hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04891
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ABRAXAS1 | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | UniProt NCBI |
| BABAM1 | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | UniProt NCBI |
| ABRAXAS2 | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | UniProt NCBI |
| BRCC3 | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | UniProt NCBI |
| BABAM2 | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | UniProt NCBI |
| UIMC1 | BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5689901 | 2.51625477219e-14 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | Metalloprotease DUBs |
| GO:0070531 | 1.03206737618e-12 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | BRCA1-A complex |
| GO:0070536 | 1.96017005921e-12 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | protein K63-linked deubiquitination |
| KEGG:03440 | 2.98877484701e-11 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Homologous recombination |
| GO:0072425 | 6.3229743118e-11 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | signal transduction involved in G2 DNA damage checkpoint |
| REAC:R-HSA-5693571 | 1.80462896099e-09 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Nonhomologous End-Joining (NHEJ) |
| GO:0070552 | 1.82947049513e-09 | 0.666666666667 | BABAM1 ABRAXAS2 BRCC3 BABAM2 | BRISC complex |
| REAC:R-HSA-5693565 | 2.96543875946e-09 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 3.17119379763e-09 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA Double Strand Break Response |
| GO:0031572 | 3.96312010577e-09 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | G2 DNA damage checkpoint |
| REAC:R-HSA-5688426 | 5.03116420316e-09 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | Deubiquitination |
| REAC:R-HSA-69473 | 8.80177087213e-09 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 1.03321715655e-08 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Processing of DNA double-strand break ends |
| REAC:R-HSA-5693567 | 4.58062236292e-08 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 5.75788970652e-08 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Homology Directed Repair |
| GO:0031593 | 7.52182719667e-08 | 0.833333333333 | BRCC3 ABRAXAS2 ABRAXAS1 UIMC1 BABAM2 | polyubiquitin modification-dependent protein binding |
| REAC:R-HSA-5693532 | 1.4847948255e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 1.62719833986e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | G2/M Checkpoints |
| GO:0045739 | 2.91493398728e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | positive regulation of DNA repair |
| GO:0072422 | 5.50411833103e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | signal transduction involved in DNA damage checkpoint |
| GO:0072401 | 5.50411833103e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | signal transduction involved in DNA integrity checkpoint |
| GO:0072395 | 5.92717909488e-07 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | signal transduction involved in cell cycle checkpoint |
| GO:0016579 | 9.32277453109e-07 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | protein deubiquitination |
| GO:0070646 | 1.3678729472e-06 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | protein modification by small protein removal |
| GO:0006303 | 1.42085593304e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | double-strand break repair via nonhomologous end joining |
| GO:0010212 | 1.70400695485e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | response to ionizing radiation |
| GO:2001022 | 2.03057391679e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | positive regulation of response to DNA damage stimulus |
| GO:0000726 | 2.27476470409e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | non-recombinational repair |
| REAC:R-HSA-69620 | 2.48510366679e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Cell Cycle Checkpoints |
| GO:1902750 | 2.83352183919e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | negative regulation of cell cycle G2/M phase transition |
| REAC:R-HSA-73894 | 4.35751112638e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA Repair |
| GO:0006282 | 5.98038175538e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of DNA repair |
| GO:0042770 | 8.18370793251e-06 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | signal transduction in response to DNA damage |
| GO:0000077 | 1.29143311486e-05 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA damage checkpoint |
| GO:0140030 | 1.45244802245e-05 | 0.833333333333 | BRCC3 ABRAXAS2 ABRAXAS1 UIMC1 BABAM2 | modification-dependent protein binding |
| GO:0031570 | 2.03396545633e-05 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA integrity checkpoint |
| GO:0051054 | 3.08409640217e-05 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | positive regulation of DNA metabolic process |
