 4.88441118068e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| HP:0000953 | 5.26854162891e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hyperpigmentation of the skin |
| HP:0007477 | 5.38731249165e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal dermatoglyphics |
| HP:0000348 | 5.7556748482e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | High forehead |
| HP:0000476 | 6.1081767866e-05 | 0.6 | BRAF MAP2K1 RAF1 | Cystic hygroma |
| HP:0009811 | 6.14257953384e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the elbow |
| WP:WP2355 | 6.3578533693e-05 | 0.6 | BRAF MAP2K1 RAF1 | Corticotropin-releasing hormone signaling pathway |
| KEGG:05235 | 7.05133054154e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| HP:0007440 | 7.24995537039e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Generalized hyperpigmentation |
| HP:0002692 | 7.24995537039e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Hypoplastic facial bones |
| HP:0000368 | 7.26964164372e-05 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Low-set, posteriorly rotated ears |
| KEGG:04912 | 7.32179527008e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | GnRH signaling pathway |
| WP:WP615 | 7.5737611324e-05 | 0.6 | BRAF MAP2K1 RAF1 | Senescence and Autophagy in Cancer |
| HP:0002299 | 7.87058594756e-05 | 0.6 | BRAF MAP2K1 MAP2K2 | Brittle hair |
| KEGG:04540 | 8.17438290338e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Gap junction |
| KEGG:04916 | 9.73769288451e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Melanogenesis |
| KEGG:05231 | 9.73769288451e-05 | 0.6 | MAP2K2 MAP2K1 RAF1 | Choline metabolism in cancer |
| KEGG:04660 | 0.000100724565592 | 0.6 | MAP2K2 MAP2K1 RAF1 | T cell receptor signaling pathway |
| HP:0000962 | 0.000103659897095 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hyperkeratosis |
| HP:0001654 | 0.000105628631419 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal heart valve morphology |
| HP:0001639 | 0.000113784731518 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hypertrophic cardiomyopathy |
| HP:0100037 | 0.000120204380098 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the scalp hair |
| HP:0009891 | 0.000123488554224 | 0.6 | BRAF MAP2K1 MAP2K2 | Underdeveloped supraorbital ridges |
| HP:0031653 | 0.000124632211735 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal heart valve physiology |
| HP:0001965 | 0.000131501440152 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the scalp |
| HP:0000767 | 0.000133852931609 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Pectus excavatum |
| WP:WP4269 | 0.00015011307213 | 0.4 | MAP2K2 MAP2K1 | Ethanol metabolism resulting in production of ROS by CYP2E1 |
| REAC:R-HSA-1643685 | 0.000155670343335 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Disease |
| HP:0100625 | 0.000171700780036 | 0.6 | BRAF MAP2K1 RAF1 | Enlarged thorax |
| KEGG:04071 | 0.000179646697347 | 0.6 | MAP2K2 MAP2K1 RAF1 | Sphingolipid signaling pathway |
| HP:0000470 | 0.000197154877826 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Short neck |
| KEGG:04919 | 0.00020027593347 | 0.6 | MAP2K2 MAP2K1 RAF1 | Thyroid hormone signaling pathway |
| REAC:R-HSA-5210891 | 0.000202356855584 | 0.4 | MAP2K2 MAP2K1 | Uptake and function of anthrax toxins |
| HP:0000176 | 0.000205896553803 | 0.6 | BRAF MAP2K1 MAP2K2 | Submucous cleft hard palate |
| HP:0410031 | 0.000205896553803 | 0.6 | BRAF MAP2K1 MAP2K2 | Submucous cleft of soft and hard palate |
| WP:WP366 | 0.000206095076976 | 0.6 | MAP2K2 MAP2K1 RAF1 | TGF-beta Signaling Pathway |
| WP:WP3929 | 0.000206095076976 | 0.6 | BRAF MAP2K1 RAF1 | Chemokine signaling pathway |
| WP:WP3915 | 0.000206095076976 | 0.6 | MAP2K2 MAP2K1 RAF1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| HP:0007565 | 0.000218228311494 | 0.6 | BRAF MAP2K1 MAP2K2 | Multiple cafe-au-lait spots |
