hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04880
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DYNLRB1 | Dynein light chain roadblock-type 1 (Bithoraxoid-like protein) (BLP) (Dynein light chain 2A, cytoplasmic) (Dynein-associated protein Km23) (Roadblock domain-containing protein 1) | UniProt NCBI |
| MASTL | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | UniProt NCBI |
| DYNLT1 | Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog) | UniProt NCBI |
| ABHD17B | Alpha/beta hydrolase domain-containing protein 17B (Abhydrolase domain-containing protein 17B) (EC 3.1.2.22) | UniProt NCBI |
| DYNC1I1 | Cytoplasmic dynein 1 intermediate chain 1 (Cytoplasmic dynein intermediate chain 1) (Dynein intermediate chain 1, cytosolic) (DH IC-1) | UniProt NCBI |
| DYNC1LI2 | Cytoplasmic dynein 1 light intermediate chain 2 (Dynein light intermediate chain 2, cytosolic) (LIC-2) (LIC53/55) | UniProt NCBI |
| DYNLT3 | Dynein light chain Tctex-type 3 (Protein 91/23) (T-complex-associated testis-expressed 1-like) | UniProt NCBI |
| HECTD1 | E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECTD1) | UniProt NCBI |
| CLMN | Calmin (Calponin-like transmembrane domain protein) | UniProt NCBI |
| WDR60 | WD repeat-containing protein 60 | UniProt NCBI |
| TCTEX1D2 | Tctex1 domain-containing protein 2 | UniProt NCBI |
| WDR34 | WD repeat-containing protein 34 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4532 | 1.22808431466e-18 | 0.666666666667 | TCTEX1D2 DYNLT3 WDR60 WDR34 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | Intraflagellar transport proteins binding to dynein |
| GO:0005868 | 5.18612906167e-17 | 0.666666666667 | TCTEX1D2 DYNLT3 WDR60 WDR34 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | cytoplasmic dynein complex |
| CORUM:6236 | 3.48963774074e-15 | 0.5 | TCTEX1D2 DYNLT3 WDR34 WDR60 DYNLT1 DYNLRB1 | Dynein-2 complex, cytoplasmic |
| GO:0030286 | 3.9139701546e-14 | 0.666666666667 | TCTEX1D2 DYNLT3 WDR60 WDR34 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | dynein complex |
| GO:0005875 | 8.34700006544e-10 | 0.666666666667 | TCTEX1D2 DYNLT3 WDR60 WDR34 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | microtubule associated complex |
| WP:WP4352 | 4.48710296484e-07 | 0.5 | TCTEX1D2 DYNLT3 WDR34 WDR60 DYNLT1 DYNLRB1 | Ciliary landscape |
| GO:0045504 | 8.60085109304e-06 | 0.333333333333 | DYNC1LI2 WDR34 WDR60 DYNC1I1 | dynein heavy chain binding |
| REAC:R-HSA-5620924 | 1.42866027721e-05 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | Intraflagellar transport |
| WP:WP4536 | 6.88582817633e-05 | 0.333333333333 | DYNLT1 WDR34 WDR60 TCTEX1D2 | Genes related to primary cilium development (based on CRISPR) |
| GO:0015630 | 0.000132619089487 | 0.75 | TCTEX1D2 DYNLT3 MASTL WDR60 DYNC1LI2 WDR34 DYNLT1 DYNLRB1 DYNC1I1 | microtubule cytoskeleton |
| HP:0000895 | 0.00014351755231 | 0.25 | WDR34 WDR60 TCTEX1D2 | Lateral clavicle hook |