| CORUM:2786 | 5.0322056017e-05 | 0.333333333333 | ABRAXAS1 UIMC1 | BRCA1 A complex |
| REAC:R-HSA-597592 | 5.91578058515e-05 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | Post-translational protein modification |
| GO:2001020 | 7.45168011252e-05 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of response to DNA damage stimulus |
| CORUM:5400 | 8.38550741504e-05 | 0.333333333333 | BABAM2 BRCC3 | BRCC complex |
| GO:0000075 | 9.2684330741e-05 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | cell cycle checkpoint |
| GO:1902749 | 0.000100344725434 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of cell cycle G2/M phase transition |
| WP:WP4016 | 0.000112911212755 | 0.5 | UIMC1 ABRAXAS1 BRCC3 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-1640170 | 0.000115024964847 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | Cell Cycle |
| GO:1901988 | 0.000161436390872 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | negative regulation of cell cycle phase transition |
| GO:0006302 | 0.000243760878037 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | double-strand break repair |
| GO:0044839 | 0.00032179200118 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | cell cycle G2/M phase transition |
| GO:0051052 | 0.000488888442832 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of DNA metabolic process |
| REAC:R-HSA-392499 | 0.000522475750064 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | Metabolism of proteins |
| GO:0009314 | 0.000557840663852 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | response to radiation |
| GO:0010948 | 0.000744794151254 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | negative regulation of cell cycle process |
| GO:0070647 | 0.00129013354015 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | protein modification by small protein conjugation or removal |
| GO:1901987 | 0.00281949539639 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of cell cycle phase transition |
| GO:0006281 | 0.00761654730624 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | DNA repair |
| GO:0022402 | 0.00779587445301 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | cell cycle process |
| GO:0045786 | 0.0113691393447 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | negative regulation of cell cycle |
| GO:0044770 | 0.0121980983176 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | cell cycle phase transition |
| GO:0006508 | 0.0156078159661 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | proteolysis |
| GO:0070537 | 0.020283420769 | 0.333333333333 | BRCC3 UIMC1 | histone H2A K63-linked deubiquitination |
| GO:0007049 | 0.0218766736595 | 1.0 | ABRAXAS2 BABAM2 ABRAXAS1 BABAM1 BRCC3 UIMC1 | cell cycle |
| GO:0080135 | 0.0224419840427 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of cellular response to stress |
| GO:0010564 | 0.0315574423951 | 0.833333333333 | BABAM1 BABAM2 ABRAXAS1 UIMC1 BRCC3 | regulation of cell cycle process |
| CORUM:7114 | 0.0499726005494 | 0.166666666667 | ABRAXAS2 | ABRAXAS2-SHMT2 complex |
| CORUM:7113 | 0.0499726005494 | 0.166666666667 | ABRAXAS2 | ABRAXAS2-SHMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BABAM1 | BABAM2 | 1.0 | 0.949 | hein_WMM bioplex (BABAM1) bioplex_WMM boldt youn_WMM Malo fraction boldt_WMM |
| BABAM1 | ABRAXAS1 | 0.998 | 0.939 | bioplex (BABAM1) bioplex_WMM |
| BABAM1 | BRCC3 | 0.996 | 0.926 | hein_WMM bioplex (BABAM1) bioplex_WMM boldt youn_WMM boldt_WMM |
| BABAM1 | ABRAXAS2 | 0.976 | 0.892 | bioplex (BABAM1) bioplex_WMM boldt fraction boldt_WMM |
| BABAM1 | UIMC1 | 0.973 | 0.886 | bioplex (BABAM1) bioplex_WMM youn_WMM |
| ABRAXAS2 | BRCC3 | 0.681 | 0.708 | bioplex (ABRAXAS2) bioplex_WMM boldt gupta_WMM boldt_WMM |
| BRCC3 | BABAM2 | 0.016 | 0.165 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ABRAXAS1 | UIMC1 | 0.008 | 0.082 | bioplex_WMM WMM_only |
| BABAM2 | UIMC1 | 0.008 | 0.081 | bioplex_WMM youn_WMM WMM_only |
| ABRAXAS1 | BABAM2 | 0.008 | 0.011 | bioplex_WMM WMM_only |
| BRCC3 | UIMC1 | 0.008 | 0.027 | bioplex_WMM youn_WMM WMM_only |
| ABRAXAS1 | ABRAXAS2 | 0.007 | 0.013 | bioplex_WMM WMM_only |
| ABRAXAS2 | UIMC1 | 0.007 | 0.008 | bioplex_WMM WMM_only |
| ABRAXAS2 | BABAM2 | 0.003 | 0.012 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| ABRAXAS1 | BRCC3 | 0.0 | 0.01 | bioplex (ABRAXAS1) bioplex_WMM |
Images
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Complex HuMAP2_04891 has an average edge precision of 0.381 which is ranked 3519 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ABRAXAS1 | HuMAP2_02106 HuMAP2_03499 HuMAP2_04891 |
| BABAM1 | HuMAP2_02106 HuMAP2_03499 HuMAP2_04873 HuMAP2_04891 |
| ABRAXAS2 | HuMAP2_03499 HuMAP2_04891 |
| BRCC3 | HuMAP2_03499 HuMAP2_04891 |
| BABAM2 | HuMAP2_03499 HuMAP2_04873 HuMAP2_04891 |
| UIMC1 | HuMAP2_03499 HuMAP2_04891 HuMAP2_06842 |