| KEGG:04926 | 0.000240055495634 | 0.6 | MAP2K2 MAP2K1 RAF1 | Relaxin signaling pathway |
| HP:0001582 | 0.000244346608078 | 0.6 | BRAF MAP2K1 MAP2K2 | Redundant skin |
| KEGG:04915 | 0.000252313158511 | 0.6 | MAP2K2 MAP2K1 RAF1 | Estrogen signaling pathway |
| KEGG:04550 | 0.000258594789588 | 0.6 | MAP2K2 MAP2K1 RAF1 | Signaling pathways regulating pluripotency of stem cells |
| HP:0001631 | 0.000264453915681 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Atrial septal defect |
| KEGG:04371 | 0.000264979384683 | 0.6 | MAP2K2 MAP2K1 RAF1 | Apelin signaling pathway |
| WP:WP4239 | 0.000266187150529 | 0.6 | MAP2K2 MAP2K1 RAF1 | Epithelial to mesenchymal transition in colorectal cancer |
| HP:0011994 | 0.000268416035925 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal atrial septum morphology |
| KEGG:04210 | 0.000271467766564 | 0.6 | MAP2K2 MAP2K1 RAF1 | Apoptosis |
| WP:WP2380 | 0.000272163782488 | 0.6 | MAP2K2 MAP2K1 RAF1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| HP:0000637 | 0.000272465709143 | 0.6 | BRAF MAP2K1 MAP2K2 | Long palpebral fissure |
| KEGG:04072 | 0.000278060757653 | 0.6 | MAP2K2 MAP2K1 RAF1 | Phospholipase D signaling pathway |
| HP:0000917 | 0.000278784943944 | 0.4 | BRAF MAP2K1 | Superior pectus carinatum |
| HP:0100697 | 0.000278784943944 | 0.4 | BRAF MAP2K1 | Neurofibrosarcoma |
| HP:0008357 | 0.000278784943944 | 0.4 | BRAF MAP2K1 | Reduced factor XIII activity |
| HP:0011356 | 0.000293129340212 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Regional abnormality of skin |
| CORUM:7557 | 0.000301566439547 | 0.4 | MAP2K2 MAP2K1 | LGR4-RSPO supercomplex |
| KEGG:04062 | 0.000305495250573 | 0.6 | BRAF MAP2K1 RAF1 | Chemokine signaling pathway |
| HP:0005120 | 0.000306105484287 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal cardiac atrium morphology |
| HP:0003319 | 0.000306105484287 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the cervical spine |
| HP:0004422 | 0.000318556115604 | 0.6 | BRAF MAP2K1 MAP2K2 | Biparietal narrowing |
| KEGG:04140 | 0.000327209764734 | 0.6 | MAP2K2 MAP2K1 RAF1 | Autophagy - animal |
| KEGG:04921 | 0.000342240622109 | 0.6 | MAP2K2 MAP2K1 RAF1 | Oxytocin signaling pathway |
| HP:0002213 | 0.000351997622505 | 0.6 | BRAF MAP2K1 MAP2K2 | Fine hair |
| KEGG:04022 | 0.000390066928635 | 0.6 | MAP2K2 MAP2K1 RAF1 | cGMP-PKG signaling pathway |
| KEGG:04934 | 0.000390066928635 | 0.6 | BRAF MAP2K1 MAP2K2 | Cushing syndrome |
| WP:WP481 | 0.000395472085416 | 0.6 | MAP2K2 MAP2K1 RAF1 | Insulin Signaling |
| WP:WP22 | 0.000399978956636 | 0.4 | MAP2K2 MAP2K1 | IL-9 Signaling Pathway |
| WP:WP4223 | 0.000403236542348 | 0.6 | MAP2K2 MAP2K1 RAF1 | Ras Signaling |
| HP:0000358 | 0.00040391961752 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Posteriorly rotated ears |
| HP:0200102 | 0.000406414519902 | 0.6 | BRAF MAP2K1 MAP2K2 | Sparse or absent eyelashes |
| KEGG:04218 | 0.000424294655338 | 0.6 | MAP2K2 MAP2K1 RAF1 | Cellular senescence |
| HP:0001531 | 0.000425724578531 | 0.6 | BRAF MAP2K1 MAP2K2 | Failure to thrive in infancy |
| GO:0004674 | 0.000442234784145 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | protein serine/threonine kinase activity |
| KEGG:05164 | 0.000451232943381 | 0.6 | MAP2K2 MAP2K1 RAF1 | Influenza A |
| HP:0000915 | 0.00046457916755 | 0.4 | BRAF MAP2K1 | Pectus excavatum of inferior sternum |
| HP:0004859 | 0.00046457916755 | 0.4 | BRAF MAP2K1 | Amegakaryocytic thrombocytopenia |
| HP:0004841 | 0.00046457916755 | 0.4 | BRAF MAP2K1 | Reduced factor XII activity |
| HP:0040194 | 0.000516883468613 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Increased head circumference |
| HP:0000256 | 0.000516883468613 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Macrocephaly |