| GO:0007018 | 0.000572172077006 | 0.5 | TCTEX1D2 DYNLRB1 WDR34 DYNC1LI2 WDR60 DYNC1I1 | microtubule-based movement |
| GO:0044430 | 0.00112831058533 | 0.75 | TCTEX1D2 DYNLT3 MASTL WDR60 DYNC1LI2 WDR34 DYNLT1 DYNLRB1 DYNC1I1 | cytoskeletal part |
| GO:0045503 | 0.00167376753379 | 0.25 | WDR34 WDR60 DYNC1I1 | dynein light chain binding |
| GO:0010970 | 0.00170079035084 | 0.416666666667 | TCTEX1D2 DYNLRB1 WDR34 WDR60 DYNC1I1 | transport along microtubule |
| GO:0042073 | 0.00272655355007 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | intraciliary transport |
| REAC:R-HSA-5617833 | 0.00289136667653 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | Cilium Assembly |
| GO:0099111 | 0.0029548300786 | 0.416666666667 | TCTEX1D2 DYNLRB1 WDR34 WDR60 DYNC1I1 | microtubule-based transport |
| GO:0030705 | 0.00387425102711 | 0.416666666667 | TCTEX1D2 DYNLRB1 WDR34 WDR60 DYNC1I1 | cytoskeleton-dependent intracellular transport |
| GO:0098840 | 0.0057483644656 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | protein transport along microtubule |
| GO:0099118 | 0.0057483644656 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | microtubule-based protein transport |
| HP:0010480 | 0.00707169074685 | 0.166666666667 | WDR60 WDR34 | Urethral fistula |
| HP:0008716 | 0.00707169074685 | 0.166666666667 | WDR60 WDR34 | Urethrovaginal fistula |
| HP:0006644 | 0.00707169074685 | 0.166666666667 | WDR60 WDR34 | Thoracic dysplasia |
| GO:0007017 | 0.00738314857735 | 0.583333333333 | TCTEX1D2 WDR34 WDR60 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | microtubule-based process |
| GO:0005856 | 0.00742103771293 | 0.75 | TCTEX1D2 DYNLT3 MASTL WDR60 DYNC1LI2 WDR34 DYNLT1 DYNLRB1 DYNC1I1 | cytoskeleton |
| HP:0010564 | 0.00989593507166 | 0.166666666667 | WDR60 WDR34 | Bifid epiglottis |
| REAC:R-HSA-1852241 | 0.0127985326453 | 0.333333333333 | DYNLRB1 WDR34 WDR60 TCTEX1D2 | Organelle biogenesis and maintenance |
| HP:0003762 | 0.0131886734759 | 0.166666666667 | WDR60 WDR34 | Uterus didelphys |
| GO:0003777 | 0.0142357119629 | 0.333333333333 | DYNLRB1 WDR34 WDR60 DYNC1I1 | microtubule motor activity |
| KEGG:04962 | 0.0207426150079 | 0.166666666667 | DYNC1LI2 DYNC1I1 | Vasopressin-regulated water reabsorption |
| HP:0005716 | 0.0211771097175 | 0.166666666667 | WDR60 WDR34 | Lethal skeletal dysplasia |
| HP:0009106 | 0.0258715475833 | 0.166666666667 | WDR60 WDR34 | Abnormal pelvis bone ossification |
| GO:1902494 | 0.0310109063256 | 0.666666666667 | TCTEX1D2 DYNLT3 WDR60 WDR34 DYNC1LI2 DYNLT1 DYNLRB1 DYNC1I1 | catalytic complex |
| HP:0004599 | 0.0310319595847 | 0.166666666667 | WDR60 WDR34 | Absent or minimally ossified vertebral bodies |
| HP:0002006 | 0.036657717165 | 0.166666666667 | WDR60 WDR34 | Facial cleft |
| HP:0005483 | 0.036657717165 | 0.166666666667 | WDR60 WDR34 | Abnormal epiglottis morphology |
| HP:0000889 | 0.0421022432013 | 0.25 | WDR34 WDR60 TCTEX1D2 | Abnormality of the clavicle |
