hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04874
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B (Mitotic arrest deficient 2-like protein 2) (MAD2-like protein 2) (REV7 homolog) (hREV7) | UniProt NCBI |
| SHLD2 | Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7578 | 1.67592346237e-06 | 1.0 | MAD2L2 SHLD2 | Shieldin complex |
| GO:0045830 | 0.00946729163895 | 1.0 | MAD2L2 SHLD2 | positive regulation of isotype switching |
| GO:0002714 | 0.020287053512 | 1.0 | MAD2L2 SHLD2 | positive regulation of B cell mediated immunity |
| GO:0002891 | 0.020287053512 | 1.0 | MAD2L2 SHLD2 | positive regulation of immunoglobulin mediated immune response |
| GO:0045191 | 0.020287053512 | 1.0 | MAD2L2 SHLD2 | regulation of isotype switching |
| GO:2001034 | 0.0247952876258 | 1.0 | MAD2L2 SHLD2 | positive regulation of double-strand break repair via nonhomologous end joining |
| GO:0002639 | 0.0473364581948 | 1.0 | MAD2L2 SHLD2 | positive regulation of immunoglobulin production |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAD2L2 | SHLD2 | 0.066 | 0.349 | hein_WMM hein (MAD2L2) |
Images
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Complex HuMAP2_04874 has an average edge precision of 0.349 which is ranked 3979 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAD2L2 | HuMAP2_03200 HuMAP2_04874 HuMAP2_05505 |
| SHLD2 | HuMAP2_03200 HuMAP2_04874 HuMAP2_05505 |