| HP:0011368 | 0.000530015044248 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Epidermal thickening |
| KEGG:05206 | 0.000538800909475 | 0.6 | MAP2K2 MAP2K1 RAF1 | MicroRNAs in cancer |
| HP:0040070 | 0.000577947900247 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal upper limb bone morphology |
| HP:0000973 | 0.000602597659635 | 0.6 | BRAF MAP2K1 MAP2K2 | Cutis laxa |
| KEGG:05167 | 0.000625511303776 | 0.6 | MAP2K2 MAP2K1 RAF1 | Kaposi sarcoma-associated herpesvirus infection |
| HP:0008872 | 0.000629050473154 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Feeding difficulties in infancy |
| HP:0001000 | 0.000629050473154 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of skin pigmentation |
| HP:0000969 | 0.000659727172756 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Edema |
| HP:0000766 | 0.000667567988101 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the sternum |
| HP:0100538 | 0.00067978918494 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the supraorbital ridges |
| HP:0100769 | 0.000696775152219 | 0.4 | BRAF MAP2K1 | Synovitis |
| WP:WP712 | 0.000699493021643 | 0.4 | BRAF MAP2K1 | Estrogen signaling pathway |
| WP:WP306 | 0.000719570270021 | 0.6 | BRAF MAP2K1 RAF1 | Focal Adhesion |
| HP:0000494 | 0.000758491406495 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Downslanted palpebral fissures |
| WP:WP205 | 0.000769338921543 | 0.4 | MAP2K2 MAP2K1 | IL-7 Signaling Pathway |
| HP:0001072 | 0.000793745195888 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Thickened skin |
| HP:0001892 | 0.000811824431159 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal bleeding |
| HP:0005280 | 0.000839518231679 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Depressed nasal bridge |
| KEGG:04014 | 0.000867405343471 | 0.6 | MAP2K2 MAP2K1 RAF1 | Ras signaling pathway |
| KEGG:04510 | 0.000939988213226 | 0.6 | BRAF MAP2K1 RAF1 | Focal adhesion |
| HP:0000286 | 0.000967765284185 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Epicanthus |
| HP:0012714 | 0.00097535418756 | 0.4 | BRAF RAF1 | Severe hearing impairment |
| HP:0008625 | 0.00097535418756 | 0.4 | BRAF RAF1 | Severe sensorineural hearing impairment |
| HP:0009810 | 0.000978202345547 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of upper limb joint |
| WP:WP2197 | 0.000998738671819 | 0.4 | RAF1 MAP2K1 | Endothelin Pathways |
| KEGG:05170 | 0.00109699385517 | 0.6 | MAP2K2 MAP2K1 RAF1 | Human immunodeficiency virus 1 infection |
| HP:0000293 | 0.00112737333582 | 0.6 | BRAF MAP2K1 MAP2K2 | Full cheeks |
| WP:WP3888 | 0.00113645450729 | 0.6 | MAP2K2 MAP2K1 RAF1 | VEGFA-VEGFR2 Signaling Pathway |
| KEGG:05163 | 0.00114726739179 | 0.6 | MAP2K2 MAP2K1 RAF1 | Human cytomegalovirus infection |
| HP:0011032 | 0.00120516054848 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of fluid regulation |
| HP:0000325 | 0.00128396303463 | 0.6 | BRAF MAP2K1 RAF1 | Triangular face |
| HP:0002857 | 0.00128396303463 | 0.6 | BRAF MAP2K1 MAP2K2 | Genu valgum |
| HP:0001638 | 0.00130615453284 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Cardiomyopathy |
| HP:0008404 | 0.00132524710908 | 0.6 | BRAF MAP2K1 MAP2K2 | Nail dystrophy |
| WP:WP3972 | 0.00135089978967 | 0.4 | RAF1 MAP2K1 | PDGFR-beta pathway |
| HP:0001260 | 0.00145518460437 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Dysarthria |
| HP:0000464 | 0.0014979455219 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the neck |
| HP:0000309 | 0.00151240558538 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the midface |
| HP:0001637 | 0.0015862762379 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal myocardium morphology |
| WP:WP3676 | 0.00164969486671 | 0.4 | BRAF MAP2K1 | BDNF-TrkB Signaling |
| KEGG:05020 | 0.00173687115815 | 0.4 | MAP2K2 MAP2K1 | Prion diseases |
