hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04892
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NDUFAF4 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (Hormone-regulated proliferation-associated protein of 20 kDa) | UniProt NCBI |
| NDUFAF1 | Complex I intermediate-associated protein 30, mitochondrial (NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 1) | UniProt NCBI |
| NDUFC2 | NADH dehydrogenase [ubiquinone] 1 subunit C2 (Complex I-B14.5b) (CI-B14.5b) (Human lung cancer oncogene 1 protein) (HLC-1) (NADH-ubiquinone oxidoreductase subunit B14.5b) | UniProt NCBI |
| TMEM126B | Complex I assembly factor TMEM126B, mitochondrial (Transmembrane protein 126B) | UniProt NCBI |
| ECSIT | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC) | UniProt NCBI |
| ACAD9 | Acyl-CoA dehydrogenase family member 9, mitochondrial (ACAD-9) (EC 1.3.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4324 | 6.26340777732e-14 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | Mitochondrial complex I assembly model OXPHOS system |
| REAC:R-HSA-6799198 | 2.20352613855e-13 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | Complex I biogenesis |
| REAC:R-HSA-611105 | 8.81276206977e-12 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | Respiratory electron transport |
| REAC:R-HSA-163200 | 3.21158656886e-11 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| GO:0010257 | 1.83300360778e-10 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | NADH dehydrogenase complex assembly |
| GO:0032981 | 1.83300360778e-10 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial respiratory chain complex I assembly |
| REAC:R-HSA-1428517 | 2.76704216455e-10 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0033108 | 2.05537544719e-09 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial respiratory chain complex assembly |
| HP:0011923 | 2.12183364255e-07 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Decreased activity of mitochondrial complex I |
| HP:0008972 | 2.10884864935e-06 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 2.25404354073e-06 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal activity of mitochondrial respiratory chain |
| GO:0005743 | 9.41166912664e-06 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial inner membrane |
| GO:0019866 | 1.50473516239e-05 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | organelle inner membrane |
| CORUM:2942 | 2.51655344529e-05 | 0.333333333333 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, NDUFS3, NDUFAF1) |
| GO:0007005 | 2.64507899301e-05 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrion organization |
| HP:0003287 | 3.18888121689e-05 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormality of mitochondrial metabolism |
| GO:0031966 | 6.07883504192e-05 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial membrane |
| HP:0012103 | 6.50332428373e-05 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormality of the mitochondrion |
| HP:0003128 | 8.10896824872e-05 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Lactic acidosis |
| HP:0012748 | 8.1604724041e-05 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Focal T2 hyperintense brainstem lesion |
| CORUM:2936 | 8.38550741504e-05 | 0.333333333333 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, MT-CO2, GAPDH, TRAF6, NDUFAF1) |
| GO:0005740 | 9.01236094939e-05 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial envelope |
| HP:0008316 | 9.03344198146e-05 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.000120203751216 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal brainstem MRI signal intensity |
| CORUM:2939 | 0.000125760085813 | 0.333333333333 | ECSIT NDUFAF1 | Ecsit complex (ECSIT, MT-CO2, NDUFA1, MT-ND1, TRAF6, NDUFAF1) |
| HP:0007704 | 0.000131452960702 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Paroxysmal involuntary eye movements |
| HP:0025116 | 0.000131452960702 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Fetal distress |
| HP:0001943 | 0.000143895251076 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Hypoglycemia |
| HP:0000114 | 0.00015600923299 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Proximal tubulopathy |
| HP:0011015 | 0.000196658016002 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal blood glucose concentration |
| HP:0003542 | 0.000198284628693 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Increased serum pyruvate |
| HP:0004366 | 0.000198284628693 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormality of glycolysis |
| HP:0011013 | 0.000304375323156 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal circulating carbohydrate concentration |
| HP:0001298 | 0.000350498256174 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Encephalopathy |
| HP:0001639 | 0.000363675748405 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Hypertrophic cardiomyopathy |
| HP:0003737 | 0.000442726382359 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Mitochondrial myopathy |
| HP:0001138 | 0.000442726382359 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Optic neuropathy |
| REAC:R-HSA-1430728 | 0.000652155399247 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | Metabolism |
| HP:0000817 | 0.00079420087652 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Poor eye contact |
| HP:0003800 | 0.000873314294634 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Muscle abnormality related to mitochondrial dysfunction |
| HP:0001941 | 0.00106154285913 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Acidosis |
| GO:0044429 | 0.00111031461365 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrial part |
| HP:0002490 | 0.00124200653741 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Increased CSF lactate |
