hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_04908
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SLC25A3 | Phosphate carrier protein, mitochondrial (Phosphate transport protein) (PTP) (Solute carrier family 25 member 3) | UniProt NCBI |
| PHB2 | Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) | UniProt NCBI |
| SLC25A6 | ADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed] | UniProt NCBI |
| SLC25A5 | ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5) [Cleaved into: ADP/ATP translocase 2, N-terminally processed] | UniProt NCBI |
| SLC25A4 | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4) | UniProt NCBI |
| PHB | Prohibitin | UniProt NCBI |
| VDAC2 | Voltage-dependent anion-selective channel protein 2 (VDAC-2) (hVDAC2) (Outer mitochondrial membrane protein porin 2) | UniProt NCBI |
| VDAC3 | Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6289 | 7.90426989013e-12 | 0.5 | PHB SLC25A5 PHB2 VDAC2 | prohibitin 2 complex, mitochondrial |
| REAC:R-HSA-180897 | 1.80348945294e-08 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization |
| REAC:R-HSA-8949215 | 5.34040294723e-08 | 0.5 | PHB VDAC3 PHB2 VDAC2 | Mitochondrial calcium ion transport |
| GO:0031966 | 6.38514815718e-08 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | mitochondrial membrane |
| KEGG:05012 | 1.05553925768e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Parkinson disease |
| GO:0005740 | 1.08056764447e-07 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | mitochondrial envelope |
| KEGG:04022 | 1.8636632807e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | cGMP-PKG signaling pathway |
| KEGG:04218 | 2.14627808645e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Cellular senescence |
| REAC:R-HSA-382551 | 2.33267742294e-07 | 0.875 | PHB SLC25A6 VDAC3 PHB2 SLC25A5 SLC25A4 VDAC2 | Transport of small molecules |
| KEGG:04217 | 2.72243427558e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Necroptosis |
| KEGG:04020 | 3.41580616407e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Calcium signaling pathway |
| KEGG:05016 | 5.69517547609e-07 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Huntington disease |
| KEGG:05166 | 1.0032341149e-06 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-83936 | 2.9697670258e-06 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
| GO:0044429 | 3.09096943241e-06 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | mitochondrial part |
| GO:0031975 | 4.16707823762e-06 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | envelope |
| GO:0031967 | 4.16707823762e-06 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | organelle envelope |
| GO:0005471 | 2.03382379613e-05 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | ATP:ADP antiporter activity |
| GO:0005739 | 7.28887471646e-05 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | mitochondrion |
| REAC:R-HSA-176033 | 9.76573076151e-05 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Interactions of Vpr with host cellular proteins |
| GO:0015217 | 0.000101639975642 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | ADP transmembrane transporter activity |
| REAC:R-HSA-425397 | 0.000127702698548 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Transport of vitamins, nucleosides, and related molecules |
| GO:0005743 | 0.000252926140752 | 0.75 | SLC25A6 PHB SLC25A4 PHB2 SLC25A3 SLC25A5 | mitochondrial inner membrane |
| GO:0019866 | 0.000403001091552 | 0.75 | SLC25A6 PHB SLC25A4 PHB2 SLC25A3 SLC25A5 | organelle inner membrane |
| GO:0005347 | 0.000609225680053 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | ATP transmembrane transporter activity |
| WP:WP111 | 0.000652989366127 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Electron Transport Chain (OXPHOS system in mitochondria) |
| GO:0000295 | 0.00184612317041 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | adenine nucleotide transmembrane transporter activity |
| GO:0005346 | 0.00184612317041 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | purine ribonucleotide transmembrane transporter activity |
| GO:0015216 | 0.0023070725905 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | purine nucleotide transmembrane transporter activity |
| KEGG:05164 | 0.00249578640531 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Influenza A |
| GO:0008509 | 0.00280539874974 | 0.625 | VDAC3 SLC25A4 VDAC2 SLC25A6 SLC25A5 | anion transmembrane transporter activity |
| GO:0140323 | 0.00344619549436 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | solute:anion antiporter activity |
| GO:0015301 | 0.00344619549436 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | anion:anion antiporter activity |
| GO:0015215 | 0.00490835417906 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | nucleotide transmembrane transporter activity |