| HP:0001028 | 0.00178757045499 | 0.6 | BRAF MAP2K1 MAP2K2 | Hemangioma |
| WP:WP3932 | 0.00181204447901 | 0.6 | MAP2K2 MAP2K1 RAF1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| HP:0100742 | 0.00189129875245 | 0.6 | BRAF MAP2K1 MAP2K2 | Vascular neoplasm |
| HP:0000975 | 0.00189129875245 | 0.6 | BRAF MAP2K1 MAP2K2 | Hyperhidrosis |
| HP:0001622 | 0.00189129875245 | 0.6 | BRAF MAP2K1 MAP2K2 | Premature birth |
| GO:0004672 | 0.00204929477256 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | protein kinase activity |
| HP:0001671 | 0.00206923010627 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal cardiac septum morphology |
| HP:0000914 | 0.00208920255027 | 0.4 | BRAF MAP2K1 | Shield chest |
| HP:0002046 | 0.00208920255027 | 0.4 | MAP2K2 MAP2K1 | Heat intolerance |
| HP:0000768 | 0.00228570439764 | 0.6 | BRAF MAP2K1 RAF1 | Pectus carinatum |
| REAC:R-HSA-112409 | 0.00230284247734 | 0.4 | MAP2K2 MAP2K1 | RAF-independent MAPK1/3 activation |
| HP:0000218 | 0.00231811633149 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | High palate |
| WP:WP4172 | 0.00254843909372 | 0.6 | MAP2K2 MAP2K1 RAF1 | PI3K-Akt Signaling Pathway |
| REAC:R-HSA-445144 | 0.00255837003151 | 0.4 | MAP2K2 MAP2K1 | Signal transduction by L1 |
| WP:WP2526 | 0.00259148909572 | 0.4 | RAF1 MAP2K1 | PDGF Pathway |
| WP:WP2203 | 0.00272401961957 | 0.4 | MAP2K2 MAP2K1 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| REAC:R-HSA-5339562 | 0.00282729215335 | 0.4 | MAP2K2 MAP2K1 | Uptake and actions of bacterial toxins |
| WP:WP2586 | 0.00285983596887 | 0.4 | RAF1 MAP2K1 | Aryl Hydrocarbon Receptor |
| WP:WP364 | 0.00285983596887 | 0.4 | MAP2K2 MAP2K1 | IL-6 signaling pathway |
| WP:WP286 | 0.00285983596887 | 0.4 | RAF1 MAP2K1 | IL-3 Signaling Pathway |
| HP:0008064 | 0.00286833354554 | 0.6 | BRAF MAP2K1 MAP2K2 | Ichthyosis |
| HP:0200006 | 0.00295332132996 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Slanting of the palpebral fissure |
| WP:WP4535 | 0.00314132080553 | 0.4 | MAP2K2 MAP2K1 | Envelope proteins and their potential roles in EDMD physiopathology |
| HP:0100840 | 0.00323092150032 | 0.6 | BRAF MAP2K1 MAP2K2 | Aplasia/Hypoplasia of the eyebrow |
| GO:0043406 | 0.00326130002182 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | positive regulation of MAP kinase activity |
| REAC:R-HSA-168256 | 0.00339317023665 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Immune System |
| WP:WP4566 | 0.00343593293187 | 0.4 | MAP2K2 MAP2K1 | Translation inhibitors in chronically activated PDGFRA cells |
| HP:0000508 | 0.00357043490873 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Ptosis |
| HP:0000377 | 0.00368195710745 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the pinna |
| HP:0000316 | 0.00373868304213 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Hypertelorism |
| KEGG:04151 | 0.00373902224905 | 0.6 | MAP2K2 MAP2K1 RAF1 | PI3K-Akt signaling pathway |
| WP:WP2637 | 0.00390244145107 | 0.4 | MAP2K2 MAP2K1 | Structural Pathway of Interleukin 1 (IL-1) |
| HP:0000369 | 0.00391277858584 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Low-set ears |
| HP:0000028 | 0.00406242032099 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Cryptorchidism |
| KEGG:05165 | 0.00420236199627 | 0.6 | MAP2K2 MAP2K1 RAF1 | Human papillomavirus infection |
| HP:0011381 | 0.00422256197273 | 0.4 | BRAF RAF1 | Aplasia of the semicircular canal |
| WP:WP195 | 0.00422982513182 | 0.4 | MAP2K2 MAP2K1 | IL-1 signaling pathway |
| HP:0010490 | 0.00431306699981 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the palmar creases |
| HP:0001231 | 0.00440504317323 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal fingernail morphology |
| HP:0000126 | 0.00459288028975 | 0.6 | BRAF MAP2K1 MAP2K2 | Hydronephrosis |
