hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04884
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DPP8 | Dipeptidyl peptidase 8 (DP8) (EC 3.4.14.5) (Dipeptidyl peptidase IV-related protein 1) (DPRP-1) (Dipeptidyl peptidase VIII) (DPP VIII) (Prolyl dipeptidase DPP8) | UniProt NCBI |
| TRMT6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | UniProt NCBI |
| TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) | UniProt NCBI |
| ARHGEF12 | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | UniProt NCBI |
| CC2D1A | Coiled-coil and C2 domain-containing protein 1A (Akt kinase-interacting protein 1) (Five prime repressor element under dual repression-binding protein 1) (FRE under dual repression-binding protein 1) (Freud-1) (Putative NF-kappa-B-activating protein 023N) | UniProt NCBI |
| EVL | Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like) | UniProt NCBI |
| METTL1 | tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (miRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.-) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) | UniProt NCBI |
| WDR4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (Protein Wuho homolog) (hWH) (WD repeat-containing protein 4) | UniProt NCBI |
| SNRPD3 | Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6782315 | 1.22791327062e-06 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | tRNA modification in the nucleus and cytosol |
| GO:0043527 | 3.05058200216e-05 | 0.333333333333 | TRMT61A WDR4 TRMT6 | tRNA methyltransferase complex |
| REAC:R-HSA-72306 | 5.06866182303e-05 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | tRNA processing |
| GO:0008175 | 9.60189204298e-05 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | tRNA methyltransferase activity |
| GO:0008173 | 0.00137843937587 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | RNA methyltransferase activity |
| GO:0006400 | 0.00261126879832 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | tRNA modification |
| REAC:R-HSA-8953854 | 0.0034315371114 | 0.555555555556 | TRMT6 TRMT61A SNRPD3 WDR4 METTL1 | Metabolism of RNA |
| GO:0008033 | 0.0122267246852 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | tRNA processing |
| GO:0140101 | 0.0148561819053 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | catalytic activity, acting on a tRNA |
| GO:0034708 | 0.015428956119 | 0.444444444444 | TRMT61A SNRPD3 WDR4 TRMT6 | methyltransferase complex |
| GO:0008176 | 0.0162296428096 | 0.222222222222 | WDR4 METTL1 | tRNA (guanine-N7-)-methyltransferase activity |
| GO:0009451 | 0.0307315716986 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | RNA modification |
| GO:0008757 | 0.0454250718624 | 0.444444444444 | TRMT6 TRMT61A WDR4 METTL1 | S-adenosylmethionine-dependent methyltransferase activity |
| GO:0031515 | 0.0486736709081 | 0.222222222222 | TRMT61A TRMT6 | tRNA (m1A) methyltransferase complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRMT61A | TRMT6 | 1.0 | 0.949 | bioplex (TRMT61A) bioplex_WMM Guru youn_WMM Malo fraction |
| TRMT61A | ARHGEF12 | 0.591 | 0.664 | bioplex (TRMT61A) bioplex_WMM |
| TRMT61A | EVL | 0.148 | 0.41 | bioplex (EVL) bioplex_WMM |
| TRMT6 | SNRPD3 | 0.144 | 0.405 | youn_WMM fraction |
| METTL1 | TRMT61A | 0.14 | 0.406 | fraction |
| METTL1 | WDR4 | 0.09 | 0.354 | bioplex (METTL1,WDR4) bioplex_WMM fraction |
| TRMT61A | SNRPD3 | 0.086 | 0.352 | youn_WMM fraction |
| WDR4 | SNRPD3 | 0.081 | 0.35 | bioplex (WDR4) fraction |
| DPP8 | WDR4 | 0.071 | 0.352 | bioplex () bioplex_WMM |
| TRMT6 | CC2D1A | 0.029 | 0.232 | youn_WMM fraction |
| CC2D1A | SNRPD3 | 0.02 | 0.185 | youn_WMM gupta_WMM fraction |
| METTL1 | TRMT6 | 0.011 | 0.144 | fraction |
| METTL1 | ARHGEF12 | 0.008 | 0.066 | fraction |
| TRMT6 | ARHGEF12 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| ARHGEF12 | CC2D1A | 0.007 | 0.001 | youn_WMM WMM_only |
| EVL | SNRPD3 | 0.007 | 0.002 | gupta_WMM WMM_only |
| DPP8 | SNRPD3 | 0.007 | 0.0 | bioplex_WMM WMM_only boldt_WMM |
| WDR4 | ARHGEF12 | 0.006 | 0.004 | fraction |
| ARHGEF12 | SNRPD3 | 0.004 | 0.011 | youn_WMM fraction |
| METTL1 | SNRPD3 | 0.0 | 0.01 | fraction |
| WDR4 | TRMT6 | 0.0 | 0.012 | fraction |
| WDR4 | CC2D1A | 0.0 | 0.006 | fraction |
| METTL1 | CC2D1A | 0.0 | 0.002 | fraction |
Images
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Complex HuMAP2_04884 has an average edge precision of 0.215 which is ranked 5952 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DPP8 | HuMAP2_00198 HuMAP2_00410 HuMAP2_00705 HuMAP2_01299 HuMAP2_02196 HuMAP2_02717 HuMAP2_04884 HuMAP2_05049 HuMAP2_06940 |
| TRMT6 | HuMAP2_00423 HuMAP2_04884 HuMAP2_06453 |
| TRMT61A | HuMAP2_00423 HuMAP2_04884 HuMAP2_06453 |
| ARHGEF12 | HuMAP2_00871 HuMAP2_04884 HuMAP2_06453 |
| CC2D1A | HuMAP2_02042 HuMAP2_04884 HuMAP2_06235 |
| EVL | HuMAP2_00542 HuMAP2_04884 HuMAP2_06959 |
| METTL1 | HuMAP2_00198 HuMAP2_00410 HuMAP2_02717 HuMAP2_04884 |
| WDR4 | HuMAP2_00198 HuMAP2_00410 HuMAP2_01299 HuMAP2_02717 HuMAP2_04884 |
| SNRPD3 | HuMAP2_04884 HuMAP2_06616 |