| REAC:R-HSA-162909 | 0.0051670652774 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | Host Interactions of HIV factors |
| REAC:R-HSA-8949664 | 0.00535134694013 | 0.25 | PHB PHB2 | Processing of SMDT1 |
| GO:0015605 | 0.00577307926818 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | organophosphate ester transmembrane transporter activity |
| GO:0015075 | 0.0064346523694 | 0.75 | SLC25A6 SLC25A4 SLC25A3 SLC25A5 VDAC3 VDAC2 | ion transmembrane transporter activity |
| KEGG:04216 | 0.00845055478099 | 0.25 | VDAC3 VDAC2 | Ferroptosis |
| WP:WP4313 | 0.0088953208221 | 0.25 | VDAC3 VDAC2 | Ferroptosis |
| KEGG:04979 | 0.0108401162484 | 0.25 | VDAC3 VDAC2 | Cholesterol metabolism |
| GO:0015207 | 0.0126230555186 | 0.25 | SLC25A4 SLC25A5 | adenine transmembrane transporter activity |
| GO:0022857 | 0.0157114233078 | 0.75 | SLC25A6 SLC25A4 SLC25A3 SLC25A5 VDAC3 VDAC2 | transmembrane transporter activity |
| GO:0031090 | 0.0160038940184 | 1.0 | PHB SLC25A6 VDAC3 PHB2 SLC25A3 VDAC2 SLC25A4 SLC25A5 | organelle membrane |
| REAC:R-HSA-425407 | 0.0181710734818 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | SLC-mediated transmembrane transport |
| GO:1901505 | 0.0184623087477 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | carbohydrate derivative transmembrane transporter activity |
| GO:0015291 | 0.0206899822098 | 0.5 | SLC25A3 SLC25A4 SLC25A5 SLC25A6 | secondary active transmembrane transporter activity |
| GO:0015932 | 0.0301968453576 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | nucleobase-containing compound transmembrane transporter activity |
| REAC:R-HSA-162906 | 0.0311064874663 | 0.375 | SLC25A6 SLC25A5 SLC25A4 | HIV Infection |
| GO:0005215 | 0.0350656249177 | 0.75 | SLC25A6 SLC25A4 SLC25A3 SLC25A5 VDAC3 VDAC2 | transporter activity |
| GO:0007005 | 0.0487710786588 | 0.625 | PHB SLC25A4 PHB2 SLC25A6 SLC25A5 | mitochondrion organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PHB2 | PHB | 1.0 | 0.949 | hein_WMM bioplex (PHB2) bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | SLC25A4 | 0.998 | 0.937 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| SLC25A5 | VDAC2 | 0.988 | 0.901 | bioplex (SLC25A5,VDAC2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PHB | VDAC2 | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM treiber_WMM |
| SLC25A5 | PHB | 0.988 | 0.902 | hein_WMM bioplex (PHB,SLC25A5) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| SLC25A5 | PHB2 | 0.987 | 0.902 | hein_WMM bioplex (PHB2) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| SLC25A5 | SLC25A3 | 0.974 | 0.886 | hein_WMM bioplex (SLC25A5) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| PHB2 | SLC25A4 | 0.807 | 0.767 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| VDAC3 | PHB | 0.733 | 0.738 | hein_WMM bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| VDAC2 | SLC25A4 | 0.71 | 0.729 | bioplex (SLC25A4) bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| PHB | SLC25A3 | 0.665 | 0.7 | bioplex (PHB) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| VDAC3 | SLC25A4 | 0.616 | 0.675 | bioplex (VDAC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM |
| PHB2 | SLC25A6 | 0.601 | 0.671 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | SLC25A3 | 0.579 | 0.661 | bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A5 | VDAC3 | 0.549 | 0.643 | bioplex (VDAC3) bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| VDAC3 | SLC25A6 | 0.532 | 0.637 | bioplex (SLC25A6,VDAC3) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A6 | VDAC2 | 0.523 | 0.633 | bioplex (SLC25A6,VDAC2) bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM |
| PHB | SLC25A4 | 0.43 | 0.578 | bioplex (PHB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| SLC25A5 | SLC25A6 | 0.186 | 0.44 | bioplex (SLC25A5,SLC25A6) bioplex_WMM boldt boldt_WMM treiber_WMM |
| VDAC3 | PHB2 | 0.176 | 0.435 | hein_WMM bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A3 | SLC25A6 | 0.168 | 0.425 | bioplex (SLC25A6) bioplex_WMM boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| SLC25A5 | SLC25A4 | 0.157 | 0.416 | bioplex_WMM boldt fraction boldt_WMM |
| PHB | SLC25A6 | 0.143 | 0.405 | bioplex (PHB) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| PHB2 | VDAC2 | 0.114 | 0.383 | hein_WMM bioplex (PHB2,VDAC2) bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
| SLC25A6 | SLC25A4 | 0.039 | 0.266 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| VDAC3 | SLC25A3 | 0.034 | 0.263 | bioplex (VDAC3) bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM treiber_WMM |
| VDAC3 | VDAC2 | 0.022 | 0.209 | hein_WMM bioplex (VDAC3) bioplex_WMM boldt boldt_WMM treiber_WMM |
| SLC25A3 | VDAC2 | 0.004 | 0.011 | bioplex_WMM Guru boldt fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_04908 has an average edge precision of 0.609 which is ranked 1896 out of all 6965 complexes.
Related Complexes