| HP:0010946 | 0.00459288028975 | 0.6 | BRAF MAP2K1 MAP2K2 | Dilatation of the renal pelvis |
| HP:0001018 | 0.00468875889337 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal palmar dermatoglyphics |
| HP:0002979 | 0.00478595596144 | 0.6 | BRAF MAP2K1 MAP2K2 | Bowing of the legs |
| HP:0010944 | 0.00478595596144 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal renal pelvis morphology |
| GO:0016773 | 0.00479827601007 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | phosphotransferase activity, alcohol group as acceptor |
| HP:0000357 | 0.00494556523319 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal location of ears |
| HP:0008050 | 0.00505184645775 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the palpebral fissures |
| HP:0007550 | 0.00518810524287 | 0.6 | BRAF MAP2K1 MAP2K2 | Hypohidrosis or hyperhidrosis |
| HP:0001928 | 0.00572151472074 | 0.6 | BRAF MAP2K1 RAF1 | Abnormality of coagulation |
| HP:0025276 | 0.00583238097885 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of skin adnexa physiology |
| REAC:R-HSA-162582 | 0.00595743543191 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | Signal Transduction |
| HP:0004426 | 0.00605836815217 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the cheek |
| HP:0000606 | 0.0061735066244 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the periorbital region |
| HP:0002223 | 0.00630809873773 | 0.4 | BRAF MAP2K2 | Absent eyebrow |
| WP:WP3680 | 0.00646864373199 | 0.4 | RAF1 MAP2K1 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| HP:0000400 | 0.00652760684787 | 0.6 | BRAF MAP2K1 MAP2K2 | Macrotia |
| GO:0000165 | 0.00661510979699 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | MAPK cascade |
| HP:0000276 | 0.0066485644099 | 0.6 | BRAF MAP2K1 MAP2K2 | Long face |
| WP:WP3651 | 0.00667641105618 | 0.4 | MAP2K2 RAF1 | Pathways Affected in Adenoid Cystic Carcinoma |
| WP:WP2324 | 0.00688743357746 | 0.4 | RAF1 MAP2K1 | AGE/RAGE pathway |
| HP:0000280 | 0.00702033217347 | 0.6 | BRAF MAP2K1 MAP2K2 | Coarse facial features |
| HP:0002648 | 0.00708652002063 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of calvarial morphology |
| HP:0011380 | 0.00709565752293 | 0.4 | BRAF RAF1 | Morphological abnormality of the semicircular canal |
| GO:0016301 | 0.00732992354676 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | kinase activity |
| HP:0001197 | 0.0079005654453 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of prenatal development or birth |
| GO:0023014 | 0.00798187083116 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | signal transduction by protein phosphorylation |
| HP:0000144 | 0.00807848245275 | 0.6 | BRAF MAP2K1 RAF1 | Decreased fertility |
| GO:0071902 | 0.00828847580995 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | positive regulation of protein serine/threonine kinase activity |
| HP:0000499 | 0.00835857328951 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal eyelash morphology |
| HP:0011355 | 0.00846318146995 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Localized skin lesion |
| HP:0011793 | 0.00894528033019 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Neoplasm by anatomical site |
| HP:0000765 | 0.00927785594799 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the thorax |
| HP:0100729 | 0.00938943928499 | 0.6 | BRAF MAP2K1 MAP2K2 | Large face |
| GO:0001934 | 0.00963681682922 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | positive regulation of protein phosphorylation |
| HP:0002981 | 0.00969870168399 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the calf |
| HP:0011376 | 0.00973521215689 | 0.4 | BRAF RAF1 | Morphological abnormality of the vestibule of the inner ear |
| HP:0006487 | 0.0105012068371 | 0.6 | BRAF MAP2K1 MAP2K2 | Bowing of the long bones |