| HP:0000774 | 0.0434406376172 | 0.25 | WDR34 WDR60 TCTEX1D2 | Narrow chest |
| GO:0003774 | 0.0454340466991 | 0.333333333333 | DYNLRB1 WDR34 WDR60 DYNC1I1 | motor activity |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WDR60 | TCTEX1D2 | 0.98 | 0.896 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2,WDR60) gupta_WMM boldt_WMM |
| DYNLT1 | DYNC1LI2 | 0.96 | 0.867 | hein_WMM bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) youn_WMM Malo gupta_WMM fraction boldt_WMM |
| TCTEX1D2 | DYNLT1 | 0.912 | 0.835 | bioplex_WMM gupta (DYNLT1) boldt (DYNLT1,TCTEX1D2) gupta_WMM boldt_WMM |
| DYNLT1 | WDR34 | 0.857 | 0.794 | bioplex (WDR34) bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| WDR34 | DYNLRB1 | 0.771 | 0.75 | hein_WMM bioplex (WDR34) bioplex_WMM boldt (WDR34) hein (DYNLRB1) gupta_WMM boldt_WMM |
| DYNLT1 | DYNLRB1 | 0.7 | 0.722 | hein_WMM bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| WDR60 | DYNLT1 | 0.344 | 0.534 | bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) gupta_WMM boldt_WMM |
| DYNLRB1 | DYNC1LI2 | 0.332 | 0.524 | hein_WMM bioplex_WMM boldt youn_WMM hein (DYNLRB1) gupta_WMM fraction boldt_WMM |
| TCTEX1D2 | WDR34 | 0.254 | 0.478 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2,WDR34) gupta_WMM boldt_WMM |
| WDR60 | DYNLRB1 | 0.219 | 0.465 | hein_WMM bioplex_WMM boldt hein (DYNLRB1) gupta_WMM boldt_WMM |
| TCTEX1D2 | CLMN | 0.175 | 0.435 | bioplex (TCTEX1D2) bioplex_WMM |
| DYNC1I1 | DYNLT3 | 0.059 | 0.328 | bioplex (DYNC1I1) bioplex_WMM |
| WDR60 | WDR34 | 0.057 | 0.324 | hein_WMM bioplex_WMM boldt (WDR34,WDR60) gupta_WMM boldt_WMM |
| DYNLT3 | DYNLRB1 | 0.055 | 0.309 | hein_WMM bioplex_WMM boldt hein (DYNLRB1) boldt_WMM |
| TCTEX1D2 | ABHD17B | 0.045 | 0.282 | bioplex (TCTEX1D2) bioplex_WMM boldt (TCTEX1D2) boldt_WMM |
| DYNLT1 | MASTL | 0.038 | 0.263 | gupta (DYNLT1) boldt (DYNLT1) youn_WMM gupta_WMM boldt_WMM |
| DYNC1I1 | DYNC1LI2 | 0.037 | 0.266 | bioplex (DYNC1I1) bioplex_WMM gupta_WMM |
| DYNLT1 | HECTD1 | 0.024 | 0.212 | bioplex_WMM gupta (DYNLT1) boldt (DYNLT1) youn_WMM gupta_WMM boldt_WMM |
| TCTEX1D2 | DYNLRB1 | 0.013 | 0.144 | bioplex_WMM boldt (TCTEX1D2) gupta_WMM boldt_WMM |
| DYNLT3 | DYNLT1 | 0.013 | 0.155 | boldt (DYNLT1) boldt_WMM |
| DYNC1I1 | DYNLRB1 | 0.012 | 0.144 | bioplex (DYNC1I1) bioplex_WMM gupta_WMM |
| DYNLT3 | TCTEX1D2 | 0.011 | 0.142 | boldt (TCTEX1D2) boldt_WMM |
| DYNLT3 | WDR34 | 0.01 | 0.14 | hein_WMM bioplex_WMM boldt boldt_WMM |
| DYNLT3 | DYNC1LI2 | 0.01 | 0.126 | hein_WMM bioplex_WMM boldt boldt_WMM |
| DYNC1I1 | WDR34 | 0.01 | 0.126 | bioplex (DYNC1I1) bioplex_WMM gupta_WMM |
| WDR34 | DYNC1LI2 | 0.009 | 0.102 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| WDR60 | CLMN | 0.008 | 0.095 | bioplex_WMM WMM_only |
| CLMN | WDR34 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| DYNLT3 | WDR60 | 0.008 | 0.032 | hein_WMM boldt boldt_WMM |
