hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04879
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| STRADB | STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2) | UniProt NCBI |
| ATP6V1C1 | V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1) | UniProt NCBI |
| STRADA | STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96) | UniProt NCBI |
| STK11 | Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19) | UniProt NCBI |
| CAB39 | Calcium-binding protein 39 (MO25alpha) (Protein Mo25) | UniProt NCBI |
| WDR45B | WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein) | UniProt NCBI |
| CAB39L | Calcium-binding protein 39-like (Antigen MLAA-34) (MO25beta) (Mo25-like protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380972 | 5.64001821847e-11 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | Energy dependent regulation of mTOR by LKB1-AMPK |
| KEGG:04150 | 2.67777182901e-10 | 0.857142857143 | CAB39 ATP6V1C1 STRADB CAB39L STRADA STK11 | mTOR signaling pathway |
| REAC:R-HSA-165159 | 3.30003828923e-10 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | mTOR signalling |
| CORUM:6053 | 3.38154272427e-09 | 0.428571428571 | CAB39 STRADA STK11 | LKB1-STRAD-MO25 complex |
| KEGG:04152 | 2.39024614212e-08 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | AMPK signaling pathway |
| WP:WP1403 | 5.7157777521e-07 | 0.571428571429 | STRADB CAB39 STRADA STK11 | AMP-activated Protein Kinase (AMPK) Signaling |
| WP:WP3595 | 0.000150938581911 | 0.285714285714 | STRADB STK11 | mir-124 predicted interactions with cell cycle and differentiation |
| WP:WP3932 | 0.000152413265395 | 0.571428571429 | CAB39 STK11 CAB39L STRADA | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| GO:0007050 | 0.000321055197854 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | cell cycle arrest |
| REAC:R-HSA-162582 | 0.00544066626924 | 0.857142857143 | CAB39 ATP6V1C1 STRADB CAB39L STRADA STK11 | Signal Transduction |
| GO:0004674 | 0.00891451540705 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | protein serine/threonine kinase activity |
| GO:0045786 | 0.0387059497805 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | negative regulation of cell cycle |
| GO:0004672 | 0.0406938796461 | 0.714285714286 | STRADB CAB39 STK11 CAB39L STRADA | protein kinase activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP6V1C1 | CAB39 | 0.997 | 0.93 | fraction |
| CAB39L | CAB39 | 0.992 | 0.912 | bioplex (CAB39L) bioplex_WMM |
| STRADA | STK11 | 0.976 | 0.889 | bioplex (STK11) bioplex_WMM |
| CAB39 | STRADB | 0.907 | 0.83 | bioplex (STRADB) bioplex_WMM |
| CAB39L | STRADA | 0.893 | 0.819 | bioplex (CAB39L) bioplex_WMM |
| STK11 | STRADB | 0.602 | 0.671 | bioplex (STK11,STRADB) bioplex_WMM |
| ATP6V1C1 | CAB39L | 0.59 | 0.664 | fraction |
| STK11 | CAB39 | 0.09 | 0.354 | bioplex (STK11) bioplex_WMM |
| ATP6V1C1 | WDR45B | 0.055 | 0.305 | fraction |
| CAB39L | STK11 | 0.029 | 0.231 | bioplex (CAB39L) bioplex_WMM |
| STRADA | CAB39 | 0.012 | 0.15 | bioplex_WMM WMM_only |
| STRADA | STRADB | 0.008 | 0.038 | bioplex_WMM WMM_only |
| STK11 | WDR45B | 0.007 | 0.004 | bioplex_WMM WMM_only |
| STRADA | WDR45B | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CAB39 | WDR45B | 0.0 | 0.008 | bioplex_WMM fraction |
Images
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Complex HuMAP2_04879 has an average edge precision of 0.454 which is ranked 2850 out of all 6965 complexes.
Related Complexes