| HP:0002664 | 0.0106387322837 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Neoplasm |
| HP:0000035 | 0.0107010867528 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal testis morphology |
| HP:0200007 | 0.0110031816712 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal size of the palpebral fissures |
| HP:0006504 | 0.0111739705033 | 0.6 | BRAF MAP2K1 MAP2K2 | Anomaly of the limb diaphyses |
| HP:0010668 | 0.0111739705033 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the zygomatic bone |
| GO:0043405 | 0.0112418496521 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | regulation of MAP kinase activity |
| HP:0011968 | 0.0113397146668 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Feeding difficulties |
| HP:0100886 | 0.0113397146668 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of globe location |
| HP:0040211 | 0.0116968496783 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the skin of the palm |
| HP:0011354 | 0.0118033507746 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Generalized abnormality of skin |
| HP:0000486 | 0.0119383735197 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Strabismus |
| GO:0032147 | 0.0125305574836 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | activation of protein kinase activity |
| HP:0000290 | 0.0126308245049 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the forehead |
| WP:WP75 | 0.0126363339816 | 0.4 | MAP2K2 MAP2K1 | Toll-like Receptor Signaling Pathway |
| HP:0002683 | 0.0128442724502 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the calvaria |
| GO:0042327 | 0.0131173204366 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | positive regulation of phosphorylation |
| HP:0000422 | 0.0134266053844 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the nasal bridge |
| GO:0018105 | 0.0134490676813 | 0.8 | BRAF ARAF RAF1 MAP2K2 | peptidyl-serine phosphorylation |
| HP:0012210 | 0.0136499696929 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal renal morphology |
| HP:0000549 | 0.0136499696929 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal conjugate eye movement |
| HP:0000159 | 0.0137250357747 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal lip morphology |
| HP:0010989 | 0.0138999712057 | 0.4 | BRAF MAP2K1 | Abnormality of the intrinsic pathway |
| HP:0000940 | 0.0149679510763 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal diaphysis morphology |
| KEGG:04620 | 0.0155166515839 | 0.4 | MAP2K2 MAP2K1 | Toll-like receptor signaling pathway |
| HP:0000174 | 0.0162084757532 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal palate morphology |
| KEGG:04666 | 0.0162467151192 | 0.4 | RAF1 MAP2K1 | Fc gamma R-mediated phagocytosis |
| HP:0000639 | 0.0164653870409 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Nystagmus |
| GO:0010562 | 0.0169699469456 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | positive regulation of phosphorus metabolic process |
| GO:0045937 | 0.0169699469456 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | positive regulation of phosphate metabolic process |
| HP:0012547 | 0.0173436957279 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal involuntary eye movements |
| HP:0001999 | 0.0174334049204 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal facial shape |
| HP:0000912 | 0.0175069025895 | 0.4 | BRAF RAF1 | Sprengel anomaly |
| HP:0002650 | 0.0176138590684 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Scoliosis |
| GO:0018209 | 0.0179259894308 | 0.8 | BRAF ARAF RAF1 MAP2K2 | peptidyl-serine modification |
| HP:0003196 | 0.0180762300558 | 0.6 | BRAF MAP2K1 MAP2K2 | Short nose |
| HP:0008070 | 0.0185523330327 | 0.6 | BRAF MAP2K1 MAP2K2 | Sparse hair |
| GO:0016772 | 0.0188407727751 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | transferase activity, transferring phosphorus-containing groups |