| WDR60 | DYNC1LI2 | 0.007 | 0.005 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| CLMN | ABHD17B | 0.007 | 0.004 | bioplex_WMM WMM_only |
| WDR60 | ABHD17B | 0.007 | 0.006 | bioplex_WMM boldt boldt_WMM |
| TCTEX1D2 | DYNC1LI2 | 0.007 | 0.003 | boldt gupta_WMM boldt_WMM |
| HECTD1 | DYNC1LI2 | 0.007 | 0.003 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CLMN | HECTD1 | 0.007 | 0.004 | youn_WMM WMM_only |
| WDR60 | MASTL | 0.007 | 0.005 | boldt youn_WMM gupta_WMM boldt_WMM |
| WDR34 | MASTL | 0.007 | 0.002 | boldt gupta_WMM boldt_WMM |
| CLMN | DYNLRB1 | 0.007 | 0.002 | youn_WMM WMM_only |
| CLMN | DYNC1LI2 | 0.007 | 0.004 | youn_WMM WMM_only |
| ABHD17B | WDR34 | 0.007 | 0.001 | bioplex_WMM boldt boldt_WMM |
| CLMN | DYNLT1 | 0.007 | 0.0 | youn_WMM WMM_only |
| HECTD1 | MASTL | 0.007 | 0.001 | boldt youn_WMM gupta_WMM boldt_WMM |
| CLMN | MASTL | 0.007 | 0.002 | youn_WMM WMM_only |
| ABHD17B | DYNC1LI2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| DYNC1I1 | WDR60 | 0.007 | 0.006 | gupta_WMM WMM_only |
| DYNC1I1 | TCTEX1D2 | 0.007 | 0.006 | gupta_WMM WMM_only |
| DYNC1I1 | MASTL | 0.007 | 0.006 | gupta_WMM WMM_only |
| DYNLRB1 | MASTL | 0.007 | 0.004 | boldt gupta_WMM boldt_WMM |
| TCTEX1D2 | MASTL | 0.007 | 0.003 | boldt gupta_WMM boldt_WMM |
| ABHD17B | DYNLRB1 | 0.007 | 0.004 | bioplex_WMM boldt boldt_WMM |
| WDR60 | HECTD1 | 0.007 | 0.006 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| DYNLRB1 | HECTD1 | 0.007 | 0.001 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| DYNC1LI2 | MASTL | 0.007 | 0.005 | boldt youn_WMM gupta_WMM boldt_WMM |
| WDR34 | HECTD1 | 0.007 | 0.001 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| DYNLT3 | ABHD17B | 0.007 | 0.006 | boldt boldt_WMM |
| DYNLT3 | MASTL | 0.006 | 0.005 | boldt boldt_WMM |
| DYNLT3 | HECTD1 | 0.006 | 0.003 | boldt boldt_WMM |
| ABHD17B | DYNLT1 | 0.006 | 0.007 | bioplex_WMM boldt boldt_WMM |
| TCTEX1D2 | HECTD1 | 0.006 | 0.007 | bioplex (TCTEX1D2) boldt gupta_WMM boldt_WMM |
| DYNC1I1 | HECTD1 | 0.005 | 0.009 | bioplex (DYNC1I1) gupta_WMM |
| DYNC1I1 | DYNLT1 | 0.004 | 0.014 | gupta (DYNLT1) gupta_WMM |
Images
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Complex HuMAP2_04880 has an average edge precision of 0.175 which is ranked 6472 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DYNLRB1 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |
| MASTL | HuMAP2_04880 HuMAP2_04987 HuMAP2_05294 HuMAP2_05566 |
| DYNLT1 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |
| ABHD17B | HuMAP2_01183 HuMAP2_01932 HuMAP2_04880 HuMAP2_06863 |
| DYNC1I1 | HuMAP2_00600 HuMAP2_04880 |
| DYNC1LI2 | HuMAP2_02747 HuMAP2_02795 HuMAP2_04880 |
| DYNLT3 | HuMAP2_00600 HuMAP2_04880 |
| HECTD1 | HuMAP2_02254 HuMAP2_03761 HuMAP2_04880 |
| CLMN | HuMAP2_01183 HuMAP2_01932 HuMAP2_04880 HuMAP2_06863 |
| WDR60 | HuMAP2_01183 HuMAP2_04167 HuMAP2_04880 |
| TCTEX1D2 | HuMAP2_01183 HuMAP2_01932 HuMAP2_04167 HuMAP2_04880 HuMAP2_06863 |
| WDR34 | HuMAP2_01183 HuMAP2_03026 HuMAP2_04880 |