| HP:0030085 | 0.00124200653741 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal CSF lactate level |
| GO:0031967 | 0.00138876075568 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | organelle envelope |
| GO:0031975 | 0.00138876075568 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | envelope |
| HP:0004360 | 0.00150361987026 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormality of acid-base homeostasis |
| GO:0034622 | 0.00167500343618 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | cellular protein-containing complex assembly |
| HP:0000124 | 0.00176606420523 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Renal tubular dysfunction |
| HP:0000735 | 0.00183201380014 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Impaired social interactions |
| HP:0025454 | 0.00211215101544 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal CSF metabolite level |
| KEGG:04714 | 0.00244472448991 | 0.5 | NDUFC2 NDUFAF4 NDUFAF1 | Thermogenesis |
| HP:0002415 | 0.00266824580105 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Leukodystrophy |
| HP:0000543 | 0.00341367027294 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Optic disc pallor |
| HP:0001638 | 0.00413322926791 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Cardiomyopathy |
| HP:0011017 | 0.00417431131054 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal cellular physiology |
| HP:0025354 | 0.00460204819931 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal cellular phenotype |
| HP:0001637 | 0.00501415242466 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal myocardium morphology |
| HP:0012433 | 0.00614519903403 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal social behavior |
| HP:0011014 | 0.00706351662251 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal glucose homeostasis |
| HP:0001254 | 0.00758494304221 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Lethargy |
| HP:0002421 | 0.00758494304221 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Poor head control |
| HPA:048040_02 | 0.00817145519848 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | soft tissue 2; peripheral nerve[Uncertain,Medium] |
| HP:0002352 | 0.0088473929681 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Leukoencephalopathy |
| HP:0002363 | 0.0102416371513 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormality of brainstem morphology |
| HP:0002151 | 0.0104519436081 | 0.5 | NDUFAF1 TMEM126B ACAD9 | Increased serum lactate |
| GO:0005739 | 0.0118519643143 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | mitochondrion |
| HP:0011400 | 0.0194106697136 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Abnormal CNS myelination |
| HP:0002013 | 0.0213861967068 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Vomiting |
| HPA:029010_03 | 0.026065179374 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | nasopharynx; respiratory epithelial cells[Uncertain,High] |
| HPA:035020_03 | 0.0276474923479 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | placenta; trophoblastic cells[Uncertain,High] |
| HP:0410042 | 0.0277519282935 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Abnormal liver morphology |
| GO:0065003 | 0.0297226505367 | 1.0 | ACAD9 NDUFAF1 ECSIT NDUFAF4 NDUFC2 TMEM126B | protein-containing complex assembly |
| HP:0000618 | 0.035118668508 | 0.5 | NDUFAF1 NDUFAF4 TMEM126B | Blindness |
| HPA:051010_03 | 0.0391528013173 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | stomach 1; glandular cells[Uncertain,High] |
| HP:0001508 | 0.0410662348168 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Failure to thrive |
| HP:0001324 | 0.0455085239677 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | Muscle weakness |
| HPA:011020_03 | 0.0470731845757 | 0.666666666667 | NDUFAF1 NDUFAF4 TMEM126B ACAD9 | colon; glandular cells[Uncertain,High] |
| CORUM:2943 | 0.0499726005494 | 0.166666666667 | NDUFAF1 | Respiratory chain complex I (incomplete NDUFAF1 assembly), mitochondrial |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ACAD9 | ECSIT | 1.0 | 0.949 | bioplex (ACAD9,ECSIT) bioplex_WMM boldt youn_WMM boldt_WMM |
| ECSIT | NDUFAF1 | 0.999 | 0.949 | bioplex (ECSIT) bioplex_WMM youn_WMM |
| ACAD9 | NDUFAF1 | 0.806 | 0.767 | bioplex (ACAD9) bioplex_WMM youn_WMM |
| ECSIT | NDUFC2 | 0.194 | 0.446 | bioplex (ECSIT) bioplex_WMM |
| ECSIT | TMEM126B | 0.192 | 0.446 | bioplex (ECSIT) bioplex_WMM |
| ECSIT | NDUFAF4 | 0.044 | 0.279 | bioplex (ECSIT) bioplex_WMM youn_WMM |
| ACAD9 | NDUFC2 | 0.011 | 0.144 | bioplex (ACAD9) bioplex_WMM |
| ACAD9 | NDUFAF4 | 0.01 | 0.12 | bioplex (ACAD9) bioplex_WMM youn_WMM |
| NDUFC2 | NDUFAF1 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| NDUFC2 | NDUFAF4 | 0.006 | 0.004 | bioplex_WMM WMM_only |
| NDUFAF1 | NDUFAF4 | 0.006 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| NDUFC2 | TMEM126B | 0.003 | 0.013 | bioplex (TMEM126B) bioplex_WMM |
| TMEM126B | NDUFAF4 | 0.0 | 0.012 | bioplex (TMEM126B) bioplex_WMM |
| ACAD9 | TMEM126B | 0.0 | 0.004 | bioplex (ACAD9,TMEM126B) bioplex_WMM |
| NDUFAF1 | TMEM126B | 0.0 | 0.001 | bioplex (TMEM126B) bioplex_WMM |
Images
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Complex HuMAP2_04892 has an average edge precision of 0.283 which is ranked 4840 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NDUFAF4 | HuMAP2_00408 HuMAP2_01573 HuMAP2_03703 HuMAP2_04606 HuMAP2_04892 HuMAP2_05273 |
| NDUFAF1 | HuMAP2_00306 HuMAP2_02635 HuMAP2_04089 HuMAP2_04892 |
| NDUFC2 | HuMAP2_00306 HuMAP2_04089 HuMAP2_04583 HuMAP2_04892 |
| TMEM126B | HuMAP2_00306 HuMAP2_01439 HuMAP2_04892 HuMAP2_06446 |
| ECSIT | HuMAP2_00306 HuMAP2_02635 HuMAP2_04089 HuMAP2_04583 HuMAP2_04892 |
| ACAD9 | HuMAP2_00106 HuMAP2_00306 HuMAP2_02635 HuMAP2_04892 HuMAP2_05964 |