| HP:0011792 | 0.0197787034757 | 0.6 | BRAF MAP2K1 RAF1 | Neoplasm by histology |
| HP:0002120 | 0.0197787034757 | 0.6 | BRAF MAP2K1 MAP2K2 | Cerebral cortical atrophy |
| HP:0003251 | 0.0201414164419 | 0.4 | BRAF MAP2K1 | Male infertility |
| HP:0000032 | 0.0201885758558 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of male external genitalia |
| HP:0001367 | 0.0207967987511 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal joint morphology |
| KEGG:04066 | 0.020974746694 | 0.4 | MAP2K2 MAP2K1 | HIF-1 signaling pathway |
| HP:0011357 | 0.0215839586173 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of hair density |
| HP:0002815 | 0.0218504122467 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the knee |
| WP:WP1449 | 0.0226950547009 | 0.4 | MAP2K2 MAP2K1 | Regulation of toll-like receptor signaling pathway |
| HP:0010461 | 0.0230334244903 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the male genitalia |
| HP:0000811 | 0.0231442083502 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal external genitalia |
| HP:0010674 | 0.0234789391763 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the curvature of the vertebral column |
| HP:0000356 | 0.0239308330272 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the outer ear |
| HP:0010318 | 0.0244376541782 | 0.4 | BRAF RAF1 | Aplasia/Hypoplasia of the abdominal wall musculature |
| HP:0000343 | 0.0255144387308 | 0.6 | BRAF MAP2K1 MAP2K2 | Long philtrum |
| HP:0011821 | 0.0258033904131 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of facial skeleton |
| HP:0002298 | 0.0259615168254 | 0.4 | BRAF MAP2K2 | Absent hair |
| KEGG:05135 | 0.0262966325762 | 0.4 | MAP2K2 MAP2K1 | Yersinia infection |
| HP:0001156 | 0.0264139121191 | 0.6 | BRAF MAP2K1 RAF1 | Brachydactyly |
| HP:0001595 | 0.0267794985168 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal hair morphology |
| GO:0090170 | 0.0270421395626 | 0.4 | MAP2K2 MAP2K1 | regulation of Golgi inheritance |
| HP:0000545 | 0.0273340886952 | 0.6 | BRAF MAP2K1 MAP2K2 | Myopia |
| HP:0002167 | 0.0284239020962 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Neurological speech impairment |
| HP:0001547 | 0.0285935876638 | 0.6 | BRAF MAP2K1 RAF1 | Abnormality of the rib cage |
| HP:0004376 | 0.0291468055875 | 0.4 | BRAF RAF1 | Neuroblastic tumor |
| HP:0030067 | 0.0291468055875 | 0.4 | BRAF RAF1 | Peripheral primitive neuroectodermal neoplasm |
| HP:0011869 | 0.0291468055875 | 0.4 | BRAF RAF1 | Abnormal platelet function |
| HP:0003006 | 0.0291468055875 | 0.4 | BRAF RAF1 | Neuroblastoma |
| HP:0100871 | 0.0295629530581 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormality of the palm |
| GO:0031401 | 0.0295837795507 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | positive regulation of protein modification process |
| HP:0000492 | 0.0300073830984 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal eyelid morphology |
| HP:0006695 | 0.0308081945037 | 0.4 | BRAF RAF1 | Atrioventricular canal defect |
| HP:0030065 | 0.0325153883173 | 0.4 | BRAF RAF1 | Primitive neuroectodermal tumor |
| HP:0011025 | 0.0335159803875 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal cardiovascular system physiology |
| HP:0002007 | 0.0336572505221 | 0.6 | BRAF MAP2K1 MAP2K2 | Frontal bossing |
| HP:0011218 | 0.0336572505221 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal shape of the frontal region |
| WP:WP1984 | 0.0337317416567 | 0.4 | BRAF ARAF | Integrated Breast Cancer Pathway |
| GO:0018193 | 0.0346157101499 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | peptidyl-amino acid modification |
| HP:0000238 | 0.0351008048623 | 0.6 | BRAF MAP2K1 MAP2K2 | Hydrocephalus |
| HP:0011710 | 0.0379116132621 | 0.4 | BRAF RAF1 | Bundle branch block |
| HP:0001480 | 0.0379116132621 | 0.4 | BRAF RAF1 | Freckling |
| HP:0010438 | 0.0384968933304 | 0.6 | BRAF MAP2K1 MAP2K2 | Abnormal ventricular septum morphology |
| HP:0000135 | 0.0388870874414 | 0.6 | BRAF MAP2K1 RAF1 | Hypogonadism |
| HP:0000077 | 0.0399184873082 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the kidney |
| HP:0004306 | 0.0417377803311 | 0.4 | BRAF RAF1 | Abnormal endocardium morphology |
| HP:0010990 | 0.0417377803311 | 0.4 | BRAF MAP2K1 | Abnormality of the common coagulation pathway |
| HP:0001872 | 0.0421029548475 | 0.6 | BRAF MAP2K1 RAF1 | Abnormal thrombocyte morphology |
| HP:0011138 | 0.0437068046207 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of skin adnexa morphology |
| HP:0010935 | 0.0446037445864 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of the upper urinary tract |
| HP:0010991 | 0.0457467210618 | 0.4 | BRAF RAF1 | Abnormal morphology of the abdominal musculature |
| HP:0004322 | 0.0462525985754 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Short stature |
| HP:0001871 | 0.0471879554362 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormality of blood and blood-forming tissues |
| HP:0004097 | 0.0472480670031 | 0.6 | BRAF MAP2K1 RAF1 | Deviation of finger |
| CORUM:0000000 | 0.0474603483533 | 1.0 | RAF1 BRAF ARAF MAP2K1 MAP2K2 | CORUM root |
| HP:0002208 | 0.0478196851342 | 0.4 | BRAF RAF1 | Coarse hair |
| HP:0001627 | 0.047946296424 | 0.8 | RAF1 BRAF MAP2K1 MAP2K2 | Abnormal heart morphology |
| HP:0000995 | 0.0499382869304 | 0.4 | BRAF RAF1 | Melanocytic nevus |
| HP:0001641 | 0.0499382869304 | 0.4 | BRAF RAF1 | Abnormal pulmonary valve morphology |
| HP:0004415 | 0.0499382869304 | 0.4 | BRAF RAF1 | Pulmonary artery stenosis |
| CORUM:5924 | 0.0499494897235 | 0.2 | RAF1 | RAF1-CNK1 complex, RAS stimulated |
| CORUM:5925 | 0.0499494897235 | 0.2 | BRAF | BRAF-CNK1 complex, not RAS stimulated |
| CORUM:7361 | 0.0499494897235 | 0.2 | ARAF | ARAF-PIK3R1 complex |
| CORUM:5922 | 0.0499494897235 | 0.2 | RAF1 | RAF1-RAS complex, EGF induced |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAP2K1 | BRAF | 0.956 | 0.862 | hein_WMM bioplex (BRAF) bioplex_WMM boldt hein (MAP2K1) boldt_WMM |
| MAP2K1 | MAP2K2 | 0.843 | 0.788 | bioplex (MAP2K2) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| BRAF | MAP2K2 | 0.598 | 0.668 | bioplex (BRAF) bioplex_WMM boldt boldt_WMM |
| BRAF | RAF1 | 0.186 | 0.44 | hein_WMM bioplex (BRAF) bioplex_WMM boldt (RAF1) boldt_WMM |
| BRAF | ARAF | 0.184 | 0.437 | hein_WMM bioplex (BRAF) bioplex_WMM boldt boldt_WMM |
| CIRBP-AS1 | BRAF | 0.055 | 0.305 | bioplex (BRAF) bioplex_WMM boldt_WMM |
| CIRBP-AS1 | MAP2K1 | 0.009 | 0.091 | bioplex_WMM WMM_only boldt_WMM |
| CIRBP-AS1 | MAP2K2 | 0.009 | 0.097 | bioplex_WMM WMM_only boldt_WMM |
| ARAF | RAF1 | 0.008 | 0.041 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CIRBP-AS1 | RAF1 | 0.008 | 0.023 | bioplex_WMM WMM_only boldt_WMM |
| CIRBP-AS1 | ARAF | 0.007 | 0.007 | bioplex_WMM WMM_only |
| MAP2K1 | ARAF | 0.006 | 0.001 | hein_WMM bioplex_WMM youn_WMM hein (MAP2K1) |
| MAP2K2 | RAF1 | 0.005 | 0.011 | bioplex (MAP2K2) bioplex_WMM boldt (RAF1) youn_WMM boldt_WMM |
| MAP2K2 | ARAF | 0.005 | 0.009 | bioplex (MAP2K2) bioplex_WMM youn_WMM |
| MAP2K1 | RAF1 | 0.005 | 0.009 | hein_WMM bioplex_WMM boldt (RAF1) youn_WMM hein (MAP2K1) boldt_WMM |
Images
Click to enlarge
Complex HuMAP2_04871 has an average edge precision of 0.253 which is ranked 5345 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAP2K2 | HuMAP2_01070 HuMAP2_03036 HuMAP2_04784 HuMAP2_04871 HuMAP2_06922 |
| ARAF | HuMAP2_01070 HuMAP2_04871 |
| BRAF | HuMAP2_01070 HuMAP2_03036 HuMAP2_04871 |
| MAP2K1 | HuMAP2_01070 HuMAP2_03036 HuMAP2_04487 HuMAP2_04871 |
| RAF1 | HuMAP2_01070 HuMAP2_01698 HuMAP2_04211 HuMAP2_04871 |
| CIRBP-AS1 | HuMAP2_01070 HuMAP2_04871 |